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Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort. MADRES 妊娠队列中的母体血糖水平与妊娠晚期循环细胞外囊泡和颗粒 miRNAs。
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-09-18 DOI: 10.1080/15592294.2024.2404198
Elizabeth C Anderson,Helen B Foley,Joshua J Levy,Megan E Romano,Jiang Gui,Jessica L Bentz,Luis E Maldonado,Shohreh F Farzan,Theresa M Bastain,Carmen J Marsit,Carrie V Breton,Caitlin G Howe
{"title":"Maternal glucose levels and late pregnancy circulating extracellular vesicle and particle miRNAs in the MADRES pregnancy cohort.","authors":"Elizabeth C Anderson,Helen B Foley,Joshua J Levy,Megan E Romano,Jiang Gui,Jessica L Bentz,Luis E Maldonado,Shohreh F Farzan,Theresa M Bastain,Carmen J Marsit,Carrie V Breton,Caitlin G Howe","doi":"10.1080/15592294.2024.2404198","DOIUrl":"https://doi.org/10.1080/15592294.2024.2404198","url":null,"abstract":"Maternal hyperglycemia during pregnancy adversely affects maternal and child outcomes. While mechanisms are not fully understood, maternal circulating miRNAs may play a role. We examined whether continuous glucose levels and hyperglycemia subtypes (gestational diabetes, type 2 diabetes, and glucose intolerance) were associated with circulating miRNAs during late pregnancy. Seven miRNAs (hsa-miR-107, hsa-let-7b-5p, hsa-miR-126-3p, hsa-miR-181a-5p, hsa-miR-374a-5p, hsa-miR-382-5p, and hsa-miR-337-5p) were associated (p < 0.05) with either hyperglycemia or continuous glucose levels prior to multiple testing correction. These miRNAs target genes involved in pathways relevant to maternal and child health, including insulin signaling, placental development, energy balance, and appetite regulation.","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"13 1","pages":"2404198"},"PeriodicalIF":3.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142249958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health. 探索从蜂王浆中提取脂肪酸作为组蛋白去乙酰化酶抑制剂的来源：从蜂巢到在人类福祉和健康中的应用。
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-09-10 DOI: 10.1080/15592294.2024.2400423
Fernanda Aparecida Dos Santos France,Debora Kazumi Maeda,Ana Beatriz Rodrigues,Mai Ono,Franciele Lopes Nogueira Marchetti,Marcos Martins Marchetti,Allana Cristina Faustino Martins,Roberto da Silva Gomes,Cláudia Aparecida Rainho
{"title":"Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health.","authors":"Fernanda Aparecida Dos Santos France,Debora Kazumi Maeda,Ana Beatriz Rodrigues,Mai Ono,Franciele Lopes Nogueira Marchetti,Marcos Martins Marchetti,Allana Cristina Faustino Martins,Roberto da Silva Gomes,Cláudia Aparecida Rainho","doi":"10.1080/15592294.2024.2400423","DOIUrl":"https://doi.org/10.1080/15592294.2024.2400423","url":null,"abstract":"A differential diet with royal jelly (RJ) during early larval development in honeybees shapes the phenotype, which is probably mediated by epigenetic regulation of gene expression. Evidence indicates that small molecules in RJ can modulate gene expression in mammalian cells, such as the fatty acid 10-hydroxy-2-decenoic acid (10-HDA), previously associated with the inhibition of histone deacetylase enzymes (HDACs). Therefore, we combined computational (molecular docking simulations) and experimental approaches for the screening of potential HDAC inhibitors (HDACi) among 32 RJ-derived fatty acids. Biochemical assays and gene expression analyses (Reverse Transcriptase - quantitative Polymerase Chain Reaction) were performed to evaluate the functional effects of the major RJ fatty acids, 10-HDA and 10-HDAA (10-hydroxy-decanoic acid), in two human cancer cell lines (HCT116 and MDA-MB-231). The molecular docking simulations indicate that these fatty acids might interact with class I HDACs, specifically with the catalytic domain of human HDAC2, likewise well-known HDAC inhibitors (HDACi) such as SAHA (suberoylanilide hydroxamic acid) and TSA (Trichostatin A). In addition, the combined treatment with 10-HDA and 10-HDAA inhibits the activity of human nuclear HDACs and leads to a slight increase in the expression of HDAC-coding genes in cancer cells. Our findings indicate that royal jelly fatty acids collectively contribute to HDAC inhibition and that 10-HDA and 10-HDAA are weak HDACi that facilitate the acetylation of lysine residues of chromatin, triggering an increase in gene expression levels in cancer cells.","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"2 1","pages":"2400423"},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142222205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Folate-mediated transgenerational inheritance of sperm DNA methylation patterns correlate with spinal axon regeneration 叶酸介导的精子DNA甲基化模式转代遗传与脊髓轴突再生相关
