European Journal of Clinical Microbiology & Infectious Diseases最新文献

{"title":"Neonatal syphilis: clinical and laboratory assessments and postnatal treatments for infants born to infected mothers.","authors":"Nursel Atay Ünal, Zeynep Savaş Şen, Ömer Güneş, Eda Tüfekçioğlu, Pınar Yükkaldıran, Ferit Kulalı, Fatma Nur Öz, Türkan Aydın Teke, Ayşe Kaman","doi":"10.1007/s10096-025-05073-0","DOIUrl":"https://doi.org/10.1007/s10096-025-05073-0","url":null,"abstract":"<p><strong>Purpose: </strong>This study aims to assess congenital syphilis incidence, main clinical presentations and the relation to maternal treatment during pregnancy, with the goal of raising awareness of this emerging public health issue and offering local epidemiological data.</p><p><strong>Methods: </strong>Infants born to mothers diagnosed with syphilis at Etlik City Hospital between June 1, 2023 and June 1, 2024 were included to the study. Patient records were reviewed retrospectively.</p><p><strong>Results: </strong>During the study period, 12,892 live births were recorded, with congenital syphilis detected in 0.12% of cases, corresponding to a rate of 116 cases per 100,000 live births. Fifteen neonates born to mothers with syphilis were evaluated. Penicillin treatment was administered to 93.3% of the neonates, including 73.3% classified as highly probable or probable cases. Bone abnormalities such as periostitis and osteitis were detected in two patients. Only 46.7% of mothers received adequate prenatal treatment, and 40% lacked prenatal care altogether. Co-infections with hepatitis C virus, human papillomavirus, and herpes simplex virus type 2 were noted in 26% of mothers, though none had HIV. Substance addiction was reported in 26.7% of mothers.</p><p><strong>Conclusion: </strong>This study highlights a significant burden of congenital syphilis, with many cases stemming from untreated or inadequately managed maternal infections. Some neonates were infected despite maternal treatment, underscoring gaps in prevention. The limited data from our center, despite high case rates, likely underestimates the regional burden and risks missed diagnoses. These findings emphasize the urgent need for enhanced prenatal screening, timely treatment, and comprehensive care to mitigate congenital syphilis rates.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro synergistic effects of mefloquine combined with other antimicrobial agents on carbapenem-resistant Enterobacterales.","authors":"Chunhong Zou, Zixin Wen, Wen Wang, Ke Gao, Shimei Shen, Lisha Shang, Xue Li, Jie Yu, Jinyi Shen, Yujin Li, Liang Chen, Jianglin Wu, Jie Wei, Deqiang Wang, Siqiang Niu","doi":"10.1007/s10096-025-05060-5","DOIUrl":"https://doi.org/10.1007/s10096-025-05060-5","url":null,"abstract":"<p><strong>Purpose: </strong>Human health is seriously threatened by carbapenem-resistant Enterobacterales (CRE) due to the lack of effective treatment. The purpose of this study is to examine the efficacy of mefloquine (MEF) together with multiple drugs against 96 clinical CRE isolates including 94 Klebsiella pneumoniae carbapenemase (KPC)-producers or Metallo-β-lactamases (MBLs)-producers and 2 colistin antibiotic resistance enzyme MCR-1-producers.</p><p><strong>Methods: </strong>Using the broth microdilution method, MICs of MEF in combination with multiple antimicrobial agents, including colistin (COL), imipenem, aztreonam-avibactam (ATM-AVI), ceftazidime-avibactam (CAZ-AVI) for 96 CRE isolates were determined. Time-kill assays were implemented for 3 colistin-resistant (COL-R) isolates to analyze in vitro synergistic impacts of COL combined with MEF.