{"title":"Insulin resistance versus dysregulation—a distinction without a difference","authors":"E. M. Kellon","doi":"10.1111/eve.14082","DOIUrl":"https://doi.org/10.1111/eve.14082","url":null,"abstract":"<p>For the last 10 years, the term ‘insulin dysregulation’ has replaced ‘insulin resistance’ when referring to horses with hyperinsulinaemia. The rationale was that this was an all-inclusive term that covered all possible causes of hyperinsulinaemia. The implication is that hyperinsulinaemia has been shown to occur outside of insulin resistance; with insulin resistance being defined as failure of the insulin-sensitive cells to respond normally to insulin, as best documented by the euglycaemic hyperinsulinaemic clamp. This article will show the evidence for that is weak to nonexistent in the horse and the term ‘insulin dysregulation’ is a misnomer that should be abandoned.</p>","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 4","pages":"210-215"},"PeriodicalIF":0.8,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eve.14082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identifying the causes of chronic unilateral nasal discharge in the horse","authors":"P. M. Dixon","doi":"10.1111/eve.14077","DOIUrl":"https://doi.org/10.1111/eve.14077","url":null,"abstract":"<div>\u0000 \u0000 <p>This article briefly reviews the causes of unilateral nasal discharge associated with sinonasal disease in the horse. While computed tomographic and radiographic imaging are often of great diagnostic value, clinical and nasal endoscopic examinations are the initial steps in investigating these disorders. This article reviews the use of oral examination and nasal endoscopy in the investigation of nasal discharge caused by sinonasal disease.</p>\u0000 </div>","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 3","pages":"117-124"},"PeriodicalIF":0.8,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143253410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Jahn, T. Novotná, R. Brumarová, D. Dobešová, L. Ottová, D. Friedecký, P. Maršálek
{"title":"Horse with myopathy caused by consumption of box elder tree seedlings in the Czech Republic","authors":"P. Jahn, T. Novotná, R. Brumarová, D. Dobešová, L. Ottová, D. Friedecký, P. Maršálek","doi":"10.1111/eve.14081","DOIUrl":"https://doi.org/10.1111/eve.14081","url":null,"abstract":"<p>An 18-year-old Saxon Warmblood gelding was referred to an equine clinic in the Czech Republic in May 2019 for mild colic. The horse had 7 h of grazing and 30–45 min of exercise every day. At the clinic, physical examination ruled out gastrointestinal disease, while clinical pathology confirmed rhabdomyolysis (creatine kinase 29,088 IU/L; reference range 110–250 IU/L). Because of the suspicion of atypical myopathy (AM), metabolomic analysis of hypoglycin A (HGA), 31 acylcarnitines (ACs) and free carnitine was performed in four dry serum and one blood spot. After laboratory confirmation of AM in the patient studied (HGA: 0.757–0.415 μmol/L, ACs elevation), an incriminated pasture was visited and searched for the source of the toxin. No sycamore (<i>Acer pseudoplatanus</i>) was found in the vicinity of the pasture. However, several box elder (<i>Acer negundo</i>) trees were found, and toxicological analysis revealed HGA in the samaras (7.66–296.00 mg/kg), leaves (2.12–9.39 mg/kg) and seedlings (339.00 mg/kg). Not only sycamore but also the box elder tree can be a potential source of poisoning in horses in Europe, particularly in lowland areas with a warm climate.</p>","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 5","pages":"e77-e84"},"PeriodicalIF":0.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/eve.14081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
O. Fletcher, J. Mackinder, R. Agass, C. Bianco, A. Ortiz, J. Dixon
