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Reply letter to comments on: Impact of age and sex on the efficacy and safety of ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line oxaliplatin-based chemotherapy: a subgroup analysis of the ARMANI phase III trial 年龄和性别对ramucirumab +紫杉醇作为切换维持与继续一线奥沙利铂化疗的有效性和安全性的影响：ARMANI III期试验的亚组分析
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105766
R. Fazio, G. Randon, F. Pietrantonio
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引用次数: 0
Response to: Re: ‘Development of a risk score based on clinical–pathological features to predict the presence of germline BRCA1/2 pathogenic variants in ovarian cancer patients’ 回复：“基于临床病理特征的风险评分的发展，以预测卵巢癌患者中生殖系BRCA1/2致病变异的存在”
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105762
G. Innella , G. Erini , A. De Leo , L. Godino , L. Caramanna , S. Ferrari , S. Miccoli , A.M. Perrone , C. Zamagni , P. De Iaco , D. Turchetti , P. Rucci
{"title":"Response to: Re: ‘Development of a risk score based on clinical–pathological features to predict the presence of germline BRCA1/2 pathogenic variants in ovarian cancer patients’","authors":"G. Innella , G. Erini , A. De Leo , L. Godino , L. Caramanna , S. Ferrari , S. Miccoli , A.M. Perrone , C. Zamagni , P. De Iaco , D. Turchetti , P. Rucci","doi":"10.1016/j.esmoop.2025.105762","DOIUrl":"10.1016/j.esmoop.2025.105762","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 9","pages":"Article 105762"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144932678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
5eP Unveiling prognostic chromosome segregation signatures in glioblastoma through integrated bioinformatics and machine learning 通过综合生物信息学和机器学习揭示胶质母细胞瘤的预后染色体分离特征
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105582
M.E. Ragab , M.Y. El-Mezayen , A.H. Alashker , B. Farouk
{"title":"5eP Unveiling prognostic chromosome segregation signatures in glioblastoma through integrated bioinformatics and machine learning","authors":"M.E. Ragab , M.Y. El-Mezayen , A.H. Alashker , B. Farouk","doi":"10.1016/j.esmoop.2025.105582","DOIUrl":"10.1016/j.esmoop.2025.105582","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105582"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
87P Establishment of a mouse hepatocellular carcinoma tumoroid panel for disease modelling and combinatorial drug discovery 87P建立小鼠肝细胞癌类肿瘤模型，用于疾病建模和联合药物开发
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105663
M. Grattarola, N. Pons, C. Sequera Hurtado, F. Maina
{"title":"87P Establishment of a mouse hepatocellular carcinoma tumoroid panel for disease modelling and combinatorial drug discovery","authors":"M. Grattarola, N. Pons, C. Sequera Hurtado, F. Maina","doi":"10.1016/j.esmoop.2025.105663","DOIUrl":"10.1016/j.esmoop.2025.105663","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105663"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
45P Phenotypic diversity of lynch syndrome and the role of NGS in its molecular characterization lynch综合征表型多样性及NGS在其分子表征中的作用
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105621
A. Stroganova , T. Lisitsa , I. Prokopev , T. Muzaffarova , D. Golovina , E. Korotkova , A. Lebedeva , S. Dranko , N. Pospekhova
{"title":"45P Phenotypic diversity of lynch syndrome and the role of NGS in its molecular characterization","authors":"A. Stroganova , T. Lisitsa , I. Prokopev , T. Muzaffarova , D. Golovina , E. Korotkova , A. Lebedeva , S. Dranko , N. Pospekhova","doi":"10.1016/j.esmoop.2025.105621","DOIUrl":"10.1016/j.esmoop.2025.105621","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105621"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
52P Transcriptomic profiling of CDKN2A/B-deleted B-ALL reveals key coding and non-coding biomarkers CDKN2A/B-deleted B-ALL的52P转录组学分析揭示了关键的编码和非编码生物标志物
