Endocrine journal最新文献_第3页

Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice. 单次注射烟酰胺单核苷酸增加全身胰岛素敏感性，与小鼠肝脏和脂肪组织中NAD挽救通路的激活有关。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-06-03 DOI: 10.1507/endocrj.EJ24-0312

Shunsuke Hiroshige, Yasuko Kajimura, Yuko Nagao, Akihiko Taguchi, Ryoko Hatanaka, Chika Yodokawa, Yuka Fujioka, Masaru Akiyama, Yukio Tanizawa, Yasuharu Ohta

{"title":"Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice.","authors":"Shunsuke Hiroshige, Yasuko Kajimura, Yuko Nagao, Akihiko Taguchi, Ryoko Hatanaka, Chika Yodokawa, Yuka Fujioka, Masaru Akiyama, Yukio Tanizawa, Yasuharu Ohta","doi":"10.1507/endocrj.EJ24-0312","DOIUrl":"10.1507/endocrj.EJ24-0312","url":null,"abstract":"Rising nicotinamide adenine dinucleotide (NAD+) levels mitigate the onset and progression of age-related diseases including metabolic disorders. Several studies have demonstrated that NAD+ levels can be efficiently replenished via nicotinamide mononucleotide (NMN) intake and thereby prevent metabolic disorders. However, the acute effects of NMN administration on metabolism remain unclear. We observed metabolic dynamics after a single bolus injection of NMN. Sirt1 and Nampt mRNA levels were increased in the liver suggesting that intracellular NAD+ increased after injection. During OGTT, glucose tolerance and insulin secretion did not change significantly in response to NMN administration, while during ITT, increased insulin sensitivity was observed in muscle. NMN administration decreased serum non-esterified free fatty acid (NEFA) concentrations, which would presumably be responsible for the increased muscle insulin sensitivity. Furthermore, NMN administration reduced the respiratory quotient, confirming that NMN promotes utilization of lipids as an energy source. Our data demonstrate acute effects of NMN on metabolism and raise the possibility of NMN as a treatment for metabolic disorders.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"1051-1060"},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436074/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biased antibodies and beyond: a new era in the diagnosis of PTH-dependent hypercalcemia. 偏倚抗体及其他：甲状旁腺激素依赖性高钙血症诊断的新时代。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-05-03 DOI: 10.1507/endocrj.EJ25-0051

Noriko Makita, Katsunori Manaka, Maho Taguchi, Hirofumi Horikoshi, Junichiro Sato, Taroh Iiri

{"title":"Biased antibodies and beyond: a new era in the diagnosis of PTH-dependent hypercalcemia.","authors":"Noriko Makita, Katsunori Manaka, Maho Taguchi, Hirofumi Horikoshi, Junichiro Sato, Taroh Iiri","doi":"10.1507/endocrj.EJ25-0051","DOIUrl":"10.1507/endocrj.EJ25-0051","url":null,"abstract":"Hypercalcemia, a common electrolyte imbalance, requires accurate differential diagnosis to guide appropriate management. PTH-dependent hypercalcemia, predominantly caused by primary hyperparathyroidism (PHPT) and rarely by familial hypocalciuric hypercalcemia (FHH)-mainly due to heterozygous loss-of-function mutations in the CASR gene encoding the calcium-sensing receptor (CaSR)-now includes acquired hypocalciuric hypercalcemia (AHH) as an emerging disease entity. Initially identified as analogous to FHH, AHH was characterized by blocking antibodies targeting the CaSR. However, our research has identified unique autoantibodies, termed biased antibodies, that paradoxically regulate signaling by enhancing Gq activity while suppressing Gi activity. Investigating their mechanisms has not only provided insights into specific treatments for AHH but also suggested novel activation mechanisms and binding sites of the CaSR, offering a fresh perspective on the regulation of PTH secretion. In clinical practice, recognizing AHH is crucial. A key diagnostic feature is fluctuating serum calcium levels, making a wait-and-see approach viable for mild hypercalcemia. Conversely, hypercalcemic crises necessitate immediate diagnostic and therapeutic interventions. The most important diagnostic clue to differentiate AHH from PHPT is hypermagnesemia. Additionally, AHH is less likely to involve AVP resistance (i.e., nephrogenic diabetes insipidus) and acute kidney injury (AKI), owing to preserved medullary hyperosmolarity and minimal interference with AVP signaling. Finally, a relatively low PTH level serves as another distinguishing feature. Based on these observations, we propose a novel diagnostic guide for PTH-dependent hypercalcemia. We anticipate that this guide will help identify previously undiagnosed AHH cases in routine practice, enabling timely and effective management of this rare condition.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"967-978"},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models. kisspeptin在雌二醇诱导的抑制素亚基基因表达调节中的潜在作用：来自活体大鼠模型和下丘脑细胞模型的见解。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-05-23 DOI: 10.1507/endocrj.EJ25-0044

Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zhuoma Cairang, Batjargal Lkhagvajav, Aki Oride, Hiroe Okada, Satoru Kyo

{"title":"Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models.","authors":"Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zhuoma Cairang, Batjargal Lkhagvajav, Aki Oride, Hiroe Okada, Satoru Kyo","doi":"10.1507/endocrj.EJ25-0044","DOIUrl":"10.1507/endocrj.EJ25-0044","url":null,"abstract":"The hypothalamic-pituitary-gonadal (HPG) axis is primarily regulated by kisspeptin neurons. In addition, activin and inhibin within the central nervous system might contribute to the regulation of the HPG axis because they are expressed near kisspeptin and gonadotropin-releasing hormone (GnRH) neurons. We investigated the effects of inhibin and activin within the hypothalamus in the estradiol (E2)-induced negative feedback mechanism. Inhibin α subunit gene within the posterior hypothalamus in female rats increased after ovariectomy, and this increase was completely suppressed by E2 supplementation. In contrast, inhibin βA subunit decreased after ovariectomy and this reduction was recovered by E2. In ovary-intact rats, E2 reduced inhibin α subunit and increased inhibin βA expression within the hypothalamus. In the rHypoE8 and GT1-7 hypothalamic cell models, E2 stimulation increased inhibin α subunit gene expression. Activin and inhibin A increased Kiss1 gene expression in GT1-7 cells, while inhibin B reduced it. Kisspeptin increased inhibin α subunit expression in rHypoE8 cells, GT1-7 cells, and the mHypoA55 hypothalamic KNDy neuron cell model. Our findings suggest that the expression of inhibin subunits, especially inhibin α, could be increased by E2 in hypothalamic cells and that kisspeptin, inhibin, and activin mutually influence each other under the actions of E2, but their regulation might be controlled mainly by kisspeptin neurons in vivo. Although the effects of activin and inhibin on Kiss1 gene expression varied depending on the hypothalamic cell model examined, intracerebral inhibin and activin might have potential roles in the E2-induced negative feedback mechanism under the influence of kisspeptin neurons.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"1011-1021"},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436079/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia in children with acute leukemia worsened after induction therapy. 急性白血病患儿肌少症诱导治疗后加重。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-05-16 DOI: 10.1507/endocrj.EJ25-0055

Tomoyo Itonaga, Fumika Matsuda, Naoki Hirano, Miwako Maeda, Souichi Suenobu, Kenji Ihara

