Endocrinology and Metabolic Syndrome最新文献

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Refractory Hypocalcemia Effectively Treated with Steroids in Prostate Cancer Metastatic to Bone 顽固性低钙血症用类固醇有效治疗前列腺癌骨转移
Endocrinology and Metabolic Syndrome Pub Date : 2017-07-08 DOI: 10.4172/2161-1017.1000269
N. Gebara, C. Beaini, F. Karak, G. Hajje
{"title":"Refractory Hypocalcemia Effectively Treated with Steroids in Prostate Cancer Metastatic to Bone","authors":"N. Gebara, C. Beaini, F. Karak, G. Hajje","doi":"10.4172/2161-1017.1000269","DOIUrl":"https://doi.org/10.4172/2161-1017.1000269","url":null,"abstract":"Nicole Gebara1, Chadia Beaini2, Fadi El Karak3 and Georges Hajje4* 1Departments of Medicine, Bellevue Medical Center, Saint Joseph University, Beirut, Lebanon 2Department of Nephrology, Bellevue Medical Center, Saint Joseph University, Beirut, Lebanon 3Department of Oncology, Bellevue Medical Center, Saint Joseph University, Beirut, Lebanon 4Department of Endocrinology, Bellevue Medical Center, Saint Joseph University, Beirut, Lebanon","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"47 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84974185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Association of serum Vitamin D level with Glycemic Status in Patients of Type 2Diabetes Mellitus 2型糖尿病患者血清维生素D水平与血糖状态的关系
Endocrinology and Metabolic Syndrome Pub Date : 2017-06-13 DOI: 10.4172/2161-1017.1000268
Arindam Sur, G. Priya
{"title":"Association of serum Vitamin D level with Glycemic Status in Patients of Type 2Diabetes Mellitus","authors":"Arindam Sur, G. Priya","doi":"10.4172/2161-1017.1000268","DOIUrl":"https://doi.org/10.4172/2161-1017.1000268","url":null,"abstract":"Introduction: For development of Type 2 Diabetes mellitus, Vitamin D is thought to be a risk factor. Various studies have established the fact that Vitamin D replenishment improves glycemic status and insulin secretion in patients with Type 2 Diabetes mellitus with established hypovitaminosis D. This study was done to find out the degree of association between glycemic status and vitamin D levels in type 2 Diabetes Mellitus patients in a tertiary care center. \u0000Patient and methods: The study was done in the Department of Biochemistry, SCB Medical College, and Cuttack 48 patients of type 2 Diabetes Mellitus were taken as cases 42 healthy subjects were taken as controls. Biochemical parameters like FBS, PPBS, Urea, Creatinine, HbA1c, Lipid profile parameters were measured in both cases and controls. \u0000Results: The serum urea and creatinine levels were significantly elevated in complicated type 2 Diabetes mellitus patients as compared to healthy controls. Serum cholesterol, triglycerides, LDL Cholesterol levels also showed significant increase Vitamin D and FBS levels showed a significant negative correlation in cases and vitamin D levels were decreased in cases as compared to controls. \u0000Conclusion: As Vitamin D and FBS levels showed a significant negative correlation, and vitamin D levels were decreased in cases as compared to controls, so it can be proved that vitamin D can lead to good glycemic control and hypovitaminosis D can thereby lead to Type 2 Diabetes Mellitus.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"292 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79511479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Nailfold Capillaroscopy in Diabetes Mellitus: Potential Technique for the Microvasculature Evaluation 甲襞毛细血管镜在糖尿病中的应用:微血管评估的潜在技术
Endocrinology and Metabolic Syndrome Pub Date : 2017-06-09 DOI: 10.4172/2161-1017.1000E125
G. Maldonado, C. Rios
