European Journal of Clinical Microbiology & Infectious Diseases最新文献

{"title":"Risk factors for severe lower respiratory tract infection among children under 5 years of age hospitalized with respiratory syncytial virus.","authors":"Yanjun Wang, Yuanxuan Xiang, Ruohong Jin, Bin Li, Xingxing Feng, Qian Han, Xishu Deng, Yunfang Lu, Chengyan Zhang, Shufang Xiao","doi":"10.1007/s10096-025-05191-9","DOIUrl":"10.1007/s10096-025-05191-9","url":null,"abstract":"<p><p>In 2023, a resurgence of acute lower respiratory tract infections (ALRTI) linked to respiratory syncytial virus (RSV) was noted following the COVID-19 pandemic. Patients' outcomes, disease severity, and demographics all changed. This study aims to identify risk factors for severe disease and the impact of other viral co-infection on severity, which has not yet been extensively studied in China. This observational cohort study comprised cases of RSV-associated ALRTI among children younger than 5 years who were admitted to the hospital from January to December 2023. Demographic characteristics, co-infection status, and laboratory parameters were compared between severe and mild groups. Logistic regression analysis was used to identify risk factors for severe RSV-ALRTI and viral co-infection, with the corresponding 95% CI and P value. Receiver Operating Characteristic (ROC) curve was drawn to analyze the efficacy of specific risk factors. A total of 1036 cases with a median age of 16 (6, 38) months; 662 boys (63.9%) were admitted with RSV-associated ALRTI; 764 (73.7%) were younger than 3 years. The cohort suggests out-of-season epidemic of RSV. Severe disease was documented for 405 cases (39.1%), with a younger median age (10 (4, 32) and a higher proportion with a history of prematurity and low-body weight (P < 0.01). The most common co-infections were bacterial co-infection (18.9%) and co-infection with other respiratory viruses (15.5%). Age combined with neutrophil proportion, concentration of lactic dehydrogenase (LDH) and Na⁺ had predictive value for severe RSV-ALRTI (P < 0.001, AUC: 0.723, 95% CI: 0.691-0.754). Bacterial co-infection, particularly with Streptococcus pneumoniae, was identified as an independent risk factor for severe RSV-ALRTI (OR = 1.587, 95% CI: 1.054-2.389). There was no significant correlation between co-infection with other viruses and severe RSV-ALRTI. Patients with viral co-infection displayed stronger humoral immune activation (higher IgG, IgM, IgA, and C3 levels) and elevated serum IgM was an independent risk factor (OR = 2.641, 95%CI: 1.868-3.734), demonstrating predictive value for identifying co-infection subtypes. In this cohort study of younger than 5 years old children without serious underlying diseases hospitalized with RSV in 2023, severe RSV disease was more likely among infants. Prematurity, low body weight, younger age and bacterial co-infection were the main risk factors. Age combined with neutrophil proportion, concentration of LDH and Na⁺ had predictive value for severe RSV-ALRTI. Increased serum IgM had certain predictive value for other viral co-infection.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2239-2251"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mobile genetic elements of global Escherichia coli ST131 clades with carbapenemases.","authors":"Gisele Peirano, Yasufumi Matsumara, Johann D D Pitout","doi":"10.1007/s10096-025-05187-5","DOIUrl":"10.1007/s10096-025-05187-5","url":null,"abstract":"<p><strong>Introduction: </strong>Escherichia coli ST131 is an important clone linked with carbapenemases. Limited data is available about the international distribution of ST131 clades and mobile genetic elements (MGEs) linked with carbapenemases.</p><p><strong>Methods: </strong>Short and long read WGS were performed on ST131 with carbapenemases (n=53) obtained from 21 countries (2010-19). We fully assembled 51 of the carbapenenemase containing plasmids that were grouped into MOB-clusters using MOB-suite v3.1.9.