Endocrine Connections最新文献_第4页

Validation of a new non-invasive predictive score (KASAI) for primary aldosteronism subtyping. 原发性醛固酮增多症亚型分型新的无创预测评分（KASAI）的验证。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-09-03 Print Date: 2025-09-01 DOI: 10.1530/EC-25-0156

Guillaume Pierman, Karin Zibar Tomsic, Darko Kastelan, De Herdt Carlien, Natacha Driessens, Laurent Vroonen, Audrey Loumaye, Dominique Maiter, Raluca Maria Furnica

{"title":"Validation of a new non-invasive predictive score (KASAI) for primary aldosteronism subtyping.","authors":"Guillaume Pierman, Karin Zibar Tomsic, Darko Kastelan, De Herdt Carlien, Natacha Driessens, Laurent Vroonen, Audrey Loumaye, Dominique Maiter, Raluca Maria Furnica","doi":"10.1530/EC-25-0156","DOIUrl":"10.1530/EC-25-0156","url":null,"abstract":"Introduction: Adrenal venous sampling (AVS) is considered the gold standard test for primary aldosteronism (PA) subtyping. Considering the limited availability of this challenging procedure, we propose a noninvasive score predicting unilateral (UPA) or bilateral (BPA) form of PA in order to reduce the need for AVS.Material and methods: The score was retrospectively developed from a cohort of 72 patients who underwent AVS (21 patients with BPA and 51 with UPA) at Cliniques Universitaires Saint Luc between 1993 and 2021. Another multicenter cohort of 130 patients who underwent AVS (67 patients with BPA and 63 with UPA) served as external validation.Results: Four predictive parameters of UPA highlighted by logistic regression analysis were integrated into the KASAI score: minimal serum potassium value, supine resting aldosteronemia, aldosteronemia at the end of the saline infusion test, and results of adrenal imaging. Depending on the results, 0, 1, or 3 points were assigned to each parameter. In both cohorts, a score greater than 9/12 identified UPA and a score less than 4/12 identified BPA with 100% specificity, while performing AVS remained indicated for scores between 4 and 9. The score may have avoided AVS in 40% of patients in the primary cohort and in 42% of patients in the validation cohort. The area under the ROC curve for discrimination of UPA from BPA was 0.81 (95% CI, 0.70-0.90) in the primary cohort and 0.86 (95% CI, 0.80-0.90) in the validation cohort.Conclusion: We propose a new biological-radiological score that could simplify the diagnostic assessment of PA.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":"14 9","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144947154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks. 揭示子宫肌瘤SP/ kr<s:1> ppel样因子作为分娩驱动因素：来自转录和内分泌调节网络的见解。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-09-02 Print Date: 2025-09-01 DOI: 10.1530/EC-25-0296

Frank A Simmen, Rosalia C M Simmen

{"title":"Unveiling myometrial SP/Krüppel-like factors as drivers of parturition: insights from transcriptional and endocrine regulatory networks.","authors":"Frank A Simmen, Rosalia C M Simmen","doi":"10.1530/EC-25-0296","DOIUrl":"10.1530/EC-25-0296","url":null,"abstract":"Graphical abstract: Abstract: Parturition is a complex process that is subject to multifactorial regulation by signals originating from the fetus, placenta, and uterus. The uterine myometrium is a central player for achieving successful pregnancy to term, requiring its transformation from a quiescent and growing entity to one of significant contractility within a narrow window of intricately regulated events. Receptors for the steroid hormones progesterone and estrogen are critical to myometrial transformative processes. Specificity protein/Krüppel-like factor (SP/KLF) family members are transcriptional regulators that play key roles in human physiology and pathology, in part as members of steroid hormone signaling networks. Here we review findings to establish the molecular rationale for a novel function of multiple SP/KLF proteins in human parturition. Support for their potential crucial roles includes: i) differential levels of myometrial expression at labor; ii) transcriptional regulation of myometrial expressed genes; iii) functional abilities to mechanistically influence steroid hormone signaling; and iv) parturition-associated hormonal control of their expression. Understanding myometrial SP/KLF networks in the physiologic control of myometrial contractility may have therapeutic relevance for management of aberrant labor onset to reduce maternal and neonatal morbidity and mortality.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutational landscapes of HNF MODY gene products display a wide distribution with functional implications. HNF MODY基因产物的突变格局具有广泛的分布和功能意义。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-09-02 Print Date: 2025-09-01 DOI: 10.1530/EC-25-0345

