Typical morphological characteristics of the immunohistochemical subtypes of pituitary microadenomas: a dual center study.

IF 2.6 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Endocrine Connections Pub Date : 2024-11-14 Print Date: 2024-12-01 DOI:10.1530/EC-24-0378

Li Zhang, Shuai Yan, Shen-Ke Xie, Yi-Tong Wei, Hua-Peng Liu, Yin Li, Hai-Bo Wu, Hai-Liang Wang, Peng-Fei Xu

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引用次数: 0

Abstract

Purpose: This study aimed to investigate the relationship between magnetic resonance image (MRI) features and the immunohistochemical subtypes of pituitary microadenomas (PMAs) characterized by location and growth pattern.

Materials and methods: A double-center, retrospective review of MRI characteristics was conducted in 57 PMA cases recorded from February 2014 to September 2023, identified based on the 2017 World Health Organization classification of pituitary gland tumors. The geometric center of the tumor was defined, and the possibility of PMA vertical or lateral growth patterns was evaluated according to the ratio of maximum diameter between the X and Y axes.

Results: Among the PMAs, somatotroph adenomas (STAs) significantly frequented the lateral-anteroinferior portion of the pituitary gland (P = 0.036). Lactotroph adenomas (LTAs) showed a significant locational preference for the lateral-posteroinferior portion (P = 0.037), and gonadotroph adenomas (GTAs) were predominantly located in the central-anteroinferior portion (P = 0.022). Furthermore, PMAs in the suprasellar portion exhibited vertical extension with statistical significance (P = 0.0).

Conclusion: In our cohort, micro-STAs were predominantly located in the lateral-anteroinferior portion of the pituitary gland, micro-LTAs in the lateral-posteroinferior portion, and micro-GTAs in the central-anteroinferior portion. The growth pattern of PMAs was highly correlated with their vertical position instead of their immunohistochemical subtypes. Therefore, MRI shows potential in differentiating partial PMA subgroups, especially cases within the silent groups.

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垂体微腺瘤免疫组化亚型的典型形态学特征：一项双中心研究。

目的：本研究旨在探讨以位置和生长模式为特征的垂体微腺瘤（PMAs）的磁共振图像（MRI）特征与免疫组化亚型的关系：对2014年2月至2023年9月期间记录的57例PMA病例的MRI特征进行双中心回顾性研究，并根据2017年WHO垂体瘤分类进行鉴定。界定了肿瘤的几何中心，并根据X轴和Y轴之间最大直径的比值评估了PMA垂直或侧向生长模式的可能性：结果：在垂体腺瘤中，体养腺瘤（STA）明显多发于垂体的外侧-内侧部分（P=0.036）。泌乳腺腺瘤（LTA）明显偏爱外侧-前内侧部分（P=0.037），而促性腺激素腺瘤（GTA）则主要位于中央-前内侧部分（P=0.022）。此外，位于鞍上部分的 PMAs 呈垂直延伸，具有统计学意义（P=0.0）：在我们的队列中，微小STAs主要位于垂体外侧-前内侧部分，微小LTAs位于垂体外侧-前内侧部分，微小GTAs位于垂体中央-前内侧部分。PMA的生长模式与其垂直位置而非免疫组化亚型高度相关。因此，核磁共振成像在区分部分 PMA 亚组，尤其是沉默组病例方面具有潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Connections Medicine-Internal Medicine

CiteScore

5.00

自引率

3.40%

发文量

361

审稿时长

6 weeks

期刊介绍： Endocrine Connections publishes original quality research and reviews in all areas of endocrinology, including papers that deal with non-classical tissues as source or targets of hormones and endocrine papers that have relevance to endocrine-related and intersecting disciplines and the wider biomedical community.