</p><p><strong>Results: </strong>KPCs (n=37) were the most frequent carbapenemases followed by NDMs (n=8), OXA-48-like (n=7), VIMs (n=1) and IMPs (n=2). ST131 subclades were linked with different carbapenemases and clade C dominated the population structure. Plasmids with bla_KPCs (n=35) belonged to eight MOB-clusters that included IncU, IncF, ColRNAI, IncN1, IncR, pKPC-CAV1193, Col-pHAD28; bla_NDMs plasmids (n=7) belonged to four MOB-clusters that included IncF, IncX3, IncC, IncN2; bla_OXA-48-like plasmids (n=6) belonged to six MOB-clusters that included IncL. IncM1, Col(pHAD28), ColKP3, IncF, IncX3; bla_IMPs plasmids (n=2) belonged to IncN1 and IncC, while the bla_VIM-1 (n=1) plasmid belonged to IncC. Multiple transposable and antimicrobial resistance determinants were harboured on these plasmids.</p><p><strong>Conclusions: </strong>The global spread of carbapenemase genes in ST131 clades were driven by multiple underlying mechanisms, including the local and international spread of highly similar plasmids as well as diverse plasmids, within the same geographical locations. This study provided references for future ST131 genomic studies on MGEs linked with carbapenemases.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2119-2128"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Cholecystitis associated with Q fever: case report and systematic review.","authors":"Aymery Stheme de Jubecourt, Marie Hocquart, Olivier Picaud, Georges Farvacque, Sophie Edouard, Louis Beaudoin, Romain Bitoun, Hubert Lepidi, Florence Fenollar, Pierre-Edouard Fournier, Matthieu Million","doi":"10.1007/s10096-025-05237-y","DOIUrl":"10.1007/s10096-025-05237-y","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A European survey on anaerobes from paediatric blood cultures: a comparative analysis with adults.","authors":"Matteo Boattini, Arianna Aceti, Paulo Bastos, Viktoria Eirini Mavromanolaki, Sofia Maraki, Anastasia Spiliopoulou, Vasileios Kakouris, Yordan Kalchev, Ana Budimir, Branka Bedenić, Zana Rubic, Monica Licker, Corina Musuroi, Emese Juhász, Katalin Kristóf, Mateja Pirs, Ivana Velimirovic, Michael Berktold, Adriána Liptáková, Adriana Krajčíková, Pavel Drevinek, Anezka Gryndlerova, Monika Brzychczy-Wloch, Aldona Olechowska-Jarząb, Filip Bielec, Małgorzata Brauncajs, Edyta Podsiadly, Grażyna Nurzyńska, Patrycja Zalas-Więcek, Anna Michalska, Kristian Riesbeck, Hanna-Sofia Andersson, Tone Tønjum, Johan Christian Berild, Truls Michael Leegaard, Asger Nellemann Rasmussen, Kristian Schønning, Stefan Glöckner, Jürgen Rödel, Mohamed Tarek Badr, Georg Alexander Häcker, Denise Stark, Axel Hamprecht, Anna Dudakova, Jonathan Jantsch, Stefano Mancini, Chantal Quiblier, Damien Jacot, Gilbert Greub, Tiziano Ferniani, Simone Ambretti, Maddalena Calvo, Stefania Stefani, Rogier Schade, Erlangga Yusuf, Stefanie van Kleef-van Koeveringe, Sarah Vandamme, Alexia Verroken, Hector Rodriguez-Villalobos, François Duigou, Stéphane Corvec, Pauline Floch, Clémence Massip, Delphine Chainier, Olivier Barraud, Marie-Bossuète Louissaint, Assaf Mizrahi, Saied Ali, Maeve Doyle, Clarice Egan, Sinead McNicholas, Javier Colomina-Rodriguez, Ignacio Torres, Raul Gillaranz Luengo, Maria Nieves Larrosa Escartín, Maria Belen Viñado Perez, Ana Verónica Halperin, Sergio Fuente García, Rafael Cantón, Miguel Seruca, Vasco Santos Mendes, Dinah Carvalho, Rossana Cavallo, José Melo Cristino, Cristina Costa, Gabriele Bianco","doi":"10.1007/s10096-025-05185-7","DOIUrl":"10.1007/s10096-025-05185-7","url":null,"abstract":"<p><p>Infections caused by anaerobes are common in children. However, limited data are available on bloodstream infections caused by these bacteria in Europe. A multicentre retrospective observational study was conducted over a 4-year period (2020-2023) across 44 European hospitals to analyze all anaerobes isolated from blood cultures. The study examined the epidemiology and antimicrobial resistance profiles of anaerobes identified in paediatric patients, comparing the findings with those observed in adults. Among the 14,527 total anaerobic isolates, 186 (1.3%) were detected from paediatric patients. These were predominantly Gram-positive (70%) and Gram-negative (22%) bacilli. The most prevalent species in paediatric patients were Cutibacterium acnes (24.7%), Schaalia odontolytica (9.7%), Actinomyces oris (8.1%), and Bacteroides fragilis (7.5%). Relative feature importance based on the mean SHAP (SHapley Additive exPlanations) values distinguished paediatric patients and adults based on their antibiotic resistance patterns with high accuracy. Compared to those from adult patients, Gram-positive bacilli detected in paediatric samples displayed higher resistance rates for meropenem (15% vs. 