Endocrine journal最新文献

Improvement in body composition of Japanese participants with Prader-Willi syndrome following somatropin treatment: an open-label, multi cohort Phase 3 study. 生长激素治疗后普瑞德-威利综合征日本患者身体成分的改善：一项开放标签、多队列的3期研究

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-28 DOI: 10.1507/endocrj.EJ24-0659

Masanobu Kawai, Nobuyuki Murakami, Reiko Horikawa, Koji Muroya, Yasuko Fujisawa, Yuko Hoshino, Akifumi Okayama, Takahiro Sato, Nozomi Ebata, Tsutomu Ogata

{"title":"Improvement in body composition of Japanese participants with Prader-Willi syndrome following somatropin treatment: an open-label, multi cohort Phase 3 study.","authors":"Masanobu Kawai, Nobuyuki Murakami, Reiko Horikawa, Koji Muroya, Yasuko Fujisawa, Yuko Hoshino, Akifumi Okayama, Takahiro Sato, Nozomi Ebata, Tsutomu Ogata","doi":"10.1507/endocrj.EJ24-0659","DOIUrl":"https://doi.org/10.1507/endocrj.EJ24-0659","url":null,"abstract":"Recombinant human growth hormone (GH; somatropin) treatment has beneficial effects on body composition in patients with Prader-Willi syndrome (PWS). However, this treatment option is limited to children in most countries and to children with short stature in countries such as the USA and Japan. The aim of this multicohort study was to evaluate the effect of somatropin on body composition and to assess its safety in Japanese pediatric and adult participants with PWS. GH-naïve pediatric participants (n = 6) received somatropin 0.245 mg/kg/week, GH-treated pediatric participants (n = 7) received somatropin 0.084 mg/kg/week, and adult participants (n = 20) received somatropin 0.042 mg/kg/week for 1 month, followed by 0.084 mg/kg/week. The study met its primary endpoint in the adult cohort because the least squares mean (95% CI) of the change from baseline to Month 12 in lean body mass (LBM) (%) was greater than the prespecified efficacy criterion of 0. LBM (%) was higher at 12 months in GH-naïve pediatric participants, while GH-treated pediatric participants showed little deterioration in LBM despite reduced GH dosage. Treatment-emergent adverse events (TEAEs) were experienced by five (83.3%), five (71.4%), and 19 (95.0%) participants in the GH-naïve pediatric cohort, GH-treated pediatric cohort, and adult cohort, respectively. Most TEAEs were mild or moderate in severity. Three participants reported four serious TEAEs, and none were treatment related. Somatropin improved body composition in adult participants, enabled maintenance of body composition in pediatric participants, and demonstrated a favorable safety and tolerability profile in all PWS cohorts. (ClinicalTrials.gov ID: NCT04697381).","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of excessive iodine intake during the perinatal period on thyroid function and higher brain functions in mouse offspring. 围产期过量碘摄入对小鼠后代甲状腺功能和高级脑功能的影响。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-28 DOI: 10.1507/endocrj.EJ24-0723

Izuki Amano, Ayane Ninomiya, Hiroyuki Yajima, Machiko Suda-Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Yusuke Takatsuru, Reika Kawabata-Iwakawa, Satomi Kameo, Shogo Haraguchi, Asahi Haijima, Noriyuki Koibuchi

{"title":"Effects of excessive iodine intake during the perinatal period on thyroid function and higher brain functions in mouse offspring.","authors":"Izuki Amano, Ayane Ninomiya, Hiroyuki Yajima, Machiko Suda-Yajima, Michifumi Kokubo, Miski Aghnia Khairinisa, Yusuke Takatsuru, Reika Kawabata-Iwakawa, Satomi Kameo, Shogo Haraguchi, Asahi Haijima, Noriyuki Koibuchi","doi":"10.1507/endocrj.EJ24-0723","DOIUrl":"https://doi.org/10.1507/endocrj.EJ24-0723","url":null,"abstract":"Iodine is an essential trace element crucial for thyroid hormone synthesis. While iodine deficiency has been recognized as a global health concern due to its association with hypothyroidism, certain regions may face challenges related to excessive iodine intake. The impact of excessive iodine intake during the perinatal period on higher brain functions remains unclear. To address this gap, we conducted a study using an animal model to elucidate the effects of perinatal iodine excess on higher brain functions. Dams received specific drinking water (control, ×20 iodine (KIO3 37.4 mg/L), ×200 iodine (KIO3 374 mg/L)) from prior to mating until weaning. Pups received the corresponding drinking water until the end of the experiment. Behavior test battery was utilized to investigate the behavioral outcomes associated with perinatal iodine excess. Excessive iodine intake increased learning acquisition in females whereas it decreased exploration of social novelty in males. Conversely, mRNA levels of several genes related to learning and memory in the hippocampus were rarely affected. Overall, the present study highlights the consequences of excessive iodine intake during developmental periods. However, these effects were mild and varied by sex, warranting the further investigation.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid metabolic reprogramming in immune regulation and chronic inflammatory diseases. 脂质代谢重编程在免疫调节和慢性炎性疾病中的作用。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-27 DOI: 10.1507/endocrj.EJ25-0180

