Epidemiology最新文献_第6页

The Role of Epidemiology in Addressing Ableism. 流行病学在解决歧视问题中的作用。

IF 4.7 2区医学

Epidemiology Pub Date : 2025-01-01 Epub Date: 2024-11-25 DOI: 10.1097/EDE.0000000000001790

Bonnielin K Swenor, Varshini Varadaraj, Franz F Castro

引用次数: 0

Rejoinder: Using negative control populations to assess unmeasured confounding and direct effects. 反驳：使用阴性对照人群来评估未测量的混杂和直接影响。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-12-17 DOI: 10.1097/EDE.0000000000001829

Marco Piccininni, Mats Julius Stensrud

引用次数: 0

Re. Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects. 使用阴性对照人群评估未测量的混杂和直接影响。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-12-17 DOI: 10.1097/EDE.0000000000001828

Fernando Pires Hartwig, Neil Martin Davies, George Davey Smith

引用次数: 0

Adjusting adjustments: Using external data to estimate the impact of different confounder sets on published associations. 调整调整：使用外部数据估算不同混杂因素集对已公布关联的影响。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-11-22 DOI: 10.1097/EDE.0000000000001821

Thomas P Ahern, Lindsay J Collin, Richard F MacLehose, Benjamin Littenberg, Laura Haines, Michaela Bonnett, Fanny Børne Asmussen, Jennifer Chen, Timothy L Lash

{"title":"Adjusting adjustments: Using external data to estimate the impact of different confounder sets on published associations.","authors":"Thomas P Ahern, Lindsay J Collin, Richard F MacLehose, Benjamin Littenberg, Laura Haines, Michaela Bonnett, Fanny Børne Asmussen, Jennifer Chen, Timothy L Lash","doi":"10.1097/EDE.0000000000001821","DOIUrl":"https://doi.org/10.1097/EDE.0000000000001821","url":null,"abstract":"Background: A 2013 meta-analysis observed a protective association between overweight BMI (versus normal BMI) and all-cause mortality that was particularly strong in people aged ≥65. Estimates informing this meta-analysis were highly heterogeneous, and critics raised insufficient or inappropriate confounder adjustment in many studies as an explanation for the protective summary association. Using this topic as an example, we demonstrate a novel approach for external adjustment of individual studies for a uniform and sufficient confounder set before meta-analysis.Methods: We abstracted summary data on the 33 associations comprising the age ≥65 stratum of the 2013 meta-analysis. Using an external dataset (NHANES III), we derived covariates used in each study's multivariable model of the overweight-mortality association. We then calculated a bias factor to quantify the direction and magnitude of displacement of the ratio measure of association after changing from the original adjustment set to a sufficient adjustment set. After applying bias factors to adjust original associations, we compared summary results from random effects meta-analyses with and without such adjustment.Results: We reproduced the original meta-analysis of overweight-mortality estimates among older participants and found a protective association similar to that reported in 2013 (summary RR=0.88, 95% CI: 0.84, 0.92, I2=38.4%). After we simulated uniform adjustment of all 33 associations for a minimally sufficient confounder set (age, sex, and smoking status), the meta-analysis showed a similar summary association (summary RR=0.90, 95% CI: 0.86, 0.94), but with reduced heterogeneity (I2=34.6%).Conclusion: Simulated uniform adjustment for a sufficient confounder set may improve rigor and promote consensus in meta-analysis.","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":""},"PeriodicalIF":4.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventable Fraction in the Context of Disease Progression. 在疾病进展过程中可预防的分数。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.1097/EDE.0000000000001770

Bronner P Gonçalves, Etsuji Suzuki

引用次数: 0

Methods for Extending Inferences From Observational Studies: Considering Causal Structures, Identification Assumptions, and Estimators. 扩展观察研究推论的方法：考虑因果结构、识别假设和估算器。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.1097/EDE.0000000000001780

Eleanor Hayes-Larson, Yixuan Zhou, L Paloma Rojas-Saunero, Crystal Shaw, Marissa J Seamans, M Maria Glymour, Audrey R Murchland, Daniel Westreich, Elizabeth Rose Mayeda

