ERJ Open Research最新文献

{"title":"Effects of eHealth exercise on paediatric suppurative lung diseases: a systematic review and meta-analysis.","authors":"Aspasia Mavronasou, Eleni A Kortianou, Vaia Sapouna, Konstantinos Douros, Arietta Spinou","doi":"10.1183/23120541.00977-2024","DOIUrl":"10.1183/23120541.00977-2024","url":null,"abstract":"<p><strong>Background: </strong>Utilising information and communication technologies through eHealth in exercise programmes could support their delivery and improve clinical outcomes in children and adolescents with chronic suppurative lung diseases (CSLDs). This study aimed to systematically investigate the effects of eHealth exercise programmes on clinical outcomes for this population.</p><p><strong>Methods: </strong>Five databases were searched from inception to 12 April 2024. Two researchers independently screened the retrieved results and rated the methodological quality of the included studies using the revised Cochrane Risk of Bias (RoB2) tool for randomised trials and the Risk Of Bias In Non-randomised Studies - of Interventions (ROBINS-I) tool. The quality of evidence was graded using the GRADE approach. A narrative synthesis of findings was performed, and a meta-analysis was conducted to evaluate the effects of eHealth exercise programmes on clinical outcomes that had data from at least two studies.</p><p><strong>Results: </strong>Seven studies used eHealth exercise programmes through active video games (n=3), videoconferencing (n=3) and a digital spirometer (n=1) lasting from 3 to 12 weeks. Five studies had participants with cystic fibrosis (CF). Results showed a greater improvement in the 6-min walk test following the intervention compared to the control group (pooled estimate mean difference 37.2 m, 95% CI 7.91-66.48 m; p=0.013). Pulmonary function, exercise capacity, balance, peripheral and respiratory muscle strength, and health-related quality of life were also improved. Still, most studies involved a considerable risk of bias.</p><p><strong>Conclusions: </strong>eHealth exercise programmes can improve clinical outcomes in children and adolescents with CF. Further research is needed for other paediatric populations with CSLDs and also for comparisons with conventional exercise programmes.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resistive breathing aggravates cigarette smoke-induced pulmonary inflammation.","authors":"Eleftheria Mizi, Vyronia Vassilakopoulou, Athanasia Chatzianastasiou, Theocharis Georgiadis, Constantinos Glynos, Stamatios Theocharis, Theodoros Vassilakopoulos, Dimitrios Toumpanakis","doi":"10.1183/23120541.00974-2024","DOIUrl":"10.1183/23120541.00974-2024","url":null,"abstract":"<p><strong>Introduction: </strong>Resistive breathing (RB) is the hallmark of diseases of airway obstruction, especially during exacerbations, resulting in significant mechanical stress on the lung. RB induces pulmonary inflammation and injury in previously healthy animals. Whether RB exerts additional injurious effects when superimposed on cigarette smoke (CS) exposure is unknown.</p><p><strong>Methods: </strong>Adult mice were exposed to CS for 1 or 6 months, followed by RB for 24 h, induced through tracheal banding. Subsequently, respiratory system mechanics were assessed, bronchoalveolar lavage (BAL) was performed and cytokine levels were measured by ELISA in lung tissue samples. Surfactant protein D (SP-D) was measured in blood, and BAL and histology were performed. Emphysema was quantified by the mean linear intercept (Lm) and the destructive index (DI).</p><p><strong>Results: </strong>CS exposure for 1 and 6 months increased BAL cellularity (∼8-fold and ∼1.9-fold to air, respectively, p<0.01). RB aggravated BAL cellularity at both time points (p=0.025 and p=0.002 to CS) and increased MCP-1 levels at 1 month (p=0.002 to control). Histology revealed augmented focal membrane thickening at 1 month following combination of RB with CS exposure (p=0.011), while at 6 months emphysema was more severe after RB in CS-exposed mice (p=0.001 to CS for both Lm and DI). CS increased Sp-D levels in BAL (p<0.01 at both time points), while RB caused increased levels in blood (p<0.01 to CS). RB decreased static compliance at 1 month of air exposure (p=0.007).