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-07-27 DOI: 10.1080/15592294.2024.2380930
Andy Madrid, Joyce Koueik, Ligia A. Papale, Roy Chebel, Isabelle Renteria, Emily Cannon, Kirk J. Hogan, Reid S. Alisch, Bermans J. Iskandar
{"title":"Folate-mediated transgenerational inheritance of sperm DNA methylation patterns correlate with spinal axon regeneration","authors":"Andy Madrid, Joyce Koueik, Ligia A. Papale, Roy Chebel, Isabelle Renteria, Emily Cannon, Kirk J. Hogan, Reid S. Alisch, Bermans J. Iskandar","doi":"10.1080/15592294.2024.2380930","DOIUrl":"https://doi.org/10.1080/15592294.2024.2380930","url":null,"abstract":"In mammals, the molecular mechanisms underlying transgenerational inheritance of phenotypic traits in serial generations of progeny after ancestral environmental exposures, without variation in DNA...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"31 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141783799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
H4K20me3, H3K4me2 and H3K9me2 mediate the effect of ER on prognosis in breast cancer H4K20me3、H3K4me2 和 H3K9me2 介导 ER 对乳腺癌预后的影响
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-21 DOI: 10.1080/15592294.2024.2343593
Cheng-Kun Xiao, Yuexiang Ren, Qianxin Chen, Yuanzhong Yang, Luying Tang, Lin Xu, Zefang Ren
{"title":"H4K20me3, H3K4me2 and H3K9me2 mediate the effect of ER on prognosis in breast cancer","authors":"Cheng-Kun Xiao, Yuexiang Ren, Qianxin Chen, Yuanzhong Yang, Luying Tang, Lin Xu, Zefang Ren","doi":"10.1080/15592294.2024.2343593","DOIUrl":"https://doi.org/10.1080/15592294.2024.2343593","url":null,"abstract":"Previous studies have indicated that histone methylations act as mediators in the relationship between oestrogen receptor (ER) and breast cancer prognosis, yet the mediating role has never been ass...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"9 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140636791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SOX6 AU controls myogenesis by cis-modulation of SOX6 in cattle SOX6 AU 通过顺式调节控制牛的肌肉发生
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-14 DOI: 10.1080/15592294.2024.2341578
Xin Li, Shan-Shan Xing, Sheng-Bo Meng, Zhong-Yi Hou, Lei Yu, Meng-Juan Chen, Dong-Dong Yuan, Hui-Fen Xu, Han-Fang Cai, Ming Li
{"title":"SOX6 AU controls myogenesis by cis-modulation of SOX6 in cattle","authors":"Xin Li, Shan-Shan Xing, Sheng-Bo Meng, Zhong-Yi Hou, Lei Yu, Meng-Juan Chen, Dong-Dong Yuan, Hui-Fen Xu, Han-Fang Cai, Ming Li","doi":"10.1080/15592294.2024.2341578","DOIUrl":"https://doi.org/10.1080/15592294.2024.2341578","url":null,"abstract":"Long non-coding RNAs (lncRNAs) have been shown to be involved in the regulation of skeletal muscle development through multiple mechanisms. The present study revealed that the lncRNA SOX6 AU (SRY-b...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"77 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140602907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site PhiC31 整合位点表达载体的染色质调控模式研究
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-09 DOI: 10.1080/15592294.2024.2337085
Xueli Liu, Qina Chen, Xudong Yin, Xiao Wang, Jinshan Ran, Wei Yu, Bin Wang
{"title":"Study on chromatin regulation patterns of expression vectors in the PhiC31 integration site","authors":"Xueli Liu, Qina Chen, Xudong Yin, Xiao Wang, Jinshan Ran, Wei Yu, Bin Wang","doi":"10.1080/15592294.2024.2337085","DOIUrl":"https://doi.org/10.1080/15592294.2024.2337085","url":null,"abstract":"The PhiC31 integration system allows for targeted and efficient transgene integration and expression by recognizing pseudo attP sites in mammalian cells and integrating the exogenous genes into the...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"45 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells 维生素 C 可提高结直肠癌细胞中新型 TET1 核体与 Cajal 和 PML 体的共定位能力
