Translational Biophotonics: Diagnostics and Therapeutics最新文献

{"title":"Numerical analysis on ex-vivo second harmonic generation images of collagen structure of unstained basal cell carcinoma sections","authors":"L. Fésűs, N. Wikonkál, R. Szipőcs","doi":"10.1117/12.2615071","DOIUrl":"https://doi.org/10.1117/12.2615071","url":null,"abstract":"","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129627118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple wavelength excitation 5-ALA induced PpIX fluorescence spectroscopy in guided neurosurgery for improving glioma classification","authors":"A. Gautheron, M. Hébert, L. Mahieu-Williame, J. Guyotat, B. Montcel","doi":"10.1117/12.2614590","DOIUrl":"https://doi.org/10.1117/12.2614590","url":null,"abstract":"","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"337 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133083660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative measurement of low-concentration analytes using Raman spectroscopy during droplet evaporation for therapeutic drug monitoring","authors":"Sora Tomita, Terumasa Ito, Kazuyuki Iwaikawa, G. Hayase, D. Yoshino, K. Misawa","doi":"10.1117/12.2614937","DOIUrl":"https://doi.org/10.1117/12.2614937","url":null,"abstract":"We propose a new method for therapeutic drug monitoring using Raman spectroscopy to quantify the concentration of analytes during droplet evaporation. The proposed method is demonstrated for quantitative measurement of methotrexate down to 0.5 mM.","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127310904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of multi-modal system for quantitative phase and fluorescence imaging of osteo cancer cells","authors":"Shilpa Tayal, Veena Singh, T. Kaur, Neetu Singh, D. Mehta","doi":"10.1117/12.2615020","DOIUrl":"https://doi.org/10.1117/12.2615020","url":null,"abstract":"","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127007680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Noble metal nanoparticles modified by cyanines and stilbenes for enhanced signal optical tomography and hyperthermal therapy","authors":"A. N. Smirnov, O. V. Odintsova, V. V. Lashkul, V. V. Sharoiko, E. Solovyeva","doi":"10.1117/12.2615046","DOIUrl":"https://doi.org/10.1117/12.2615046","url":null,"abstract":"The report describes the synthesis of core-shell noble metal anisotropic nanoparticles modified with cyanine-class fluorophores and stilbene-based Raman reporters. In perspective, it may be used for optical diagnostics and therapeutic hyperthermia. Modern chemistry of optical tags offers solutions for invasive biomedical optical diagnostics and therapy methods such as Raman and SERS labeling, immune fermentative reaction utilizing fluorescent reporter and tomography with vectors-conjugated fluorophores, photodynamic and hyperthermal therapy. The last method consists in using of energy dissipated by particle to overheat neighboring tumor cells leading to their death and has two different implementations: the first is based on the superparamagnetic nanoparticles together with NMR excitation while the second one utilizes lasers to excite the plasmonic nanoparticles. There is a proble related to ability of using visible light in diagnostics and treatment to see things with naked eyes: light passing through biological tissues undergoes absorption and scattering. Thus, it is hard to see definite shape of the luminous region, especially if it is at a depth. For this reason, fluorescence tomography and photodynamic therapy are applied only to superficial tissues. The present study is devoted to development of nanocomposite tags for optical tomography with improved capability for determining the size, shape and location of malignant tumors. The idea of the research is to use the plasmon resonance effect. The plasmon resonance effect is the ability of noble metal nanoparticles to absorb visible and near infrared light. In this way, the generated local electromagnetic field of nanoparticles leads to hyperpolarization of neighboring molecules, the scattering intensity of which increases by orders of magnitude compared to the usual one. Fig. 1. Schematic representation of conception Gold and silver nanoparticles of anisotropic shape (nanorods, nanoprisms and nanobones) were synthetized, the plasmon resonance peak of which is shifted to the red border of the visible spectrum range. This region is also known as the region of transparency of biological tissues. The region of 600-700 nm refers to visible light, so red light emission can be observed with naked eyes, thus the developed tags may be applied directly during surgical intervention These nanoparticles were modified with cyanine-based fluorophores (e.g. Cy 5.5 and Cy 7) and Raman reporters (e.g. 4,4'-dimercaptostilbene, 4,4'-diaminostilbene) and subsequently coated with a silica dioxide shell using the Strober method. The principal scheme of optically responsive nanotag conjugated to a delivery vector is shown on Fig. 1. Translational Biophotonics: Diagnostics and Therapeutics, edited by Zhiwei Huang, Lothar D. Lilge, Proc. of SPIE-OSA Vol. 11919, 119192E · © 2021 OSA-SPIE CCC code: 1605-7422/21/$21 · doi: 10.1117/12.2615046 Proc. of SPIE-OSA Vol. 11919 119192E-1 Fig. 2. Comparison of the fluorescence spe","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117056358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of tissue classification for colorectal cancer detection using support vector machines and diffuse reflectance spectroscopy","authors":"M. Nogueira, Michael Amissah, Siddra Maryam, Noel Lynch, S. Killeen, Micháel O'Riordain, S. Andersson-Engels","doi":"10.1117/12.2615033","DOIUrl":"https://doi.org/10.1117/12.2615033","url":null,"abstract":"Optimizing support vector machine models for colorectal cancer detection using diffuse reflectance spectroscopy at extended wavelength ranges and tissue layers up to 2mm deep achieved 96.1% sensitivity and 95.7% specificity on tissue classification.","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125776660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-wavelength excitation spectroscopy for non-invasive detection of the iron deficiency indicator zinc protoporphyrin IX","authors":"H. Stepp, Christian Homann, G. Hennig, M. Vogeser","doi":"10.1117/12.2614588","DOIUrl":"https://doi.org/10.1117/12.2614588","url":null,"abstract":"Increased formation of fluorescent zinc protoporphyrin IX (ZnPP) inside erythrocytes indicates functional iron deficiency. Two-wavelength excitation spectroscopy detects ZnPP even through intact skin. Its suitability was successfully tested in women, surgical patients, infants and blood donors.","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121051160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined fingerprint and high wavenumber spatially offset Raman spectroscopy for depth-resolved hydration and biochemical assessment","authors":"Laura E. Masson, Rekha Gautam, A. Locke, G. Thomas, A. Mahadevan-Jansen","doi":"10.1117/12.2614933","DOIUrl":"https://doi.org/10.1117/12.2614933","url":null,"abstract":"Combined fingerprint and high wavenumber spatially offset Raman spectroscopy was implemented for depth-dependent biochemical characterization. Quantitative spectral analysis of water and other components was conducted in layered optical phantoms.","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132730889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of spectral characteristics of dentin materials during their demineralization","authors":"P. Timchenko, E. Timchenko, L. Volova, O. Frolov, M. Zybin","doi":"10.1117/12.2615044","DOIUrl":"https://doi.org/10.1117/12.2615044","url":null,"abstract":"","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129761128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Front Matter: Volume 11919","authors":"","doi":"10.1117/12.2625679","DOIUrl":"https://doi.org/10.1117/12.2625679","url":null,"abstract":"","PeriodicalId":117188,"journal":{"name":"Translational Biophotonics: Diagnostics and Therapeutics","volume":"34 4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123357685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}