</p><p><strong>Conclusion: </strong>Combining resistive breathing with cigarette smoke exposure results in augmented inflammatory responses, increased lung injury and augmented emphysema.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatable traits in chronic cough: a prospective evaluation for predicting cough persistence.","authors":"Yeonhee Kim, Seung-Eun Lee, Eun-Jung Jo, Sung-Yoon Kang, Ha-Kyeong Won, Noeul Kang, Ji-Yoon Oh, Ji-Hyang Lee, Young-Chan Kim, Ji-Ho Lee, Han-Ki Park, Hwa Young Lee, So-Young Park, Youngsang Yoo, Mi-Yeong Kim, Sae-Hoon Kim, Sang-Heon Kim, Yoon-Seok Chang, Sang-Hoon Kim, Byung-Jae Lee, Sang-Heon Cho, Surinder S Birring, Woo-Jung Song","doi":"10.1183/23120541.01357-2024","DOIUrl":"10.1183/23120541.01357-2024","url":null,"abstract":"<p><strong>Background: </strong>The concept of treatable traits has been proposed for managing chronic cough; however, evidence supporting its clinical utility remains limited. This study investigated the relationship between baseline traits and cough persistence in a prospective registry of patients with chronic cough.</p><p><strong>Methods: </strong>We analysed data from 426 patients with chronic cough enrolled in the Korean Chronic Cough Registry. 11 potential treatable traits were assessed at baseline. The primary outcome was cough persistence, defined as a cough severity visual analogue scale (VAS) score >20 at the last follow-up visit.</p><p><strong>Results: </strong>After a median follow-up of 12 months (interquartile range: 6-24 months), 215 patients (50.5%) had persistent cough (VAS >20 mm). The most prevalent traits were sputum production (60.5%), cough hypersensitivity symptoms (41.8%) and type 2 inflammation (39.1%). Among baseline traits, only cough hypersensitivity symptoms were significantly associated with cough persistence (p=0.024). In multivariate analysis, cough hypersensitivity symptoms (adjusted OR 1.78, 95% CI 1.15-2.78; p=0.010) and older age (≥60 years) (adjusted OR 2.07, 95% CI 1.34-3.20; p=0.001) were independently associated with cough persistence.</p><p><strong>Conclusions: </strong>These findings suggest that cough hypersensitivity symptoms are associated with long-term outcomes of chronic cough. Further studies are needed to validate the role of treatable traits in chronic cough management and to better understand factors associated with cough persistence.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12378597/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilation defect burden predicts lung cancer resection outcomes.","authors":"Nisarg Radadia, Eldar Priel, Yonni Friedlander, Norman B Konyer, Chynna Huang, Mobin Jamal, Troy Farncombe, Christopher Marriott, Christian Finley, John Agzarian, Michael D Noseworthy, Parameswaran Nair, Yaron Shargall, Sarah Svenningsen","doi":"10.1183/23120541.01317-2024","DOIUrl":"10.1183/23120541.01317-2024","url":null,"abstract":"<p><strong>Background: </strong>Abnormal ventilation prior to lung cancer resection has not been investigated using modern ventilation imaging modalities and may better predict postoperative outcomes than guideline-recommended lung function tests. Our objective was to quantify the burden of ventilation defects observed using Technegas single-photon emission computed tomography (SPECT) and ¹²⁹Xe magnetic resonance imaging (MRI) before lung cancer resection, and to evaluate their association with postoperative pulmonary complications and length of hospital stay.</p><p><strong>Methods: </strong>This was a prospective, 6-week, observational study of adults undergoing lung cancer resection at a single centre. Before lung resection, participants underwent Technegas-SPECT, ¹²⁹Xe-MRI, spirometry and measurement of diffusing capacity of the lung for carbon monoxide. Preoperative ventilation defect burden was quantified by the Technegas-SPECT and ¹²⁹Xe-MRI ventilation defect percent (VDP). Predictors of complications during the 4-week postoperative period and length of hospital stay were evaluated by logistic and linear regression.