</p><p><strong>Results: </strong>MEF alone showed little antibacterial activity with MICs greater than 128 µg/mL for all the 96 clinical CRE isolates. The addition of MEF (32 µg/mL) increased the sensitivity of almost all strains (98.9%, 95/96) to COL, reducing the MICs range of COL from ≤ 0.0625->8 µg/mL to ≤ 0.004-0.5 µg/mL. In particular, we observed that COL-MEF combination therapy had a significant effect on COL-R isolates, reducing their MICs from resistance to susceptibility. Moreover, the MIC₅₀ and MIC₉₀ of imipenem were both reduced by 2-fold in almost all strains with the addition of MEF (32 µg/mL), and in single MBL-producers, the MIC₅₀ (from 16 to 4 µg/mL) and MIC₉₀ (from 128 to 32 µg/mL) were both reduced by 4-fold. In addition, the MIC₅₀ and MIC₉₀ values of 96 CRE isolates of CAZ-AVI and ATM-AVI did not decrease significantly after combined with MEF (32 µg/mL). For the time-kill assays of 3 COL-R isolates, COL or MEF alone had almost no killing effect, however, when MEF was combined with COL, the isolates were completely killed within 4 h, and NDM-5-producing Klebsiella pneumoniae did not regenerate within 24 h.</p><p><strong>Conclusions: </strong>According to our study, COL-MEF may offer a potential alternative for treating CRE infections, especially COL-R Gram-negative bacterial infections.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Variations in respiratory pathogen carriage among a homeless population in a shelter for men in Marseille, France, March-July 2020: cross-sectional 1-day surveys.","authors":"Tran Duc Anh Ly, Van Thuan Hoang, Ndiaw Goumballa, Meriem Louni, Naomie Canard, Thi Loi Dao, Hacene Medkour, Audrey Borg, Kevin Bardy, Véra Esteves-Vieira, Véronique Filosa, Bernard Davoust, Oleg Mediannikov, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret","doi":"10.1007/s10096-025-05076-x","DOIUrl":"https://doi.org/10.1007/s10096-025-05076-x","url":null,"abstract":"","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Septic arthritis - symptoms, diagnosis and new therapy.","authors":"Angelika Domagała, Barbara Macura, Karolina Piekarz, Aneta Kiecka","doi":"10.1007/s10096-025-05066-z","DOIUrl":"https://doi.org/10.1007/s10096-025-05066-z","url":null,"abstract":"<p><p>Septic arthritis (SA) is an infection of one or more joints caused mainly by Staphylococcus aureus, to a lesser extent by streptococci and Gram-negative bacilli. It poses a huge medical problem due to its high mortality rate of 2-15%. Disease symptoms are often vague, resulting in a risk that SA may be diagnosed too late. This shows the urgency of finding a rapid diagnostic method for SA and an effective therapy. Basic treatment of SA including joint drain or empirical antimicrobial therapy does not always provide the desired results. Hence, new therapies are being sought, including the use of antimicrobial peptide or phage therapy.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Addressing carbapenemase-producing extensively drug-resistant Pseudomonas aeruginosa: the potential of cefiderocol and ceftazidime/avibactam plus aztreonam therapy.","authors":"María Milagro Montero, Sandra Domene-Ochoa, Núria Prim, Eliana Ferola, Carla López-Causapé, Marian Gomis-Font, Mario F Ampuero-Morisaki, Daniel Echeverria, Luisa Sorlí, Sonia Luque, Eduardo Padilla, Santiago Grau, Antonio Oliver, Juan P Horcajada","doi":"10.1007/s10096-025-05061-4","DOIUrl":"https://doi.org/10.1007/s10096-025-05061-4","url":null,"abstract":"<p><p>This study evaluated the activity of cefiderocol and the combination of ceftazidime/avibactam (CZA) plus aztreonam against carbapenemase-producing extensively drug-resistant (XDR) Pseudomonas aeruginosa isolates. Nine clinical XDR P. aeruginosa isolates with different sequence types and class A (GES) or B (VIM, IMP or NDM) carbapenemases were analysed. Time-kill assays assessed bacterial load reduction for each treatment, while chemostat experiments on four isolates validated these findings. All isolates showed resistance to CZA, with four also resistant to aztreonam. Seven