Ayaka Ito

{"title":"Lipid metabolic reprogramming in immune regulation and chronic inflammatory diseases.","authors":"Ayaka Ito","doi":"10.1507/endocrj.EJ25-0180","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0180","url":null,"abstract":"Immune cells undergo substantial metabolic rewiring during differentiation and activation to satisfy the energy demands of an appropriate immune response. Lipids serve as energy sources and function as essential components of cellular membranes and signaling molecules. Recent studies have revealed that reprogramming of lipid metabolism, including lipid uptake, de novo synthesis of cholesterol and fatty acids, and fatty acid oxidation, leads to dynamic alterations in the quantity and quality of intracellular lipids. These metabolic changes play crucial roles in shaping immune cell functions, promoting anti-inflammatory responses, and facilitating the resolution of inflammation. Conversely, dysregulation of lipid metabolism can result in immune cell dysfunction, contributing to the onset and progression of chronic inflammatory diseases such as autoimmune diseases and metabolic syndrome. Notably, cholesterol and fatty acid metabolism influence immune responses by modulating membrane lipid composition and downstream inflammatory signaling. Given these insights, targeting lipid metabolism has emerged as a promising therapeutic approach for restoring immune homeostasis and treating chronic inflammatory diseases.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144172994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing liver metabolic zonation with single-cell and spatial omics. 单细胞组学和空间组学促进肝脏代谢分区。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-27 DOI: 10.1507/endocrj.EJ25-0140

Masanori Fujimoto, Tomoaki Tanaka

{"title":"Advancing liver metabolic zonation with single-cell and spatial omics.","authors":"Masanori Fujimoto, Tomoaki Tanaka","doi":"10.1507/endocrj.EJ25-0140","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0140","url":null,"abstract":"Hepatic carbohydrate and lipid metabolism is strictly regulated by hormones such as insulin, glucagon, cortisol, and adrenaline, dynamically adapting to diet and stress. Metabolic zonation, a key feature of liver function, has been studied for decades. It refers to the spatial arrangement of hepatocytes with distinct metabolic roles along the portal-to-central vein axis, shaped by nutrient and oxygen gradients, as well as signaling molecules. However, traditional methods have struggled to reveal the spatial regulation of gene expression and signaling within these zones. Recent advances in single-cell and spatial omics technologies now allow detailed analysis of gene expression, signaling pathways, and cell-cell interactions with spatial resolution, providing new insights beyond classical models. Metabolic zonation research is rapidly advancing, and the concept of immune zonation, describing the spatial distribution of immune cells, has gained attention for its role in liver metabolism. These findings have improved our understanding of metabolic changes in conditions like fatty liver disease and diabetes. However, many questions remain, including the dynamic effects of diet and hormones and disease-related alterations. This review summarizes past and recent findings on metabolic zonation, explores the role of immune zonation and hormonal regulation, and discusses the latest technologies and future challenges.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models. kisspeptin在雌二醇诱导的抑制素亚基基因表达调节中的潜在作用：来自活体大鼠模型和下丘脑细胞模型的见解。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-23 DOI: 10.1507/endocrj.EJ25-0044

Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zhuoma Cairang, Batjargal Lkhagvajav, Aki Oride, Hiroe Okada, Satoru Kyo