</p><p><strong>Results: </strong>Abnormal ventilation was observed preoperatively by Technegas-SPECT and ¹²⁹Xe-MRI for 58% (60 of 103) and 73% (74 of 102) of participants, respectively. Preoperative VDPs were higher for participants with postoperative complications compared with those without (SPECT: p=0.01; MRI: p=0.0006) and correlated with length of hospital stay (SPECT: r=0.44, p<0.0001; MRI: r=0.51, p<0.0001). Multivariable models revealed preoperative VDP to be the strongest predictor of postoperative complications (SPECT: OR 1.06, 95% CI 1.01-1.11, p=0.02; MRI: OR 1.11, 95% CI 1.02-1.21, p=0.02) and length of hospital stay (SPECT: β=0.16, p<0.001; MRI: β=0.23, p<0.001).</p><p><strong>Conclusion: </strong>Abnormal ventilation is prevalent prior to lung cancer resection and may be a stronger predictor of postoperative complications and length of hospital stay than standard clinical lung function measures.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12359065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors, molecular analysis and treatment outcomes of amikacin-resistant <i>Mycobacterium avium</i> complex pulmonary disease.","authors":"Tatsuya Kodama, Akio Aono, Keiji Fujiwara, Koji Furuuchi, Masashi Ito, Keisuke Kamada, Fumiya Watanabe, Kinuyo Chikamatsu, Yuriko Igarashi, Yoshiro Murase, Hideo Ogata, Yuji Shiraishi, Takashi Yoshiyama, Ken Ohta, Satoshi Mitarai, Kozo Morimoto","doi":"10.1183/23120541.01084-2024","DOIUrl":"10.1183/23120541.01084-2024","url":null,"abstract":"<p><strong>Background: </strong>Although the incidence of amikacin (AMK)-resistant <i>Mycobacterium avium</i> complex (MAC) pulmonary disease (PD) is suspected to have increased, limited data are available on AMK-resistant MAC-PD. This study evaluated the risk factors associated with AMK resistance, the molecular characteristics of the AMK-resistant isolates, and treatment outcomes of patients with AMK-resistant MAC-PD.</p><p><strong>Methods: </strong>This retrospective case-control study included 73 patients with severe and refractory MAC-PD who had a history of aminoglycoside drug use. Patients with initial and repeat AMK minimum inhibitory concentration (MIC) ≥64 μg·mL^-1 were classified as AMK-resistant. To clarify the clinical outcomes and prognosis, an observational study was conducted. 21 patients with AMK resistance (AMK-resistant) and 52 controls (AMK-susceptible) were analysed.</p><p><strong>Results: </strong>In all cases of AMK resistance where previous isolates were available, the AMK MICs were elevated compared to the levels prior to aminoglycoside administration. In the multivariate analysis of risk factors, clarithromycin resistance (OR 6.31, 95% CI 1.68-23.7) and >12 months of total duration of aminoglycoside use (OR 4.69, 95% CI 1.09-20.2) were identified as independent risk factors for AMK resistance. 12 (57%) out of 21 AMK-resistant isolates were found to have mutations in the <i>rrs</i> region. There was a significant difference between the AMK-resistant and AMK-susceptible groups in terms of worsening outcomes, including the introduction of home oxygen therapy (38% <i>versus</i> 12%; p=0.01) and 3-year mortality (33% <i>versus</i> 10%; p=0.02).</p><p><strong>Conclusions: </strong>Better management strategies for patients with severe and refractory MAC-PD are crucial. This includes placing a strong emphasis on preventing AMK resistance.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trajectories of gut microbiota and nonatopic wheeze: an early-life microbial footprint on preschool asthma.","authors":"Hideaki Miyachi, Heidi Makrinioti","doi":"10.1183/23120541.00437-2025","DOIUrl":"10.1183/23120541.00437-2025","url":null,"abstract":"<p><p><b>Early-life gut microbial trajectories are associated with nonatopic preschool asthma and are possibly modified by breastfeeding practices</b> https://bit.ly/4jNAPgI.