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Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site PhiC31 整合位点表达载体的染色质调控模式研究
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-09 DOI: 10.1080/15592294.2024.2337085
Xueli Liu, Qina Chen, Xudong Yin, Xiao Wang, Jinshan Ran, Wei Yu, Bin Wang
{"title":"Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site","authors":"Xueli Liu, Qina Chen, Xudong Yin, Xiao Wang, Jinshan Ran, Wei Yu, Bin Wang","doi":"10.1080/15592294.2024.2337085","DOIUrl":"https://doi.org/10.1080/15592294.2024.2337085","url":null,"abstract":"The PhiC31 integration system allows for targeted and efficient transgene integration and expression by recognizing pseudo attP sites in mammalian cells and integrating the exogenous genes into the...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"45 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells 维生素 C 可提高结直肠癌细胞中新型 TET1 核体与 Cajal 和 PML 体的共定位能力
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-07 DOI: 10.1080/15592294.2024.2337142
Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki
{"title":"Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells","authors":"Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki","doi":"10.1080/15592294.2024.2337142","DOIUrl":"https://doi.org/10.1080/15592294.2024.2337142","url":null,"abstract":"Deregulation of ten-eleven Translocation protein 1 (TET1) is commonly reported to induce imbalances in gene expression and subsequently to colorectal cancer development (CRC). On the other hand, vi...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma context exerts intergenerational effects on child mental health via DNA methylation 创伤环境通过 DNA 甲基化对儿童心理健康产生代际影响
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-05 DOI: 10.1080/15592294.2024.2333654
Stefanie Pilkay, Andie Riffer, Andrew Carroll
{"title":"Trauma context exerts intergenerational effects on child mental health via DNA methylation","authors":"Stefanie Pilkay, Andie Riffer, Andrew Carroll","doi":"10.1080/15592294.2024.2333654","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333654","url":null,"abstract":"Many people experience traumatic or negative events, but few develop mental health issues as a result. This study investigated whether newborn DNA methylation (DNAm) previously associated with mate...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations 不同种族和民族人群中与 C 反应蛋白相关的甲基化模式
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-03 DOI: 10.1080/15592294.2024.2333668
Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg, On Behalf of the PAGE Study
{"title":"Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations","authors":"Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg, On Behalf of the PAGE Study","doi":"10.1080/15592294.2024.2333668","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333668","url":null,"abstract":"Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflam...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays 对 Illumina MethylationEPIC v1.0 BeadChip 芯片上 DNA 甲基化探针可靠性的严格评估
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-02 DOI: 10.1080/15592294.2024.2333660
Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang
{"title":"Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays","authors":"Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang","doi":"10.1080/15592294.2024.2333660","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333660","url":null,"abstract":"DNA methylation (DNAm) plays a crucial role in a number of complex diseases. However, the reliability of DNAm levels measured using Illumina arrays varies across different probes. Previous research...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"2 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage GPR133表达上调会损害复发性自然流产患者巨噬细胞的吞噬功能
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-02 DOI: 10.1080/15592294.2024.2337087
Jia-Xue Sun, Yongli Yao, Wen-Xuan Li, Xin Su, Haoyu Yang, Zhouping Lu, Chenfei Liu, Xiang-Hong Xu, Liping Jin
{"title":"Upregulation of GPR133 expression impaired the phagocytosis of macrophages in recurrent spontaneous miscarriage","authors":"Jia-Xue Sun, Yongli Yao, Wen-Xuan Li, Xin Su, Haoyu Yang, Zhouping Lu, Chenfei Liu, Xiang-Hong Xu, Liping Jin","doi":"10.1080/15592294.2024.2337087","DOIUrl":"https://doi.org/10.1080/15592294.2024.2337087","url":null,"abstract":"Decidual macrophages are the second-largest immune cell group at the maternal-foetal interface. They participate in apoptotic cell removal, and protect the foetus from microorganisms or pathogens. ...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"52 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium 婴儿期动物和植物蛋白摄入量与儿童 DNA 甲基化：NutriPROGRAM 联合体的荟萃分析