{"title":"Sarcopenia in children with acute leukemia worsened after induction therapy.","authors":"Tomoyo Itonaga, Fumika Matsuda, Naoki Hirano, Miwako Maeda, Souichi Suenobu, Kenji Ihara","doi":"10.1507/endocrj.EJ25-0055","DOIUrl":"10.1507/endocrj.EJ25-0055","url":null,"abstract":"Sarcopenia is a prevalent condition among elderly individuals and is characterized by the loss of skeletal muscle mass accompanied by physical dysfunction. In older adults, decreased insulin-like growth factor 1 (IGF-1) has been implicated as a contributing factor to the development of sarcopenia. Children with chronic conditions associated with sarcopenia are rarely evaluated. This study aimed to evaluate muscle mass using cross-sectional computed tomography (CT) images in pediatric patients with acute leukemia and patients without chronic diseases, and to examine the relationship between skeletal muscle mass volume and various growth parameters in children with acute leukemia. The study included 44 pediatric patients (age: 1-15 years) with newly diagnosed acute leukemia (B-cell lymphoblastic leukemia, n = 30; T-cell lymphoblastic leukemia, n = 5; other types, n = 9) who underwent abdominal CT before treatment initiation. Among these, 15 underwent abdominal CT after induction therapy. The total psoas muscle area at lumbar vertebrae levels 3-4, body height, weight, and IGF-1 levels were retrospectively analyzed. The total psoas muscle area significantly decreased after induction therapy in all 15 patients. A significant correlation was observed between the rate of change in total psoas muscle area and IGF-1 levels (n = 9; p < 0.05; r = -0.84). However, no correlation was identified between the rate of change in total psoas muscle area and height velocity before and after treatment. In conclusion, skeletal muscle mass decreased following treatment initiation in pediatric patients with acute leukemia. The degree of muscle mass loss was more severe in patients with higher pre-treatment IGF-1 levels.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"1023-1030"},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of excessive iodine intake during the perinatal period on thyroid function and higher brain functions in mouse offspring. 围产期过量碘摄入对小鼠后代甲状腺功能和高级脑功能的影响。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-05-28 DOI: 10.1507/endocrj.EJ24-0723

Izuki Amano, Ayane Ninomiya, Hiroyuki Yajima, Machiko Suda-Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Yusuke Takatsuru, Reika Kawabata-Iwakawa, Satomi Kameo, Shogo Haraguchi, Asahi Haijima, Noriyuki Koibuchi

{"title":"Effects of excessive iodine intake during the perinatal period on thyroid function and higher brain functions in mouse offspring.","authors":"Izuki Amano, Ayane Ninomiya, Hiroyuki Yajima, Machiko Suda-Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Yusuke Takatsuru, Reika Kawabata-Iwakawa, Satomi Kameo, Shogo Haraguchi, Asahi Haijima, Noriyuki Koibuchi","doi":"10.1507/endocrj.EJ24-0723","DOIUrl":"10.1507/endocrj.EJ24-0723","url":null,"abstract":"Iodine is an essential trace element crucial for thyroid hormone synthesis. While iodine deficiency has been recognized as a global health concern due to its association with hypothyroidism, certain regions may face challenges related to excessive iodine intake. The impact of excessive iodine intake during the perinatal period on higher brain functions remains unclear. To address this gap, we conducted a study using an animal model to elucidate the effects of perinatal iodine excess on higher brain functions. Dams received specific drinking water (control, ×20 iodine (KIO3 37.4 mg/L), ×200 iodine (KIO3 374 mg/L)) from prior to mating until weaning. Pups received the corresponding drinking water until the end of the experiment. Behavior test battery was utilized to investigate the behavioral outcomes associated with perinatal iodine excess. Excessive iodine intake increased learning acquisition in females whereas it decreased exploration of social novelty in males. Conversely, mRNA levels of several genes related to learning and memory in the hippocampus were rarely affected. Overall, the present study highlights the consequences of excessive iodine intake during developmental periods. However, these effects were mild and varied by sex, warranting the further investigation.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"999-1010"},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of diabetes on patients undergoing total ankle arthroplasty: a meta-analysis and systematic review. 糖尿病对全踝关节置换术患者的影响：荟萃分析和系统回顾。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-05-20 DOI: 10.1507/endocrj.EJ24-0626