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"C-BIOPRED severe asthma clinical phenotypes: link to complement and coagulation pathways and galectin 10.","authors":"Changxing Ou, Zhenan Deng, Yongkang Liao, Xiaomin Cen, Penghui Wu, Chenyang Lu, Xiuhua Fu, Changzheng Wang, Meilin Jin, Guochao Shi, Zhongmin Qiu, Xiaoyang Wei, Wei Gu, Jian Kang, Yunhui Zhang, Mao Huang, Jinfu Xu, Kewu Huang, Qiang Li, Xiangyan Zhang, Chunhua Wei, Guangfa Wang, Kian Fan Chung, Nanshan Zhong, Qingling Zhang, Jiaxing Xie","doi":"10.1183/23120541.01016-2024","DOIUrl":"10.1183/23120541.01016-2024","url":null,"abstract":"<p><strong>Background: </strong>Severe asthma is a heterogeneous airway inflammatory disease presenting with varying clinicophysiological characteristics and response to treatments. The objectives of the present study were to determine the clinical phenotypes of the Chinese C-BIOPRED cohort and their link to the sputum proteome.</p><p><strong>Methods: </strong>Partition-around-medoids clustering was applied to a training set of 362 nonsmoking, smoking or ex-smoking severe asthma patients, and nonsmoking mild-moderate asthma patients using eight clinicophysiological variables, with validation performed in the remaining 181.</p><p><strong>Results: </strong>Three stable clusters were defined, with Cluster T1 composed of predominantly female patients with severe nonsmoking asthma experiencing frequent exacerbations with moderate airflow obstruction, and Cluster T3 of elderly male patients with smoking/ex-smoking late-onset severe asthma and severe airflow obstruction and a moderate number of exacerbations. Cluster T2 was composed of nonsmokers with a mild-moderate airflow obstruction and no previous exacerbations. Validation clusters (V1, V2 and V3) were similar to the training set clusters. Differentially expressed proteins in sputum supernatants measured by liquid chromatography with tandem mass spectrometry pointed to differences in the complement and coagulation cascade pathway between Cluster 1 (T1 and V1) and Cluster 3 (T3 and V3), as well as between Cluster 2 (T2 and V2) and Cluster 3. Galectin 10 was upregulated in Cluster 1 compared with Cluster 2, and correlated with exacerbations, fractional exhaled nitric oxide, blood and sputum eosinophil count and oral corticosteroid dose in Cluster 1.</p><p><strong>Conclusion: </strong>The clinical clusters were differentiated by smoking status, degree of airflow obstruction and exacerbation history, and by sputum complement and coagulation pathways, and galectin 10 levels.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351390/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Secretory IgA modifies the association between early-life gut microbiota trajectories and childhood nonatopic wheeze.","authors":"Linn E Moore, Hein M Tun, Catherine J Field, Piushkumar J Mandhane, Elinor Simons, Theo J Moraes, Padmaja Subbarao, Stuart E Turvey, Matthew Hicks, Anne Hicks, Anita L Kozyrskyj","doi":"10.1183/23120541.00240-2025","DOIUrl":"10.1183/23120541.00240-2025","url":null,"abstract":"<p><strong>Aims: </strong>Wheezing in childhood is common and evidence is accumulating for the role of the gut microbiome in the development of atopic wheeze. Changes to the early-life gut microbiota and secretory IgA (SIgA) production have been linked to childhood disease; however, their connection to nonatopic wheeze is unknown. The objectives of the present study were to evaluate the relationships between early-life gut microbiota trajectories, SIgA and childhood nonatopic wheeze.</p><p><strong>Methods: </strong>Early-life gut microbiota, SIgA and child outcome data were collected as part of the Canadian Healthy Infant Longitudinal Development (CHILD) cohort study on 1203 children. Gut microbiota trajectories were categorised as C1-C1, C1-C2, C2-C1 and C2-C2 based on low (cluster 1; C1) or high (cluster 2; C2) <i>Bacteroides</i> abundance in faecal samples collected at 3 and 12 months. SIgA was assessed in faecal samples at 3 months.