Young-In Chi, Raul Urrutia

{"title":"Mutational landscapes of HNF MODY gene products display a wide distribution with functional implications.","authors":"Young-In Chi, Raul Urrutia","doi":"10.1530/EC-25-0345","DOIUrl":"10.1530/EC-25-0345","url":null,"abstract":"Hepatocyte nuclear factors (HNFs) play an essential role in the development and function of vital organs such as the liver, kidney, intestine, and pancreas by regulating the expression of multiple genes involved in organ development, nutrient transport, and diverse metabolic pathways. Among them, HNF1α, HNF1β, and HNF4α play critical roles in glucose-stimulated insulin secretion in pancreatic β-cells and are monogenic causes of diabetes referred to as maturity-onset diabetes of the young (MODY). Numerous mutations have been identified in MODY patients, and the numbers are growing. MODY mutations disrupt protein structure/function in specific ways, and deciphering the exact molecular mechanisms of their mutational effects is vital for better understanding their molecular function and potential therapeutic intervention. This article compiles the updated overall landscapes of missense mutations in members of these transcription factors. We show that mutations are widely but unevenly distributed in their sequence and molecular structures and infer their functional implications. We map the variants to several hotspot residues. While some mutations have been previously characterized, we find that significant proportions of them remain to be mechanistically defined. Because these proteins represent ideal targets to improve β-cell function and survival, we discuss the status and prospects for therapeutic intervention.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case selection of adrenal vein sampling in young patients with primary aldosteronism: a retrospective analysis of imaging and AVS concordance, and histopathological outcomes. 原发性醛固酮增多症年轻患者肾上腺静脉取样的病例选择：影像学- avs一致性和组织病理学结果的回顾性分析。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-09-02 Print Date: 2025-09-01 DOI: 10.1530/EC-25-0326

Zin Htut, Namir Asmar, Joshua Agilinko, Rashpal Flora, Fausto Palazzo, Aimee Di Marco, Jeannie Todd, Karim Meeran, Florian Wernig, Ali Alsafi

{"title":"Case selection of adrenal vein sampling in young patients with primary aldosteronism: a retrospective analysis of imaging and AVS concordance, and histopathological outcomes.","authors":"Zin Htut, Namir Asmar, Joshua Agilinko, Rashpal Flora, Fausto Palazzo, Aimee Di Marco, Jeannie Todd, Karim Meeran, Florian Wernig, Ali Alsafi","doi":"10.1530/EC-25-0326","DOIUrl":"10.1530/EC-25-0326","url":null,"abstract":"Background: Primary aldosteronism (PA) is a common, potentially curable cause of secondary hypertension. Determining disease laterality is critical to guide treatment decisions. Adrenal vein sampling (AVS) is the gold standard but may be unnecessary in patients aged 35 years or younger who meet defined strict biochemical and imaging criteria.Objective: To assess concordance between imaging and AVS for lateralisation in young patients with PA and correlate findings with histopathology after adrenalectomy.Methods: A retrospective analysis of 35 patients aged 35 years or younger with confirmed PA who underwent unstimulated AVS between 2011 and 2024. Cross-sectional imaging findings were compared with AVS results. Histopathological outcomes were reviewed for patients who underwent adrenalectomy.Results: Imaging identified unilateral adrenal adenomas in 29 patients, with 86% (25/29) concordance with AVS. Four discordant cases were classified as bilateral by AVS; three did not meet the Endocrine Society criteria for 'marked' PA. Excluding these cases raised the concordance rate to 96%. All 25 patients with AVS-confirmed unilateral disease underwent adrenalectomy, with histopathology confirming aldosterone-producing adenomas.Conclusion: Imaging accurately predicted unilateral PA in most young patients meeting strict biochemical and imaging criteria. Some patients could avoid AVS, although even with strict criteria, uncommon discordant cases highlight the importance of careful patient selection.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12412200/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal analysis of serum alpha-fetoprotein in stable and progressive metastatic pancreatic neuroendocrine tumours. 稳定和进展性转移性胰腺神经内分泌肿瘤患者血清甲胎蛋白的纵向分析。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-08-29 DOI: 10.1530/EC-25-0350

