ESMO Open最新文献

{"title":"85P Comprehensive genomic profiling of Taiwanese triple-negative breast cancers with medium- and large-sized sequencing panels: A comparative study implicating treatment allocations","authors":"L-M. Tseng , C-C. Huang","doi":"10.1016/j.esmoop.2025.104639","DOIUrl":"10.1016/j.esmoop.2025.104639","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104639"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Durvalumab with or without tremelimumab in combination with chemotherapy in first-line metastatic non-small-cell lung cancer: outcomes by tumor mutational burden in POSEIDON","authors":"S. Peters ,&nbsp;K.S. Oliner ,&nbsp;A. L’Hernault ,&nbsp;M. Ratcliffe ,&nbsp;H. Madison ,&nbsp;Z. Lai ,&nbsp;R. Stewart ,&nbsp;H. Mann ,&nbsp;C. Lowery ,&nbsp;E.B. Garon ,&nbsp;T. Mok ,&nbsp;M.L. Johnson","doi":"10.1016/j.esmoop.2025.105058","DOIUrl":"10.1016/j.esmoop.2025.105058","url":null,"abstract":"<div><h3>Background</h3><div>In updated analyses from the phase III POSEIDON study, after a median follow-up of &gt;5 years, tremelimumab plus durvalumab and chemotherapy (T + D + CT) showed durable long-term overall survival (OS) benefit versus CT alone in first-line metastatic non-small-cell lung cancer (mNSCLC). In this article, we report the associations of tumor mutational burden (TMB) with outcomes of D with or without T in combination with CT versus CT alone.</div></div><div><h3>Patients and methods</h3><div>A total of 1013 patients with <em>EGFR/ALK</em> wild-type mNSCLC were randomized (1 : 1 : 1) to T + D + CT, D + CT, or CT, stratified by programmed cell death-ligand 1 (PD-L1) tumor cell (TC) expression ≥50% versus &lt;50%, disease stage (IVA versus IVB) and histology (squamous versus nonsquamous). Patient subgroups were defined by a range of blood TMB (bTMB) values, including at a prespecified cut-off of 20 mutations (mut)/megabase (Mb) and across further subdivisions by PD-L1 TC expression ≥1% or &lt;1% and by tissue TMB (tTMB) values.</div></div><div><h3>Results</h3><div>At the primary OS data cut-off (12 March 2021), at each bTMB or tTMB cut-off, the magnitude of OS benefit appeared greater among patients in the bTMB- or tTMB-high subgroups for the T + D + CT arm versus the CT arm but was similar between subgroups for the D + CT arm versus the CT arm. Updated OS analyses in the bTMB ≥20 and &lt;20 mut/Mb subgroups, after median follow-up of &gt;5 years (data cut-off 24 August 2023), were similar to those obtained at the primary OS data cut-off.</div></div><div><h3>Conclusions</h3><div>First-line treatment with T (limited course) plus D (until progression) and four cycles of CT consistently improved clinical outcomes versus CT alone in both bTMB-high and -low subgroups, and also in both high and low tTMB subgroups, in patients with mNSCLC. Benefit appeared greater in the TMB-high versus TMB-low subgroups; the addition of anti-cytotoxic T lymphocyte-associated antigen-4 to anti-PD-L1 and CT seemed to increase the magnitude of this difference.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 5","pages":"Article 105058"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-assistant methods improve stromal tumor-infiltrating lymphocytes (sTILs) assessment in breast cancer: results of multi-institutional ring studies","authors":"M. Zhao ,&nbsp;P. Dong ,&nbsp;Z. Li ,&nbsp;J. Li ,&nbsp;S. Wu ,&nbsp;H. Xing ,&nbsp;P. Zhang ,&nbsp;J. Zhang ,&nbsp;H. Shen ,&nbsp;H. Yang ,&nbsp;W. Yang ,&nbsp;X. Han ,&nbsp;Y. Liu","doi":"10.1016/j.esmoop.2025.105095","DOIUrl":"10.1016/j.esmoop.2025.105095","url":null,"abstract":"<div><h3>Background</h3><div>Stromal tumor-infiltrating lymphocytes (sTILs) have significant prognostic value for breast cancer patients, but its accurate assessment can be very challenging. We comprehensively studied the pitfalls faced by pathologists with different levels of professional experience, and explored clinical applicability of reference cards (RCs)- and artificial intelligence (AI)-assisted methods in assessing sTILs.</div></div><div><h3>Materials and methods</h3><div>Three rounds of ring studies (RSs) involving 12 pathologists from four hospitals were conducted. AI algorithms based on the field of view (FOV) and whole section were proposed to create RCs and to compute whole-slide image interpretations, respectively. Stromal regions identified and the associated sTIL scores by the AI method were provided to the pathologists as references. Fifty cases of surgical resections were used for interobserver concordance analysis in RS1. A total of 200 FOVs with challenge factors were assessed in RS2 for accuracy of the RC-assisted and AI-assisted methods, while 167 cases were used to validate their clinical performance in RS3.