Endocrine Connections最新文献

{"title":"Thyroid peroxidase antibodies do not impair the ovarian reserve in euthyroid women: a cross-sectional study.","authors":"Chongjuan Gu, Chaomin Yue, Ling Li, Jie Li, Chunting Wu, Yaojuan He","doi":"10.1530/EC-25-0151","DOIUrl":"10.1530/EC-25-0151","url":null,"abstract":"<p><strong>Aim: </strong>This study aims to investigate whether thyroid peroxidase antibodies (TPOAb) affect the ovarian reserve using the anti-Müllerian hormone (AMH), basal follicle-stimulating hormone (bFSH), and estradiol (bE2) as markers.</p><p><strong>Methods: </strong>A large retrospective cross-sectional study was conducted, including women who visited our clinic between May 2016 and April 2024 and underwent same-day assessments of basal sex hormones, thyroid function, and AMH. Women with thyroid cancer, ovarian cancer, or clinical/subclinical hypo- or hyperthyroidism were excluded. Participants were stratified into TPOAb-positive and TPOAb-negative groups. Ovarian reserve markers and thyroid function were compared between the groups, and the impact of TPOAb positivity on ovarian reserve was analyzed.</p><p><strong>Results: </strong>Totally, 3,465 women were eligible for analysis, 2,992 women were TPOAb-positive, and 543 (15.67%) were TPOAb-negative. Compared with the TPOAb-negative group, the median age of the TPOAb-positive group was significantly older (33.0 vs 32.0) (P = 0.008), and the median serum TSH levels were significantly higher (1.56 vs 1.40) (P = 0.0003). However, FT4, AMH, bFSH, and bE2 levels did not demonstrate any difference between the two groups. Multivariable median regression models showed that different TPOAb titers had no effect on serum AMH, bFSH, and bE2 levels. Age-stratified analysis showed no association of TPOAb positivity with AMH, bFSH, and bE2 levels in different age groups.</p><p><strong>Conclusion: </strong>Our study indicates that TPOAb positivity is highly unlikely to impair the ovarian reserve in euthyroid women of reproductive age. A larger prospective cohort study on population should be conducted to determine this issue.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392751/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro- and Macrovascular Complications in Early-Onset Type 2 Diabetes in Indians: Prevalence and Predictors in a Prospective Cross-Sectional Study.","authors":"Ayushi Singhal, Deepti Saxena, Ashwini G, Raviraj Singh Ahada, Navya Mary Kurian, Alok Pratap Singh, Naveen Garg, Eesh Bhatia, Subhash Chandra Yadav","doi":"10.1530/EC-25-0226","DOIUrl":"10.1530/EC-25-0226","url":null,"abstract":"<p><strong>Introduction: </strong>and Aims: The prevalence of T2DM is rising among young people, placing them at greater risk for complications. We studied the prevalence and predictors of micro- and macrovascular complications in early-onset diabetes subjects (EOD, <40 years) and compared with late-onset T2DM (LOD, ≥40 years).</p><p><strong>Methods: </strong>A total of 800 subjects (400 EOD, 400 LOD), matched for gender and diabetes duration, were prospectively recruited and assessed for the prevalence of peripheral neuropathy, retinopathy, nephropathy, and ASCVD. Multivariate logistic regression analyzed predictors of diabetes complications.</p><p><strong>Results: </strong>The median age at diagnosis of diabetes was 35 years in EOD and 48 years in LOD. Hypertension was more common in LOD (73.8% vs. 58.8%, p<0.001). EOD patients had higher HbA1c (7.9% vs. 7.7%, p<0.05) and worse lipid profiles (non-HDL-C 129 vs.118 mg/dL, p<0.05; triglycerides 146 vs.130 mg/dL, p<0.001; HDL-C 36 vs. 38 mg/dL, p<0.01). The prevalence of retinopathy and nephropathy were similar between groups, while peripheral neuropathy and ASCVD were more prevalent in LOD. Increasing diabetes duration was associated with higher risk of all microvascular complications (p<0.01-0.001), while the age at onset of T2DM predicted peripheral neuropathy, nephropathy and ASCVD (p<0.05-0.001). Retinopathy (p<0.001) and female (p<0.05) gender increased peripheral neuropathy risk. Nephropathy (p<0.05) and smoking (p<0.01) were major ASCVD predictors.