</p><p><strong>Results: </strong>The main outcome was nonatopic wheeze before age 5 years (n=105). Logistic regression analysis showed the C1-C2 trajectory, of low <i>Bacteroides</i> abundance at 3 months but higher <i>Bacteroides</i> abundance at 12 months, to be associated with increased adjusted odds ratio (aOR) for nonatopic wheeze (aOR 1.74, 95% CI 1.13-2.67). This was further increased if the child was not exclusively breastfed and had high SIgA level in combination with the C1-C2 trajectory (OR 4.10, 95% CI 1.15-14.59).</p><p><strong>Conclusions: </strong>Nonatopic wheeze is associated with a depletion of <i>Bacteroides</i> in infancy, and in children not exclusively breastfed the risk is further increased among those with high endogenous SIgA levels. These results highlight the importance of the interplay between the gut microbiota and immune system development during critical periods in early life and how it is linked to nonatopic wheeze in childhood.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: \"COVID-19 associated pulmonary aspergillosis: a nationwide survey by the Japanese Respiratory Society\" Takahiro Takazono, Hiroshi Mukae, Koichi Izumikawa, Naoki Hasegawa and Akihito Yokoyama. <i>ERJ Open Res</i> 2021; 7: 00402-2021.","authors":"","doi":"10.1183/23120541.50402-2021","DOIUrl":"https://doi.org/10.1183/23120541.50402-2021","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1183/23120541.00402-2021.].</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of bronchoscopic lung volume reduction with endobronchial valves with or without pulmonary rehabilitation on symptoms of fatigue, anxiety and depression: a multicentre randomised controlled trial.","authors":"Rein Posthuma, Marieke C van der Molen, Anouk W Vaes, Jorine E Hartman, Martijn A Spruit, Dirk-Jan Slebos, Lowie E G W Vanfleteren","doi":"10.1183/23120541.00892-2024","DOIUrl":"10.1183/23120541.00892-2024","url":null,"abstract":"<p><strong>Background: </strong>Bronchoscopic lung volume reduction using one-way endobronchial valves (BLVR-EBV) improves exercise capacity and quality of life in patients with severe emphysema. However, its effect on symptoms of fatigue, anxiety and depression is unclear. Furthermore, whether the combination of pulmonary rehabilitation (PR) and BLVR-EBV yields additional impact on these symptoms remains unknown. We hypothesised that BLVR-EBV would reduce symptoms of fatigue, anxiety and depression, and that the combination of BLVR-EBV with PR would lead to additional reduction when compared to BLVR-EBV alone.</p><p><strong>Methods: </strong>The SoLVE study (ClinicalTrials.gov: NCT03474471) was a prospective multicentre randomised controlled trial to examine the impact and optimal timing of PR on exercise physiology and patient-reported outcomes in patients receiving BLVR-EBV treatment. Subjects were randomised into three groups: PR before BLVR-EBV, PR after BLVR-EBV and BLVR-EBV alone. Fatigue severity was assessed using the Checklist Individual Strength fatigue subscale (CIS-Fatigue). The Hospital Anxiety and Depression Scale evaluated symptoms of anxiety (HADS-A) and depression (HADS-D).</p><p><strong>Results: </strong>97 participants were included. After the 6-month follow-up the overall mean change after BLVR-EBV with or without PR was -8.2±10.6 points on CIS-Fatigue, -2.2±2.9 points on HADS-A and -2.3±3.0 points on HADS-D (p<0.001). No significant differences were observed between groups for changes in CIS-Fatigue, HADS-A or HADS-D.</p><p><strong>Conclusion: </strong>BLVR-EBV is an effective intervention to improve symptoms of fatigue, anxiety and depression. The combination of PR and BLVR-EBV did not result in additional improvement when compared to BLVR-EBV alone.</p>","PeriodicalId":11739,"journal":{"name":"ERJ Open Research","volume":"11 4","pages":""},"PeriodicalIF":4.0,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}