ESMO Open最新文献

{"title":"80P A systemically administered innate immune modulator displays potent anti-tumor activity against metastatic osteosarcoma","authors":"A. Nabeshima , R. Oyama , M. Endo , C. Phelip , I. Fajnorova , K. Chettab , A. Novikov , C. Dumontet , A. Dutour , M. Caroff , J. Kerzerho","doi":"10.1016/j.esmoop.2025.104394","DOIUrl":"10.1016/j.esmoop.2025.104394","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104394"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"30P Clinical-pathological characterization of myoepithelial epithelial carcinoma of the salivary gland and investigation of new genes of interest in the tumor: A pilot study","authors":"M.S. França","doi":"10.1016/j.esmoop.2025.104340","DOIUrl":"10.1016/j.esmoop.2025.104340","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104340"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrated clinico-molecular analysis of gastric cancer in European and Latin American populations: LEGACY project","authors":"R. Dienstmann ,&nbsp;E. Ruiz-García ,&nbsp;M. Alsina ,&nbsp;F. Ruiz-Pace ,&nbsp;T.S. Groen-van Schooten ,&nbsp;C. Martínez-Ciarpaglini ,&nbsp;E.A. Fernández-Figueroa ,&nbsp;R. Herrera-Goepfert ,&nbsp;C. Díaz-Romero ,&nbsp;L. Lino-Silva ,&nbsp;A.I. Hernandez-Guerrero ,&nbsp;N.M. Valdez-Reyes ,&nbsp;A. León-Takahashi ,&nbsp;J.C. Falcón-Martínez ,&nbsp;R.E. Pouw ,&nbsp;S. Romero ,&nbsp;R. Villagrasa ,&nbsp;M. Cabeza-Segura ,&nbsp;L. Alarcón-Molero ,&nbsp;E. Jimenez-Martí ,&nbsp;T. Fleitas","doi":"10.1016/j.esmoop.2025.104482","DOIUrl":"10.1016/j.esmoop.2025.104482","url":null,"abstract":"<div><h3>Background</h3><div>Gastric cancer (GC) is recognized for intrinsic heterogeneity, although it is similarly approached in Europe and Latin America (LATAM). The LEGACY project aimed to deepen GC molecular understanding through multi-omics analysis in Europe and LATAM GC samples.</div></div><div><h3>Patients and methods</h3><div>Tumor samples were centrally reviewed for histology, human epidermal growth factor receptor 2 (HER2) expression, and mismatch repair-deficient (dMMR)/microsatellite instability (MSI) status. In addition, we assessed Epstein–Barr virus (EBV) status, programmed death-ligand 1 (PD-L1) combined positive score (CPS), and carried out tissue genomic profiling including tumor mutation burden (TMB) quantification plus targeted transcriptomics for immune microenvironment and cancer cell signaling scores.</div></div><div><h3>Results</h3><div>In total, 328 GC patients were enrolled. HER2-positive GC and high PD-L1 CPS were more frequent in Europe than in LATAM (9% versus 3% and 15% versus 3%, respectively), whereas EBV was mainly found in LATAM (7%, versus 3% in Europe), and dMMR/MSI tumors were equally distributed (16%). High TMB was enriched in dMMR/MSI and EBV tumors. Mutations in homologous recombination repair (HRR) genes were frequent in both cohorts (24.8% and 14.7% in Europe and LATAM, respectively), and mostly found in dMMR/MSI (63.6%) and intestinal HER2-negative (18.7%) tumors. The prognosis was poor in diffuse HER2-negative GC patients, whose tumors presented an immunosuppressive microenvironment and other distinct pathway activation signatures.</div></div><div><h3>Conclusions</h3><div>Our findings relate specific molecular alterations of GC tumors from Europe and LATAM to actionable biomarkers for precision cancer therapies. The proposed GC stratification can be implemented in routine care and guide drug development strategies.