Endocrine Practice最新文献_第7页

Apolipoprotein Profile in Early Pregnancy and the Link to Gestational Diabetes Mellitus: Insights From Odense Child Cohort. 载脂蛋白谱在妊娠早期和与妊娠糖尿病的联系：从欧登塞儿童队列的见解。

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-17 DOI: 10.1016/j.eprac.2025.02.009

Kaja K Faurø, Lasse M Obel, Henrik T Christesen, Dorte M Jensen, Tina K Jensen, Dorte Glintborg, Marianne S Andersen, Martin Overgaard

{"title":"Apolipoprotein Profile in Early Pregnancy and the Link to Gestational Diabetes Mellitus: Insights From Odense Child Cohort.","authors":"Kaja K Faurø, Lasse M Obel, Henrik T Christesen, Dorte M Jensen, Tina K Jensen, Dorte Glintborg, Marianne S Andersen, Martin Overgaard","doi":"10.1016/j.eprac.2025.02.009","DOIUrl":"10.1016/j.eprac.2025.02.009","url":null,"abstract":"Objectives: We aimed to investigate the potential associations between serum apolipoprotein levels in early pregnancy and the risk of gestational diabetes mellitus (GDM) and adverse pregnancy outcomes.Methods: This was an observational study of the population-based Odense Child Cohort. Pregnant women were followed from inclusion until childbirth. Apolipoprotein levels, including 12 apolipoproteins (ApoA-I, ApoA-II, ApoA-IV, ApoB, ApoC-I, ApoC-II, ApoC-III, ApoD, ApoE, ApoH, ApoJ, and ApoM) were measured by targeted proteomics using liquid chromatography mass spectrometry on late first trimester serum samples stored in a biobank. GDM was defined by WHO 2013 diagnostic criteria.Results: A total of 991 pregnant women were included, of which 415 (41.9%) were diagnosed with GDM. GDM was associated with increasing ApoB (adjusted odds ratio [OR]: 1.26, P = .002) and ApoD levels (adjusted OR: 0.84, P = .021). ApoB levels in early pregnancy correlated significantly and positively with insulin resistance (r = 0.22, P < .001) and beta-cell function in third trimester (r = 0.20, P < .001), whereas early pregnancy ApoD levels were inversely correlated with insulin resistance (r = -0.14, P < .001) and beta-cell function (r = -0.12, P < .001). Finally, high levels of ApoD was significantly associated with lower risk of large-for-gestational-age infants (adjusted OR: 0.78, P = .041).Conclusions: High levels of ApoB and low levels of ApoD in early pregnancy were independently associated with an increased risk of GDM, insulin resistance, and large-for-gestational-age infants (low ApoD only), suggesting potential roles for future management of pregnancy outcomes.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Underresourced Youth With Diabetes in a Community-Based Intervention Show Improved Diabetes Outcomes, Technology Use, and Psychosocial Functioning. 资源不足的青少年糖尿病患者在社区干预中显示出改善的糖尿病结局、技术使用和社会心理功能。

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-14 DOI: 10.1016/j.eprac.2025.02.008

Jenise C Wong, Alison Reed, Carolina Noya, Annemarie Stone, Kimberly Spiro, Maureen McGrath, Maya Lodish, Michael A Harris, David V Wagner

