Ejc Supplements最新文献_第3页

Anti-angiogenic therapy for ovarian cancer 抗血管生成治疗卵巢癌

Ejc Supplements Pub Date : 2020-08-01 Epub Date: 2020-08-22 DOI: 10.1016/j.ejcsup.2020.02.003

Yolanda García García, Maria Marín Alcalá , Clara Martínez Vila

引用次数: 7

Cell proliferation inhibitors and apoptosis promoters 细胞增殖抑制剂和细胞凋亡促进剂

Ejc Supplements Pub Date : 2020-08-01 Epub Date: 2020-08-22 DOI: 10.1016/j.ejcsup.2019.09.002

J. Alejandro Perez-Fidalgo

引用次数: 5

Exploration of Gender-Specific Authorship Disparities in the Pain Medicine Literature. 探讨疼痛医学文献中的性别作者差异。

Ejc Supplements Pub Date : 2019-11-02 DOI: 10.1136/rapm-2019-100806

Jay Karri, Sergio M Navarro, Anne Duong, Tuan Tang, Alaa Abd-Elsayed

{"title":"Exploration of Gender-Specific Authorship Disparities in the Pain Medicine Literature.","authors":"Jay Karri, Sergio M Navarro, Anne Duong, Tuan Tang, Alaa Abd-Elsayed","doi":"10.1136/rapm-2019-100806","DOIUrl":"10.1136/rapm-2019-100806","url":null,"abstract":"Background: Given the readily increasing membership of the pain physician community, efforts toward correcting notable gender disparities are instrumental. The under-representation of women is particularly prevalent within leadership roles in academic medicine, thought to be driven largely by diminished research efforts. Consequently, we aimed to characterize gender differences among the highest impact pain literature.Methods: The 20 highest cited articles per year from 2014 to 2018 were extracted from each of seven impactful journals affiliated to the largest pain medicine societies. Collected data from each article included genders of the first and last authors, the number of citations accumulated and the journal impact factor at the time of publication.Results: Across all considered literature, female authors were surprisingly not under-represented when considering the national prevalence of female pain physicians. However, more in-depth analysis found trends toward significance to suggest that female authorship was relatively diminished within more impactful and higher cited literature. When exploring gender-gender collaboration patterns, we found that male authors were favored over female counterparts with statistical significance; it must be noted that this likelihood analysis and preference toward male authors may be statistically obfuscated by the high prevalence of male authors. Nonetheless, these findings help to quantify overt, demonstrated disparity patterns. Of note, this inequity may also be fully secondary to the lower number of female pain physicians and/or those involved in research endeavors and decreased number of submissions from female physicians. Establishing gender discrimination patterns as causal factors in such disparities can be extremely challenging to determine.Conclusion: In our analysis of authorship between genders within the context of pain medicine literature, we found trends, although non-significant, toward women being lesser represented in the more impactful literature. We suggest that these inequities are possibly resultant of a markedly small and outnumbered female pain physician membership that has yet to achieve a critical mass and possible implicit gender biases that may restrict female authorship. However, further exploration and analysis of this issue are necessary to more clearly illuminate which systemic deficits exist and how they may, in turn, be corrected with cultural and macroscopic organizational-driven change.","PeriodicalId":11675,"journal":{"name":"Ejc Supplements","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78464882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Urothelial carcinoma management in elderly or unfit patients 老年或不适患者尿路上皮癌的处理。

Ejc Supplements Pub Date : 2016-03-01 Epub Date: 2016-03-22 DOI: 10.1016/j.ejcsup.2016.01.001

Joaquim Bellmunt , Nicolas Mottet , Maria De Santis

引用次数: 44

Biosimilars: Extrapolating the evidence. A roundtable discussion 生物仿制药：推断证据。圆桌讨论

Ejc Supplements Pub Date : 2015-12-01 Epub Date: 2016-01-21 DOI: 10.1016/j.ejcsup.2015.12.001

Bradley J. Monk , Morton Coleman , Philip Lammers , George Somlo

引用次数: 0

Computed tomography measurement of pulmonary artery for diagnosis of COPD and its comorbidity pulmonary hypertension. 用于诊断慢性阻塞性肺病及其合并症肺动脉高压的肺动脉计算机断层扫描测量。

IF 2.8

Ejc Supplements Pub Date : 2015-11-18 eCollection Date: 2015-01-01 DOI: 10.2147/COPD.S94211

Xuesong Chen, Kouying Liu, Zhiyue Wang, Yinsu Zhu, Yang Zhao, Hui Kong, Weiping Xie, Hong Wang