{"title":"Nailfold Capillaroscopy in Diabetes Mellitus: Potential Technique for the Microvasculature Evaluation","authors":"G. Maldonado, C. Rios","doi":"10.4172/2161-1017.1000E125","DOIUrl":"https://doi.org/10.4172/2161-1017.1000E125","url":null,"abstract":"The capillary loop consists of an arterial or afferent branch and a venous or efferent branch. The main parameters to be evaluated are: length, diameter, density, venous plexus and morphological abnormalities. These elements should be evaluated in the distal row or near the nailfold. The normal number of capillaries per millimeter is from seven to twelve arranged in an inverted U-shape (Figure 1).","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"143 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86629235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Effectiveness of Adding Flaxseed to Type 2 Diabetic PatientâÂÂs Regimen 2型糖尿病患者添加亚麻籽PatientÃⅱÂÂs治疗方案的疗效观察
Endocrinology and Metabolic Syndrome Pub Date : 2017-05-31 DOI: 10.4172/2161-1017.1000267
S. Tharwat, A. A. El-Megeid, A. Salam, L. Rashed, S. El-Hamid, S. Abdel-Shafy, D. Shaheen
{"title":"Effectiveness of Adding Flaxseed to Type 2 Diabetic PatientâÂÂs Regimen","authors":"S. Tharwat, A. A. El-Megeid, A. Salam, L. Rashed, S. El-Hamid, S. Abdel-Shafy, D. Shaheen","doi":"10.4172/2161-1017.1000267","DOIUrl":"https://doi.org/10.4172/2161-1017.1000267","url":null,"abstract":"Background and Aims: Flaxseed is a promising alternative reducing the risk of diseases associated with \u0000 obesity. The purpose of this study is to determine the effect of supplemented bakery with flaxseed or flaxseed oil on \u0000 type 2 diabetic patients \u0000Materials and Methods: Ninety type 2 diabetic on oral hypoglycemic (body weight, fasting, post prandial blood \u0000 glucose, cholesterol, LDL, HDL, Triglycerides, VLDL and leptin) were recorded at base line, and after twelve weeks. \u0000 Participants divided into 3 groups. Group 1 (control): Consists of 30 patients on regimen diet with type 2 diabetes \u0000 who received regimen diet 1350 kcal. Group 2: Consists of 30 patients with type 2 diabetes and following regimen \u0000 diet same as group (1) plus a dose of flaxseed oil bakery regimen diet for twelve weeks. Group (3): Consists of 30 \u0000 subjects with type 2 diabetes on regimen diet the same as group (1) plus supplementation with flaxseed bakery \u0000 product for twelve weeks. \u0000Results: After twelve weeks significant changes in group 2 and 3 Versus control in BMI (0.05, 0.03) fasting \u0000 (p<0.001), post prandial glucose (0.03, 0.02, 0.001), HA1c (0.02, 0.01), cholesterol (0.024, <0.001, 0.01), \u0000 triglycerides (<0.001), LDL (0.05, 0.001, 0.01), VLDL (<0.001) and leptin (<0.001). \u0000Conclusion: Regimen diet containing supplemented bakery with flaxseed or flaxseed oil for 12 weeks decrease \u0000 BMI, blood glucose, lipid profile in type 2 diabetics, thus incorporating flaxseed in bakery is recommended.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85460402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Stratification of Obstructive Sleep Apnea Risk in Obese non-Diabetics and Obese Diabetics 肥胖非糖尿病患者和肥胖糖尿病患者阻塞性睡眠呼吸暂停风险分层
Endocrinology and Metabolic Syndrome Pub Date : 2017-05-26 DOI: 10.4172/2161-1017.1000266
Av Sahasrabuddhe, Charru Singh, S. Pitale, Hs Patil
{"title":"Stratification of Obstructive Sleep Apnea Risk in Obese non-Diabetics and Obese Diabetics","authors":"Av Sahasrabuddhe, Charru Singh, S. Pitale, Hs Patil","doi":"10.4172/2161-1017.1000266","DOIUrl":"https://doi.org/10.4172/2161-1017.1000266","url":null,"abstract":"Introduction: The prevalence of OSA and its consequences are likely to increase in light of the current obesity \u0000 epidemic. Studies have shown that the prevalence of OSA is significantly higher in the diabetes population. Recent \u0000 studies have revealed that BMI and diabetes as significant independent predictors of OSA. Owing to little research \u0000 in this field and lack of data from Central India, the present study aims at