</p><p><strong>Conclusion: </strong>EOD patients had worse glycemic and lipid profiles, but similar frequency of retinopathy and nephropathy as LOD. The high prevalence of microvascular complications in EOD may reduce productivity, highlighting the importance of early screening, better glycemic control, and timely complication management.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GnRH analogs as a monotherapy in transgender and gender-diverse adolescents: clinical insights from a single-center study.","authors":"Fleur A H Lahaije, Petra A van Setten, Willemien Levels, Karlijn Becking-Malpasso, Hedi L Claahsen-van der Grinten","doi":"10.1530/EC-25-0292","DOIUrl":"10.1530/EC-25-0292","url":null,"abstract":"<p><strong>Background: </strong>Gonadotropin-releasing hormone agonists (GnRHas) are widely used in the treatment of transgender and gender-diverse adolescents to prevent the development of undesired physical changes. However, the safety of GnRHa use remains a subject of debate and objective literature on this topic is limited. In particular, there is a lack of studies comparing the effects of GnRHas at different Tanner stages, as the effectiveness of GnRHa treatment in adolescents who are close to completing puberty remains uncertain.</p><p><strong>Aim: </strong>The aim of this study was to evaluate the effects of GnRHa monotherapy in transgender adolescents with gender dysphoria (GD) at early versus late Tanner stages.</p><p><strong>Methods: </strong>This retrospective study analyzed the electronic medical records of adolescents with GD who were treated with GnRHa monotherapy at the Radboudumc Expert Center for Sex & Gender. Treatment duration ranged from 0.5 to 2 years, with follow-up every three months. The outcomes assessed included biometrics, biochemistry, and self-reported side effects.</p><p><strong>Results: </strong>The study included data from 67 assigned females at birth (AFAB) and 33 assigned males at birth (AMAB). A total of 51 adolescents were classified as Tanner stage 2 or 3, and 49 were classified as Tanner stage 4 or 5. 33% of the participants had psychiatric coexisting conditions, most commonly attention deficit hyperactivity disorder (19%) and ASD (18%). In addition, 36% of the adolescents were either overweight or obese. During follow-up, gonadotropin levels were not fully suppressed, particularly in the Tanner 4/5 group, while sex hormone levels were suppressed in nearly all adolescents. Side effects, especially hot flushes, abdominal discomfort, and emotional disturbances, were significantly more common in the Tanner 4/5 group, with 76% of this group reporting hot flushes. The impact of GnRHa treatment on pubertal development was minimal. Overweight and psychiatric comorbidities were prevalent among the adolescents.</p><p><strong>Conclusion: </strong>GnRHas effectively suppressed sex hormone levels in adolescents with GD, although gonadotropin suppression was not complete, particularly in the Tanner 4/5 group, where gonadotropin levels remained elevated. Side effects were frequently reported, particularly in the Tanner 4/5 group, while the impact on pubertal development was limited. Therefore, the benefits and drawbacks of GnRHa treatment should be carefully considered, particularly in adolescents at Tanner stages 4 and 5.