Jianhui Fan, Junfeng Liu, Yanlun Li, Asha Ajia, Pingxi Wang, Qin He

{"title":"Impact of diabetes on patients undergoing total ankle arthroplasty: a meta-analysis and systematic review.","authors":"Jianhui Fan, Junfeng Liu, Yanlun Li, Asha Ajia, Pingxi Wang, Qin He","doi":"10.1507/endocrj.EJ24-0626","DOIUrl":"10.1507/endocrj.EJ24-0626","url":null,"abstract":"Total ankle arthroplasty (TAA) is an effective treatment for end-stage ankle arthritis. However, the procedure is not without risks due to various factors, one of which is diabetes mellitus (DM). Currently, it remains uncertain whether diabetes is a risk factor for increased adverse outcomes and complications following total ankle arthroplasty. Therefore, this study aims to investigate the impact of diabetes on patients undergoing TAA. A systematic search was conducted for relevant studies published before December 2023 in PubMed, Embase, Cochrane Library, and Web of Science. The study assessed demographic data, postoperative complications, and functional outcomes of diabetic and non-diabetic patients following primary TAA. The Newcastle-Ottawa Scale (NOS) was used to evaluate study quality, and meta-analysis was performed using Stata 15.1, with forest plots generated for each variable. This meta-analysis included 14 studies involving 20,557 patients (3,847 with diabetes and 16,710 without). Compared to non-diabetic patients, those with diabetes had higher revision rates, postoperative infection rates, and 30-day readmission rates, longer hospital stays, and significantly different improvements in the SF-36 Physical Component Summary (PCS) score. Diabetic patients undergoing TAA are more likely to require revision surgery, face a higher risk of surgical site infections or periprosthetic joint infections, and experience increased hospital stay and 30-day readmission rates. These findings are crucial for guiding perioperative management of diabetic patients undergoing TAA and for explaining the associated surgical risks to patients.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"987-998"},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 10-year observational study of the effects of serum 25OH vitamin D levels on the onset of prediabetes at a preventive medicine research center. 在预防医学研究中心对血清25OH维生素D水平对前驱糖尿病发病影响的10年观察研究。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-06-14 DOI: 10.1507/endocrj.EJ25-0007

Kaoru Ogawa, Jun Ogino, Riri Oh, Yukie Sakuma, Koji Takemura, Yoshifumi Suzuki, Yukie Ito, Yuko Endo, Haruhisa Shimura, Kiyoe Kiuchi, Saburo Watanabe, Yasunori Sato, Shouji Yoshida, Naotake Hashimoto

{"title":"A 10-year observational study of the effects of serum 25OH vitamin D levels on the onset of prediabetes at a preventive medicine research center.","authors":"Kaoru Ogawa, Jun Ogino, Riri Oh, Yukie Sakuma, Koji Takemura, Yoshifumi Suzuki, Yukie Ito, Yuko Endo, Haruhisa Shimura, Kiyoe Kiuchi, Saburo Watanabe, Yasunori Sato, Shouji Yoshida, Naotake Hashimoto","doi":"10.1507/endocrj.EJ25-0007","DOIUrl":"10.1507/endocrj.EJ25-0007","url":null,"abstract":"We report the findings of a 10-year study that followed the relationship between serum 25-hydroxyvitamin D (25OH vitamin D) levels and the onset of prediabetes, analyzed based on sex. One hundred eighty-seven participants were followed who had a baseline hemoglobin A1c (HbA1c) value below 6.0% and fasting plasma glucose level below 100 mg/dL. The cut-off values for vitamin D concentration were 27.7 ng/mL for men and 17.1 ng/mL for women, based on the receiver operating characteristic curve. The prediabetes incidence was significantly higher in women with a vitamin D concentration ≤17.1 ng/mL [HR = 7.08 (2.08-24.2), p = 0.002] than in men with a concentration ≤27.7 ng/mL [HR = 2.30 (0.63-8.35), p = 0.21], based on the cumulative incidence function curve. Multivariate analysis revealed that an abdominal circumference ≥90 cm and 25OH vitamin D concentration ≤17.1 ng/mL were independent, significant and intervenable risk factors for prediabetes in women. Low levels of vitamin D in women can be a predictive factor in the development of diabetes after 10 years.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"1031-1039"},"PeriodicalIF":2.1,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world clinical experience of reduced-dose initiation of lenvatinib in Japanese patients with radioiodine-refractory differentiated thyroid cancer. 日本放射性碘难治性分化型甲状腺癌患者低剂量起始lenvatinib的实际临床经验。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-04 DOI: 10.1507/endocrj.EJ25-0251