isolates were susceptible to cefiderocol, but two displayed borderline susceptibility (MIC 2-4 mg/L). Time-kill assays demonstrated bactericidal activity by cefiderocol in six isolates at 24 h, while CZA plus aztreonam showed bactericidal effects in three isolates and synergistic/additive effects in four isolates. In the chemostat model, cefiderocol and CZA plus aztreonam were bactericidal in all four tested isolates, with cefiderocol showing greater bacterial reduction in three of these isolates. Both cefiderocol and CZA plus aztreonam achieved significant reductions in bacterial counts compared to controls, but there was no significant difference between cefiderocol monotherapy and the combination. Both cefiderocol and CZA plus aztreonam demonstrated activity against XDR P. aeruginosa carrying metallo-β-lactamase (MBL) and/or serine-β-lactamase (SBL) carbapenemases. Cefiderocol was the only consistently effective monotherapy with a bactericidal effect across all tested isolates in the chemostat model.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fulminant parvovirus B19 myocarditis in infants -report of three post-pandemic cases.","authors":"Tatjana Wahjudi, Alex Nitsch, Jan-Peter Sperhake, Peter H Hoeger","doi":"10.1007/s10096-025-05072-1","DOIUrl":"https://doi.org/10.1007/s10096-025-05072-1","url":null,"abstract":"<p><p>Lack of immune stimulation (\"immune debt\") in the wake of the COVID-19 pandemic has led to a resurgence of many paediatric infectious diseases, recently including parvovirus B19 (PVB19). We observed three cases of fulminant PVB19 myocarditis in infants. All had experienced a short prodromal illness and succumbed to cardiogenic shock within 2-72 h after admission. The risk of fulminant myocarditis appears to be increased in infants. Further studies are needed to assess the incidence of fulminant myocarditis caused by PVB19, potentially linked to immune debt.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regional distribution of carbapenemase-producing Acinetobacter baumannii isolates in southern Spain (Andalusia).","authors":"Felipe Fernández-Cuenca, Salud Rodríguez-Pallares, Lorena López-Cerero, José Gutiérrez-Fernández, María Fe Bautista, Juan Antonio Sánchez Gómez, Waldo Sánchez-Yebra Romera, Mercedes Delgado, Esther Recacha, Alvaro Pascual","doi":"10.1007/s10096-025-05047-2","DOIUrl":"https://doi.org/10.1007/s10096-025-05047-2","url":null,"abstract":"<p><strong>Objectives: </strong>This is the first study conducted in southern Spain to determine i) the population structure (PS) of carbapenem-resistant (CR) Acinetobacter baumannii isolates by multilocus sequencing typing (MLST) and core genome MLST (cgMLST) and ii) the association between the sequence type ST and the bla_OXA-51 variant, capsule polysaccharide locus (KL) and lipooligosaccharide outer core locus (OCL) types.</p><p><strong>Methods: </strong>Of 336 isolates submitted to the Andalusian reference laboratory (PIRASOA; December 2017-2020), 73 were subjected to WGS (MiSeq). The following analyses were performed: bacterial identification (ribosomal MLST), carbapenemase gene detection (Resfinder 4.0), PS delineation (MLST by MLSTfinder 2.0 and cgMLST by Ridom SeqSphere⁺), and KL types and OCL types (Kaptive tool).</p><p><strong>Results: </strong>The carbapenemases detected were bla_OXA-23 (n = 41), bla_OXA-58 (n = 26), bla_OXA-24 (n = 5), bla_OXA-72 (n = 1) and bla_NDM-1 (n = 2). The PS revealed one major ST2 clone (n = 54) and seven minor ST clones by MLST, and 41 lineages by cgMLST_. Thirty-five lineages were detected only in a single hospital whereas five lineages were observed in several hospitals and provinces. bla_OXA-66 was the most frequent bla_OXA-51 variant and was mainly associated with the ST2 clone. Eleven KL types and 3 OCL types were assigned, with KL2 (n = 27), KL7 (n = 16) and OCL1 being the most frequent.