{"title":"Methods for Extending Inferences From Observational Studies: Considering Causal Structures, Identification Assumptions, and Estimators.","authors":"Eleanor Hayes-Larson, Yixuan Zhou, L Paloma Rojas-Saunero, Crystal Shaw, Marissa J Seamans, M Maria Glymour, Audrey R Murchland, Daniel Westreich, Elizabeth Rose Mayeda","doi":"10.1097/EDE.0000000000001780","DOIUrl":"10.1097/EDE.0000000000001780","url":null,"abstract":"Most prior work in quantitative approaches to generalizability and transportability emphasizes extending causal effect estimates from randomized trials to target populations. Extending findings from observational studies is also of scientific interest, and identifiability assumptions and estimation methods differ from randomized settings when there is selection on both the exposure and exposure-outcome mediators in combination with exposure-outcome confounders (and both confounders and mediators can modify exposure-outcome effects). We argue that this causal structure is common in observational studies, particularly in the field of life course epidemiology, for example, when extending estimates of the effect of an early-life exposure on a later-life outcome from a cohort enrolled in midlife or late life. We describe identifiability assumptions and identification using observed data in such settings, highlighting differences from work extending findings from randomized trials. We describe statistical methods, including weighting, outcome modeling, and doubly robust approaches, to estimate potential outcome means and average treatment effects in the target population and illustrate performance of the methods in a simulation study. We show that in the presence of selection into the study sample on both exposure and confounders, estimators must be able to address confounding in the target population. When there is also selection on mediators of the exposure-outcome relationship, estimators need to be able to use different sets of variables to account for selection (including the mediator), and confounding. We discuss conceptual implications of our results as well as highlight unresolved practical questions for applied work to extend findings from observational studies to target populations.","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"753-763"},"PeriodicalIF":4.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141909830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mixture Models for Social Epidemiology: Opportunities and Cautions. 社会流行病学的混合模型：机遇与注意事项。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI: 10.1097/EDE.0000000000001778

Alina Schnake-Mahl, Ghassan Badri Hamra

引用次数: 0

A Counterfactual Analysis of Impact of Cesarean Birth in a First Birth on Severe Maternal Morbidity in the Subsequent Birth. 首次分娩剖腹产对再次分娩严重产妇发病率影响的反事实分析。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-07-26 DOI: 10.1097/EDE.0000000000001775

Shalmali Bane, Jonathan M Snowden, Julia F Simard, Michelle Odden, Peiyi Kan, Elliott K Main, Suzan L Carmichael

{"title":"A Counterfactual Analysis of Impact of Cesarean Birth in a First Birth on Severe Maternal Morbidity in the Subsequent Birth.","authors":"Shalmali Bane, Jonathan M Snowden, Julia F Simard, Michelle Odden, Peiyi Kan, Elliott K Main, Suzan L Carmichael","doi":"10.1097/EDE.0000000000001775","DOIUrl":"10.1097/EDE.0000000000001775","url":null,"abstract":"Background: It is known that cesarean birth affects maternal outcomes in subsequent pregnancies, but specific effect estimates are lacking. We sought to quantify the effect of cesarean birth reduction among nulliparous, term, singleton, vertex (NTSV) births (i.e., preventable cesarean births) on severe maternal morbidity (SMM) in the second birth.Methods: We examined birth certificates linked with maternal hospitalization data (2007-2019) from California for NTSV births with a second birth (N = 779,382). The exposure was cesarean delivery in the first birth and the outcome was SMM in the second birth. We used adjusted Poisson regression models to calculate risk ratios and population attributable fraction for SMM in the second birth and conducted a counterfactual impact analysis to estimate how lowering NTSV cesarean births could reduce SMM in the second birth.Results: The adjusted risk ratio for SMM in the second birth given a prior cesarean birth was 1.7 (95% confidence interval: 1.5, 1.9); 15.5% (95% confidence interval: 15.3%, 15.7%) of this SMM may be attributable to prior cesarean birth. In a counterfactual analysis where 12% of the California population was least likely to get a cesarean birth instead delivered vaginally, we observed 174 fewer SMM events in a population of individuals with a low-risk first birth and subsequent birth.Conclusion: In our counterfactual analysis, lowering primary cesarean birth among an NTSV population was associated with fewer downstream SMM events in subsequent births and overall. Additionally, our findings reflect the importance of considering the cumulative accrual of risks across the reproductive life course.","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"853-863"},"PeriodicalIF":4.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141765749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Causal Roadmap and Simulations to Improve the Rigor and Reproducibility of Real-data Applications. 改善真实数据应用的严谨性和可重复性的因果路线图和模拟。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-08-01 DOI: 10.1097/EDE.0000000000001773