Jan Musiałkiewicz, Marek Ruchała, Paweł Komarnicki, Adam Maciejewski, Joanna Sienkiewicz, Phantira Sirisachadecha, Bartłomiej Budny, Paweł Gut

{"title":"Longitudinal analysis of serum alpha-fetoprotein in stable and progressive metastatic pancreatic neuroendocrine tumours.","authors":"Jan Musiałkiewicz, Marek Ruchała, Paweł Komarnicki, Adam Maciejewski, Joanna Sienkiewicz, Phantira Sirisachadecha, Bartłomiej Budny, Paweł Gut","doi":"10.1530/EC-25-0350","DOIUrl":"10.1530/EC-25-0350","url":null,"abstract":"Background: Neuroendocrine tumours (NETs) are a heterogeneous group of rare neoplasms arising from neuroendocrine cells, most commonly found in the gastrointestinal tract and pancreas. Despite novel diagnostic techniques, identifying reliable biomarkers for NETs still remains a challenge.Objectives: Our study explores the diagnostic, monitoring and prognostic value of alpha-fetoprotein (AFP) in pancreatic NETs.Materials and methods: We recruited 41 adult patients diagnosed with liver metastatic non-functioning pancreatic NETs. Serum AFP levels were assessed at three-month intervals over a span of four years. For comparative purposes, we analysed data in relation to sex, age, liver tumour burden (LTB; <10%, 10-25%), tumour grade based on the WHO 2022 classification (G1, G2), and treatment response on baseline as defined by RECIST 1.1 criteria (SD - stable disease, PD - progressive disease). Every patient underwent treatment with somatostatin analogues during the study period.Results: Elevated AFP concentrations showed a continuous upward trend across all participants and were significantly associated with indicators of more aggressive disease: greater liver tumour burden (10-25%, p < 0.001), higher tumour grade (G2, p < 0.001), and progression of disease (PD, p < 0.001). No statistically significant differences in AFP levels were observed in relation to age or sex.Conclusion: AFP consistently increases in patients with progressive pancreatic NETs compared to patients with stable disease on baseline. Potential utility of AFP measurements requires further follow-up studies, especially as a prognostic biomarker.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated serum phoenixin levels in boys with central precocious puberty are positively correlated with BMI. 中枢性性早熟男孩血清凤凰素水平升高与BMI呈正相关。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-08-29 Print Date: 2025-08-01 DOI: 10.1530/EC-25-0358