{"title":"Computed tomography measurement of pulmonary artery for diagnosis of COPD and its comorbidity pulmonary hypertension.","authors":"Xuesong Chen, Kouying Liu, Zhiyue Wang, Yinsu Zhu, Yang Zhao, Hui Kong, Weiping Xie, Hong Wang","doi":"10.2147/COPD.S94211","DOIUrl":"10.2147/COPD.S94211","url":null,"abstract":"Computed tomography (CT) is widely used for evaluation of lung diseases. To evaluate the value of CT measurement of pulmonary artery for diagnosis of chronic obstructive pulmonary disease (COPD) and its comorbidity pulmonary hypertension (PH), we retrospectively reviewed the CT of 221 patients with COPD and 115 control patients without cardiovascular or lung disease. Patients with COPD were divided into PH (COPD-PH) and non-PH according to systolic pulmonary artery pressure. Main pulmonary artery (MPA), right pulmonary artery (RPA) and left pulmonary artery branches, and ascending aorta (AAo) and descending aorta (DAo) diameters were measured. Meanwhile, the ratios of MPA/AAo and MPA/DAo were calculated. MPA, RPA, and left pulmonary artery diameters were significantly larger in COPD than those in the controls, and this augment was more obvious in COPD-PH. AAo and DAo diameters did not vary obviously between groups, while MPA/AAo and MAP/DAo increased significantly in COPD and PH. MPA could be helpful for COPD diagnosis (MPA diameter ≥27.5 mm, sensitivity 54%, and specificity 80%), and RPA could be applied for COPD-PH diagnosis (RPA diameter ≥23.4 mm, sensitivity 67%, and specificity 76%). There was a marked correlation between MPA/DAo and systolic pulmonary artery pressure (r=0.594, P<0.001). Therefore, chest CT could be a simple and effective modality for diagnostic evaluation of COPD and its comorbidity, PH. ","PeriodicalId":11675,"journal":{"name":"Ejc Supplements","volume":"4 1","pages":"2525-33"},"PeriodicalIF":2.8,"publicationDate":"2015-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655902/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78389513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

T58: An important role of proteoglycans in the interactions of normal and cancer prostate cells with fibroblasts T58:蛋白聚糖在正常和癌前列腺细胞与成纤维细胞相互作用中的重要作用

Ejc Supplements Pub Date : 2015-11-01 DOI: 10.1016/J.EJCSUP.2015.08.104

A. V. Suhovskih, V. Kashuba, E. Grigorieva

引用次数: 0

P85: Synthesis and anti-cancer effects of CpdA enantiomers, non-steroidal glucocorticoid receptor ligands P85: CpdA对映体、非甾体糖皮质激素受体配体的合成及其抗癌作用

Ejc Supplements Pub Date : 2015-11-01 DOI: 10.1016/J.EJCSUP.2015.08.110

L. R. Tilova, O. Zadorozhnaya, A. Savinkova, K. Kirsanov, A. Ogloblina, G. Belitsky, I. Budunova, E. Lesovaya, M. Yakubovskaya

引用次数: 0

A18 那么

Ejc Supplements Pub Date : 2015-11-01 Epub Date: 2015-11-23 DOI: 10.1016/j.ejcsup.2015.08.031

T. Gening, T. Abakumova, D. Dolgova, S. Gening, I. Antoneeva

{"title":"A18","authors":"T. Gening, T. Abakumova, D. Dolgova, S. Gening, I. Antoneeva","doi":"10.1016/j.ejcsup.2015.08.031","DOIUrl":"10.1016/j.ejcsup.2015.08.031","url":null,"abstract":"<div>Tumor-associated neutrophils (TANs) are the cell population that differs in morphofunctional characteristics from peripheral blood cells (Gregory and Houghton, 2011). The first study to identify the presence of TANs as an independent poor prognostic factor and to include TANs into a prognostic risk model was published in 2006 (Donskov , 2006). Specific signals during cancer progression have been shown to induce the emergence of a pro-tumor phenotype of neutrophils (PMN). Frinlender (2013) points out an anti-tumor phenotype of TANs. Of particular interest is the study of interaction of neutrophils with T cells because the latter are considered to be cytotoxic cells mediating antitumor immunity. The aim of the study was to assess the lymphoid cell infiltration (LCI) and the functional status of TANs in ovarian cancer. LCI was assessed by immunohistochemistry and the levels of mieloproxydase (MPO) and cationic proteins (CP) were evaluated by cytochemical methods in ovarian carcinoma surgical resection specimens. The results were presented as a mean cytochemical coefficient (MCC). The intensity of nitroblue tetrazolium (NBT) test was expressed as a percentage. Obtained results were analyzed by nonparametric statistical methods. The Kruskal–Wallis test was used to evaluate the differences between groups.We established that low intensity of infiltration in general and formation of marginal lymphoid cell ridge in some tumors are typical for malignant ovarian neoplasms. More intensive infiltration was found in the regions of the rapid growth of tumor cells, i.e. invasion zone. In some cases, a group of tumor cells was separated from the main part of the parenchyma and surrounded by lymphoid elements. Conditions are created under which active spread of cancer cells in the parenchyma is associated with intensive lymphoid cells infiltration in the stroma. Total count and density of lymphoid cells can significantly vary: from single lymphoid elements uniformly scattered in the tumor tissue to focal accumulations. In tumor tissue location of lymphoid cells is irregular, so most of the infiltration is in the stroma and among the cancer cells only solitary lymphocytes are found. Lymphoid cells which make up the infiltration include 12.3±1.52% of macrophages, 22.1±2.3% of plasma cells, 62.5±1.1% of lymphocytes and 3.1±0.9% of PMN. Total amount of cells was 224.1±32.8 per 1mm2 of tumor.Lymphocytes in ovarian carcinomas do not form large clusters; they are disposed among other lymphoid cells in the stroma on the periphery of the tumor. Plasma cells have a classical morphological structure and often locate in the stroma and on the periphery of the tumor. Macrophages are an integral part of the tumor infiltrate. In the tumor they become stretched and angular. Macrophages usually have large dimensions, and they are ","PeriodicalId":11675,"journal":{"name":"Ejc Supplements","volume":"13 1","pages":"Pages 17-18"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ejcsup.2015.08.031","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54309086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