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144575081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SLPI as a dedifferentiation biomarker in BRAFV600E-mutant papillary thyroid cancer.","authors":"Wei Luo, Xin Ji, Xiang-Yu Tan, Yu-Ting Li, Zhi-Qiang Zhang, Chui-Mian Zeng","doi":"10.1530/EC-25-0349","DOIUrl":"10.1530/EC-25-0349","url":null,"abstract":"<p><p>The BRAFV600E mutation drives papillary thyroid carcinoma (PTC) progression and therapy resistance, yet its downstream effectors remain incompletely characterized. Here, we identify secretory leukocyte protease inhibitor (SLPI) as a novel dedifferentiation biomarker in BRAFV600E-mutant PTC through integrated multi-omics analyses and functional validation. SLPI expression was significantly elevated in BRAFV600E-mutant tumors and correlated with advanced TNM stage, lymph node metastasis, and poor survival. Its overexpression was caused mechanistically by AP-1 transactivation and SLPI promoter hypomethylation. SLPI knockdown in PTC cells suppressed proliferation, increased anoikis sensitivity, and reduced FAK/AKT phosphorylation. Enrichment analysis linked high SLPI expression to PI3K/AKT pathway activation. Drug sensitivity prediction revealed that SLPI-high tumors were vulnerable to MAPK/AKT inhibitors. Notably, SLPI positively correlated with immune checkpoint genes, suggesting a potential immunosuppressive role. Our findings establish SLPI as a BRAFV600E-AP-1-FAK/AKT axis effector and propose its targeting as a strategy for PTC therapy.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoplasmic reticulum stress contributes to insulin resistance in Hashimoto's thyroiditis.","authors":"Qing Zhou, Li Yong Zhang, Xue Lin Gao, Chao Chun Zou, Hui Liu","doi":"10.1530/EC-25-0158","DOIUrl":"10.1530/EC-25-0158","url":null,"abstract":"<p><p>Hashimoto's thyroiditis (HT) is one of the most common autoimmune disorders. Patients with HT are more likely to be affected by insulin resistance, even euthyroid individuals. Endoplasmic reticulum (ER) stress is related to the pathogenesis of several immunological diseases, such as HT. Thus, the aim of the present study was to explore the potential mechanism and effect of HT on insulin resistance in HT model mice in vivo and to assess the role of ER stress in this process. In this study, euthyroid HT model mice were established by simultaneously giving high amounts of iodine in drinking water and twice subcutaneously injecting thyroglobulin emulsified with Freund's adjuvant. HT mice were treated with or without 4-phenylbutyric acid (4-PBA), an inhibitor of ER stress. We detected increased protein expression of binding immunoglobulin protein (Bip), activating transcription factor 6 (ATF6), and upregulated phospho-inositol-requiring enzyme 1 (IRE1) and phospho-c-Jun N-terminal kinase (JNK) in the thyroid tissue and adipose tissue of HT mice. In addition, HT mice exhibited impaired insulin sensitivity, decreased insulin receptor substrate 1 (IRS-1) tyrosine phosphorylation and protein kinase B (AKT) phosphorylation in adipose tissue, but these effects were alleviated by 4-PBA. Moreover, HT mice had higher serum tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) levels than control mice. Similarly, the ER stress inhibitor 4-PBA significantly decreased TNF-α and IL-6 levels compared with those in HT mice. These findings suggest that HT is related to the development of insulin resistance, and that the mechanism may involve ER stress.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344398/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144752705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations among serum FGF21 levels, inflammation, and metabolic dysfunction-associated steatotic liver disease: mediation analyses in a Chinese community-based population.","authors":"Hongyu Tan, Tingting Hu, Yunhui Pan, Yiting Xu, Yufei Wang, Xiaojing Ma, Yuqian Bao","doi":"10.1530/EC-25-0351","DOIUrl":"10.1530/EC-25-0351","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to explore the relationship between serum fibroblast growth factor 21 (FGF21) levels and metabolic dysfunction-associated steatotic liver disease (MASLD), and further explore the mediation effect of inflammation in their association.</p><p><strong>Methods: </strong>This study included 1,710 community residents, including 697 men and 1,013 women, with a median age of 59 (55-63) years. Abdominal ultrasound was used to detect the liver and calculate liver fat content (LFC). MASLD was diagnosed according to the 2023 Delphi consensus. Serum FGF21 levels were measured using enzyme-linked immunosorbent assay. Inflammation levels were assessed through C-reactive protein (CRP), white blood cells (WBCs), and tumor necrosis factor-α (TNF-α).