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13P Methylation of BRCA1 and RAD51C promoters determined by droplet digital PCR predicts homologous repair deficiency in patients with high-grade serous ovarian cancer: Results of the BOVARY-pilot study in paired FFPE and plasma samples and the ICL ovarian cohort 通过液滴数字 PCR 测定 BRCA1 和 RAD51C 启动子的 13P 甲基化可预测高级别浆液性卵巢癌患者的同源修复缺陷：在配对的 FFPE 和血浆样本中进行的 BOVARY 试点研究以及 ICL 卵巢队列的结果
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103759
C. Michel , A. Witz , I. Hanriot , J. Dardare , M. Betz , M. Rouyer , M. Husson , M. Brun , M. Lefebvre , C. Gavoille , P. Gilson , J.L. Merlin , A. Harlé
{"title":"13P Methylation of BRCA1 and RAD51C promoters determined by droplet digital PCR predicts homologous repair deficiency in patients with high-grade serous ovarian cancer: Results of the BOVARY-pilot study in paired FFPE and plasma samples and the ICL ovarian cohort","authors":"C. Michel , A. Witz , I. Hanriot , J. Dardare , M. Betz , M. Rouyer , M. Husson , M. Brun , M. Lefebvre , C. Gavoille , P. Gilson , J.L. Merlin , A. Harlé","doi":"10.1016/j.esmoop.2024.103759","DOIUrl":"10.1016/j.esmoop.2024.103759","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103759"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
21P Improving early cancer screening efficacy by adjusting tumor burden spectrum bias of liquid biopsy biomarkers 21P 通过调整液体生物标记物的肿瘤负荷谱偏差提高早期癌症筛查效率
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103767
W. Zhang
{"title":"21P Improving early cancer screening efficacy by adjusting tumor burden spectrum bias of liquid biopsy biomarkers","authors":"W. Zhang","doi":"10.1016/j.esmoop.2024.103767","DOIUrl":"10.1016/j.esmoop.2024.103767","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103767"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142525908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving therapeutic landscape of advanced biliary tract cancer: from chemotherapy to molecular targets 晚期胆道癌不断演变的治疗格局：从化疗到分子靶点。
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103706
L. Kehmann , M. Jördens , S.H. Loosen , T. Luedde , C. Roderburg , C. Leyh
{"title":"Evolving therapeutic landscape of advanced biliary tract cancer: from chemotherapy to molecular targets","authors":"L. Kehmann ,&nbsp;M. Jördens ,&nbsp;S.H. Loosen ,&nbsp;T. Luedde ,&nbsp;C. Roderburg ,&nbsp;C. Leyh","doi":"10.1016/j.esmoop.2024.103706","DOIUrl":"10.1016/j.esmoop.2024.103706","url":null,"abstract":"<div><div>Biliary tract cancer, the second most common type of liver cancer, remains a therapeutic challenge due to its late diagnosis and poor prognosis. In recent years, it has become evident that classical chemotherapy might not be the optimal treatment for patients with biliary tract cancer, especially after failure of first-line therapy. Finding new treatment options and strategies to improve the survival of these patients is therefore crucial. With the rise and increasing availability of genetic testing in patients with tumor, novel treatment approaches targeting specific genetic alterations have recently been proposed and have demonstrated their safety and efficacy in numerous clinical trials. In this review, we will first consider chemotherapy options and the new possibility of combining chemotherapy with immune checkpoint inhibitors in first-line treatment. We will then provide an overview of genomic alterations and their potential for targeted therapy especially in second-line therapy. In addition to the most common alterations such as isocitrate dehydrogenase 1 or 2 (<em>IDH</em>1/2) mutations, fibroblast growth factor receptor 2 (<em>FGFR2</em>) fusions, and alterations, we will also discuss less frequently encountered alterations such as <em>BRAF</em> V600E mutation and neurotrophic tyrosine kinase receptor gene (<em>NTRK</em>) fusion. We highlight the importance of molecular profiling in guiding therapeutic decisions and emphasize the need for continued research to optimize and expand targeted treatment strategies for this aggressive malignancy.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 10","pages":"Article 103706"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142375298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
32P Clinical evaluation cancer testis antigen 45 (CT45) expression in ovarian cancer 32P 卵巢癌中癌症睾丸抗原 45 (CT45) 表达的临床评估
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103778
H. Dubey , A. Ranjan , M. Modi
