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Neuronal Excitability in Trisomy 21-Up or Down? 21 三体综合征的神经元兴奋性上升还是下降？
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241285779
Carl E Stafstrom
{"title":"Neuronal Excitability in Trisomy 21-Up or <i>Down</i>?","authors":"Carl E Stafstrom","doi":"10.1177/15357597241285779","DOIUrl":"10.1177/15357597241285779","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"440-442"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KCN Channels "Cue" Up GABA Release from Astrocytes. KCN 通道 "提示 "星形胶质细胞释放 GABA
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280504
Matthew C Weston
{"title":"KCN Channels \"Cue\" Up GABA Release from Astrocytes.","authors":"Matthew C Weston","doi":"10.1177/15357597241280504","DOIUrl":"10.1177/15357597241280504","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"429-430"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556643/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Need for Speed; Investigating Channelopathy-Associated Epilepsy Using High Throughput Electrophysiological Approaches. 需要速度；利用高通量电生理学方法研究通道病相关癫痫。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280484
Alfred L George, Evangelos Kiskinis
{"title":"The Need for Speed; Investigating Channelopathy-Associated Epilepsy Using High Throughput Electrophysiological Approaches.","authors":"Alfred L George, Evangelos Kiskinis","doi":"10.1177/15357597241280484","DOIUrl":"10.1177/15357597241280484","url":null,"abstract":"<p><p>Pathogenic variants in genes encoding ion channels are frequently discovered in monogenic disorders associated with epilepsy and neurodevelopmental disorders. This review covers advances in the use of automated patch clamp recording for determining the functional consequences of epilepsy-associated ion channel variants and the use of induced pluripotent stem cell (iPSC) derived neurons for in-depth investigations of the physiological consequences of such variants. The combination of these advanced technologies was a focus of the recently completed NINDS-funded Channelopathy-associated Epilepsy Research Center without Walls.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"345-349"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536426/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
More is Different in mTORopathies. 在 mTOR 病症中，"更多 "就是 "不同"。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-16 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280470
Yu Wang
{"title":"More is Different in mTORopathies.","authors":"Yu Wang","doi":"10.1177/15357597241280470","DOIUrl":"10.1177/15357597241280470","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"358-360"},"PeriodicalIF":5.8,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Are High-Frequency Activities Reliable Biomarkers of the FCDII Lesion? 高频活动是 FCDII 病变的可靠生物标志物吗？
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-15 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280482
Guru Prasad Padmasola, Gabriele Lignani
{"title":"Are High-Frequency Activities Reliable Biomarkers of the FCDII Lesion?","authors":"Guru Prasad Padmasola, Gabriele Lignani","doi":"10.1177/15357597241280482","DOIUrl":"10.1177/15357597241280482","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"364-366"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitigating Risk, Optimizing Care: Antiseizure Medications, Pregnancy, and Autism Spectrum Disorder Risk. 降低风险，优化护理：抗癫痫药物、怀孕和自闭症谱系障碍风险。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-15 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280479
Yi Li
{"title":"Mitigating Risk, Optimizing Care: Antiseizure Medications, Pregnancy, and Autism Spectrum Disorder Risk.","authors":"Yi Li","doi":"10.1177/15357597241280479","DOIUrl":"10.1177/15357597241280479","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"412-414"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142635947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wnt Signaling: The Next Step on the Road to Anti-Epileptogenic Therapies? Wnt 信号：抗致痫疗法之路的下一步？
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-15 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280467
Carolina Moncion, Peter J West, Cameron S Metcalf
{"title":"Wnt Signaling: The Next Step on the Road to Anti-Epileptogenic Therapies?","authors":"Carolina Moncion, Peter J West, Cameron S Metcalf","doi":"10.1177/15357597241280467","DOIUrl":"10.1177/15357597241280467","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"355-357"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dopamine Dilemma Overexcites the Hippocampus in Alzheimer's Disease. 多巴胺困境会过度刺激阿尔茨海默病的海马体
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-15 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280475
Jennifer C Wong
{"title":"Dopamine Dilemma Overexcites the Hippocampus in Alzheimer's Disease.","authors":"Jennifer C Wong","doi":"10.1177/15357597241280475","DOIUrl":"10.1177/15357597241280475","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"361-363"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142590246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Why Did My Seizures Start Now?": A Singular Question With Multiple Potential Answers. "为什么我的癫痫现在才开始发作？一个有多种潜在答案的单一问题。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-15 eCollection Date: 2024-09-01 DOI: 10.1177/15357597241280476
Elizabeth E Gerard
{"title":"\"Why Did My Seizures Start Now?\": A Singular Question With Multiple Potential Answers.","authors":"Elizabeth E Gerard","doi":"10.1177/15357597241280476","DOIUrl":"10.1177/15357597241280476","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 5","pages":"331-333"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sharper Minds: Cognitive Recovery After Epilepsy Surgery in Children. 更敏锐的头脑：儿童癫痫手术后的认知恢复。
IF 5.8 2区 医学
Epilepsy Currents Pub Date : 2024-10-15 eCollection Date: 2024-11-01 DOI: 10.1177/15357597241280032
Dario J Englot
{"title":"Sharper Minds: Cognitive Recovery After Epilepsy Surgery in Children.","authors":"Dario J Englot","doi":"10.1177/15357597241280032","DOIUrl":"10.1177/15357597241280032","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"24 6","pages":"393-395"},"PeriodicalIF":5.8,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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