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105627
G. Krishna Leons
{"title":"52P Transcriptomic profiling of CDKN2A/B-deleted B-ALL reveals key coding and non-coding biomarkers","authors":"G. Krishna Leons","doi":"10.1016/j.esmoop.2025.105627","DOIUrl":"10.1016/j.esmoop.2025.105627","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105627"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
64P Circadian inflammatory patterns during NSCLC immunotherapy: Real-world trends by time of infusion NSCLC免疫治疗期间的昼夜炎症模式：输注时间的真实世界趋势
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105639
I. Bivolarski
{"title":"64P Circadian inflammatory patterns during NSCLC immunotherapy: Real-world trends by time of infusion","authors":"I. Bivolarski","doi":"10.1016/j.esmoop.2025.105639","DOIUrl":"10.1016/j.esmoop.2025.105639","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105639"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
70eP Decoding ambiguity of variants of uncertain significance (VUS) of non-small cell lung carcinoma (NSCLC) using a comprehensive NGS panel: Landmark study from an Indian cohort 70eP解码非小细胞肺癌（NSCLC）不确定意义变异（VUS）的模糊性：来自印度队列的里程碑式研究
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105645
Y. Rohil, M. Gurav, N. Karnik, O. Shetty, R.K. Kaushal
{"title":"70eP Decoding ambiguity of variants of uncertain significance (VUS) of non-small cell lung carcinoma (NSCLC) using a comprehensive NGS panel: Landmark study from an Indian cohort","authors":"Y. Rohil, M. Gurav, N. Karnik, O. Shetty, R.K. Kaushal","doi":"10.1016/j.esmoop.2025.105645","DOIUrl":"10.1016/j.esmoop.2025.105645","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105645"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
15P Finding personalized drugs from the integration of clinical and molecular data into a semantic knowledge graph 从临床和分子数据集成到语义知识图中寻找个性化药物
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105592
M. Najm , M. Baric , T.A. Muranen , A.I. Maarala , S. Lobentanzer , J. Oikkonen , E. Carreño , F. Bolelli , V. Pipoli , V-M. Isoviita , E. Gaydukova , E. Quaglio , I. Ulusoy , J. Hynninen , B. Schwikowski , J. Dreo
{"title":"15P Finding personalized drugs from the integration of clinical and molecular data into a semantic knowledge graph","authors":"M. Najm , M. Baric , T.A. Muranen , A.I. Maarala , S. Lobentanzer , J. Oikkonen , E. Carreño , F. Bolelli , V. Pipoli , V-M. Isoviita , E. Gaydukova , E. Quaglio , I. Ulusoy , J. Hynninen , B. Schwikowski , J. Dreo","doi":"10.1016/j.esmoop.2025.105592","DOIUrl":"10.1016/j.esmoop.2025.105592","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105592"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
75eP Mutational spectrum of KRAS, TP53, BRAF, ERBB2, and POLE in GI malignancies across diverse populations 不同人群胃肠道恶性肿瘤中KRAS、TP53、BRAF、ERBB2和POLE的75eP突变谱
IF 8.3 2区 医学
ESMO Open Pub Date : 2025-09-01 DOI: 10.1016/j.esmoop.2025.105650
N.S. Ghadyalpatil , U. Disel , O. Zilola , V. Khobragade , A. Bharde , S. Degirmencioglu , A. Dirican , D. Farrukh , A. Abdelaziz , S. Sapkota , K. Ratnavelu , Y. Urun , L. Sbeih , H.V. Kothavade , J. Khandare , K. Prabhash , G. Shafi , V.P. Maniar
{"title":"75eP Mutational spectrum of KRAS, TP53, BRAF, ERBB2, and POLE in GI malignancies across diverse populations","authors":"N.S. Ghadyalpatil , U. Disel , O. Zilola , V. Khobragade , A. Bharde , S. Degirmencioglu , A. Dirican , D. Farrukh , A. Abdelaziz , S. Sapkota , K. Ratnavelu , Y. Urun , L. Sbeih , H.V. Kothavade , J. Khandare , K. Prabhash , G. Shafi , V.P. Maniar","doi":"10.1016/j.esmoop.2025.105650","DOIUrl":"10.1016/j.esmoop.2025.105650","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 105650"},"PeriodicalIF":8.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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