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-01-10 DOI: 10.1080/15592294.2023.2299045
Mohammed El Sharkawy, Janine F. Felix, Veit Grote, Trudy Voortman, Vincent W. V. Jaddoe, Berthold Koletzko, Leanne K. Küpers
{"title":"Animal and plant protein intake during infancy and childhood DNA methylation: a meta-analysis in the NutriPROGRAM consortium","authors":"Mohammed El Sharkawy, Janine F. Felix, Veit Grote, Trudy Voortman, Vincent W. V. Jaddoe, Berthold Koletzko, Leanne K. Küpers","doi":"10.1080/15592294.2023.2299045","DOIUrl":"https://doi.org/10.1080/15592294.2023.2299045","url":null,"abstract":"Higher early-life animal protein intake is associated with a higher childhood obesity risk compared to plant protein intake. Differential DNA methylation may represent an underlying mechanism.We an...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"48 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139413328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronic intermittent ethanol exposure-induced m6A modifications around mRNA stop codons of opioid receptor genes 慢性间歇性乙醇暴露诱导阿片受体基因 mRNA 终止密码子周围的 m6A 修饰
IF 3.7 3区 生物学
Epigenetics Pub Date : 2023-12-20 DOI: 10.1080/15592294.2023.2294515
Ying Liu, Ji Sun Koo, Huiping Zhang
{"title":"Chronic intermittent ethanol exposure-induced m6A modifications around mRNA stop codons of opioid receptor genes","authors":"Ying Liu, Ji Sun Koo, Huiping Zhang","doi":"10.1080/15592294.2023.2294515","DOIUrl":"https://doi.org/10.1080/15592294.2023.2294515","url":null,"abstract":"Chronic alcohol consumption may alter mRNA methylation and expression levels of genes related to addiction and reward in the brain, potentially contributing to alcohol tolerance and dependence. Neu...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"35 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2023-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138818442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cut&tag: a powerful epigenetic tool for chromatin profiling Cut&tag：用于染色质分析的强大表观遗传工具
IF 3.7 3区 生物学
Epigenetics Pub Date : 2023-12-17 DOI: 10.1080/15592294.2023.2293411
Zhijun Fu, Sanjie Jiang, Yiwen Sun, Shanqiao Zheng, Liang Zong, Peipei Li
{"title":"Cut&tag: a powerful epigenetic tool for chromatin profiling","authors":"Zhijun Fu, Sanjie Jiang, Yiwen Sun, Shanqiao Zheng, Liang Zong, Peipei Li","doi":"10.1080/15592294.2023.2293411","DOIUrl":"https://doi.org/10.1080/15592294.2023.2293411","url":null,"abstract":"Analysis of transcription factors and chromatin modifications at the genome-wide level provides insights into gene regulatory processes, such as transcription, cell differentiation and cellular res...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"37 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2023-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138717082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth 母亲的不良童年经历（ACE）与后代出生时的印记基因 DMR 甲基化
IF 3.7 3区 生物学
Epigenetics Pub Date : 2023-12-15 DOI: 10.1080/15592294.2023.2293412
Adriana C. Vidal, David W. Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K. Murphy, Sara B. Johnson, Billy Schlief, Cathrine Hoyo
{"title":"Maternal adverse childhood experiences (ACEs) and offspring imprinted gene DMR methylation at birth","authors":"Adriana C. Vidal, David W. Sosnowski, Joddy Marchesoni, Carole Grenier, John Thorp, Susan K. Murphy, Sara B. Johnson, Billy Schlief, Cathrine Hoyo","doi":"10.1080/15592294.2023.2293412","DOIUrl":"https://doi.org/10.1080/15592294.2023.2293412","url":null,"abstract":"Adverse childhood experiences (ACEs) contribute to numerous negative health outcomes across the life course and across generations. Here, we extend prior work by examining the association of matern...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"129 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2023-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138741560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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