{"title":"Imaging and histopathological findings of a third metacarpal aneurysmal bone cyst and pathological proximal suspensory ligament avulsion fracture","authors":"O. Fletcher, J. Mackinder, R. Agass, C. Bianco, A. Ortiz, J. Dixon","doi":"10.1111/eve.14080","DOIUrl":"https://doi.org/10.1111/eve.14080","url":null,"abstract":"<div>\u0000 \u0000 <p>A 10-year-old Quarter Horse mare presented with acute and severe lameness, persisting despite initial farriery intervention. Upon physical examination, palpation of the proximal thirds of the third and fourth metacarpal bones elicited marked pain. Radiographic evaluation revealed a well-defined radiolucency within the proximal third of the left third metacarpal bone, localised to the enthesis of the proximal suspensory ligament. Ultrasonographic findings demonstrated moderate thickening and increased vascularity of the suspensory ligament at this level. Surgical intervention was considered; however, its feasibility was constrained by the atypical nature and location of the lesion. Subsequent magnetic resonance imaging (MRI) provided a detailed characterisation of the lesion, confirming its expansile nature and the suspected associated avulsion fracture presence. Histopathological examination corroborated the diagnosis of an aneurysmal bone cyst (ABC) with an accompanying bone fracture and bone remodelling. Cases like the one described here define the importance of utilising advanced imaging techniques in combination with conventional modalities, especially when diagnosing and assessing the extent of unusual or complex lesions, to inform prognosis and guide treatment decisions. Due to the lesion's intramedullary location, expansile nature and involvement of critical anatomical structures, surgical interventions were limited which led to a recommendation for humane euthanasia.</p>\u0000 </div>","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 5","pages":"265-270"},"PeriodicalIF":0.8,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Calewaert, A. Dufourni, K. Stee, R. Hiltrop, E. Raes, G. van Loon
{"title":"Neurological dysfunction and fatal encephalitis due to Halicephalobus gingivalis in two horses in Belgium","authors":"A. Calewaert, A. Dufourni, K. Stee, R. Hiltrop, E. Raes, G. van Loon","doi":"10.1111/eve.14068","DOIUrl":"https://doi.org/10.1111/eve.14068","url":null,"abstract":"<div>\u0000 \u0000 <p>Two horses kept on different farms at a geographical distance of 150 km were presented with acute neurological dysfunction. Ante-mortem diagnostic tests including bloodwork, CT scan and cerebrospinal fluid analysis did not provide a diagnosis in either case. Due to rapid deterioration, both horses were euthanised shortly after admission. Postmortem histopathological examination revealed granulomatous meningoencephalitis with intralesional nematodes that were morphologically identified as <i>Halicephalobus gingivalis</i>. This is the first documentation of central nervous system infestation by <i>H. gingivalis</i> in horses residing in Belgium, emphasising the importance of considering aberrant parasitic migration in the differential diagnosis of acute neurological dysfunction.</p>\u0000 </div>","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 5","pages":"e92-e97"},"PeriodicalIF":0.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143749946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to letter from Dr Lane","authors":"L. M. Rubio-Martínez, C. Morelli","doi":"10.1111/eve.14069","DOIUrl":"https://doi.org/10.1111/eve.14069","url":null,"abstract":"","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 1","pages":"54-55"},"PeriodicalIF":0.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142764380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hepatic disease in the donkey","authors":"R. Sullivan","doi":"10.1111/eve.14075","DOIUrl":"https://doi.org/10.1111/eve.14075","url":null,"abstract":"","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 4","pages":"174-176"},"PeriodicalIF":0.8,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SGLT2 inhibitors: Exploring the effects in humans and horses","authors":"T. Sundra, V. Matthews, P. Harris, D. Rendle","doi":"10.1111/eve.14071","DOIUrl":"https://doi.org/10.1111/eve.14071","url":null,"abstract":"<div>\u0000 \u0000 <p>Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are human antidiabetic drugs that are increasingly used in equine practice for the management of hyperinsulinaemia and hyperinsulinaemia-associated laminitis. However, the understanding of SGLT2i use in horses is in its infancy compared to human medicine. This review article aims to briefly examine the literature in both species, highlighting current knowledge gaps, potential similarities in therapeutic outcomes and possible adverse effects.</p>\u0000 </div>","PeriodicalId":11786,"journal":{"name":"Equine Veterinary Education","volume":"37 4","pages":"216-224"},"PeriodicalIF":0.8,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}