{"title":"Potential role of kisspeptin in the estradiol-induced modulation of inhibin subunit gene expression: Insights from in vivo rat models and hypothalamic cell models.","authors":"Tuvshintugs Tumurbaatar, Haruhiko Kanasaki, Zhuoma Cairang, Batjargal Lkhagvajav, Aki Oride, Hiroe Okada, Satoru Kyo","doi":"10.1507/endocrj.EJ25-0044","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0044","url":null,"abstract":"The hypothalamic-pituitary-gonadal (HPG) axis is primarily regulated by kisspeptin neurons. In addition, activin and inhibin within the central nervous system might contribute to the regulation of the HPG axis because they are expressed near kisspeptin and gonadotropin-releasing hormone (GnRH) neurons. We investigated the effects of inhibin and activin within the hypothalamus in the estradiol (E2)-induced negative feedback mechanism. Inhibin α subunit gene within the posterior hypothalamus in female rats increased after ovariectomy, and this increase was completely suppressed by E2 supplementation. In contrast, inhibin βA subunit decreased after ovariectomy and this reduction was recovered by E2. In ovary-intact rats, E2 reduced inhibin α subunit and increased inhibin βA expression within the hypothalamus. In the rHypoE8 and GT1-7 hypothalamic cell models, E2 stimulation increased inhibin α subunit gene expression. Activin and inhibin A increased Kiss1 gene expression in GT1-7 cells, while inhibin B reduced it. Kisspeptin increased inhibin α subunit expression in rHypoE8 cells, GT1-7 cells, and the mHypoA55 hypothalamic KNDy neuron cell model. Our findings suggest that the expression of inhibin subunits, especially inhibin α, could be increased by E2 in hypothalamic cells and that kisspeptin, inhibin, and activin mutually influence each other under the actions of E2, but their regulation might be controlled mainly by kisspeptin neurons in vivo. Although the effects of activin and inhibin on Kiss1 gene expression varied depending on the hypothalamic cell model examined, intracerebral inhibin and activin might have potential roles in the E2-induced negative feedback mechanism under the influence of kisspeptin neurons.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of diabetes on patients undergoing total ankle arthroplasty: a meta-analysis and systematic review. 糖尿病对全踝关节置换术患者的影响：荟萃分析和系统回顾。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-20 DOI: 10.1507/endocrj.EJ24-0626

Jianhui Fan, Junfeng Liu, Yanlun Li, Asha Ajia, Pingxi Wang, Qin He

{"title":"Impact of diabetes on patients undergoing total ankle arthroplasty: a meta-analysis and systematic review.","authors":"Jianhui Fan, Junfeng Liu, Yanlun Li, Asha Ajia, Pingxi Wang, Qin He","doi":"10.1507/endocrj.EJ24-0626","DOIUrl":"https://doi.org/10.1507/endocrj.EJ24-0626","url":null,"abstract":"Total ankle arthroplasty (TAA) is an effective treatment for end-stage ankle arthritis. However, the procedure is not without risks due to various factors, one of which is diabetes mellitus (DM). Currently, it remains uncertain whether diabetes is a risk factor for increased adverse outcomes and complications following total ankle arthroplasty. Therefore, this study aims to investigate the impact of diabetes on patients undergoing TAA. A systematic search was conducted for relevant studies published before December 2023 in PubMed, Embase, Cochrane Library, and Web of Science. The study assessed demographic data, postoperative complications, and functional outcomes of diabetic and non-diabetic patients following primary TAA. The Newcastle-Ottawa Scale (NOS) was used to evaluate study quality, and meta-analysis was performed using Stata 15.1, with forest plots generated for each variable. This meta-analysis included 14 studies involving 20,557 patients (3,847 with diabetes and 16,710 without). Compared to non-diabetic patients, those with diabetes had higher revision rates, postoperative infection rates, and 30-day readmission rates, longer hospital stays, and significantly different improvements in the SF-36 Physical Component Summary (PCS) score. Diabetic patients undergoing TAA are more likely to require revision surgery, face a higher risk of surgical site infections or periprosthetic joint infections, and experience increased hospital stay and 30-day readmission rates. These findings are crucial for guiding perioperative management of diabetic patients undergoing TAA and for explaining the associated surgical risks to patients.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of fetal Graves' disease among pregnant women with Graves' disease who have undergone thyroidectomy or radioactive iodine therapy: A retrospective observational study. Graves病孕妇行甲状腺切除术或放射性碘治疗对胎儿Graves病的预测：一项回顾性观察研究