{"title":"Underresourced Youth With Diabetes in a Community-Based Intervention Show Improved Diabetes Outcomes, Technology Use, and Psychosocial Functioning.","authors":"Jenise C Wong, Alison Reed, Carolina Noya, Annemarie Stone, Kimberly Spiro, Maureen McGrath, Maya Lodish, Michael A Harris, David V Wagner","doi":"10.1016/j.eprac.2025.02.008","DOIUrl":"10.1016/j.eprac.2025.02.008","url":null,"abstract":"Objective: The primary objective of this study was to evaluate the first full-scale implementation of the behavioral health program Novel Interventions in Children's Healthcare (NICH) in racially and ethnically diverse youth with diabetes and high degrees of social risk. We hypothesized that youth would demonstrate improved health outcomes and psychosocial functioning following program involvement.Methods: Youth with diabetes who enrolled in NICH (n = 26) and their caregivers completed measures of diabetes distress, depression, and diabetes strengths prior to and following program enrollment. Electronic health records were reviewed to describe change in hemoglobin A1C, change in continuous glucose monitoring use, and change in the number of hospital admission days from baseline to the time following program participation. Parametric and nonparametric tests were used to compare data.Results: Youth (mean age, 13.7 ± 3.5 years, 92% from historically marginalized racial or ethnic groups, 96% with public insurance) demonstrated a significant (P < .01) mean hemoglobin A1C reduction of -1.1% (-12 mmol/mol) and increase in continuous glucose monitoring use (27%-73%) 1 year following NICH enrollment, and they had significantly fewer hospital admission days over time. Youth reported significant reductions in depressive symptoms, and caregivers reported significant reductions in diabetes distress after participation in NICH (P < .05).Conclusion: This study is the first to show successful full-scale implementation of NICH in a new geographic location with unique racial and ethnic diversity and social challenges, demonstrating associations with improved health and well-being.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143432717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Delivery Mode and Neonatal Thyrotropin Levels: Insights From a Systematic Review and Meta-Analysis. 分娩方式和新生儿促甲状腺激素水平：来自系统回顾和荟萃分析的见解。

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-13 DOI: 10.1016/j.eprac.2025.02.006

Mohadese Dashtkoohi, Mohammadamin Parsaei, Mohammad Sadeq Najafi, Elahe Amirkhalili, Mohammadreza Chashmyazdan, Pantea Nazeri

{"title":"Delivery Mode and Neonatal Thyrotropin Levels: Insights From a Systematic Review and Meta-Analysis.","authors":"Mohadese Dashtkoohi, Mohammadamin Parsaei, Mohammad Sadeq Najafi, Elahe Amirkhalili, Mohammadreza Chashmyazdan, Pantea Nazeri","doi":"10.1016/j.eprac.2025.02.006","DOIUrl":"10.1016/j.eprac.2025.02.006","url":null,"abstract":"Background: Optimal thyroid function is particularly crucial during infancy. This systematic review and meta-analysis aimed to investigate the relationship between the mode of delivery and neonatal thyrotropin levels at birth.Methods: We conducted a systematic search of MEDLINE/PubMed, Web of Science, Embase, Scopus, and the Cochrane Library for studies published up to 2023. Hedges' g with 95% confidence intervals was calculated to compare mean thyroid-stimulating hormone (TSH) levels based on the mode of delivery. Additionally, TSH levels were compared based on blood sampling methods, heel blood vs cord blood, using the same meta-analytic approach. A random effects model was employed due to the presence of heterogeneity. This study is registered with PROSPERO under the number CRD42024533649.Results: A total of 1438 studies were identified, of which 18 met the criteria for the systematic review. The meta-analysis of ten studies revealed significantly higher pooled TSH levels in neonates born via vaginal delivery compared to those delivered by cesarean section (Hedges' g = 0.390; P = .002). In the heel blood subgroup, no significant difference in TSH levels was found between vaginal and cesarean deliveries (Hedges' g = 0.167; P = .111). However, in the cord blood subgroup, neonates delivered vaginally exhibited significantly higher TSH levels than those delivered by cesarean section (Hedges' g = 0.493; P = .002).Conclusion: The study found that the method of delivery has a significant impact on neonatal TSH levels, especially in umbilical cord blood samples, highlighting the need to consider delivery mode in evaluating neonatal health.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous Glucose Monitoring in Hospitalized Patients With Type 2 Diabetes: A Step Forward in Inpatient Glycemic Control. 2型糖尿病住院患者持续血糖监测：住院患者血糖控制的新进展

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-13 DOI: 10.1016/j.eprac.2025.02.007

Alejandra Rivas-Montenegro, Roberto Añez-Ramos, Alba Galdón-Sanz Pastor, Olga González-Albarrán