assessing the risk of development of \u0000 obstructive sleep apnoea in obese and obese diabetic patients. \u0000Objectives: To find out the prevalence of OSA risk in obese patients with Diabetes mellitus using Berlin \u0000 Questionnaire, to find out the prevalence of OSA risk in obese non diabetic patients, correlation of OSA risk with Body Mass Index, fasting blood sugar, HbA1c and Blood Pressure. \u0000Methodology: Twenty four obese diabetic patients (Group I) and thirty-five obese – non- diabetic patients (Group \u0000 II) were selected from medicine OPD randomly. Results were matched with thirty-one healthy non-obese nondiabetic \u0000 controls (Group III). Risk of OSA was assessed using pre designed, validated Berlin questionnaire. HbA1C \u0000 and fasting blood sugars were done. \u0000Results: As per Berlin Questionnaire Category 1 showed 19 (79.17%), 21 (60%) and 7 (22.58%) cases as \u0000 positive in ‘DM and Obese’, ‘No DM but Obese’ and ‘Control’ groups respectively, P-value<0.0001 using Chi-square \u0000 test, Category 2 had 7 (29.17%), 6 (17.14%) and 0 cases as positive in ‘DM and Obese’, ‘No DM but Obese’ and \u0000 Control groups respectively with P-value of 0.008 (P<0.05) using Chi-square test and Category 3 had 18 (75%), 25 \u0000 (71.4%) and 1(3.23%) positive cases in ‘DM and Obese’, ‘No DM but Obese’ and ‘Control’ groups respectively, and \u0000 the difference in the proportions was statistically significant with P-value<0.0001 using Chi-square test. Age above \u0000 40 years, female sex increased the risk of OSA. HbA1C was found out to be an independent risk factor for OSA risk. \u0000 After adjusting for covariates for HbA1C, the OR obtained was 6.20 [95% CI: 1.37-28.07], with a P-value of 0.018 \u0000 (P<0.05). \u0000Conclusion: Our study shows that the risk of OSA is significantly increases with increasing BMI, fasting blood \u0000 glucose levels, mean arterial pressure and HbA1c levels. High risk of OSA was 58.9% in our study.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"6 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87200186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Retrospective Analysis of Diabetic Ketoacidosis in Pregnant Women over a Period of 3 Years 3年来孕妇糖尿病酮症酸中毒的回顾性分析
Endocrinology and Metabolic Syndrome Pub Date : 2017-05-10 DOI: 10.4172/2161-1017.1000265
K. Baagar, A. Aboudi, H. Khaldi, B. Alowinati, A. Abou-Samra, S. Lindow
{"title":"Retrospective Analysis of Diabetic Ketoacidosis in Pregnant Women over a Period of 3 Years","authors":"K. Baagar, A. Aboudi, H. Khaldi, B. Alowinati, A. Abou-Samra, S. Lindow","doi":"10.4172/2161-1017.1000265","DOIUrl":"https://doi.org/10.4172/2161-1017.1000265","url":null,"abstract":"Objective: The incidence of diabetic ketoacidosis in pregnancy (DKP) varies from 0.5%, the lowest reported rate in western countries, to 8.9% in a study conducted in China. The associated fetal mortality is 9-36%. This study aimed to assess the current incidence, causes, and outcomes of diabetic ketoacidosis in pregnancy and identify factors associated with favorable outcomes. \u0000Methods: A retrospective chart review of 20 diabetic ketoacidosis hospital admissions of 19 pregnant women from 3,679 diabetic pregnancies delivered between June 2012 and May 2015 was conducted. Those with successful DKP management (group A) or with intrauterine fetal death or urgent delivery during diabetic ketoacidosis management (group B) were compared. \u0000Results: Thirteen cases had type 1 diabetes, and 6 cases had type 2 diabetes, including 2 new diagnoses. The most common precipitating factors were vomiting (55%) and insulin non-compliance (45%). Plasma glucose was <200 mg/dl in 50% of the patients. There was no maternal mortality, but there was one fetal death (5%). Only mean gestational age (21.8 ± 11.0 versus 33.7 ± 4.6 weeks, P=0.005) was significantly different between groups A (14 admissions) and B (6 admissions). \u0000Conclusion: The incidence of diabetic ketoacidosis was 0.5%, similar to the lowest incidence previously reported. Fetal mortality was 5%, lower than previously reported. The only factor associated with a favorable outcome was early gestational age at presentation. We recommend antenatal screening for diabetes, patient education, and compliance with insulin treatment as preventive measures against DKP.