{"title":"甲状腺眼病:管理、进展和未来机遇。","authors":"Tamaryn Fox, Andrea Kossler, Chrysoula Dosiou","doi":"10.1016/j.eprac.2025.06.011","DOIUrl":null,"url":null,"abstract":"<p><p>Thyroid eye disease (TED), the most common extrathyroidal manifestation of Graves' disease, is a debilitating autoimmune condition that significantly impacts quality of life and can threaten vision. This review highlights advances in TED's understanding, particularly in pathophysiology, emerging treatments, novel surgical techniques, and the use of imaging and artificial intelligence (AI). Teprotumumab, the first FDA-approved drug for TED, has shown effectiveness in reducing proptosis, improving diplopia, and enhancing quality of life. Other therapies in development include alternative IGF-1 receptor antagonists, FcRn inhibitors, interleukin pathway antagonists, and TSH receptor inhibitors, all of which offer promising potential. Surgical approaches such as orbital decompression and eyelid correction have also evolved, with minimally invasive techniques gaining favor. Diagnostic advancements in biomarkers could further enhance early detection and disease monitoring. AI tools for assessing disease severity and predicting treatment outcomes are also emerging. Despite significant progress in molecular understanding and treatment options, TED remains complex, and continued research is essential to improve diagnostic precision and therapeutic outcomes.</p>","PeriodicalId":11682,"journal":{"name":"Endocrine Practice","volume":" ","pages":""},"PeriodicalIF":3.7000,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Thyroid eye disease: Management, Advances and Future Opportunities.\",\"authors\":\"Tamaryn Fox, Andrea Kossler, Chrysoula Dosiou\",\"doi\":\"10.1016/j.eprac.2025.06.011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Thyroid eye disease (TED), the most common extrathyroidal manifestation of Graves' disease, is a debilitating autoimmune condition that significantly impacts quality of life and can threaten vision. This review highlights advances in TED's understanding, particularly in pathophysiology, emerging treatments, novel surgical techniques, and the use of imaging and artificial intelligence (AI). Teprotumumab, the first FDA-approved drug for TED, has shown effectiveness in reducing proptosis, improving diplopia, and enhancing quality of life. Other therapies in development include alternative IGF-1 receptor antagonists, FcRn inhibitors, interleukin pathway antagonists, and TSH receptor inhibitors, all of which offer promising potential. Surgical approaches such as orbital decompression and eyelid correction have also evolved, with minimally invasive techniques gaining favor. Diagnostic advancements in biomarkers could further enhance early detection and disease monitoring. AI tools for assessing disease severity and predicting treatment outcomes are also emerging. Despite significant progress in molecular understanding and treatment options, TED remains complex, and continued research is essential to improve diagnostic precision and therapeutic outcomes.</p>\",\"PeriodicalId\":11682,\"journal\":{\"name\":\"Endocrine Practice\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":3.7000,\"publicationDate\":\"2025-06-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endocrine Practice\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.eprac.2025.06.011\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENDOCRINOLOGY & METABOLISM\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine Practice","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.eprac.2025.06.011","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
Thyroid eye disease: Management, Advances and Future Opportunities.
Thyroid eye disease (TED), the most common extrathyroidal manifestation of Graves' disease, is a debilitating autoimmune condition that significantly impacts quality of life and can threaten vision. This review highlights advances in TED's understanding, particularly in pathophysiology, emerging treatments, novel surgical techniques, and the use of imaging and artificial intelligence (AI). Teprotumumab, the first FDA-approved drug for TED, has shown effectiveness in reducing proptosis, improving diplopia, and enhancing quality of life. Other therapies in development include alternative IGF-1 receptor antagonists, FcRn inhibitors, interleukin pathway antagonists, and TSH receptor inhibitors, all of which offer promising potential. Surgical approaches such as orbital decompression and eyelid correction have also evolved, with minimally invasive techniques gaining favor. Diagnostic advancements in biomarkers could further enhance early detection and disease monitoring. AI tools for assessing disease severity and predicting treatment outcomes are also emerging. Despite significant progress in molecular understanding and treatment options, TED remains complex, and continued research is essential to improve diagnostic precision and therapeutic outcomes.
期刊介绍:
Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.