9%), metronidazole (52% vs. 24%), and vancomycin (27% vs. 6%), and lower resistance to benzylpenicillin (11% vs. 17%), amoxicillin/clavulanate (9% vs. 17%), and clindamycin (30% vs. 36%). Gram-negative bacilli in paediatric samples displayed lower resistance to benzylpenicillin (18% vs. 29%), piperacillin/tazobactam (26% vs. 33%), and clindamycin (20% vs. 27%), and they were highly susceptible to imipenem, meropenem, and metronidazole as those detected in adult patients. Bacteroides species detected in paediatric and adult patients displayed high resistance to piperacillin/tazobactam (33% vs. 39%) and clindamycin (38% vs. 29%), while they were highly susceptible to metronidazole. Compared to those from adult samples, Cutibacterium acnes in paediatric patients displayed lower resistance to benzylpenicillin (none vs. 15%) and clindamycin (17% vs. 29%). The comparison of species and susceptibility profiles of anaerobes detected in paediatric and adult patients highlighted the importance of reporting antimicrobial susceptibility surveillance data by age group.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2207-2217"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144332660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic practices in kidney transplant recipients with urosepsis are associated with treatment outcomes - a post-hoc analysis of an observational study.","authors":"Tomasz Królicki, Tobiasz Kudla, Anna Królicka, Klaudia Bardowska, Krzysztof Letachowicz, Ryszard Gawda, Tomasz Czarnik, Magdalena Krajewska, Dorota Kamińska","doi":"10.1007/s10096-025-05181-x","DOIUrl":"10.1007/s10096-025-05181-x","url":null,"abstract":"<p><p>This study is a post-hoc analysis of a previously published observational study. The aim is to characterize the epidemiology, etiology and antibiotic practices in KTRs admitted due to urosepsis (US) and urinary tract infection (UTI) to a tertiary transplantation center between the period 2014-2019.The two study groups consisted of 101 KTRs with a primary episode of US and 100 randomly selected KTRs hospitalized for UTI as a control group. A post-hoc analysis of clinical and microbiological data was performed, and a local microbiological map was created.The estimated yearly incidence of US in the study population was 21.1 (95% CI: 15.3-26.9) cases per 1000 KTRs per year. Urosepsis accounted for 85% of all sepsis cases. The most common causative pathogen in both groups was Escherichia coli. In 46% and 11% of US and UTI cases, initial empiric antibiotic therapy had to be escalated until day 3 due to lack of clinical response or proven bacterial resistance. This delay in appropriate antibiotic treatment in the US group was significantly associated with mortality (OR = 10.1 with p = 0.021), need for acute renal replacement therapy (OR = 4.73 with p = 0.012) and non-recovery from AKI (OR = 3.18 with p = 0.031). After discharge from hospital, almost 60% of all study subjects received a prophylactic antibiotic course for prevention of UTI recurrence, which did not translate into a lower frequency of readmission due to UTI in a multivariable analysis.US is a common insult that contributes to graft failure in KTRs. We recommend adjusting US and UTI treatments to center-specific microbiological maps in order to optimize treatment outcomes, reduce development of antibiotic resistance, and avoid unnecessary exposure to nephrotoxic antimicrobial drugs.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2129-2138"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457448/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144247053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors associated with long-term shedding infections of non-typhoidal Salmonella in humans.","authors":"Andreas Rohringer, Lamprini Veneti, Anke Stüken, Elburg van Boetzelaer, Hilde M Lund, Zuzana Nordeng, Emily MacDonald, Umaer Naseer","doi":"10.1007/s10096-025-05165-x","DOIUrl":"10.1007/s10096-025-05165-x","url":null,"abstract":"<p><strong>Purpose: </strong>Non-typhoidal Salmonella (NTS) gastroenteritis in humans is typically self-limited, resolving within 48-72 h. However, some infections result in a carrier state characterised by persistent gut colonisation and long-term shedding (LTS). This study aimed to investigate risk factors associated with LTS of NTS in humans.