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 3","pages":"Article 104482"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143534907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"51P External validation of Rachel score: A prognostic tool for lung neuroendocrine tumors","authors":"A. La Salvia ,&nbsp;B. Marcozzi ,&nbsp;G. Lamberti ,&nbsp;C. Manai ,&nbsp;R. Mazzilli ,&nbsp;L. Landi ,&nbsp;M. Pallocca ,&nbsp;G. Ciliberto ,&nbsp;F. Cappuzzo ,&nbsp;D. Campana ,&nbsp;A. Faggiano","doi":"10.1016/j.esmoop.2025.104362","DOIUrl":"10.1016/j.esmoop.2025.104362","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104362"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"101P Comparative accuracy of core-needle and open biopsy in diagnosis, subtyping, and grading of head and neck bone and soft tissue sarcomas","authors":"G. Sadeghian,&nbsp;D. Sinha","doi":"10.1016/j.esmoop.2025.104414","DOIUrl":"10.1016/j.esmoop.2025.104414","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104414"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3MO Beyond the expected: Circulating tumor cells in glioblastoma reveal hidden heterogeneity and become potential diagnostic biomarkers","authors":"F. Di Lorenzo ,&nbsp;F. Lessi ,&nbsp;M. Morelli ,&nbsp;A. Di Gangi ,&nbsp;S. Franceschi ,&nbsp;M. Menicagli ,&nbsp;P. Aretini ,&nbsp;C. Gambacciani ,&nbsp;A.L. Di Stefano ,&nbsp;O.S. Santonocito ,&nbsp;C.M. Mazzanti","doi":"10.1016/j.esmoop.2025.104306","DOIUrl":"10.1016/j.esmoop.2025.104306","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104306"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143681373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"43P Immunosuppressive microenvironment can be reverted by neoadjuvant chemotherapy in TNBC","authors":"F. De Santis ,&nbsp;M. Lecchi ,&nbsp;F. Putti ,&nbsp;S. Brich ,&nbsp;A. Vingiani ,&nbsp;A. Indini ,&nbsp;A. Iacobucci ,&nbsp;G. Pruneri ,&nbsp;F.G.M. De Braud ,&nbsp;P. Verderio ,&nbsp;M. Di Nicola","doi":"10.1016/j.esmoop.2025.104202","DOIUrl":"10.1016/j.esmoop.2025.104202","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104202"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"12P A novel anti-TCR Vb targeted bispecific antibody in combination with a poly ADP ribose polymerase inhibitor (PARPi) enhances anti-tumor immune response in a prostate cancer model","authors":"G.S. Santiago-Sanchez ,&nbsp;F. Rosato ,&nbsp;M. Padget ,&nbsp;J. Schlom ,&nbsp;J. Gulley ,&nbsp;A.I. Bayliffe ,&nbsp;Z. Su ,&nbsp;J. Moisan ,&nbsp;M. Katragadda ,&nbsp;J. Hodge","doi":"10.1016/j.esmoop.2025.104168","DOIUrl":"10.1016/j.esmoop.2025.104168","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104168"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"14P Dipeptidyl peptidase 4 (DPP4) as a new senescence-associated target to eliminate cancer cells","authors":"B. Le Calvé ,&nbsp;D. Dayde ,&nbsp;V. Lelarge ,&nbsp;G. Jouffroy ,&nbsp;J. Choeur ,&nbsp;E. Angevin","doi":"10.1016/j.esmoop.2025.104170","DOIUrl":"10.1016/j.esmoop.2025.104170","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104170"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"61P Targeting ATR and PKMYT1 to overcome carboplatin resistance in triple-negative breast cancer patient-derived models","authors":"J. Guay ,&nbsp;H. Kuasne ,&nbsp;C. Chabot ,&nbsp;K. Bozek ,&nbsp;M. Buchanan ,&nbsp;A. Aguilar ,&nbsp;T. Kong ,&nbsp;C. Yang ,&nbsp;G. Morin ,&nbsp;S. Huang ,&nbsp;M. Park ,&nbsp;M. Basik","doi":"10.1016/j.esmoop.2025.104221","DOIUrl":"10.1016/j.esmoop.2025.104221","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104221"},"PeriodicalIF":7.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143552590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}