{"title":"Continuous Glucose Monitoring in Hospitalized Patients With Type 2 Diabetes: A Step Forward in Inpatient Glycemic Control.","authors":"Alejandra Rivas-Montenegro, Roberto Añez-Ramos, Alba Galdón-Sanz Pastor, Olga González-Albarrán","doi":"10.1016/j.eprac.2025.02.007","DOIUrl":"10.1016/j.eprac.2025.02.007","url":null,"abstract":"Objective: To determine the effect and safety of continuous glucose monitoring (CGM) use in glycemic control compared to standard approach in hospitalized patients with type 2 diabetes.Methods: This was a pilot randomized controlled clinical trial that enrolled 37 hospitalized patients with type 2 diabetes admitted in medical and surgical wards. All patients used CGM (Abbott FreeStyle2 or FreeStyle3) and concomitantly 6-point point of care glucose. In group A (n = 19), daily CGM profiles, alarms, and trend arrows were considered for glycemic therapeutic decisions and in group B (n = 18) were based on point of care glucose. Primary outcomes included the difference in time in range 70-180 mg/dL, hospital glycemia risk index, time below range measured as the percentage below 70 mg/dL and below 54 mg/dL, and time above range measured as the percentage above 180 mg/dL and above 250 mg/dL.Results: Time in range was higher in group A: 78.26 ± 10.83% vs 67.39 ± 19.13% P = .04. Time above range level 1 in group A: 14.37 ± 8.33% vs group B: 23.28 ± 16.62% P = .04. Asymptomatic hypoglycemic events were more detected by CGM-group (1.65 ± 2.03 vs 0.31 ± 0.60 P = .01). Overall mean absolute relative difference: 14.7%. Diabetes technology society error grid: 69.5% zone A and 29.3% zone B.Conclusions: The implementation of CGM in hospitals could represent a significant advancement in diabetes management, offering a more comprehensive and dynamic approach to monitoring glucose levels. Further research is needed to explore the long-term impacts of CGM on clinical outcomes and to optimize its integration into hospital protocols.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Teprotumumab in Thyroid Eye Disease: A Systematic Review and Meta-Analysis. Teprotumumab治疗甲状腺眼病的疗效和安全性：一项系统综述和荟萃分析

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-12 DOI: 10.1016/j.eprac.2025.01.012

Wenxin Huang, Xiaodan Ou, Shuzhen Lin, Wei Lin, Gang Chen, Huibin Huang, Junping Wen

{"title":"Efficacy and Safety of Teprotumumab in Thyroid Eye Disease: A Systematic Review and Meta-Analysis.","authors":"Wenxin Huang, Xiaodan Ou, Shuzhen Lin, Wei Lin, Gang Chen, Huibin Huang, Junping Wen","doi":"10.1016/j.eprac.2025.01.012","DOIUrl":"10.1016/j.eprac.2025.01.012","url":null,"abstract":"Objective: Teprotumumab was approved by the US Food and Drug Administration (FDA) for treating Graves' orbitopathy in adults on January 21, 2020. This study evaluates its efficacy and safety in treating thyroid eye disease (TED).Methods: We reviewed studies on teprotumumab for TED treatment from PubMed, Web of Science, EMBASE, Cochrane library, and Clinical trials. gov up to January 1, 2024. Outcomes included proptosis response, diplopia, Clinical Activity Score (CAS) score, and adverse events (AEs).Results: Our analysis included 10 studies, 4 randomized controlled trials, and 6 observational studies. The randomized controlled trials involved 210 teprotumumab patients and 193 controls. Teprotumumab significantly improved proptosis response (relative risk [RR] 4.18, 2.72-6.43), diplopia regression (RR 2.29, 1.54-3.41), and CAS score (RR 3.09, 1.98-4.80) compared to placebo. A significant reduction in proptosis was observed (standardized mean difference -8.38, -9.25 - -7.52). The risk of AEs and serious AEs was higher with teprotumumab. The 6 observational studies included 211 patients, showing an 82% proptosis response rate, a -3.31 mm change in proptosis, a 0.58 diplopia improvement rate, and a 0.66 pooled effect size for CAS score. AE incidence was 0.78, and serious AEs were 0.31.Conclusion: Teprotumumab effectively reduces proptosis, improves diplopia, and lowers disease activity in TED, regardless of previous treatments, severity, or dosage, albeit with increased AEs. It has the potential to become a vital first-line treatment for TED, enhancing patient quality of life.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Link Between Thyroid Disorders and Obesity: Mechanisms, Impacts, and Clinical Implications. 探讨甲状腺疾病和肥胖之间的联系：机制、影响和临床意义。