Tao Xie, Wei Qin, Dan Zeng, Runqi Wang, Yanfei Chen, Dan Lan

{"title":"Elevated serum phoenixin levels in boys with central precocious puberty are positively correlated with BMI.","authors":"Tao Xie, Wei Qin, Dan Zeng, Runqi Wang, Yanfei Chen, Dan Lan","doi":"10.1530/EC-25-0358","DOIUrl":"10.1530/EC-25-0358","url":null,"abstract":"Objective: This study investigated changes in serum phoenixin (PNX) levels in boys with central precocious puberty (CPP), aiming to evaluate its diagnostic and therapeutic relevance and identify factors influencing its expression.Method: Serum samples were collected from 43 boys with CPP and 48 age-matched prepubertal controls. Participants were further divided into overweight/obese and normal-weight subgroups based on body mass index (BMI). Levels of phoenixin-14 (PNX-14) and phoenixin-20 (PNX-20) were measured using enzyme-linked immunosorbent assay (ELISA). Correlations with luteinizing hormone (LH), testosterone, and BMI were analyzed. Multiple linear regression identified independent influencing factors, and receiver operating characteristic (ROC) analysis assessed the diagnostic performance of PNX. Twelve CPP boys were followed for 6 months after gonadotropin-releasing hormone analog (GnRHa) treatment.Results: PNX-20 and PNX-14 levels were significantly higher in the CPP group than in controls (P = 0.001). Among subgroups, the overweight/obese CPP group exhibited the highest levels. Both PNX forms were positively correlated with baseline LH, testosterone, and BMI; PNX-14 was most strongly associated with LH, and PNX-20 with BMI. ROC analysis showed moderate diagnostic value for PNX-14 (AUC: 0.710) and PNX-20 (AUC: 0.696), with a combined AUC of 0.718. Following treatment, levels of PNX-20, LH, follicle-stimulating hormone (FSH), and testosterone significantly declined, while PNX-14 remained unchanged.Conclusions: PNX is associated with pubertal progression and BMI in boys with CPP. While not suitable as a standalone diagnostic marker, PNX - especially PNX-20 - may serve as a useful adjunct for diagnosis and treatment monitoring.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Longitudinal trajectories of insulin resistance in women with polycystic ovary syndrome: a functional data analysis approach. 多囊卵巢综合征妇女胰岛素抵抗的纵向轨迹：一种功能数据分析方法。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-08-29 Print Date: 2025-08-01 DOI: 10.1530/EC-25-0266

Fahimeh Ramezani Tehrani, Mohammad Fayaz, Faegheh Firouzi, Fereidoun Azizi, Maryam Tohidi, Samira Behboudi-Gandevani

{"title":"Longitudinal trajectories of insulin resistance in women with polycystic ovary syndrome: a functional data analysis approach.","authors":"Fahimeh Ramezani Tehrani, Mohammad Fayaz, Faegheh Firouzi, Fereidoun Azizi, Maryam Tohidi, Samira Behboudi-Gandevani","doi":"10.1530/EC-25-0266","DOIUrl":"10.1530/EC-25-0266","url":null,"abstract":"Introduction: Insulin resistance (IR) plays a central role in the pathophysiology of polycystic ovary syndrome (PCOS), yet its long-term trajectory across different phenotypes and obesity statuses remains unclear. This study aimed to model longitudinal IR patterns in women with PCOS, those meeting an isolated PCOS criterion, and healthy controls.Methods: This population-based prospective study included 1,759 reproductive-aged women (18-49 years) from the Tehran Lipid and Glucose Study, categorized into PCOS (n = 287), isolated PCOS criterion (n = 536), and healthy control (n = 936) groups, stratified by BMI (<25 kg/m2, 25-29.99 kg/m2, and ≥30 kg/m2) and WC (<88 cm and ≥88 cm). Functional principal component analysis modeled HOMA-IR and fasting insulin level trajectories as sparse functional data.Results: Women with PCOS were younger (23.5 vs 25 and 28 years, P < 0.05) and had lower BMI than healthy controls (23.38 vs 24.46 kg/m2, P < 0.05), with no baseline differences in HOMA-IR. Both HOMA-IR and fasting insulin trajectories varied by obesity status. Women with PCOS and either obesity or central obesity showed a pronounced upward trend in IR over time, while those without general or central obesity exhibited more stable or improving patterns. In contrast, healthy and isolated criterion groups showed relatively stable or mildly increasing HOMA-IR and fasting insulin levels, with steeper increases in the presence of obesity.Conclusion: This study provides new insights into the diverse trajectories of IR among women with PCOS, those with an isolated PCOS criterion, and healthy controls. Progressive worsening of IR was observed in women with PCOS and obesity, while those with PCOS without obesity showed improvement. Healthy and isolated criterion groups exhibited more stable patterns.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of increased serum I-309 with renal function impairment and diabetic kidney disease in type 2 diabetes mellitus. 2型糖尿病患者血清I-309升高与肾功能损害和糖尿病肾病的关系