P67 P67

Ejc Supplements Pub Date : 2015-11-01 Epub Date: 2015-11-23 DOI: 10.1016/j.ejcsup.2015.08.014

O. Bryzgunova , E. Lekhnov , T. Skvortsova , E. Morozkin , I. Zaporozhchenko , A. Grigorieva , M. Zaripov , E. Ryabchikova , V. Vlassov , P. Laktionov

{"title":"P67","authors":"O. Bryzgunova , E. Lekhnov , T. Skvortsova , E. Morozkin , I. Zaporozhchenko , A. Grigorieva , M. Zaripov , E. Ryabchikova , V. Vlassov , P. Laktionov","doi":"10.1016/j.ejcsup.2015.08.014","DOIUrl":"10.1016/j.ejcsup.2015.08.014","url":null,"abstract":"<div>Differently sized microparticles, including exosomes (30–100nm), prostasomes (50–500nm), oncosomes (50–500nm) and other microparticles (100–1000nm) were found in blood and urine. Exosomes from prostate cancer (PCa) patients can potentially contain cancer-specific nucleic acids, and thus can represent a valuable source of diagnostic material. In this study, we have investigated microvesicles and miRNA from urine of healthy donors and PCa patients. To isolate miRNAs from urine and microparticles, novel methods for miRNA isolation were elaborated (Rus. patent application No 2014137763, priority date 17.09.2014). The study population included 14 patients with PCa (63–82years, T2-3NxMx1) and control group of 20 healthy volunteers with no previous history of prostate disease (48–73years). Urine was clarified by two serial centrifugations at 400g, 20°C, 20min and at 17000g, 20°C, 20min. Microparticles were precipitated from the resulting supernatant by high-speed centrifugation at 100000g, 18°C, 90min, the pellet was resuspended and pelleted by centrifugation under the same conditions. To isolate exosomes, total microparticles were filtered through 0.1μm pore filters and reprecipitated. The resulting pellets were resuspended and exosome samples were investigated by transmission electron microscopy (TEM). MiRNAs were isolated by one-step single-phase protocol and purified using “BioSilica” spin- columns (Zaporozhchenko et al., Anal. Biochem, upcoming, doi: 10.1016/j.ab.2015.03.028) and by recently developed method based on precipitation of excess biopolymers, allowing to isolate miRNAs with better efficiency than commercially available kits. The size and quantity assessment of extracellular RNA were performed using capillary electrophoresis system on Agilent 2100 Bioanalyzer. Concentrations of miRNAs (miR19b, miR25, miR205, miR125b, miR126) were measured by qRT-PCR and normalized to miR-16 using dCq method.TEM demonstrated the presence of 20–300nm microparticles in urine of healthy donors and PCa patients. Approximately 50–70% of all urine microparticles are represented by 30–100nm exosomes and residual 30–50% by particles larger than 100nm. (The pool of urine microvesicles consists of 50–70% exosomes and 30–50% particles larger than 100nm.).The major part of extracellular RNA found both in exosomes and total microparticles fraction of healthy donors and patients with PCa, is 25–200nt long and can include tRNA (73–93n.), 5.8 rRNA (∼150 n.), snoRNK (10–20 n.), snRNA (60–300n.) piRNAs (29–30 n.), miRNAs (20–25 n.), siRNA (21–25 n.). Concentration of extracellular urine RNA in exosomes and total microparticles of healthy donors and patients with PCa amounts to100pg/ml of urine on av","PeriodicalId":11675,"journal":{"name":"Ejc Supplements","volume":"13 1","pages":"Page 8"},"PeriodicalIF":0.0,"publicationDate":"2015-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ejcsup.2015.08.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54308765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0