Yomi Nakashima, Ichiro Horie, Haruka Arimori, Mayu Ueda, Shinpei Nishikido, Yuta Nakamura, Keita Nakaji, Tetsuro Niri, Ayaka Sako, Ai Haraguchi, Toshiyuki Ikeoka, Satoru Akazawa, Akie Moriuchi, Misa Imaizumi, Toshiro Usa, Atsushi Kawakami

{"title":"Real-world clinical experience of reduced-dose initiation of lenvatinib in Japanese patients with radioiodine-refractory differentiated thyroid cancer.","authors":"Yomi Nakashima, Ichiro Horie, Haruka Arimori, Mayu Ueda, Shinpei Nishikido, Yuta Nakamura, Keita Nakaji, Tetsuro Niri, Ayaka Sako, Ai Haraguchi, Toshiyuki Ikeoka, Satoru Akazawa, Akie Moriuchi, Misa Imaizumi, Toshiro Usa, Atsushi Kawakami","doi":"10.1507/endocrj.EJ25-0251","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0251","url":null,"abstract":"Lenvatinib is approved for the first-line treatment for radioiodine-refractory differentiated thyroid cancer (RR-DTC) at a starting dose of 24 mg/day, but its high toxicity often necessitates dose reductions and interruptions. To clarify the efficacy and safety of the reduced dose-initiation of lenvatinib, especially for smaller-build and/or frail Asians, we retrospectively examined outcomes of 43 Japanese individuals with RR-DTC who were treated with lenvatinib, focusing on the initial dose. Twenty-three patients initiated lenvatinib at a full-dose (24 mg/day) and 20 patients initiated at a reduced-dose (≤14 mg/day). In the full dose-initiation group, 14 of 23 (60.8%) patients required discontinuation of lenvatinib within ~30 days due to adverse effects, which was significantly higher rate compared to that (25.0%) of the reduced dose-initiation group (p = 0.018), and 5 patients of the full dose-initiation group did not resume treatment. Compared to the full dose-initiation group, the reduced dose-initiation group were older (nonsignificant) and had significantly lower body weights, lower overall daily dose exposure, and a lower frequency of adverse events (≥grade 2) but a comparable dose interruption rate and daily dose exposure per kg during overall observation period. In multivariate analyses for progression-free survival and overall survival, malignant pleural effusion and symptomatic metastases but not the starting dose of lenvatinib were significantly associated with worse outcomes. Initiating lenvatinib at a reduced dose based on patients' physical status may be an option, with not only lower adverse events but also efficacy comparable to that of the full dose.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive analysis of clinical factors interacting with ectopic intrathyroidal thymus in children and adolescents: The Fukushima Health Management Survey. 儿童和青少年甲状腺内腺异位的临床因素综合分析：福岛健康管理调查。

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-09-03 DOI: 10.1507/endocrj.EJ25-0241

Satoshi Suzuki, Masanori Nagao, Natsuki Nagamine, Yurie Kobashi, Manabu Iwadate, Takashi Matsuzuka, Tetsuya Ohira, Satoru Suzuki, Fumihiko Furuya, Hiroki Shimura, Shinichi Suzuki, Susumu Yokoya, Shunichi Yamashita, Hitoshi Ohto, Seiji Yasumura