</p><p><strong>Conclusions: </strong>The PS of CR A. baumannii in Andalusia is characterized by a dominant ST2/bla_OXA-23 clone and several lineages, showing local spread of lineages in most hospitals, and intercenter or interregional spread of a few lineages. Single-locus bla_OXA-51-like typing and KL typing may be useful as complementary preliminary typing tool.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whether to continue combining carbapenems to treat carbapenem-resistant Acinetobacter baumannii nosocomial pneumonia in critically ill patients: a retrospective efficacy and safety analysis.","authors":"Cheng Shiqi, Wang Chuhui, Zhang Yijing, Qiu Yulan, Chen Jiaojiao, Chen Keyu, Shi Qindong, Zeng Xiaoyan, Dong Yalin","doi":"10.1007/s10096-025-05063-2","DOIUrl":"https://doi.org/10.1007/s10096-025-05063-2","url":null,"abstract":"<p><p>To explore the efficacy and safety of non-carbapenem-containing (NCC) regimens and carbapenem-containing regimens (CC) regimens, along with the factors influencing the outcomes in critically ill patients with carbapenem-resistant Acinetobacter baumannii (CRAB) pneumonia. This study retrospectively enrolled critically ill patients with CRAB pneumonia who were treated with NCC and CC regimens in a teaching hospital. The primary efficacy outcome was the 28-day clinical efficacy rate, and the safety outcome was the incidence of nephrotoxicity. After the propensity score matching analysis removed the differences between the two groups, the differences in outcomes were statistically analyzed. Cox regression and logistic regression models were used to analyze the factors influencing the outcomes of critically ill patients with CRAB pneumonia. Data from 168 critically ill patients with CRAB pneumonia were eventually included in this study for analysis (NCC = 84, CC = 84). The 28-day clinical efficacy rate was significantly lower in the CC group compared to the NCC group (40.5% vs. 57.1%, P = 0.031), and the incidence of nephrotoxicity was not significantly different in the two groups (P > 0.05). Logistic analysis showed that the prescription of carbapenems was the risk factor of decreased clinical efficacy (aOR = 0.494, 95%CI = 0.262-0.932, P = 0.029) and reduced microbiological eradication (aOR = 0.397, 95%CI = 0.201-0.783, P = 0.008) in patients. CC regimen may not contribute to the 28-day clinical efficacy of CRAB pneumonia and further studies are necessary to elucidate the CC regimen when treating CRAB pneumonia in critically ill patients.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Multicenter evaluation of leprosy rapid test Fast ML Flow Hanseníase in Brazil.","authors":"Djairo Pastor Saavedra, Maurício Lisboa Nobre, Rafael Alves Guimarães, Matheus Bernardes Torres Fogaça, Isabela Maria Bernardes Goulart, Jaison Antônio Barreto, Vânia Nieto Brito de Souza, Selma Maria Bezerra Jeronimo, Francianne Medeiros Amorim, Tatiana Pereira da Silva, Roberta Olmo Pinheiro, Mariane Martins de Araújo Stefani, Samira Bührer-Sékula","doi":"10.1007/s10096-025-05071-2","DOIUrl":"https://doi.org/10.1007/s10096-025-05071-2","url":null,"abstract":"<p><strong>Purpose: </strong>Leprosy represents a public health concern; its diagnosis remains clinical. Recently, the Brazilian public health system/SUS incorporated the leprosy-specific IgM anti-PGL-I rapid test Fast ML Flow Hanseníase (MLFH/Bioclin, Brazil; originally ML Flow) to aid leprosy contacts surveillance and diagnosis. Anti-PGL-I antibody levels correlate with bacterial load. This multicenter study evaluated MLFH performance in confirmed leprosy cases from four Brazilian reference centers.