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"42 1","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2017-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80049206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lester Adaptation of Cardio Metabolic Measurements: An Inpatient Interventional Framework for Women with Mental Illness 莱斯特适应心脏代谢测量:一个住院妇女精神疾病介入框架
Endocrinology and Metabolic Syndrome Pub Date : 2017-03-24 DOI: 10.4172/2161-1017.1000264
M. Godbole, M. Lotfy, L. McGowen
{"title":"Lester Adaptation of Cardio Metabolic Measurements: An Inpatient Interventional Framework for Women with Mental Illness","authors":"M. Godbole, M. Lotfy, L. McGowen","doi":"10.4172/2161-1017.1000264","DOIUrl":"https://doi.org/10.4172/2161-1017.1000264","url":null,"abstract":"Aims of the study: To assess the prevalence of metabolic syndrome and implement a framework for screening and management of cardio metabolic risks in women on psychiatric in-patient wards. Background: An estimated 29-48% of psychiatric in-patients have metabolic syndrome. Severe mood disorders and psychotic illnesses are independent risk factors. 20-25% of the world’s adult population have metabolic syndrome and they are twice as likely to die from and three times as likely to have a heart attack or stroke compared with people without the syndrome. This study gives an overview of the application of Lester Tool on busy in-patient units and interventional approaches adapted by the team. Method: 46 admissions between April to July 2015 were included in Phase 1. Information on physical health medication and menopausal status was recorded in addition to metabolic syndrome parameters. Data on 47 admissions in Phase 2 between March to May 2016 was obtained. Advice on healthy lifestyle, diet, medication and smoking cessation was offered as routine. Results: Phase 1: Of the total 46 patients, 38 (82.60%) were on antipsychotics, 6 (13.04%) had metabolic syndrome and 14 (30.43%) did not and data was not available on 26 (56.52%). Most frequently missing criteria were waist circumference and triglyceride measurements. Phase 2: Of the total 45 patients, 14 (31.1%) had metabolic syndrome, 12 (26.6%) did not and data was unknown in 13 (28.8%). 2/3rd of admissions were compliant with investigations, as opposed to 1/3rd in Phase 1. 86.6% compliance was achieved in BMI checks. 20% were prescribed anti-hypertensive or anti-diabetic medication during admission and were referred to the dietician and diabetes clinic. Conclusion: Clinical identification and management of metabolic syndrome is essential and preventative measures by referral to specialist services or use of 3DFD model could be implemented. Lester Adaptation has been an effective tool for recording cardio metabolic risks; but in reality an effective interventional process could prove hard to achieve in mental health settings.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"23 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86992373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Levels of Zinc, Magnesium and Selenium among First Trimester Pregnant Saudi Women with Pre-Diabetes and Diabetes 沙特阿拉伯妊娠早期糖尿病前期和糖尿病妇女血清锌、镁和硒水平
Endocrinology and Metabolic Syndrome Pub Date : 2017-03-10 DOI: 10.4172/2161-1017.1000262
S. Hammouda, E. Sultan, A. Mohamadin