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-07 DOI: 10.1080/15592294.2024.2337142
Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki
{"title":"Vitamin C enhances co-localization of novel TET1 nuclear bodies with both Cajal and PML bodies in colorectal cancer cells","authors":"Nour El Osmani, Corinne Prévostel, Laurence Picque Lasorsa, Mohammad El Harakeh, Zeina Radwan, Hiba Mawlawi, Marwan El Sabban, Margret Shirinian, Zeina Dassouki","doi":"10.1080/15592294.2024.2337142","DOIUrl":"https://doi.org/10.1080/15592294.2024.2337142","url":null,"abstract":"Deregulation of ten-eleven Translocation protein 1 (TET1) is commonly reported to induce imbalances in gene expression and subsequently to colorectal cancer development (CRC). On the other hand, vi...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trauma context exerts intergenerational effects on child mental health via DNA methylation 创伤环境通过 DNA 甲基化对儿童心理健康产生代际影响
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-05 DOI: 10.1080/15592294.2024.2333654
Stefanie Pilkay, Andie Riffer, Andrew Carroll
{"title":"Trauma context exerts intergenerational effects on child mental health via DNA methylation","authors":"Stefanie Pilkay, Andie Riffer, Andrew Carroll","doi":"10.1080/15592294.2024.2333654","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333654","url":null,"abstract":"Many people experience traumatic or negative events, but few develop mental health issues as a result. This study investigated whether newborn DNA methylation (DNAm) previously associated with mate...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations 不同种族和民族人群中与 C 反应蛋白相关的甲基化模式
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-03 DOI: 10.1080/15592294.2024.2333668
Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg, On Behalf of the PAGE Study
{"title":"Methylation patterns associated with C-reactive protein in racially and ethnically diverse populations","authors":"Jessica I. Lundin, Ulrike Peters, Yao Hu, Farah Ammous, Christy L. Avery, Emelia J. Benjamin, Joshua C. Bis, Jennifer A. Brody, Chris Carlson, Mary Cushman, Chris Gignoux, Xiuqing Guo, Jeff Haessler, Chris Haiman, Roby Joehanes, Silva Kasela, Eimear Kenny, Tuuli Lapalainien, Daniel Levy, Chunyu Liu, Yongmei Liu, Ruth J.F. Loos, Ake Lu, Tara Matise, Kari E. North, Sungshim L. Park, Scott M. Ratliff, Alex Reiner, Stephen S. Rich, Jerome I. Rotter, Jennifer A. Smith, Nona Sotoodehnia, Russell Tracy, David Van den Berg, Huichun Xu, Ting Ye, Wei Zhao, Laura M. Raffield, Charles Kooperberg, On Behalf of the PAGE Study","doi":"10.1080/15592294.2024.2333668","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333668","url":null,"abstract":"Systemic low-grade inflammation is a feature of chronic disease. C-reactive protein (CRP) is a common biomarker of inflammation and used as an indicator of disease risk; however, the role of inflam...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"8 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays 对 Illumina MethylationEPIC v1.0 BeadChip 芯片上 DNA 甲基化探针可靠性的严格评估
IF 3.7 3区 生物学
Epigenetics Pub Date : 2024-04-02 DOI: 10.1080/15592294.2024.2333660
Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang
{"title":"Critical evaluation of the reliability of DNA methylation probes on the Illumina MethylationEPIC v1.0 BeadChip microarrays","authors":"Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, David Lukacsovich, Achintya Varma, X. Steven Chen, Brian Kunkle, Eden R. Martin, Lily Wang","doi":"10.1080/15592294.2024.2333660","DOIUrl":"https://doi.org/10.1080/15592294.2024.2333660","url":null,"abstract":"DNA methylation (DNAm) plays a crucial role in a number of complex diseases. However, the reliability of DNAm levels measured using Illumina arrays varies across different probes. Previous research...","PeriodicalId":11767,"journal":{"name":"Epigenetics","volume":"2 1","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140573752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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