ESMO Open最新文献

{"title":"Clinical validation of liquid biopsy-RECIST (LB-RECIST) in metastatic colorectal cancer (mCRC) patients: findings from the PLATFORM-B study","authors":"V. Martelli ,&nbsp;J. Vidal ,&nbsp;J. Gibert ,&nbsp;M.C. Fernández-Rodríguez ,&nbsp;J. Linares ,&nbsp;P. García-Alfonso ,&nbsp;D. Páez ,&nbsp;V. Alonso ,&nbsp;M.A. Gomez-España ,&nbsp;M. Guix ,&nbsp;C. Santos ,&nbsp;G. Duran ,&nbsp;E. Élez ,&nbsp;R. Garcia-Carbonero ,&nbsp;R. Ferreiro ,&nbsp;E. Pineda ,&nbsp;J. Sastre ,&nbsp;M.T. Cano ,&nbsp;J.L. Manzano ,&nbsp;F. Losa ,&nbsp;C. Montagut","doi":"10.1016/j.esmoop.2025.105760","DOIUrl":"10.1016/j.esmoop.2025.105760","url":null,"abstract":"<div><h3>Background</h3><div>Circulating tumor DNA (ctDNA) variations predict tumor response to systemic treatment (so-called molecular response) earlier than radiological assessment. However, a standardized categorization of molecular response is an unmet clinical need. Liquid biopsy-RECIST (LB-RECIST), based on aggregate variant allele frequency (aggVAF; sum of all detected variant allele frequencies in a sample) variations, has been proposed to stratify molecular response. Metastatic colorectal cancer (mCRC) may be an attractive clinical scenario for LB-RECIST clinical implementation; however, specific data on clinical validity is still lacking.</div></div><div><h3>Patients and methods</h3><div>The prospective PLATFORM-B study enrolled 130 mCRC patients who received standard frontline treatment and underwent serial ctDNA analysis at baseline and week 8 of treatment. ctDNA was analyzed by next-generation sequencing (Oncomine Colon cfDNA Assay; Ion Torrent S5). LB-RECIST, both qualitative (changes in ctDNA detection) and quantitative (percentage variations of aggVAF), were used to categorize molecular response, and were correlated with clinical outcomes, including progression-free survival (PFS) and overall survival (OS).</div></div><div><h3>Results</h3><div>ctDNA results were available for 106 patients at baseline and 90 patients at week 8 of treatment. Single timepoint aggVAF_WEEK8 &gt;0% showed significantly worse survival outcomes compared to aggVAF_WEEK8 = 0% (PFS <em>P</em> &lt; 0.0001; OS <em>P</em> = 0.0069). Complete clearance of ctDNA at week 8 (ctDNA complete response, CCR) demonstrated the best prognostic and predictive values [median (m) OS 41.8 months; mPFS not reached (NR)], similar to persistent undetectable ctDNA (ctDNA non-measurable disease, CND; mOS 41.1 months; mPFS NR). Conversely, patients with ctDNA partial response (CPR) and ctDNA progressive disease (CPD) had the worst clinical outcomes (mOS 16.4 and 25.5 months, and mPFS 12.7 and 11.9 months, respectively).</div></div><div><h3>Conclusions</h3><div>LB-RECIST is prognostic and predictive of clinical outcomes in frontline mCRC. The clinical utility of LB-RECIST to guide early treatment decisions is warranted through interventional trials.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 9","pages":"Article 105760"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"109eP Identification of potential novel therapies of leukemia","authors":"A. Fatahian ,&nbsp;M. Krstic-Demonacos ,&nbsp;A. Aziz ,&nbsp;A. Othman ,&nbsp;M-N. Nurudeen ,&nbsp;E.Y. Bakker ,&nbsp;C. Demonacos","doi":"10.1016/j.esmoop.2025.105685","DOIUrl":"10.1016/j.esmoop.2025.105685","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105685"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"36P Next-generation sequencing in liquid biopsy for advanced NSCLC: Indian tertiary