{"title":"Serum Levels of Zinc, Magnesium and Selenium among First Trimester Pregnant Saudi Women with Pre-Diabetes and Diabetes","authors":"S. Hammouda, E. Sultan, A. Mohamadin","doi":"10.4172/2161-1017.1000262","DOIUrl":"https://doi.org/10.4172/2161-1017.1000262","url":null,"abstract":"Background: Glycosylated hemoglobin (HbA1c) was found to be a valuable predictor of the risk of congenital malformations. Other studies documented diabetic complications in subjects with HbA1c at the pre-diabetic levels. \u0000Objectives: This study was done to compare serum levels of zinc, magnesium and selenium between pregnant women with normal glycemic control, diabetes and pre-diabetes. \u0000Subjects/Methods: The data was part of a large prospective cohort study aimed at identifying some preventable risk factors that cause congenital malformations among Saudi women. 1103 healthy first trimester pregnant were randomly selected from antenatal clinics in twenty one health care centers and two hospitals at Al-Madinah Al- Monawarah, KSA. Clinical history, examination and lab analysis were done (serum levels of magnesium, zinc, selenium, and HbA1c). Subjects were classified by their HbA1c levels as normal (HbA1c<5.7%), pre-diabetic (HbA1c 5.7<6.5%), and undiagnosed type 2 diabetics (HbA1c≥6.5%), comparison in the lab results was done between the groups. \u0000Results: About 78. 9% (870 subjects) had normal HbA1c, 19.1% (211 subjects) had HbA1c in the range of prediabetes and 1.99% (22 subjects) had HbA1c>6.5% denoting undiagnosed type 2 diabetes \u0000Serum levels of nutrients were significantly lower among pre-diabetics compared to normal subjects, same results were obtained when comparing diabetics and pre-diabetics and diabetics and normal subjects. There was a significant negative correlation between the levels of HbA1c and zinc, magnesium and selenium. \u0000Conclusion and Recommendations: Changes in serum levels of zinc, magnesium and selenium occurs at the pre-diabetic stage and precedes the development of diabetes & may be responsible for medical complications that are recently reported at this stage. Studies should be done for re-establishment of safe target levels of HbA1c.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"181 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77539164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Magnitude, Clinical Presentation and Outcome of Patients with Pituitary Lesions:An Experience from Tikur Anbessa Specialized Hospital, Ethiopia 垂体病变患者的大小、临床表现和预后:来自埃塞俄比亚蒂库尔安贝萨专科医院的经验
Endocrinology and Metabolic Syndrome Pub Date : 2017-03-08 DOI: 10.4172/2161-1017.1000263
Tiruneh Gg, Regasa Kd, Y. Feleke, T. Kebede, Yifru Ym
{"title":"Magnitude, Clinical Presentation and Outcome of Patients with Pituitary Lesions:An Experience from Tikur Anbessa Specialized Hospital, Ethiopia","authors":"Tiruneh Gg, Regasa Kd, Y. Feleke, T. Kebede, Yifru Ym","doi":"10.4172/2161-1017.1000263","DOIUrl":"https://doi.org/10.4172/2161-1017.1000263","url":null,"abstract":"Background: Pituitary tumors are frequently encountered intracranial neoplasms. The prevalence of these tumors in autopsy series is reported to be significant in many studies. However, there are no adequate studies on magnitude, clinical presentation and outcome of pituitary lesions in our country. Patients and methods: A retrospective study, data collected using chart review was conducted at national endocrine referral clinics of the hospital. A five years data from June 2010 to June 2015 was collected. The patients’ clinico-demographic and radiologic features were documented using a prestructured data collection tool. Data was entered into SPSS version 20 and analyzed. Frequencies and means were computed for description of the various variables. Individuals aged 14 years and above from both sexes who started follow-up in