</p><p><strong>Methods: </strong>MLFH results were compared to anti-PGL-I ELISA, bacilloscopy/BI and analyzed in indeterminate/I, pure neuritic/PN and in Ridley Jopling/RJ categories (tuberculoid/TT, borderline-tuberculoid/BT, borderline/BB, borderline-lepromatous/BL, lepromatous/LL). Leprosy patients' serum samples (N = 158; 95 multibacillary/MB, 63 paucibacillary/PB) were evaluated. Additionally, 20 previously tested leprosy samples were distributed to each center to assess MLFH repeatability, inter-center and inter-operator reproducibility.</p><p><strong>Results: </strong>Higher MLFH seropositivity (84.8%) compared to ELISA (60.8%; p < 0.001) and bacilloscopy (50.6%; p < 0.001), indicated moderate and fair agreement, respectively. Visual intensity readings (0 to 4 + range) from 20 samples showed excellent agreement (ICC: 0.954); test repeatability was 95.57%. Compared to ELISA and bacilloscopy, positivity difference was statistically significant (p < 0.05) in TT, BT, and I forms. Lower MLFH positivity was observed in indeterminate, BT and PN forms.</p><p><strong>Conclusion: </strong>The change in MLFH result criteria adopted by Bioclin/SUS considering faint test line (0.5) as positive (originally negative in ML Flow), increased MLFH sensitivity leading to higher seropositivity in MB and especially in PB, known as weak antibody producers. However, when screening asymptomatic leprosy contacts, this modified criterion may lead to reduced specificity since in endemic areas, anti-PGL-I positivity alone does not necessarily indicate active disease.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Streptococcus pneumoniae keratitis: epidemiology and outcomes over 6 years in a French eye care center.","authors":"Thibaud Garcin, Gautier Hoarau, Valentin Leger, Lilia Merabet, Françoise Brignole-Baudouin, Vincent Borderie, Nacim Bouheraoua","doi":"10.1007/s10096-025-05057-0","DOIUrl":"https://doi.org/10.1007/s10096-025-05057-0","url":null,"abstract":"<p><strong>Purpose: </strong>We evaluated the epidemiology, clinical features, microbiology, management and visual outcome of Streptococcus pneumoniae keratitis.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical charts of patients diagnosed with culture-proven Streptococcus pneumoniae keratitis in a French tertiary center between January 2015 and December 2020.</p><p><strong>Results: </strong>We analyzed data from 51 eyes of 51 patients with Streptococcus pneumoniae keratitis followed for 64 (19-105) days, out of a total of 1222 eyes with documented bacterial keratitis (4.17%). Most cases (55%) occurred in winter or spring (p = 0.037). A local or systemic risk factor was identified in 39 (76%) and 32 (63%) eyes respectively: previous ocular surgery (55%) followed by glaucoma (24%), and diabetes (18%). Forty-one patients (80%) with severe keratitis remained in hospital for 7 (1-60) days. Polymicrobial infection was detected in 6 eyes (12%) and multidrug resistant strain in 9 eyes (18%). Medical treatment lasted 36 (21-60) days. Adjuvant surgery was required in 13 eyes (25%) mainly for delayed ulcer healing (n = 10), with amniotic membrane transplantation (n = 12) or tectonic keratoplasty (n = 1). In multivariate analysis, endothelial plaque (OR 65.87, p = 0.028), hypopyon (OR 17.8, p = 0.040), and infiltrate > 5mm² (OR 2.49, p = 0.012) were significantly associated with the need for adjuvant surgery. Baseline visual acuity (VA) 2.00(1.33-2.00) logMAR did not improve significantly at final visit (p = 0.121). Eyes requiring adjuvant surgery had worse final VA (p = 0.009).</p><p><strong>Conclusion: </strong>Streptococcus pneumoniae keratitis are rare in France but may be sight-threatening. Overall VA is poor, most of patients require hospitalization, and some local factors at presentation predict the need for adjuvant surgery.</p>","PeriodicalId":11782,"journal":{"name":"European Journal of Clinical Microbiology & Infectious Diseases","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}