</p><p><strong>Methods: </strong>Salmonellosis cases reported to the Norwegian surveillance system in 2019 were invited to participate. Participants submitted a follow-up stool sample and a questionnaire five weeks after initial sampling (detecting infection). Stool samples were cultured, and isolates were sequenced to determine genotype, serotype and antimicrobial resistance genotype. NTS cases were classified as LTS if the isolates from both samples differed by ≤ 5 alleles. Adjusted odds ratios (aORs) with 95% confidence intervals (95%CIs) were calculated using logistic regression to investigate potential risk factors associated with LTS.</p><p><strong>Results: </strong>Of 1,094 reported cases, 255 (23%) with NTS participated; 24% were classified as LTS. Children aged 0-5 years were 6.7 times more likely to exhibit LTS compared to adults aged 18-44 years (aOR = 6.71, 95%CI:1.67-26.94). Participants who received regular medication and those following a lactose-free diet were 2.2 (aOR = 2.17, 95%CI:1.02-4.64) and 7.2 (aOR = 7.24, 95%CI:1.48-35.40) times more likely to exhibit LTS than those who did not, respectively. Participants with S. Agbeni or S. Bron were 6 times more likely to exhibit LTS compared to S. Typhimurium cases (aOR = 6.29, 95%CI:1.40-28.16).</p><p><strong>Conclusions: </strong>Observed risk factors associated with LTS included young age, regular medication use, lactose-free diet, and specific Salmonella serotypes. Further research is needed to increase knowledge regarding LTS and inform infection control measures.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2047-2057"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic drug monitoring in patients treated with vancomycin: a single center, prospective, observational, real-world study.","authors":"Cansu Zeynep Dogan, Emre Kara, Asli Pinar, Kutay Demirkan, Gokhan Metan","doi":"10.1007/s10096-025-05182-w","DOIUrl":"10.1007/s10096-025-05182-w","url":null,"abstract":"<p><strong>Purpose: </strong>Therapeutic drug monitoring of vancomycin targeting an AUC/MIC ratio of 400-650 mg*h/L is required to ensure optimal therapeutic efficacy and safety in patients treated with vancomycin. The objectives of this study were to monitor vancomycin plasma peak and trough concentrations to calculate the area under the curve (AUC) to assess target achievement in real-world settings and to evaluate the relationship between AUC and acute kidney injury (AKI).</p><p><strong>Methods: </strong>In this single-center cohort study, prospectively calculated vancomycin AUC and trough concentrations were extracted from the database and evaluated for achievement of therapeutic ranges for AUC and trough concentrations at a university hospital. Patients were evaluated for the development of AKI according to KDIGO guidelines.</p><p><strong>Results: </strong>A total of 114 patients were included in the study. Vancomycin loading doses were initiated in 83.3% of patients, and 82.1% of patients received the appropriate weight-based dose. 79.8% of maintenance doses were appropriate. The median (min-max) values for peak, trough, and AUC were 23.25 (3.3-131.8) mg/L, 10.35 (0.6-56.4) mg/L, and 403(49-1786) mg/L*hour, respectively. The majority of values were outside the therapeutic target for both trough (65.3%) and AUC (63.7%). AKI was observed in 15.8% of patients. In patients without AKI, the median (min-max) trough concentration was 9.65 (0.60-45.30) mg/L and the AUC was 370 (49-1390) mg/L*hour.</p><p><strong>Conclusions: </strong>In this study, only one-third of baseline concentrations were in the therapeutic range and were increased by up to two-thirds with dose adjustments. Therapeutic drug monitoring to achieve target concentrations is critical in patients treated with vancomycin.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2159-2165"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144282955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined resistance mechanisms leading to high-level of cefiderocol resistance among NDM-like producing E. coli ST167 clinical isolates.","authors":"Mustafa Sadek, Juan Bosch Duran, Trinad Chakraborty, Laurent Poirel, Patrice Nordmann","doi":"10.1007/s10096-025-05166-w","DOIUrl":"10.1007/s10096-025-05166-w","url":null,"abstract":"<p><strong>Purpose: </strong>A series of NDM-producing Escherichia coli ST167 clinical isolates exhibiting resistance to cefiderocol (FDC), with no previous exposure to this antibiotic, were analyzed in this study.