the study years at Tikur Anbessa Specialized Hospital Endocrinology Clinics were included in the study. Results: Out of the total of 1124 patients seen at endocrine clinics 51 (4.54%) were diagnosed to have pituitary lesions. A total of 42 patients with confirmed pituitary lesions were included in the analysis out of which 30 (71.4%) were females and 12 (28.6%) were males. The age range was 14 to 60 years old (mean age was 32.5 years). Among the 42 patients 20 (47.6%) had prolactinoma, 9 (21.43%) Cushing’s disease, 7 (16.67%) acromegaly, 2 (4.76%) features of both prolactinoma and acromegaly, 2 (4.76%) panhypopituitarism, 1 (2.38%) hypogonadism and 1 (2.38%) nonfunctional pituitary adenoma. The most common presenting symptoms were headache in 33(78.6%) and visual disturbances in 20(47.6%) of patients. Among the 42 patients 26 (61.9%) had pituitary macroadenoma, 5 (11.9%) pituitary microadenoma, 7 (16.7%) normal Magnetic Resonance Imaging (MRI) and 4 (9.5%) of patients had no MRI. Of all patients included in the analysis 24 (57.1%) were treated medically only to control hormone secretion, 11(26.2%) patients were referred for surgical intervention and the rest were treated with both medical and surgical approaches or with regular follow-up only. Most of the patients with prolactinoma (80%) had improvement with medical treatment only. Conclusion: Pituitary lesions accounted 4.54% of endocrine patients and Prolactinomas were the most common followed by Cushing’s disease and Acromegaly. The patients with Prolactinomas had a good outcome with medical treatment only.","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"1 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89535198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synergistic Actions of Thyroid-Adipokines Axis during Development 甲状腺脂肪因子轴在发育过程中的协同作用
Endocrinology and Metabolic Syndrome Pub Date : 2017-01-01 DOI: 10.4172/2161-1017.1000280
Ahmed Rg
{"title":"Synergistic Actions of Thyroid-Adipokines Axis during Development","authors":"Ahmed Rg","doi":"10.4172/2161-1017.1000280","DOIUrl":"https://doi.org/10.4172/2161-1017.1000280","url":null,"abstract":"Thyroid hormones (THs) are involved in the programming of early prenatal period [1-37]. Moreover, adipokines [leptin (LEP), resistin (RETN), adiponectin (ADP), inflammatory cytokines [interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1) and tumor necrosis factor-α (TNF-α)], and chemokines [interleukin-8 (IL-8)] play an important role during the fetal development and early life [12,32,33]. THs also control the actions of LEP [8,9], interferon-γ [38], ADP [8,9,39], TNF-α [8,26], and growth factors [8,28,32,33,35,40,41] by non-genomic mechanisms. Alternatively, LEP, ADP, and TNF-ɑ modulate the functions of thyroid axis and insulin sensitivity [8]. Also, adipokines can regulate the hypothalamic-pituitary-thyroid axis (HPTA), thermogenesis, body weight, basal metabolic rate and appetite [42]. The nuclear receptors such as thyroid receptors (TRs), peroxisome proliferator-activated receptor-α (PPARα), and liver X receptor (LXR) are vital for the triiodothyronine (T3) regulation of cholesterol metabolism and transcription of lipogenic and lipolytic genes [42]. In white adipose tissue (WAT), the expression and secretion of ADP was decreased throughout the pregnancy [13,43]. Moreover, the expression of LEP and RETN was observed in the developing placenta [44] with reducing the insulin level [45]. Also, the coordination in the secretion these cytokines is involved in the availability of energy during the gestation [46].","PeriodicalId":11670,"journal":{"name":"Endocrinology and Metabolic Syndrome","volume":"79 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90858861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
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