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-12 DOI: 10.1016/j.eprac.2025.02.005

Ashni Dharia, Dimpi Desai, Kaniksha Desai

{"title":"Exploring the Link Between Thyroid Disorders and Obesity: Mechanisms, Impacts, and Clinical Implications.","authors":"Ashni Dharia, Dimpi Desai, Kaniksha Desai","doi":"10.1016/j.eprac.2025.02.005","DOIUrl":"10.1016/j.eprac.2025.02.005","url":null,"abstract":"Objective: Obesity and thyroid dysfunction are among the most significant challenges in endocrinology, frequently overlapping to create complexities in weight management. Even after achieving euthyroidism, weight variations persist, significantly affecting patients' quality of life. This review explores the mechanisms linking hypothyroidism and hyperthyroidism to weight fluctuations, emphasizing their impact on basal metabolic rate, appetite regulation, glucose and lipid metabolism, and thermogenesis.Methods: We conducted a comprehensive review using PubMed and Google Scholar, applying the search criteria: (obesity OR overweight) AND (Hashimoto's thyroiditis OR hyperthyroidism OR hypothyroidism OR Thyroid Cancer). From this search, we reviewed 500 publications and finally included 71 publications, focusing on broad clinical questions regarding the role of thyroid hormones in weight regulation and metabolism, the impact of thyroid disorders and their treatments on obesity, and approaches for managing obesity in the context of thyroid dysfunction.Results: In hypothyroidism, the impact of levothyroxine therapy on weight changes is discussed, along with the potential role of T3 supplementation. For hyperthyroid patients, the effects of antithyroid medications, radioactive iodine therapy, and thyroidectomy on weight regulation are explored. Pharmacological and nonpharmacological strategies for managing obesity in thyroid disorders are reviewed. Lifestyle interventions and pharmacotherapies are evaluated for their efficacy and potential effects on thyroid function. Lastly, the implications of bariatric surgery are explored, including its effects on thyroid function, medication absorption, and postsurgical management of thyroid disorders.Conclusion: This review underscores the importance of an integrated, multidisciplinary approach to managing obesity in the context of thyroid dysfunction to optimize patient outcomes.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143424789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central Hypothyroidism: Advances in Etiology, Diagnostic Challenges, Therapeutic Targets, and Associated Risks. 中枢性甲状腺功能减退：病因、诊断挑战、治疗靶点和相关风险的进展。

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-11 DOI: 10.1016/j.eprac.2025.02.004

Pedro Iglesias

{"title":"Central Hypothyroidism: Advances in Etiology, Diagnostic Challenges, Therapeutic Targets, and Associated Risks.","authors":"Pedro Iglesias","doi":"10.1016/j.eprac.2025.02.004","DOIUrl":"10.1016/j.eprac.2025.02.004","url":null,"abstract":"Objective: Central hypothyroidism is a rare disorder resulting from impaired thyroid hormone production due to deficiencies in TSH secretion from the pituitary or TRH secretion from the hypothalamus. This review aims to summarize recent advances in the etiology, diagnosis, and treatment of central hypothyroidism, with an emphasis on diagnostic and therapeutic challenges.Methods: A comprehensive review of the literature was conducted, focusing on genetic and acquired causes, particularly those related to hypothalamic-pituitary tumors and the effects of surgical and radiotherapeutic interventions. Diagnostic approaches and treatment strategies, including levothyroxine therapy and monitoring, are analyzed.Results: Early diagnosis requires simultaneous measurement of free T4 and TSH to prevent neurological sequelae, especially in congenital cases. Central hypothyroidism is associated with risks such as growth and developmental impairment, as well as metabolic and cardiovascular disturbances. Levothyroxine therapy is crucial for correcting hormonal deficits and improving patient outcomes; however, careful dosing is necessary to avoid potential complications, particularly in vulnerable populations.Conclusions: Personalized treatment and continuous monitoring are essential to optimize clinical outcomes and enhance the quality of life in affected individuals. A thorough understanding of central hypothyroidism's etiology and management is necessary to improve early detection and therapeutic strategies.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-Term Impact of Thyroid Eye Disease on Quality of Life: Insights From a Retrospective Cohort Study. 甲状腺眼病对生活质量的长期影响：来自回顾性队列研究的见解