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-08-29 Print Date: 2025-08-01 DOI: 10.1530/EC-25-0252

Bing Zhao, Miaomiao Zhang, Zhiyu Zhang, Yan Liang, Zaixing Yang

{"title":"Association of increased serum I-309 with renal function impairment and diabetic kidney disease in type 2 diabetes mellitus.","authors":"Bing Zhao, Miaomiao Zhang, Zhiyu Zhang, Yan Liang, Zaixing Yang","doi":"10.1530/EC-25-0252","DOIUrl":"10.1530/EC-25-0252","url":null,"abstract":"Objective: The aim of this study was to determine serum I-309 levels in type 2 diabetes mellitus (T2DM) patients, as well as the association with clinical/laboratory phenotypes and disease complications.Methods: A total of 155 T2DM patients and 30 healthy controls (HC) were enrolled. The concentrations of serum I-309, interleukin-4 (IL-4), IL-6, IL-10, IL-12, IL-17, IL-23, tumor necrosis factor-α (TNF-α), and interferon (IFN)-γ were measured. The relationships between I-309 and various clinical and laboratory variables were analyzed.Results: The serum concentrations of I-309 were significantly higher in T2DM patients than in HC (P < 0.001). The serum I-309 levels were significantly elevated in T2DM patients with diabetic kidney disease (DKD), hypertension, coronary artery disease, peripheral neuropathy, peripheral artery disease, and diabetic ketosis (all P < 0.05), but reduced in drinkers (P = 0.018). The Spearman analysis showed that serum I-309 correlated positively with age, disease duration, CKD stages, urea, creatinine, urinary albumin-to-creatinine ratio, C-reactive protein, red blood cell distribution width, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, IL-6, IL-12, and IFN-γ, but negatively with estimated glomerular filtration rate (eGFR), fasting blood glucose, total bilirubin, albumin, lymphocyte count, red blood cell count, and hemoglobin. The multiple linear regression analysis indicated that serum I-309 was independently correlated only with eGFR and IFN-γ. The multivariate logistic regression analysis demonstrated that serum I-30 and IL-17A remained independently associated with DKD.Conclusion: Serum I-309 is markedly elevated in T2DM patients and is associated with increased DKD risk, suggesting its potential role as both a promising biomarker and a pathogenic mediator in the progression of T2DM, particularly DKD.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical bone status and its determinants in pediatric Klinefelter syndrome. 儿童克氏综合征的皮质骨状态及其决定因素。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-08-28 Print Date: 2025-08-01 DOI: 10.1530/EC-25-0216

Maartje Hickmann, Elise Nauwynck, Caroline Ernst, Inneke Willekens, Ellen Anckaert, Jesse Vanbesien, Willem Staels, Jean De Schepper, Inge Gies

