Body mass index and metabolic complications in individuals with treatment-naïve acromegaly.

IF 2.1 4区 医学 Q4 ENDOCRINOLOGY & METABOLISM
Endocrine journal Pub Date : 2025-09-05 Epub Date: 2025-06-06 DOI:10.1507/endocrj.EJ25-0047
Naoki Yamamoto, Shin Urai, Masaaki Yamamoto, Masaki Suzuki, Yasutaka Tsujimoto, Hironori Bando, Yuma Motomura, Yuka Ohmachi, Yuriko Sasaki, Yuka Oi-Yo, Michiko Takahashi, Genzo Iguchi, Hidenori Fukuoka, Wataru Ogawa
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Abstract

Body mass index (BMI) can be used to define obesity-a global health concern and a risk factor for various complications. However, it does not accurately represent body composition. Furthermore, a correlation between BMI and the frequency of comorbidities in patients with acromegaly, a condition that affects body composition, remains unclear. This study aimed to investigate the association between BMI and frequency of metabolic complications in patients with acromegaly. This single-center, retrospective, cross-sectional study included patients with untreated acromegaly. The patients were divided into two groups: BMI <25 kg/m2 and BMI ≥25 kg/m2, and the prevalence of metabolic complications was compared between the groups. Of the 66 patients, the BMI <25 kg/m2 group included 39 patients (BMI: 22.7 [20.0-24.1], insulin-like growth factor-1 [IGF-1] standard deviation score [SDS]: 6.7 [4.7-7.9]), and the BMI ≥25 kg/m2 group included 27 patients (BMI: 27.6 [25.9-29.8], IGF-1 [SDS]: 8.5 [6.0-10.2]). The prevalence of metabolic complications did not differ between the groups, except for a lower incidence of fatty liver in the BMI <25 kg/m2 group (8% vs. 29%, p = 0.04). In these patients, BMI was positively correlated with serum IGF-1 levels (r = 0.29, p = 0.01). Our results suggest that BMI is not useful in predicting metabolic complications in individuals with acromegaly, except for fatty liver disease.

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treatment-naïve肢端肥大症患者的体重指数和代谢并发症。
身体质量指数(BMI)可以用来定义肥胖——一个全球性的健康问题和各种并发症的风险因素。然而,它并不能准确地代表身体成分。此外,肢端肥大症(一种影响身体成分的疾病)患者的BMI与合并症发生率之间的相关性尚不清楚。本研究旨在探讨肢端肥大症患者BMI与代谢并发症发生频率的关系。这项单中心、回顾性、横断面研究纳入了未经治疗的肢端肥大症患者。将患者分为BMI 2组和BMI≥25 kg/m2两组,比较两组间代谢并发症的发生率。66例患者中,BMI 2组39例(BMI: 22.7[20.0-24.1],胰岛素样生长因子-1 [IGF-1]标准差评分[SDS]: 6.7 [4.7-7.9]), BMI≥25 kg/m2组27例(BMI: 27.6 [25.9-29.8], IGF-1 [SDS]: 8.5[6.0-10.2])。代谢并发症的发生率在两组之间没有差异,除了BMI 2组的脂肪肝发病率较低(8%对29%,p = 0.04)。BMI与血清IGF-1水平呈正相关(r = 0.29, p = 0.01)。我们的研究结果表明,BMI在预测肢端肥大症患者的代谢并发症方面没有用处,除了脂肪肝疾病。
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来源期刊
Endocrine journal
Endocrine journal 医学-内分泌学与代谢
CiteScore
4.30
自引率
5.00%
发文量
224
审稿时长
1.5 months
期刊介绍: Endocrine Journal is an open access, peer-reviewed online journal with a long history. This journal publishes peer-reviewed research articles in multifaceted fields of basic, translational and clinical endocrinology. Endocrine Journal provides a chance to exchange your ideas, concepts and scientific observations in any area of recent endocrinology. Manuscripts may be submitted as Original Articles, Notes, Rapid Communications or Review Articles. We have a rapid reviewing and editorial decision system and pay a special attention to our quick, truly scientific and frequently-citable publication. Please go through the link for author guideline.
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