cancer centre experience","authors":"T. Pai ,&nbsp;A. Arora ,&nbsp;N. Karnik ,&nbsp;M. Gurav ,&nbsp;P. Joshi ,&nbsp;P. Gogte ,&nbsp;A. Juneja ,&nbsp;G. Deshpande ,&nbsp;R. Iyer ,&nbsp;P. Shah ,&nbsp;R.K. Kaushal ,&nbsp;O. Shetty","doi":"10.1016/j.esmoop.2025.105612","DOIUrl":"10.1016/j.esmoop.2025.105612","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105612"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"91P Investigating the mechanism of cisplatin resistance in relation to the potassium channel KCNMA1 in hexokinase-2 knockout non-small cell lung cancer (NSCLC)","authors":"M. Öztürk ,&nbsp;U. Shemsu ,&nbsp;H.N. Gürbüz ,&nbsp;Ş. Imarli ,&nbsp;S. Çimen ,&nbsp;E. Vatandaslar ,&nbsp;C. Özgül ,&nbsp;Y. Yozgat Byrne","doi":"10.1016/j.esmoop.2025.105667","DOIUrl":"10.1016/j.esmoop.2025.105667","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105667"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"94P Therapeutic targeting of CDK2 in gynecological malignancies","authors":"M. Cubells-Quiñonero,&nbsp;I. García-Cao,&nbsp;G.C. Bonel-Pérez,&nbsp;E. Aliagas,&nbsp;M. Malumbres","doi":"10.1016/j.esmoop.2025.105670","DOIUrl":"10.1016/j.esmoop.2025.105670","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105670"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"99P Targeting matrix metalloproteinases: Gallic acid and NSC405020 suppress papillary thyroid carcinoma cell migration and invasion","authors":"D. Rocco ,&nbsp;M. Vitale","doi":"10.1016/j.esmoop.2025.105675","DOIUrl":"10.1016/j.esmoop.2025.105675","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105675"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"44P Signal-adjusted ctDNA methylation profiling captures epigenetic dynamics of treatment resistance in metastatic colorectal cancer","authors":"D.G. Camblor ,&nbsp;F. Gimeno-Valiente ,&nbsp;J. Martin-Arana ,&nbsp;B. García-Mico ,&nbsp;B. Martínez-Castedo ,&nbsp;F. Martínez-Picó ,&nbsp;C.M. Bravo ,&nbsp;V. Segui-Manzaneque ,&nbsp;M. Bartolomé ,&nbsp;B. de Lucas ,&nbsp;C. Martinez Ciarpaglini ,&nbsp;A. Cervantes ,&nbsp;N. Tarazona Llavero","doi":"10.1016/j.esmoop.2025.105620","DOIUrl":"10.1016/j.esmoop.2025.105620","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105620"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"56P Detection of cytokines in cervical mucus has the potential to improve prevention of cervical intraepithelial neoplasia and invasive development in a manner never observed before","authors":"A.N. Riger ,&nbsp;M. Attila ,&nbsp;N. Kharchenko ,&nbsp;A. Kaprin","doi":"10.1016/j.esmoop.2025.105631","DOIUrl":"10.1016/j.esmoop.2025.105631","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105631"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"62P Prognostic plasma proteome-based nomogram in metastatic castrate-resistant prostate cancer (mCRPC)","authors":"M. Kohli ,&nbsp;L. Wang ,&nbsp;C. Hanson ,&nbsp;R. Gutowski ,&nbsp;J. Finklestein ,&nbsp;B. Schmidt ,&nbsp;B.L. Maughan ,&nbsp;U. Swami ,&nbsp;S. Gupta ,&nbsp;J. Tward ,&nbsp;S. Johnson ,&nbsp;B. Oneil ,&nbsp;C. Dechet ,&nbsp;A.C. Tan ,&nbsp;Z. Wilmot","doi":"10.1016/j.esmoop.2025.105637","DOIUrl":"10.1016/j.esmoop.2025.105637","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105637"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"UNICANCER Society Profile","authors":"","doi":"10.1016/S2059-7029(25)01691-6","DOIUrl":"10.1016/S2059-7029(25)01691-6","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105822"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}