</div></div><div><h3>Results</h3><div>With the assistance of RCs, the intraclass correlation coefficient (ICC) in RS1 increased significantly to 0.834 [95% confidence interval (CI) 0.772-0.889]. The largest enhancement in ICC, from moderate (ICC: 0.592; 95% CI 0.499-0.677) to good (ICC: 0.808; 95% CI 0.746-0.857) was observed for heterogeneity. Accuracy evaluation showed significant grade improvement for heterogeneity and stromal factor FOVs among senior, intermediate, and junior groups. The ICC of heterogeneity and stromal factor analysis by the AI-assisted method achieved a level comparable to that of the senior group with RC assistance. The area under the receiver operating characteristic (ROC) curve, denoted as AUC, for AI-assisted sTIL scores in predicting pathological complete response after neoadjuvant therapy was 0.937, which was superior to visual assessment with an AUC of 0.775.</div></div><div><h3>Conclusion</h3><div>RC- and AI-assisted technology can reduce the uncertainty of interpretation caused by heterogeneous distribution.</div></div>","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 5","pages":"Article 105095"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143943577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"38P AI-enhanced genomic analyses of histological traits","authors":"A. Voigts ,&nbsp;S. Chaudhary ,&nbsp;F.P. Casale","doi":"10.1016/j.esmoop.2025.104592","DOIUrl":"10.1016/j.esmoop.2025.104592","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104592"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"87P PR inhibition stimulates G6PD expression to enhance malignancy in luminal breast cancer","authors":"J. Lee ,&nbsp;J.W. Jeong ,&nbsp;S.J. Bae ,&nbsp;Y.J. Cha ,&nbsp;S. Fang ,&nbsp;H-K. Lee ,&nbsp;S.G. Ahn","doi":"10.1016/j.esmoop.2025.104641","DOIUrl":"10.1016/j.esmoop.2025.104641","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104641"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"8P Genomic variants associated with interstitial lung disease in patients treated with trastuzumab-deruxtecan: Results from the PROCURE project","authors":"R. Sanchez Bayona ,&nbsp;J. De Nicolás ,&nbsp;C. Saura Manich ,&nbsp;M. Gion Cortes ,&nbsp;J.M. Cejalvo ,&nbsp;E. Llabres Valenti ,&nbsp;J. Cortés ,&nbsp;A. Falcon Gonzalez ,&nbsp;S. Pernas Simon ,&nbsp;A. López de Sá ,&nbsp;M.J. Vidal Losada ,&nbsp;C. Hinojo González ,&nbsp;T. Curiel ,&nbsp;J. Cruz Jurado ,&nbsp;M.J. Echarri ,&nbsp;M.I. Gallegos Sancho ,&nbsp;A. Arenas ,&nbsp;G. Villacampa ,&nbsp;E.M. Ciruelos ,&nbsp;C. Rodriguez-Antona","doi":"10.1016/j.esmoop.2025.104562","DOIUrl":"10.1016/j.esmoop.2025.104562","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104562"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"25P Comprehensive clinical and molecular characterization of triple-positive breast cancer: Refining criteria for FGFR-targeted therapy with PAM50 intrinsic subtyping","authors":"M. Braun ,&nbsp;B. Galikowska ,&nbsp;B. Tomasik ,&nbsp;D. Piasecka ,&nbsp;J. Solek ,&nbsp;A. Zielinska ,&nbsp;I. Drodz ,&nbsp;J. Kopczynski ,&nbsp;D. Nejc ,&nbsp;J. Jassem ,&nbsp;R. Kordek ,&nbsp;R. Sadej ,&nbsp;H. Romanska","doi":"10.1016/j.esmoop.2025.104579","DOIUrl":"10.1016/j.esmoop.2025.104579","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104579"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"18P Intra-tumoral T cells and subset of myeloid cells determine the response to neoadjuvant chemotherapy in triple-negative breast cancer","authors":"N. van den Ende ,&nbsp;M. Smid ,&nbsp;S.M. Wilting ,&nbsp;A.H. Nguyen ,&nbsp;F. Tutucu ,&nbsp;Z. Kain ,&nbsp;A. Jager ,&nbsp;J. Martens ,&nbsp;R. Debets ,&nbsp;C. van Deurzen","doi":"10.1016/j.esmoop.2025.104572","DOIUrl":"10.1016/j.esmoop.2025.104572","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104572"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144070449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"51P Clinico-pathological models for predicting molecular signature-based chemotherapy indications using the French HAS recommendations and the PREDICT NHS tool: Data from a French cohort","authors":"B.V. Popescu ,&nbsp;H. Bischoff ,&nbsp;L. Bender ,&nbsp;C. Hild ,&nbsp;M. Gharbi ,&nbsp;S. Guihard ,&nbsp;M-P. Chenard ,&nbsp;T. Petit ,&nbsp;X. Pivot","doi":"10.1016/j.esmoop.2025.104605","DOIUrl":"10.1016/j.esmoop.2025.104605","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104605"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"52P Dynamics of ctDNA and serum thymidine kinase activity in patients with ER+/HER2- metastatic breast cancer receiving abemaciclib vs palbociclib or ribociclib: Early results of the TIRESIAS trial","authors":"G. Anichini ,&nbsp;F. Galardi ,&nbsp;C. Biagioni ,&nbsp;M. Paoli ,&nbsp;D. Romagnoli ,&nbsp;M. Bergqvist ,&nbsp;G. Arpino ,&nbsp;M.A. Colleoni ,&nbsp;L. Gianni ,&nbsp;L. Del Mastro ,&nbsp;D. Boggiani ,&nbsp;C. Zamagni ,&nbsp;P. Poletti ,&nbsp;A. Cariello ,&nbsp;C. Guarducci ,&nbsp;I. Migliaccio ,&nbsp;E. Risi ,&nbsp;M. Benelli ,&nbsp;L. Biganzoli ,&nbsp;L. Malorni","doi":"10.1016/j.esmoop.2025.104606","DOIUrl":"10.1016/j.esmoop.2025.104606","url":null,"abstract":"","PeriodicalId":11877,"journal":{"name":"ESMO Open","volume":"10 ","pages":"Article 104606"},"PeriodicalIF":7.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}