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29P BRCA1 reversion mutations confer a fitness benefit to PARP inhibitor-resistant subclones in high grade serous ovarian cancer models
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104187
M.A. Khan , A. Hall , M. Guscott , N. Bakali , S. McClelland , T. Graham , M. Lockley
{"title":"29P BRCA1 reversion mutations confer a fitness benefit to PARP inhibitor-resistant subclones in high grade serous ovarian cancer models","authors":"M.A. Khan , A. Hall , M. Guscott , N. Bakali , S. McClelland , T. Graham , M. Lockley","doi":"10.1016/j.esmoop.2025.104187","DOIUrl":"10.1016/j.esmoop.2025.104187","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104187"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
31P Impact of HOXD10 and epigenetic silencing by HDACi on oral cancer progression
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104189
D.S. Basavarajappa , U.S. Shenoy , S. Chakrabarty , R. Radhakrishna
{"title":"31P Impact of HOXD10 and epigenetic silencing by HDACi on oral cancer progression","authors":"D.S. Basavarajappa , U.S. Shenoy , S. Chakrabarty , R. Radhakrishna","doi":"10.1016/j.esmoop.2025.104189","DOIUrl":"10.1016/j.esmoop.2025.104189","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104189"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
59P Efficacy of immune checkpoint inhibitors in BCG-unresponsive non-muscle invasive bladder cancer: A systematic review and meta-analysis
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104218
I.A. Qutob , M.R. Murad , G. Ramzi Jabrieh , Z. Belabaci , A.S. Albarbary , T.E. Ghanm , E.M. Jasim , A. Soliman
{"title":"59P Efficacy of immune checkpoint inhibitors in BCG-unresponsive non-muscle invasive bladder cancer: A systematic review and meta-analysis","authors":"I.A. Qutob , M.R. Murad , G. Ramzi Jabrieh , Z. Belabaci , A.S. Albarbary , T.E. Ghanm , E.M. Jasim , A. Soliman","doi":"10.1016/j.esmoop.2025.104218","DOIUrl":"10.1016/j.esmoop.2025.104218","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104218"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143548351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
7O Trastuzumab deruxtecan (T-DXd) ± pertuzumab (P) in previously untreated HER2+ metastatic breast cancer (mBC): Clinical efficacy and exploratory subgroup analyses in DESTINY-Breast07
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104163
F. André , G. Fabbri , R. McEwen , T. Vaclova , S. Boston , A. Konpa , E.P. Hamilton , S. Loi , C. Anders , P. Schmid , R. Kim , M. Markowska , P. Herbolsheimer , K. Jhaveri
{"title":"7O Trastuzumab deruxtecan (T-DXd) ± pertuzumab (P) in previously untreated HER2+ metastatic breast cancer (mBC): Clinical efficacy and exploratory subgroup analyses in DESTINY-Breast07","authors":"F. André , G. Fabbri , R. McEwen , T. Vaclova , S. Boston , A. Konpa , E.P. Hamilton , S. Loi , C. Anders , P. Schmid , R. Kim , M. Markowska , P. Herbolsheimer , K. Jhaveri","doi":"10.1016/j.esmoop.2025.104163","DOIUrl":"10.1016/j.esmoop.2025.104163","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104163"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
46P Targeting transforming growth factor beta (TGF-β) using pirfenidone: A potential repurposing therapeutic strategy in colorectal cancer
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104205
A. Avan
{"title":"46P Targeting transforming growth factor beta (TGF-β) using pirfenidone: A potential repurposing therapeutic strategy in colorectal cancer","authors":"A. Avan","doi":"10.1016/j.esmoop.2025.104205","DOIUrl":"10.1016/j.esmoop.2025.104205","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104205"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
13P B cell TuLibs: Immortalized tumor-derived B cell libraries allowing for the interrogation and unbiased discovery of novel therapeutic targets and antibodies from patients
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104169
C. Marsman
{"title":"13P B cell TuLibs: Immortalized tumor-derived B cell libraries allowing for the interrogation and unbiased discovery of novel therapeutic targets and antibodies from patients","authors":"C. Marsman","doi":"10.1016/j.esmoop.2025.104169","DOIUrl":"10.1016/j.esmoop.2025.104169","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104169"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
94P Impact of online education on improving physicians’ knowledge and confidence in implementing precision oncology in practice
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104254
Z. Fiske , K. Peters , S. Dunn , A. Carothers , J. Habib , A. Schram , F. Lopez-Rios
{"title":"94P Impact of online education on improving physicians’ knowledge and confidence in implementing precision oncology in practice","authors":"Z. Fiske , K. Peters , S. Dunn , A. Carothers , J. Habib , A. Schram , F. Lopez-Rios","doi":"10.1016/j.esmoop.2025.104254","DOIUrl":"10.1016/j.esmoop.2025.104254","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104254"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
87P Are we doing enough to enhance inclusion in novel therapies for neuro-oncology? An analysis of ongoing phase I trials
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104247
A. Di Muzio , D.A. Gomez Puerto , O. Mirallas , A. Hernando Calvo , V. Galvao Aguiar , M.J. Lostes Bardaji , A. Oberoi , G. Alonso Casal , S. Herbera , J. Garre , I. Braña , E. Garralda , M. Vieito
{"title":"87P Are we doing enough to enhance inclusion in novel therapies for neuro-oncology? An analysis of ongoing phase I trials","authors":"A. Di Muzio , D.A. Gomez Puerto , O. Mirallas , A. Hernando Calvo , V. Galvao Aguiar , M.J. Lostes Bardaji , A. Oberoi , G. Alonso Casal , S. Herbera , J. Garre , I. Braña , E. Garralda , M. Vieito","doi":"10.1016/j.esmoop.2025.104247","DOIUrl":"10.1016/j.esmoop.2025.104247","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104247"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
33P LncRNAs as regulators of the PI3K/AKT/mTOR pathway in resistant gastric cancer: A novel strategy to enhance the response to chemotherapy
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104191
I. Riquelme , B. Mora , V. Fritz , S.R. Piccolo , P.E. Yanez Weber , J.C. Roa , C. Ili , P. Brebi
{"title":"33P LncRNAs as regulators of the PI3K/AKT/mTOR pathway in resistant gastric cancer: A novel strategy to enhance the response to chemotherapy","authors":"I. Riquelme , B. Mora , V. Fritz , S.R. Piccolo , P.E. Yanez Weber , J.C. Roa , C. Ili , P. Brebi","doi":"10.1016/j.esmoop.2025.104191","DOIUrl":"10.1016/j.esmoop.2025.104191","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104191"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
37P Mutations in ARFGEF3: A driver for breast to brain metastasis
IF 7.1 2区 医学
ESMO Open Pub Date : 2025-03-01 DOI: 10.1016/j.esmoop.2025.104195
A. Budhiraja
{"title":"37P Mutations in ARFGEF3: A driver for breast to brain metastasis","authors":"A. Budhiraja","doi":"10.1016/j.esmoop.2025.104195","DOIUrl":"10.1016/j.esmoop.2025.104195","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104195"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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