{"title":"Cortical bone status and its determinants in pediatric Klinefelter syndrome.","authors":"Maartje Hickmann, Elise Nauwynck, Caroline Ernst, Inneke Willekens, Ellen Anckaert, Jesse Vanbesien, Willem Staels, Jean De Schepper, Inge Gies","doi":"10.1530/EC-25-0216","DOIUrl":"10.1530/EC-25-0216","url":null,"abstract":"Purpose: Cortical bone deficiency in adults with Klinefelter syndrome (KS) is a well-established concern. Whether this deficit originates from impaired bone accumulation during childhood or adolescence remains unclear. Thus, we aimed to assess cortical bone status in children and adolescents with KS using automated digital X-ray radiogrammetry (DXR) while examining associations with hormonal, radiographic, and anthropometric factors.Methods: In a cohort of 50 pediatric patients with KS, we retrospectively collected anthropometric measurements, bone health index (BHI), and bone age readings by the BoneXpert method. Digit 2 (D2) and 4 (D4) lengths and ratio were calculated. Lumbar spine bone mineral density (LS BMD) data and hormonal measurements were accessible for 30 and 22 patients, respectively.Results: While mean bone age was not significantly advanced, the mean BHI Z-score was significantly decreased (-0.56 (0.99)). LS BMD Z-scores were normal. Half of the patients had a serum 25-hydroxyvitamin D (25-OHD) level below 20 μg/L. KS males with a BHI Z-score below -1 were significantly older and had significantly lower 25-OHD levels. BHI Z-score did not correlate with serum hormones, Z-scores of bone age, LS BMD, and D2:D4 ratio.Conclusion: Cortical bone accumulation, evaluated through DXR, is only slightly reduced in pediatric KS. Advanced age and lower circulating 25-OHD emerged as clinical risk factors for a lower BHI. BHI Z-scores were not associated with the D2:D4 ratio or LS BMD Z-scores. Therefore, BHI Z-scores are inapt to predict LS BMD Z-scores, though their potential to predict fractures warrants further study.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12400500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144845046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower ghrelin in depression might be connected to the absence of psychotic-like experiences. 抑郁症中较低的胃饥饿素可能与缺乏类似精神病的经历有关。

IF 2.8 3区医学

Endocrine Connections Pub Date : 2025-08-27 Print Date: 2025-08-01 DOI: 10.1530/EC-25-0263

Michał Lis, Maciej Majdowski, Tymoteusz Miłuch, Tomasz Zawodny, Olivia Wasilewska, Adriana Kwiatkowska

{"title":"Lower ghrelin in depression might be connected to the absence of psychotic-like experiences.","authors":"Michał Lis, Maciej Majdowski, Tymoteusz Miłuch, Tomasz Zawodny, Olivia Wasilewska, Adriana Kwiatkowska","doi":"10.1530/EC-25-0263","DOIUrl":"10.1530/EC-25-0263","url":null,"abstract":"Major depressive disorder (MDD) prevalence increases every year, with approximately 30% of patients remaining treatment-resistant. Ghrelin, a stomach-derived appetite-stimulating hormone, has been implicated in mood disorders, stress response, sleep-cycle regulation, reward behaviour, and neuroplasticity. However, findings in humans remain unconclusive, with reports of higher, unchanged, or lowered ghrelin concentration in patients with MDD. Psychotic-like experiences (PLEs), which are more common in the course of depression, might contribute to reported inconsistencies. This study aims to assess serum total ghrelin concentrations in individuals with depressive symptoms and investigate whether the presence of PLEs modulates the relationship. A cross-sectional study was conducted among 56 individuals screened for depressive symptoms (with patient health questionnaire-9 (PHQ-9)) and presence of PLEs in the past year (with prodromal questionnaire-16 (PQ-16)). Serum total ghrelin levels were determined by enzyme-linked immunosorbent assay (ELISA). The relationship between PHQ-9 scores and total ghrelin was analysed using linear regression and analysis of covariates (ANCOVA) when controlled for sex, age, and body mass index. Initially, depressive symptoms predicted lower ghrelin levels (P = 0.044). However, the model lost its significance when adjusted for covariates (P = 0.100). Pairwise comparisons revealed lower total ghrelin among patients with MDD but without PLEs when compared to controls (P = 0.037). No significant differences were observed within patients with a history of PLEs. This study provides preliminary evidence that PLEs modulate ghrelin secretion in patients with MDD symptoms. Further studies with larger samples are needed to clarify ghrelin's role in MDD pathophysiology.","PeriodicalId":11634,"journal":{"name":"Endocrine Connections","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12392750/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144872038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0