Nerissa Nance, Maya L Petersen, Mark van der Laan, Laura B Balzer

{"title":"The Causal Roadmap and Simulations to Improve the Rigor and Reproducibility of Real-data Applications.","authors":"Nerissa Nance, Maya L Petersen, Mark van der Laan, Laura B Balzer","doi":"10.1097/EDE.0000000000001773","DOIUrl":"10.1097/EDE.0000000000001773","url":null,"abstract":"The Causal Roadmap outlines a systematic approach to asking and answering questions of cause and effect: define the quantity of interest, evaluate needed assumptions, conduct statistical estimation, and carefully interpret results. To protect research integrity, it is essential that the algorithm for statistical estimation and inference be prespecified prior to conducting any effectiveness analyses. However, it is often unclear which algorithm will perform optimally for the real-data application. Instead, there is a temptation to simply implement one's favorite algorithm, recycling prior code or relying on the default settings of a computing package. Here, we call for the use of simulations that realistically reflect the application, including key characteristics such as strong confounding and dependent or missing outcomes, to objectively compare candidate estimators and facilitate full specification of the statistical analysis plan. Such simulations are informed by the Causal Roadmap and conducted after data collection but prior to effect estimation. We illustrate with two worked examples. First, in an observational longitudinal study, we use outcome-blind simulations to inform nuisance parameter estimation and variance estimation for longitudinal targeted minimum loss-based estimation. Second, in a cluster randomized trial with missing outcomes, we use treatment-blind simulations to examine type-I error control in two-stage targeted minimum loss-based estimation. In both examples, realistic simulations empower us to prespecify an estimation approach with strong expected finite sample performance, and also produce quality-controlled computing code for the actual analysis. Together, this process helps to improve the rigor and reproducibility of our research.","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"791-800"},"PeriodicalIF":4.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11444352/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations Between Gestational Residential Radon Exposure and Term Low Birthweight in Connecticut, USA. 美国康涅狄格州妊娠期住宅氡暴露与足月低出生体重之间的关系。

IF 4.7 2区医学

Epidemiology Pub Date : 2024-11-01 Epub Date: 2024-07-23 DOI: 10.1097/EDE.0000000000001771

Seulkee Heo, Longxiang Li, Ji-Young Son, Petros Koutrakis, Michelle L Bell

{"title":"Associations Between Gestational Residential Radon Exposure and Term Low Birthweight in Connecticut, USA.","authors":"Seulkee Heo, Longxiang Li, Ji-Young Son, Petros Koutrakis, Michelle L Bell","doi":"10.1097/EDE.0000000000001771","DOIUrl":"10.1097/EDE.0000000000001771","url":null,"abstract":"Background: Studies suggest biologic mechanisms for gestational exposure to radiation and impaired fetal development. We explored associations between gestational radon exposure and term low birthweight, for which evidence is limited.Methods: We examined data for 68,159 singleton full-term births in Connecticut, United States, 2016-2018. Using a radon spatiotemporal model, we estimated ZIP code-level basement and ground-level exposures during pregnancy and trimesters for each participant's address at birth or delivery. We used logistic regression models, including confounders, to estimate odds ratios (ORs) for term low birth weight in four exposure quartiles (Q1-Q4) with the lowest exposure group (Q1) as the reference.Results: Exposure levels to basement radon throughout pregnancy (0.27-3.02 pCi/L) were below the guideline level set by the US Environmental Protection Agency (4 pCi/L). The ORs for term low birth weight in the second-highest (Q3; 1.01-1.33 pCi/L) exposure group compared with the reference (<0.79 pCi/L) group for basement radon during the first trimester was 1.22 (95% confidence interval [CI] = 1.02, 1.45). The OR in the highest (Q4; 1.34-4.43 pCi/L) quartile group compared with the reference group during the first trimester was 1.26 (95% CI = 1.05, 1.50). Risks from basement radon were higher for participants with lower income, lower maternal education levels, or living in urban regions.Conclusion: This study found increased term low birth weight risks for increases in basement radon. Results have implications for infants' health for exposure to radon at levels below the current national guideline for indoor radon concentrations and building remediations.","PeriodicalId":11779,"journal":{"name":"Epidemiology","volume":" ","pages":"834-843"},"PeriodicalIF":4.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11560713/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141751373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0