Epilepsy CurrentsPub Date : 2026-05-30eCollection Date: 2026-07-01DOI: 10.1177/15357597261433585
Gewalin Aungaroon
{"title":"Wearable Data in Epilepsy Care.","authors":"Gewalin Aungaroon","doi":"10.1177/15357597261433585","DOIUrl":"10.1177/15357597261433585","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"352-354"},"PeriodicalIF":4.6,"publicationDate":"2026-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13222214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148143371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epilepsy CurrentsPub Date : 2026-05-27eCollection Date: 2026-07-01DOI: 10.1177/15357597261450773
Lena H Nguyen
{"title":"Mosaic Matters: A Transcriptomic Window into FCDII Epileptogenesis.","authors":"Lena H Nguyen","doi":"10.1177/15357597261450773","DOIUrl":"10.1177/15357597261450773","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"349-351"},"PeriodicalIF":4.6,"publicationDate":"2026-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13219111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148137167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epilepsy CurrentsPub Date : 2026-05-25DOI: 10.1177/15357597261442391
Hannah Pickard, Elaine K O'Loughlin, Mary Holmay, Gardiner Lapham, Jeffrey Buchhalter, Ben Donovan, Amol Bhandare, Rob C Wykes, Arjune Sen, Laura S Lubbers
{"title":"Towards a Unified Research Agenda: International Consensus to Advance Understanding and Prevention of Sudden Unexpected Death in Epilepsy.","authors":"Hannah Pickard, Elaine K O'Loughlin, Mary Holmay, Gardiner Lapham, Jeffrey Buchhalter, Ben Donovan, Amol Bhandare, Rob C Wykes, Arjune Sen, Laura S Lubbers","doi":"10.1177/15357597261442391","DOIUrl":"10.1177/15357597261442391","url":null,"abstract":"<p><p>Sudden unexpected death in epilepsy (SUDEP) is a significant research and community priority. In recent years, diverse stakeholders, including researchers, clinicians, charity organizations, people affected by epilepsy, and bereaved families, have collectively identified priorities and recommendations to accelerate understanding of SUDEP risk and prevention. Through comprehensive discussions, shared learnings and priorities have emerged across three broad areas, including clinical research, preclinical science, and awareness and education. To address these priorities, actionable recommendations that focus on providing better infrastructure, tools, data, access and education to advance prevention of SUDEP have been defined.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261442391"},"PeriodicalIF":4.6,"publicationDate":"2026-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201376/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148041434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epilepsy CurrentsPub Date : 2026-05-20eCollection Date: 2026-07-01DOI: 10.1177/15357597261441236
Jason M Schwalb
{"title":"Avoiding Insularity: Insights in Insular Semiology From sEEG.","authors":"Jason M Schwalb","doi":"10.1177/15357597261441236","DOIUrl":"10.1177/15357597261441236","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"313-314"},"PeriodicalIF":4.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epilepsy CurrentsPub Date : 2026-05-20DOI: 10.1177/15357597261454275
R A Sarkis, E L Johnson, A D Lam
{"title":"The Saga of Late-Onset Unexplained Epilepsy.","authors":"R A Sarkis, E L Johnson, A D Lam","doi":"10.1177/15357597261454275","DOIUrl":"10.1177/15357597261454275","url":null,"abstract":"<p><p>Late-onset epilepsy is increasingly recognized as a major and growing neurological condition in older adults, driven by population aging and rising incidence rates, yet approximately one-third of cases remain unexplained (late-onset unexplained epilepsy, LoUE). LoUE is diagnostically challenging, as seizures are often subtle and nonconvulsive, routine EEG has limited sensitivity. Converging evidence from animal models and clinical studies suggests that aging-related reductions in seizure threshold, vascular dysfunction, neurodegenerative processes, and immune dysregulation (\"inflammaging\") all contribute to epileptogenesis, often through interacting and cumulative pathways. Clinically, while many patients respond to antiseizure medications, a subset experience refractory disease. Importantly, LoUE should not be viewed as a single entity but rather as a heterogeneous syndrome arising within diverse biological contexts shaped by lifetime exposures, comorbidities, and underlying pathology. Advancing the field will require prospective, multimodal studies integrating neuroimaging, fluid biomarkers, and detailed phenotyping to define mechanistic subtypes and enable a transition toward precision medicine approaches aimed at reducing the burden of seizures and their downstream consequences in older adults.</p>","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261454275"},"PeriodicalIF":4.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13190366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148014018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epilepsy CurrentsPub Date : 2026-05-20eCollection Date: 2026-07-01DOI: 10.1177/15357597261446774
Jeffrey H Goodman
{"title":"Blockade of Corticotropin-Releasing Hormone Receptor 1 Receptors in the Arcuate Nucleus May Effectively Treat Infantile Epileptic Spasms Syndrome.","authors":"Jeffrey H Goodman","doi":"10.1177/15357597261446774","DOIUrl":"10.1177/15357597261446774","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":"26 4","pages":"346-348"},"PeriodicalIF":4.6,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365712/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148445165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epilepsy CurrentsPub Date : 2026-04-24eCollection Date: 2026-07-01DOI: 10.1177/15357597261445156
Jennifer C Wong
{"title":"Seizing Control of the CA2.","authors":"Jennifer C Wong","doi":"10.1177/15357597261445156","DOIUrl":"10.1177/15357597261445156","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"343-345"},"PeriodicalIF":4.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13109240/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Epilepsy CurrentsPub Date : 2026-04-20DOI: 10.1177/15357597261439480
Cameron S Metcalf, Peter J West, Misty D Smith, Karen S Wilcox
{"title":"Epilepsy Therapy Screening From 1975 to 2026 and Beyond: Merging Established and New Approaches to Develop Novel Therapies.","authors":"Cameron S Metcalf, Peter J West, Misty D Smith, Karen S Wilcox","doi":"10.1177/15357597261439480","DOIUrl":"10.1177/15357597261439480","url":null,"abstract":"","PeriodicalId":11742,"journal":{"name":"Epilepsy Currents","volume":" ","pages":"15357597261439480"},"PeriodicalIF":4.6,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13096057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147766262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}