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-11 DOI: 10.1016/j.eprac.2025.02.003

Jan Schovanek, Martin Radvansky, Marta Karhanova, Marie Bolacka, Klara Pekarova, Roman Dohnal, Martin Radvansky, Milos Kudelka, Eva Kriegova, David Karasek

{"title":"Long-Term Impact of Thyroid Eye Disease on Quality of Life: Insights From a Retrospective Cohort Study.","authors":"Jan Schovanek, Martin Radvansky, Marta Karhanova, Marie Bolacka, Klara Pekarova, Roman Dohnal, Martin Radvansky, Milos Kudelka, Eva Kriegova, David Karasek","doi":"10.1016/j.eprac.2025.02.003","DOIUrl":"10.1016/j.eprac.2025.02.003","url":null,"abstract":"Objectives: Thyroid eye disease (TED) seriously affects patients' quality of life (QoL), even if the disease is stable and nonactive. Data on clinical factors negatively influencing the QoL of patients with TED and long-term outcomes are limited. This study aims to evaluate the lasting impact of TED on QoL, focusing on the effects of previous TED treatments and identifying factors influencing long-term outcomes.Methods: A retrospective cohort study included 151 patients treated for active, moderate-to-severe and severe TED, with a mean follow-up of 8 years.Results: Higher clinical activity scores at diagnosis correlated with lower QoL scores. Thyroidectomy before immunosuppressive treatment was associated with lower QoL and an increased likelihood of orbital decompression. Any disease progression necessitating second-line treatments also negatively affected QoL. A decrease in thyrotropin receptor antibodies during active treatment and early treatment initiation positively affected visual functioning. Time-dependent regression analysis demonstrated no significant trend in QoL changes over time.Conclusion: Our data reveal that disease severity, the timing of interventions and disease progression contribute to less favorable long-term QoL outcomes, extending years beyond active treatment. Early and accurate diagnosis and appropriate treatment can minimize poor long-term QoL in patients with TED.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Polycystic Ovary Syndrome in East Asia: A Review and Meta-Analysis. 东亚多囊卵巢综合征患者代谢功能障碍相关脂肪变性肝病的危险因素：综述和荟萃分析

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-11 DOI: 10.1016/j.eprac.2025.01.011