</p><p><strong>Results: </strong>Regardless of overweight/obese status, serum FGF21 levels were higher in individuals with MASLD than in individuals without MASLD (all P < 0.05). In the multivariate logistic regression model, for every 1-unit increase in serum FGF21 levels, the risk of MASLD was 1.46 (95% confidence interval (CI), 1.11-1.92) and 1.51 (95% CI, 1.19-1.93) in lean and overweight/obesity subjects, respectively. Moreover, serum FGF21 levels were positively correlated with LFC (P < 0.05), and the relationship between serum FGF21 and LFC could be partially mediated by CRP, WBC, and TNF-α.</p><p><strong>Conclusions: </strong>Regardless of overweight/obese status, serum FGF21 levels were significantly associated with an elevated risk of MASLD. Furthermore, serum FGF21 levels were independently associated with LFC, which could be partially mediated by inflammation.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on growth hormone therapy efficacy in pediatric patients with short stature.","authors":"Yoo-Mi Kim, Ah-Reum Oh, Heon-Seok Han, Jeesuk Yu, Jaehong Yu, Tae Kwan Lee, Gyung Min Lee, Jaewon Choe, Jun Suk Oh, Han Hyuk Lim","doi":"10.1530/EC-25-0218","DOIUrl":"10.1530/EC-25-0218","url":null,"abstract":"<p><p>The coronavirus disease (COVID-19) pandemic has affected global healthcare and raised concerns about growth hormone (GH) therapy outcomes in pediatric patients with short stature. This study compared GH therapy efficacy and outcomes before and during the pandemic. We retrospectively analyzed 2,827 pediatric patients with idiopathic GH deficiency, short stature in children born small for gestational age (SGA), Turner syndrome (TS), or idiopathic short stature (ISS) from the LG Growth Study, categorized into pre-pandemic (February 2017-January 2020, n = 1,612) and pandemic (February 2020-January 2023, n = 1,215) groups. The key outcomes included height standard deviation score (SDS), body mass index (BMI)-SDS, insulin-like growth factor 1 levels, and adverse events. Significant differences were observed between groups. During the pandemic, the proportion of SGA and TS decreased, whereas that of ISS increased. IGF-1 and total cholesterol levels were higher in the early treatment phase of the pandemic but tended to normalize over time. Reported adverse events were markedly lower during the pandemic, particularly infectious and systemic complications. GH therapy remained effective during the pandemic despite healthcare disruptions. Pandemic-related shifts in BMI, IGF-1, and adverse event reports suggest environmental influences on treatment patterns. These findings underscore the importance of monitoring chronic pediatric care under changing public health conditions.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344362/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin attenuates SARS-CoV-2 entry into cells and cell damage in 2D and 3D cultures of human subcutaneous adipocytes.","authors":"Maria Teresa De Sibio, Ester Mariane Vieira, Paula Barreto Da Rocha, Miriane De Oliveira, Regiane Marques Castro Olímpio, Vinícius Vigliazzi Peghinelli, Lucas Solla Mathias, Helena Paim Tilli, Bianca Mariani Gonçalves, Igor Deprá, Maria Beatriz Bravin, Mariana Menezes Lourenço, Giovanna Bonatto Luca, Matheus de Souza Marino, Pedro Henrique Soares Kossooski, Camila Renata Corrêa, Marna Eliana Sakalem, Cormarie Fernández Pulido, Célia Regina Nogueira","doi":"10.1530/EC-25-0046","DOIUrl":"10.1530/EC-25-0046","url":null,"abstract":"<p><strong>Introduction: </strong>COVID-19 is associated with an inflammatory pathophysiology and, when associated with chronic diseases, can trigger severe infection and increase death risk. Irisin, a hormone produced by skeletal muscle during physical activity, has demonstrated therapeutic effects against metabolic disorders and exhibits anti-inflammatory and antioxidant effects. There is great interest in investigating irisin's influence on the interaction between SARS-CoV-2 and host cells. The aim of the present study is to investigate the role of irisin in viral infection in monolayers (2D) or three-dimensional (3D) cell cultures of human subcutaneous adipocytes infected with a SARS-CoV-2 pseudovirus (PV).