ESMO Open最新文献

{"title":"Patient-reported outcomes with trastuzumab deruxtecan in hormone receptor-positive, HER2-low or HER2-ultralow metastatic breast cancer: results from the randomized DESTINY-Breast06 trial","authors":"X. Hu ,&nbsp;G. Curigliano ,&nbsp;K. Yonemori ,&nbsp;A. Bardia ,&nbsp;C.H. Barrios ,&nbsp;J. Sohn ,&nbsp;C. Lévy ,&nbsp;W. Jacot ,&nbsp;J. Tsurutani ,&nbsp;A. Roborel de Climens ,&nbsp;X. Wu ,&nbsp;A. Andrzejuk-Ćwik ,&nbsp;Z. Mbanya ,&nbsp;R. Dent","doi":"10.1016/j.esmoop.2025.105082","DOIUrl":"10.1016/j.esmoop.2025.105082","url":null,"abstract":"<div><h3>Background</h3><div>The randomized phase III DESTINY-Breast06 trial (NCT04494425) demonstrated superior efficacy with trastuzumab deruxtecan (T-DXd) versus chemotherapy treatment of physician’s choice (TPC) and no new safety signals in patients with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-low [immunohistochemistry (IHC) 1+, IHC 2+/<em>in situ</em> hybridization-negative], and HER2-ultralow (IHC 0 with membrane staining) metastatic breast cancer (mBC). Here, we report the patient-reported outcome (PRO) endpoints in the intent-to-treat (ITT; HER2-low/-ultralow) and HER2-low populations.</div></div><div><h3>Patients and methods</h3><div>Patients with progressive disease (PD) after one or more prior lines of endocrine-based therapy and no prior chemotherapy for mBC were assigned 1 : 1 to T-DXd 5.4 mg/kg once every 3 weeks (<em>n</em> = 436) or TPC [<em>n</em> = 430; 59.8% capecitabine; 24.4% nab-paclitaxel; and 15.8% paclitaxel]. PRO questionnaires included the European Organisation for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) and breast cancer-specific module (EORTC QLQ-BR45). Changes from baseline (CFB; earliest of 31 weeks or on-study PD) and time to deterioration were assessed.</div></div><div><h3>Results</h3><div>The median treatment duration was 11.0 (T-DXd) versus 5.6 (TPC) months. In the ITT, the mean CFB scores were similar across treatments in EORTC QLQ-C30 global health status/quality of life (QOL) and functioning scales. T-DXd was associated with less pain [adjusted mean difference −7.2, 95% confidence interval (CI) −9.9 to −4.5] and fewer skin/mucosal symptoms (adjusted mean difference −9.5, 95% CI −11.5 to −7.5), but more nausea/vomiting (adjusted mean difference 7.2, 95% CI 5.3-9.2), appetite loss (adjusted mean difference 6.8, 95% CI 3.6-10.0), and constipation (adjusted mean difference 5.5, 95% CI 2.6-8.4) versus TPC. T-DXd reduced the risk of clinically meaningful deterioration in physical/role/emotional functioning, pain, and fatigue versus TPC, but increased the risk of deterioration in gastrointestinal symptoms. Results were similar in the HER2-low population.</div></div><div><h3>Conclusions</h3><div>T-DXd preserved QOL while delaying deterioration in physical/role/emotional functioning, pain, and fatigue versus TPC, albeit with more gastrointestinal symptoms. PRO data complement the efficacy/safety of T-DXd in this population.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 5","pages":"Article 105082"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30P Novel integrated tumor micro-/macro-environment (TMME) subtypes for prediction of treatment response to neoadjuvant anti-HER2 therapy","authors":"I. Zerdes ,&nbsp;K. Wang ,&nbsp;G. Manikis ,&nbsp;D. Salgkamis ,&nbsp;Y. Zhu ,&nbsp;E. Tzoras ,&nbsp;A. Mezheyeuski ,&nbsp;B. Acs ,&nbsp;E.G. Sifakis ,&nbsp;J. Hartman ,&nbsp;A. Papakonstantinou ,&nbsp;A. Matikas ,&nbsp;J. Bergh ,&nbsp;T. Hatschek ,&nbsp;T. Foukakis","doi":"10.1016/j.esmoop.2025.104584","DOIUrl":"10.1016/j.esmoop.2025.104584","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104584"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"55P Single-nucleotide polymorphisms associated with haematological toxicities during adjuvant chemotherapy in high-risk early breast cancer patients: Results from the PANTHER phase III trial","authors":"D. Salgkamis ,&nbsp;X. Liu ,&nbsp;N. Rivera ,&nbsp;A. Papakonstantinou ,&nbsp;M. Hellström ,&nbsp;S. Agartz ,&nbsp;E.G. Sifakis ,&nbsp;I. Zerdes ,&nbsp;J. Bergh ,&nbsp;A. Matikas ,&nbsp;T. Foukakis","doi":"10.1016/j.esmoop.2025.104609","DOIUrl":"10.1016/j.esmoop.2025.104609","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104609"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"95P HHLA2, TMIGD2, and KIR3DL3 as novel immune checkpoints in breast carcinoma: An in vitro and clinicopathological study","authors":"Y.G. Montoyo-Pujol ,&nbsp;A. Llopis-Gómez ,&nbsp;D.A. Manresa-Crobalán ,&nbsp;E. Castellón-Molla ,&nbsp;J. Ponce ,&nbsp;I. Lozano Cubo ,&nbsp;H. Ballester ,&nbsp;T.A. Martín-Bayón ,&nbsp;S. Delgado-García ,&nbsp;G. Peiro-Cabrera","doi":"10.1016/j.esmoop.2025.104649","DOIUrl":"10.1016/j.esmoop.2025.104649","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104649"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"63P Predicting oncotype-dx outcomes in resource-limited settings: The role of NOLUS immunohistochemical score","authors":"A.L. Amylidi ,&nbsp;G. Douganiotis ,&nbsp;L. Kontovinis ,&nbsp;E. Markopoulou ,&nbsp;I. Natsiopoulos ,&nbsp;K. Papazisis","doi":"10.1016/j.esmoop.2025.104617","DOIUrl":"10.1016/j.esmoop.2025.104617","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104617"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"50P Peripheral absolute lymphocyte count and mortality among racially and ethnically diverse women","authors":"C.N. Thompson ,&nbsp;I. Luo ,&nbsp;M. Satoyoshi ,&nbsp;L. Schapira ,&nbsp;E. John ,&nbsp;S. Han ,&nbsp;A. Kurian","doi":"10.1016/j.esmoop.2025.104604","DOIUrl":"10.1016/j.esmoop.2025.104604","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104604"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"34P Assessing endocrine responsiveness of local and regionally recurrent ER+ breast cancer with neoadjuvant endocrine therapy","authors":"M.M. Mrdutt ,&nbsp;C.N. Day ,&nbsp;E. Donigan ,&nbsp;M.P. Goetz ,&nbsp;A. Degnim","doi":"10.1016/j.esmoop.2025.104588","DOIUrl":"10.1016/j.esmoop.2025.104588","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104588"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"79P Molecular features of metastatic breast cancer (MBC) among young adults (YA)","authors":"F. Giugliano ,&nbsp;E. Diab ,&nbsp;C. Roussel-Simonin ,&nbsp;M.F. Mosele ,&nbsp;T. Grinda ,&nbsp;A.A. Viansone ,&nbsp;C. Bousrih ,&nbsp;J.Z. Zeghondy ,&nbsp;T. Ben Ahmed ,&nbsp;A. Italiano ,&nbsp;S. Delaloge ,&nbsp;B. Pistilli ,&nbsp;F. André ,&nbsp;J.T.L. Ribeiro Mourato ,&nbsp;E. Rassy","doi":"10.1016/j.esmoop.2025.104633","DOIUrl":"10.1016/j.esmoop.2025.104633","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104633"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"80P Evaluation of prognostic nutritional index (PNI) and hemoglobin-albumin-lymphocyte-platelet (HALP) Index in breast cancer","authors":"S. Durmus ,&nbsp;B. Papila ,&nbsp;H. Uzun","doi":"10.1016/j.esmoop.2025.104634","DOIUrl":"10.1016/j.esmoop.2025.104634","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104634"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"67P Clinical outcomes and important prognostic biomarkers following dose-dense sequential adjuvant chemotherapy (dds-CT) in early breast cancer (eBC): Pooled-analysis of individual data from 5,378 patients - A Hellenic Cooperative Oncology Group study","authors":"A. Goussia,&nbsp;F-I.D. Dimitrakopoulos,&nbsp;N. Korfiatis,&nbsp;T. Koletsa,&nbsp;A. Batistatou,&nbsp;A. Charchanti,&nbsp;O. Tzaida,&nbsp;K. Petraki,&nbsp;S. Pervana,&nbsp;C. Magkou,&nbsp;F. Zagouri,&nbsp;H. Gogas,&nbsp;C. Christodoulou,&nbsp;A. Psyrri,&nbsp;E. Aravantinou Fatorou,&nbsp;N. Spathas,&nbsp;E. Fountzilas,&nbsp;D.G. Pectasides,&nbsp;G. Fountzilas,&nbsp;H.P. Kourea","doi":"10.1016/j.esmoop.2025.104621","DOIUrl":"10.1016/j.esmoop.2025.104621","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104621"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}