Zhao Wu, Guining Liang, Ying Zhang, Renyuan Li

{"title":"Risk Factors for Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Polycystic Ovary Syndrome in East Asia: A Review and Meta-Analysis.","authors":"Zhao Wu, Guining Liang, Ying Zhang, Renyuan Li","doi":"10.1016/j.eprac.2025.01.011","DOIUrl":"10.1016/j.eprac.2025.01.011","url":null,"abstract":"Objectives: The incidence of metabolic dysfunction-associated steatotic liver disease (MASLD) is increasing in women with polycystic ovary syndrome (PCOS). Epidemiologic literature regarding the risk factors for MASLD in PCOS women in East Asia is inconsistent. Studies of PCOS and MASLD in East Asia are restricted by limited data and various biases. Therefore, this meta-analysis was conducted.Methods: This meta-analysis followed the MOOSE statement. Relevant studies published before July 13, 2023 were retrieved from the PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, Wan Fang, KISS, and Japan medical online databases. The related data were extracted, and the weighted mean difference, odds ratios and 95% confidence intervals were calculated.Results: Twenty-four studies were included. Through univariate analysis, age, body mass index, waist-to-hip ratio (WHR), blood pressure, alanine transaminase, aspartate transaminase, fasting blood glucose, fasting insulin, homeostatic model assessment for insulin resistance (HOMA-IR), 2-hour postprandial blood glucose, 2 hour insulin, HBA1C, low-density lipoprotein cholesterol, triglyceride, total cholesterol, and testosterone were notably higher in PCOS women with MASLD, with high-density lipoprotein cholesterol markedly lower in PCOS women with MASLD. According to the pooled multivariate analysis, the WHR (P < .001), testosterone (P = .034), and HOMA-IR (P = .02) were substantially greater in PCOS women with MASLD.Conclusion: MASLD is associated with obesity, IR, and hyperandrogenemia among PCOS women in East Asia. The abnormality of WHR, HOMA-IR, and testosterone suggested early screening of MASLD in this population.","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methimazole for Prevention of Iodinated Contrast Media–Induced Exacerbation of Thyrotoxicosis in Susceptible Patients 甲巯咪唑用于预防碘化造影剂诱发的易感患者甲亢加重。

IF 3.7 3区医学

Endocrine Practice Pub Date : 2025-02-01 DOI: 10.1016/j.eprac.2024.11.008

Irit Ayalon-Dangur MD, BSc , Einat Magid-Ohayon , Ilan Shimon MD , Eyal Robenshtok MD

{"title":"Methimazole for Prevention of Iodinated Contrast Media–Induced Exacerbation of Thyrotoxicosis in Susceptible Patients","authors":"Irit Ayalon-Dangur MD, BSc , Einat Magid-Ohayon , Ilan Shimon MD , Eyal Robenshtok MD","doi":"10.1016/j.eprac.2024.11.008","DOIUrl":"10.1016/j.eprac.2024.11.008","url":null,"abstract":"<div><h3>Objective</h3><div>Iodinated contrast media (ICMs) are widely used in a variety of examinations and procedures. The aim of the current study was to investigate the efficacy of methimazole (MMI) in prevention of thyrotoxicosis after ICM exposure.</div></div><div><h3>Methods</h3><div>A retrospective cohort study included patients aged ≥18 years admitted to a tertiary medical center who underwent ICM examination or procedure and received MMI prior to iodine exposure.</div></div><div><h3>Results</h3><div>A total of 179 patients with 202 hospitalizations were included. The mean age was 72.3 ± 13.5 years (female, 64%). Nearly all patients (99%) had a history of thyroid disease, and 91% were treated with MMI prior to admission. Seventy-five patients had low thyroid-stimulating hormone (TSH) levels prior to ICM exposure. In this high-risk group, MMI led to normalization of TSH after discharge in 19%, and 64% remained with low TSH levels after discharge but with a small median difference in free thyroxine levels of −0.5 (interquartile range [IQR], −5.9 to 5.2) pmol/L. In the 8 patients with dose increase during hospitalization, treatment with MMI was beneficial with a median free thyroxine decrease of −6.2 (IQR, −9.2 to −1) pmol/L and TSH increase of 0.2 (IQR, 0.02-0.7) mIU/L. In 110 patients with normal TSH levels before admission, with MMI treatment, most (71%) remained euthyroid after discharge, 13% had low TSH levels, and 9% had high TSH levels. In the 15 patients with high TSH levels prior to admission, the TSH levels of only 2 patients normalized, 47% remained with high TSH levels, and 27% had low TSH levels after discharge.</div></div><div><h3>Conclusion</h3><div>In patients with pre-existing thyrotoxicosis treated with antithyroid drugs, MMI therapy before ICM exposure prevented exacerbations. In patients with low TSH levels before admission, increasing the dose of MMI before exposure led to improvement in thyroid functions after discharge.</div></div>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":"31 2","pages":"Pages 180-187"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0