</p><p><strong>Materials and methods: </strong>Preadipocytes were cultured to maturity in 2D or 3D conditions and divided into four groups: Group 1: adipocytes with no treatment; Group 2: adipocytes optimized for angiotensin-converting enzyme 2 (ACE2) expression; Group 3: adipocytes optimized for ACE2 expression, and then exposed to SARS-CoV-2 pseudovirus (ACE2+PV); and Group 4: adipocytes treated with irisin 20 nM for 24 h, optimized for ACE2 expression and exposed to PV (ACE2+I+PV). Fluorescence levels of SARS-CoV-2 PV and ACE2 were measured to investigate cell infection; lactate dehydrogenase (LDH) activity to investigate cytotoxicity; and malondialdehyde (MDA) and protein carbonylation to assess oxidative stress levels.</p><p><strong>Results and discussion: </strong>Irisin significantly reduced viral particle (PV) capture in 2D and 3D conditions. In addition, irisin decreased LDH release, MDA, and protein carbonylation levels, both in 2D and 3D conditions.</p><p><strong>Conclusion: </strong>The results indicate irisin as a promising therapeutic target against COVID-19 pathophysiology by reducing viral entry into adipose cells as well as reducing cytotoxicity and oxidative stress indicators.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12344243/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroid disease in ageing populations.","authors":"Xin Hou, Xiaomeng Sun, Shuhang Xu, Yushu Li","doi":"10.1530/EC-25-0393","DOIUrl":"10.1530/EC-25-0393","url":null,"abstract":"","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of clinical and histopathological characteristics of differentiated thyroid cancers in euthyroid nodular goiter and Graves' disease.","authors":"İnan Güden, Irem Karatas, Yalın Iscan, Gulcin Yegen, Semen Onder, Nihat Aksakal, Fatih Tunca, Yasemin Giles Senyurek, Ismail Cem Sormaz","doi":"10.1530/EC-25-0183","DOIUrl":"10.1530/EC-25-0183","url":null,"abstract":"<p><strong>Background: </strong>Graves' disease (GD) is characterized by autoimmune hyperthyroidism. Its association with papillary thyroid carcinoma (PTC) remains controversial, with conflicting data regarding tumor aggressiveness and clinical outcomes.</p><p><strong>Objective: </strong>To compare the clinical and histopathological features of PTC in patients with GD versus those with euthyroid nodular goiter.</p><p><strong>Methods: </strong>A retrospective review was conducted on 995 patients who underwent thyroidectomy for PTC between 2014 and 2023. Group 1 included 59 patients with GD and coexisting PTC, while group 2 comprised 936 euthyroid patients with PTC. Tumor characteristics, recurrence rates, and treatment outcomes were analyzed.</p><p><strong>Results: </strong>PTCs in the GD group were more frequently papillary microcarcinomas (85 vs 43%, P < 0.001) and exhibited significantly lower rates of multicentricity, vascular invasion, and lymph node metastasis. There were no statistically significant differences in recurrence or distant metastasis between groups. Multivariate analysis identified older age and the presence of thyroid nodules as independent predictors of PTC in patients with GD.</p><p><strong>Conclusion: </strong>PTC associated with GD appears to exhibit more favorable histopathological features. However, the risk of malignancy increases with age and ultrasonographically detected nodules in GD patients. These findings support the importance of vigilant surveillance and individualized treatment planning in this population.</p>","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12492166/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144658740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}