发布求助
文献互助 智能选刊 最新文献

Epilepsy Currents最新文献

筛选
英文 中文
Adenosine Makes a Scene. 腺苷引起轰动。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-04-16 eCollection Date: 2025-05-01 DOI: 10.1177/15357597251323126
Helen E Scharfman
{"title":"Adenosine Makes a Scene.","authors":"Helen E Scharfman","doi":"10.1177/15357597251323126","DOIUrl":"10.1177/15357597251323126","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"198-200"},"PeriodicalIF":5.8,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12003313/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spreading Depolarization and Seizures: End of the Beginning, or Beginning of the End? 扩张性去极化与癫痫：开端的终结，还是终结的开端？
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-04-13 DOI: 10.1177/15357597251328827
Isamu Aiba, Jeffrey L Noebels
{"title":"Spreading Depolarization and Seizures: End of the Beginning, or Beginning of the End?","authors":"Isamu Aiba, Jeffrey L Noebels","doi":"10.1177/15357597251328827","DOIUrl":"https://doi.org/10.1177/15357597251328827","url":null,"abstract":"<p><p>Like Janus, the Roman god of beginnings, transitions, and endings, spreading depolarizations (SDs) can be depicted with two faces: one looking backward, waving a symbolic farewell to the end of a cortical seizure; the other forward looking, opening a darker door for a fatal wave in the brainstem that ends life. There is good agreement on the distinct electrical nature of both events, but neither role is yet proven in patients. SD is a slow-moving wave of cellular depolarization that steadily silences neuronal networks and depresses EEG amplitude, whereas seizures represent fast, intermittent synchronization of neural networks with highly variable EEG activation patterns. However, the thresholds triggering both events are neither fixed nor inseparable; indeed, their co-occurrence and interaction depend on dimly-lit intrinsic brain pathophysiology. New insights into single gene control of SD and seizure thresholds are beginning to illuminate the darkness. Here, we review recent data and consider the title's question at the end.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597251328827"},"PeriodicalIF":5.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12063228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143998281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Channeling Seizure Control: Optogenetics in Human Brain Slices. 通道癫痫控制：人脑切片的光遗传学。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-04-13 eCollection Date: 2025-07-01 DOI: 10.1177/15357597251333157
John D Rolston
{"title":"Channeling Seizure Control: Optogenetics in Human Brain Slices.","authors":"John D Rolston","doi":"10.1177/15357597251333157","DOIUrl":"10.1177/15357597251333157","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"275-276"},"PeriodicalIF":5.8,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11994629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Breaking the Synaptic Vesicle Cycle: Mechanistic Insights into Presynaptic Dysfunctions in Epilepsy. 打破突触小泡循环：癫痫中突触前功能障碍的机制见解。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-04-03 eCollection Date: 2025-03-01 DOI: 10.1177/15357597251317898
Kevin Jiang, Lu-Tang Yang, Mingshan Xue
{"title":"Breaking the Synaptic Vesicle Cycle: Mechanistic Insights into Presynaptic Dysfunctions in Epilepsy.","authors":"Kevin Jiang, Lu-Tang Yang, Mingshan Xue","doi":"10.1177/15357597251317898","DOIUrl":"10.1177/15357597251317898","url":null,"abstract":"<p><p>Synaptic dysfunction is a hallmark of many neurological disorders including epilepsy. An increasing number of epilepsy-causing pathogenic variants are being identified in genes encoding presynaptic proteins that affect every step of the synaptic vesicle cycle, from vesicle loading, tethering, docking, priming, calcium sensing, fusing, to recycling. These different molecular dysfunctions result in converging impairment of presynaptic neurotransmitter release, yet lead to diverse epileptic disorders. This review focuses on representative monogenic epileptic disorders caused by pathogenic variants of key presynaptic proteins involved in different stages of the synaptic vesicle cycle: SYN1 (vesicle pool regulation), STXBP1 (vesicle docking, priming, and fusion), and DNM1 (vesicle recycling). We discuss the molecular, synaptic, and circuit mechanisms of these archetypal synaptic vesicle exocytosis and endocytosis-related epilepsies and highlight the diversity and commonality of their presynaptic dysfunctions. We further discuss future avenues of research to better connect distinct presynaptic alterations to epileptogenesis and develop novel therapeutic approaches.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"119-124"},"PeriodicalIF":5.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969472/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Out with prolactin, in with neurofilament light and glial fibrillary acidic protein. 分泌泌乳素，分泌神经丝蛋白和胶质原纤维酸性蛋白。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-04-03 eCollection Date: 2025-05-01 DOI: 10.1177/15357597251324016