{"title":"A comprehensive analysis of clinical factors interacting with ectopic intrathyroidal thymus in children and adolescents: The Fukushima Health Management Survey.","authors":"Satoshi Suzuki, Masanori Nagao, Natsuki Nagamine, Yurie Kobashi, Manabu Iwadate, Takashi Matsuzuka, Tetsuya Ohira, Satoru Suzuki, Fumihiko Furuya, Hiroki Shimura, Shinichi Suzuki, Susumu Yokoya, Shunichi Yamashita, Hitoshi Ohto, Seiji Yasumura","doi":"10.1507/endocrj.EJ25-0241","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0241","url":null,"abstract":"The ectopic intrathyroidal thymus (EIT) is located anywhere in the thyroid gland along the developmental pathway of thymic descent due to thymic migration during embryogenesis. Ultrasonographic findings of papillary thyroid carcinoma (PTC) resemble those of EIT, which is frequently found in children. We comprehensively evaluated the clinical factors associated with EIT to understand its physiological implications and to explore helpful information for clinical discrimination between EIT and PTC. Approximately 320,000 datasets of thyroid ultrasound examinations conducted in the Fukushima Health Management Survey were systematically analyzed. Trend analyses were performed following stratification into groups of the age-sex-adjusted standard deviation score (SDS) for body mass index (BMI-SDS) and body surface area-sex-adjusted SDS for both the width and thickness of the area (BWTAR) as an indicator of thyroid volume (BWTAR-SDS). The prevalence of EIT was 3.2% in the study. Compared with negative EIT, the age- and sex-adjusted odds ratios (95% confidence intervals) for the BMI-SDS, BWTAR-SDS, and presence of diffuse goiter, cysts, and nodules were 0.919 (0.901-0.939), 0.976 (0.957-0.996), 0.821 (0.602-1.121), 0.892 (0.853-0.932), and 1.602 (1.302-1.972), respectively. EIT was not associated with the presence of diffuse goiter but was independently associated with male sex, young age, small thyroid volume, low BMI, absence of cysts, and presence of nodules. The series of clinical factors related to EIT shown in the study might provide complementary information in addition to ultrasonographic findings in cases with asymptomatic thyroid nodules resembling PTC found in young patients.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Blood steroid hormone profile and clinical outcomes following switching from metyrapone to osilodrostat in patients with Cushing disease. 库欣病患者从美替拉酮转为奥西洛他后的血液类固醇激素谱和临床结果

IF 2.1 4区医学

Endocrine journal Pub Date : 2025-08-29 DOI: 10.1507/endocrj.EJ25-0089

Kei Yokozeki, Hiraku Kameda, Aika Miya, Shigeki Jin, Kotaro Matoba, Akinobu Nakamura, Tatsuya Atsumi

{"title":"Blood steroid hormone profile and clinical outcomes following switching from metyrapone to osilodrostat in patients with Cushing disease.","authors":"Kei Yokozeki, Hiraku Kameda, Aika Miya, Shigeki Jin, Kotaro Matoba, Akinobu Nakamura, Tatsuya Atsumi","doi":"10.1507/endocrj.EJ25-0089","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0089","url":null,"abstract":"Steroidogenesis inhibitors such as metyrapone and osilodrostat, target 11β-hydroxylase to inhibit cortisol synthesis, are used in inoperable or recurrent Cushing disease. While osilodrostat has been reported to be more effective at lower doses than metyrapone, there are only a few reports describing the difference between osilodrostat and metyrapone in clinical practice. In this study, we evaluated the changes in steroid hormone profiles and clinical outcomes in seven Cushing disease patients switched from metyrapone to osilodrostat after incomplete remission post-transsphenoidal sinus surgery. Three of the seven patients were using trilostane, which was discontinued at the same time as metyrapone. Steroid hormone concentrations, including cortisol, progesterone (Prog), pregnenolone (Preg), deoxycorticosterone, corticosterone, 17-hydroxyprogesterone (17Prog), 17-hydroxypregnenolone (17Preg), and 11-deoxycortisol, were measured using high-performance liquid chromatography-mass spectrometry. No adverse events occurred after switching to osilodrostat. Potassium and ACTH levels increased significantly, and dehydroepiandrosterone sulfate and testosterone levels decreased significantly. Cortisol levels did not change significantly, whereas the ratios reflecting CYP17A1 activity (17Preg/Preg and 17Prog/Prog) decreased significantly, suggesting superior inhibition of CYP17A1 with osilodrostat. Clinical improvements included reduced antihypertensive medication requirements, decreased masculinization, and resolved gastric discomfort. Different inhibition patterns of the steroid synthetic enzymes may explain the observed clinical outcomes between these drugs. These data suggest that in patients with Cushing disease receiving metyrapone, switching to osilodrostat may benefit cases with inadequate disease control and complications including hypertension, manifestation of masculinization, and gastric discomfort.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144946958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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