{"title":"Body mass index and metabolic complications in individuals with treatment-naïve acromegaly.","authors":"Naoki Yamamoto, Shin Urai, Masaaki Yamamoto, Masaki Suzuki, Yasutaka Tsujimoto, Hironori Bando, Yuma Motomura, Yuka Ohmachi, Yuriko Sasaki, Yuka Oi-Yo, Michiko Takahashi, Genzo Iguchi, Hidenori Fukuoka, Wataru Ogawa","doi":"10.1507/endocrj.EJ25-0047","DOIUrl":null,"url":null,"abstract":"<p><p>Body mass index (BMI) can be used to define obesity-a global health concern and a risk factor for various complications. However, it does not accurately represent body composition. Furthermore, a correlation between BMI and the frequency of comorbidities in patients with acromegaly, a condition that affects body composition, remains unclear. This study aimed to investigate the association between BMI and frequency of metabolic complications in patients with acromegaly. This single-center, retrospective, cross-sectional study included patients with untreated acromegaly. The patients were divided into two groups: BMI <25 kg/m<sup>2</sup> and BMI ≥25 kg/m<sup>2</sup>, and the prevalence of metabolic complications was compared between the groups. Of the 66 patients, the BMI <25 kg/m<sup>2</sup> group included 39 patients (BMI: 22.7 [20.0-24.1], insulin-like growth factor-1 [IGF-1] standard deviation score [SDS]: 6.7 [4.7-7.9]), and the BMI ≥25 kg/m<sup>2</sup> group included 27 patients (BMI: 27.6 [25.9-29.8], IGF-1 [SDS]: 8.5 [6.0-10.2]). The prevalence of metabolic complications did not differ between the groups, except for a lower incidence of fatty liver in the BMI <25 kg/m<sup>2</sup> group (8% vs. 29%, p = 0.04). In these patients, BMI was positively correlated with serum IGF-1 levels (r = 0.29, p = 0.01). Our results suggest that BMI is not useful in predicting metabolic complications in individuals with acromegaly, except for fatty liver disease.</p>","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"1041-1049"},"PeriodicalIF":2.1000,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12436081/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endocrine journal","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1507/endocrj.EJ25-0047","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/6 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}
引用次数: 0
Abstract
Body mass index (BMI) can be used to define obesity-a global health concern and a risk factor for various complications. However, it does not accurately represent body composition. Furthermore, a correlation between BMI and the frequency of comorbidities in patients with acromegaly, a condition that affects body composition, remains unclear. This study aimed to investigate the association between BMI and frequency of metabolic complications in patients with acromegaly. This single-center, retrospective, cross-sectional study included patients with untreated acromegaly. The patients were divided into two groups: BMI <25 kg/m2 and BMI ≥25 kg/m2, and the prevalence of metabolic complications was compared between the groups. Of the 66 patients, the BMI <25 kg/m2 group included 39 patients (BMI: 22.7 [20.0-24.1], insulin-like growth factor-1 [IGF-1] standard deviation score [SDS]: 6.7 [4.7-7.9]), and the BMI ≥25 kg/m2 group included 27 patients (BMI: 27.6 [25.9-29.8], IGF-1 [SDS]: 8.5 [6.0-10.2]). The prevalence of metabolic complications did not differ between the groups, except for a lower incidence of fatty liver in the BMI <25 kg/m2 group (8% vs. 29%, p = 0.04). In these patients, BMI was positively correlated with serum IGF-1 levels (r = 0.29, p = 0.01). Our results suggest that BMI is not useful in predicting metabolic complications in individuals with acromegaly, except for fatty liver disease.
期刊介绍:
Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.