</p><p><strong>Methods: </strong>The antimicrobial susceptibility testing and phenotypic detection of resistance patterns (Rapid Cefiderocol NP test and MIC determination) were performed for all tested isolates. Their entire genomes were sequenced by using the Illumina MiSeq platform and high-quality reads were de-novo assembled using the CLC Genomic Workbench. Genome-sequence based characteristics were analyzed using bioinformatics tools.</p><p><strong>Results: </strong>All NDM-producing E. coli ST167 isolates showed a high level of resistance to FDC (MICs being 64 or > 64 mg/L). The chromosomally located cirA gene, encoding a catecholate siderophore receptor in E. coli, was truncated in all FDC-resistant isolates due to a frameshift mutation (S90Y), leading to CirA-deficient isolates. A four amino acid insertion (YRIN) was also identified after residue 333 in the PBP3 protein sequence of all E. coli isolates. Among them, a single FDC-resistant NDM-5-producing E. coli isolate (1006) was additionally resistant to aztreonam/avibactam (AZA MIC of 8 mg/L). When analyzed against the genome of another FDC resistant NDM-5 producing E. coli ST167 containing a YRIN insertion in the PBP3, and exhibiting decreased susceptibility to AZA, the broad-spectrum ß-lactamase CMY-42 was identified.</p><p><strong>Conclusion: </strong>We identified a variety of NDM-producing E. coli isolates exhibiting high level of resistance to FDC as a result of the combined effect of CirA deficiency, along with production of NDM-type enzymes. The spread of such resistance phenotype across Europe poses great concern on the clinical efficacy of this novel drug. Additionally, the identification of an FDC- and AZA-resistant NDM-5 producing E. coli isolate represents one of the ultimate evolutions with a possible step towards pan-resistance.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2059-2066"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457464/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor: \"Ceftazidime-avibactam use in hematology patients: single-center experience\".","authors":"Yusuf Emre Ozdemir, Meryem Sahin Ozdemir","doi":"10.1007/s10096-025-05251-0","DOIUrl":"https://doi.org/10.1007/s10096-025-05251-0","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burden of syphilis among people living with HIV: a large cross-sectional study from Türkiye.","authors":"Selim Merdan, Yağmur Ekenoğlu Merdan, Okan Aydoğan","doi":"10.1007/s10096-025-05199-1","DOIUrl":"10.1007/s10096-025-05199-1","url":null,"abstract":"<p><strong>Background: </strong>Syphilis and HIV are closely linked infections with shared transmission routes and risk factors. Despite effective screening and treatment options, the prevalence of syphilis remains high among people living with HIV (PLWH), especially in middle-income countries like Türkiye.</p><p><strong>Objectives: </strong>To investigate the seroprevalence of syphilis among PLWH using centralized laboratory data and to assess its distribution by age and sex.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted by reviewing data derived from blood specimens submitted to our laboratory for routine CD4⁺ T cell enumeration, ultimately analyzing 2,768 PLWH between January 2022 and December 2024. Syphilis seropositivity was defined by concurrent positivity in both VDRL and TPHA tests. Demographic and clinical variables were analyzed using SPSS v.22.0.</p><p><strong>Results: </strong>Syphilis seropositivity was detected in 923 patients (33.3%). The prevalence was significantly higher among males (37.0%) compared to females (6.1%) (p < 0.001). The highest seroprevalence was observed in patients aged 31-40 years (37.4%). There was no significant difference in mean age between syphilis-positive and syphilis-negative groups (p > 0.05).</p><p><strong>Conclusion: </strong>This study reveals a high burden of syphilis among PLWH in Türkiye, particularly in younger male populations. The findings underscore the necessity for routine syphilis screening, targeted prevention strategies, and integrated STI care within HIV programs.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":"2231-2237"},"PeriodicalIF":3.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}