Danielle M Andrade
{"title":"Out with prolactin, in with neurofilament light and glial fibrillary acidic protein.","authors":"Danielle M Andrade","doi":"10.1177/15357597251324016","DOIUrl":"10.1177/15357597251324016","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"176-178"},"PeriodicalIF":5.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11969486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Is Bigger Better? Exploring the Compensatory Versus Pathological Nature of Amygdala Hypertrophy. 越大越好吗？探讨杏仁核肥大的代偿与病理性质。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-04-01 eCollection Date: 2025-07-01 DOI: 10.1177/15357597251328822
Carrie R McDonald
{"title":"Is Bigger Better? Exploring the Compensatory Versus Pathological Nature of Amygdala Hypertrophy.","authors":"Carrie R McDonald","doi":"10.1177/15357597251328822","DOIUrl":"10.1177/15357597251328822","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"272-274"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966622/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epilepsy Gene Discovery Needs Another Big Leap Forward. 癫痫基因发现需要再一次大跃进。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-04-01 eCollection Date: 2025-05-01 DOI: 10.1177/15357597251325685
Wayne N Frankel
{"title":"Epilepsy Gene Discovery Needs Another Big Leap Forward.","authors":"Wayne N Frankel","doi":"10.1177/15357597251325685","DOIUrl":"10.1177/15357597251325685","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"201-202"},"PeriodicalIF":5.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11966618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comprehensive Epilepsy Care: The Key to Cutting Costs and Seizing Better Outcomes. 癫痫综合护理：降低成本和获得更好结果的关键。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-03-28 eCollection Date: 2025-05-01 DOI: 10.1177/15357597251324024
John D Rolston
{"title":"Comprehensive Epilepsy Care: The Key to Cutting Costs and Seizing Better Outcomes.","authors":"John D Rolston","doi":"10.1177/15357597251324024","DOIUrl":"10.1177/15357597251324024","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"164-166"},"PeriodicalIF":5.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SEEG Radiofrequency Thermocoagulation and Memory: For Now, Avoid the Trap of Overpromising and Underdelivering. SEEG射频热凝和记忆：目前，避免过度承诺和交付不足的陷阱。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-03-28 eCollection Date: 2025-07-01 DOI: 10.1177/15357597251324032
Vineet Punia
{"title":"SEEG Radiofrequency Thermocoagulation and Memory: For Now, Avoid the Trap of Overpromising and Underdelivering.","authors":"Vineet Punia","doi":"10.1177/15357597251324032","DOIUrl":"10.1177/15357597251324032","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"283-285"},"PeriodicalIF":5.8,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating Transition to Adulthood in Epilepsy Patients: A Multidisciplinary Approach. 导航过渡到成年癫痫患者：一个多学科的方法。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2025-03-25 eCollection Date: 2025-05-01 DOI: 10.1177/15357597251324034
Yinchen Song, L David Klemens, Hallie Orton, Audrey Kennedy, Jana E Jones, Sucheta Joshi, Meghann Kelly
{"title":"Navigating Transition to Adulthood in Epilepsy Patients: A Multidisciplinary Approach.","authors":"Yinchen Song, L David Klemens, Hallie Orton, Audrey Kennedy, Jana E Jones, Sucheta Joshi, Meghann Kelly","doi":"10.1177/15357597251324034","DOIUrl":"10.1177/15357597251324034","url":null,"abstract":"<p><p>The transition from pediatric to adult healthcare systems is a critical yet complex process for individuals with epilepsy, requiring careful attention to both medical and psychosocial aspects. This review highlights best practices and strategies to facilitate effective transitions, focusing on the roles of multidisciplinary teams, communication strategies, shared decision-making, and transition readiness assessment. Key topics include early and ongoing communication, promoting patient autonomy, addressing mental health comorbidities, and implementing transition readiness assessments such as the Epilepsy Transition Readiness Assessment Questionnaire (EpiTRAQ). Additionally, the review evaluates models for transition clinics, emphasizing the importance of sustainability, collaboration, and tailored interventions. By leveraging these insights, healthcare professionals can support young adults with epilepsy in achieving independence and optimal health outcomes as they navigate the challenges of transitioning to adult care.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"221-228"},"PeriodicalIF":5.8,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11948259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信