{"title":"32P Clinical evaluation cancer testis antigen 45 (CT45) expression in ovarian cancer","authors":"H. Dubey ,&nbsp;A. Ranjan ,&nbsp;M. Modi","doi":"10.1016/j.esmoop.2024.103778","DOIUrl":"10.1016/j.esmoop.2024.103778","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103778"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
25P Feasibility of digital spatial profiling as a diagnostic: Comparison to immunohistochemistry (IHC) 25P 数字空间轮廓分析作为诊断方法的可行性：与免疫组织化学（IHC）的比较
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103771
H. Hibbs, J. Gerrard, S. Hoffmann, M. Scott, M. Vandenberghe, D. Duncan
{"title":"25P Feasibility of digital spatial profiling as a diagnostic: Comparison to immunohistochemistry (IHC)","authors":"H. Hibbs,&nbsp;J. Gerrard,&nbsp;S. Hoffmann,&nbsp;M. Scott,&nbsp;M. Vandenberghe,&nbsp;D. Duncan","doi":"10.1016/j.esmoop.2024.103771","DOIUrl":"10.1016/j.esmoop.2024.103771","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103771"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
40P Patient-based models to study infiltration heterogeneity in gliomas 40P 基于患者的胶质瘤浸润异质性研究模型
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103786
Manini , I.G. Rolle , S. Mastantuono , N. Gualandi , M. Skrap , M. Vindigni , A.P. Beltrami , D. Cesselli
{"title":"40P Patient-based models to study infiltration heterogeneity in gliomas","authors":"Manini ,&nbsp;I.G. Rolle ,&nbsp;S. Mastantuono ,&nbsp;N. Gualandi ,&nbsp;M. Skrap ,&nbsp;M. Vindigni ,&nbsp;A.P. Beltrami ,&nbsp;D. Cesselli","doi":"10.1016/j.esmoop.2024.103786","DOIUrl":"10.1016/j.esmoop.2024.103786","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103786"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
42P HER2 aberration as a potential predictive biomarker for extrapulmonary small cell neuroendocrine carcinoma 42P HER2畸变作为肺外小细胞神经内分泌癌的潜在预测性生物标记物
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103788
J. Dvorak , J. Hojný , E. Krkavcova , R. Michálková , N. Hajkova , P. Dundr , K. Pavlíckova , R. Matej
{"title":"42P HER2 aberration as a potential predictive biomarker for extrapulmonary small cell neuroendocrine carcinoma","authors":"J. Dvorak ,&nbsp;J. Hojný ,&nbsp;E. Krkavcova ,&nbsp;R. Michálková ,&nbsp;N. Hajkova ,&nbsp;P. Dundr ,&nbsp;K. Pavlíckova ,&nbsp;R. Matej","doi":"10.1016/j.esmoop.2024.103788","DOIUrl":"10.1016/j.esmoop.2024.103788","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103788"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
94P Clinical utility of long read sequencing for comprehensive analysis of cancer patient genomes 94P 长读数测序在全面分析癌症患者基因组方面的临床应用
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103834
R. Howell , T. Freeman , A. Giess , M. Tanguy , G. Elgar , K. Russell , A. Younger , A.A. Sosinsky , E. McCargow , M. Hubank , C. Watson , P. Talley , S. Deans , S. Hill
{"title":"94P Clinical utility of long read sequencing for comprehensive analysis of cancer patient genomes","authors":"R. Howell ,&nbsp;T. Freeman ,&nbsp;A. Giess ,&nbsp;M. Tanguy ,&nbsp;G. Elgar ,&nbsp;K. Russell ,&nbsp;A. Younger ,&nbsp;A.A. Sosinsky ,&nbsp;E. McCargow ,&nbsp;M. Hubank ,&nbsp;C. Watson ,&nbsp;P. Talley ,&nbsp;S. Deans ,&nbsp;S. Hill","doi":"10.1016/j.esmoop.2024.103834","DOIUrl":"10.1016/j.esmoop.2024.103834","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103834"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142526029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Notice and Disclaimer 通知和免责声明
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/S2059-7029(24)01719-8
{"title":"Notice and Disclaimer","authors":"","doi":"10.1016/S2059-7029(24)01719-8","DOIUrl":"10.1016/S2059-7029(24)01719-8","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103949"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
65P Multiplex immunofluorescence analysis of LRRC15 and the TME in early-stage lung adenocarcinoma 65P 早期肺腺癌中 LRRC15 和 TME 的多重免疫荧光分析
IF 7.1 2区 医学
ESMO Open Pub Date : 2024-10-01 DOI: 10.1016/j.esmoop.2024.103809
J.Y.X. Woon, I.H. Um, D. Harrison, P. Reynolds
{"title":"65P Multiplex immunofluorescence analysis of LRRC15 and the TME in early-stage lung adenocarcinoma","authors":"J.Y.X. Woon,&nbsp;I.H. Um,&nbsp;D. Harrison,&nbsp;P. Reynolds","doi":"10.1016/j.esmoop.2024.103809","DOIUrl":"10.1016/j.esmoop.2024.103809","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"9 ","pages":"Article 103809"},"PeriodicalIF":7.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142531462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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