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-17 DOI: 10.1507/endocrj.EJ24-0434

Aiko Hosoda, Naoko Arata, Nagayoshi Umehara, Shiori Sato, Akiko Sankoda, Yuko Iimura, Asako Mito, Chie Nagata, Seiji Wada, Haruna Kawaguchi, Masako Waguri, Nobuaki Mitsuda, Hitoshi Shimano

{"title":"Prediction of fetal Graves' disease among pregnant women with Graves' disease who have undergone thyroidectomy or radioactive iodine therapy: A retrospective observational study.","authors":"Aiko Hosoda, Naoko Arata, Nagayoshi Umehara, Shiori Sato, Akiko Sankoda, Yuko Iimura, Asako Mito, Chie Nagata, Seiji Wada, Haruna Kawaguchi, Masako Waguri, Nobuaki Mitsuda, Hitoshi Shimano","doi":"10.1507/endocrj.EJ24-0434","DOIUrl":"https://doi.org/10.1507/endocrj.EJ24-0434","url":null,"abstract":"Pregnant women with Graves' disease (GD) who have undergone thyroidectomy or radioactive iodine therapy can have high levels of thyroid-stimulating hormone (TSH) receptor antibodies, which are transferred to the fetus via the placenta, posing a risk for fetal GD. This retrospective observational study, conducted at two high-level perinatal medical centers in Tokyo and Osaka, Japan, aimed to identify predictors of fetal GD in pregnant women with GD who had undergone thyroidectomy or radioactive iodine therapy. In total, 65 women were included, and 79 singleton pregnancies and fetuses were analyzed. Fetal GD occurred in 17.7% of the 79 fetuses. Women in the fetal GD group had higher levels of TSH receptor antibodies and a higher prevalence of ophthalmopathies than did women in the non-fetal GD group. The receiver operating characteristic curve cutoff values of maternal TSH-binding inhibitory immunoglobulin (hereafter referred to as TRAb [TSH receptor antibody from a narrow perspective]) and thyroid-stimulating antibody (TSAb) levels predictive of fetal GD development were as follows: TRAb, 12.8 and 10.2 IU/L at 10 and 20 gestational weeks (GW), respectively; TSAb, 975.4% and 1,259.0% at 10 and 20 GW, respectively. Ophthalmopathy was a predictor of fetal GD; nonetheless, combining the ophthalmopathy and TRAb cutoff values did not improve predictive accuracy. A cutoff value of TRAb ≥10.2 IU/L at 20 GW (highest diagnostic accuracy found) could be a predictor of fetal GD risk for pregnant women with GD who undergo thyroidectomy or radioactive iodine therapy; thus, appropriate fetal monitoring should begin at around 20 GW.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sarcopenia in children with acute leukemia worsened after induction therapy. 急性白血病患儿肌少症诱导治疗后加重。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-16 DOI: 10.1507/endocrj.EJ25-0055

Tomoyo Itonaga, Fumika Matsuda, Naoki Hirano, Miwako Maeda, Souichi Suenobu, Kenji Ihara

{"title":"Sarcopenia in children with acute leukemia worsened after induction therapy.","authors":"Tomoyo Itonaga, Fumika Matsuda, Naoki Hirano, Miwako Maeda, Souichi Suenobu, Kenji Ihara","doi":"10.1507/endocrj.EJ25-0055","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0055","url":null,"abstract":"Sarcopenia is a prevalent condition among elderly individuals and is characterized by the loss of skeletal muscle mass accompanied by physical dysfunction. In older adults, decreased insulin-like growth factor 1 (IGF-1) has been implicated as a contributing factor to the development of sarcopenia. Children with chronic conditions associated with sarcopenia are rarely evaluated. This study aimed to evaluate muscle mass using cross-sectional computed tomography (CT) images in pediatric patients with acute leukemia and patients without chronic diseases, and to examine the relationship between skeletal muscle mass volume and various growth parameters in children with acute leukemia. The study included 44 pediatric patients (age: 1-15 years) with newly diagnosed acute leukemia (B-cell lymphoblastic leukemia, n = 30; T-cell lymphoblastic leukemia, n = 5; other types, n = 9) who underwent abdominal CT before treatment initiation. Among these, 15 underwent abdominal CT after induction therapy. The total psoas muscle area at lumbar vertebrae levels 3-4, body height, weight, and IGF-1 levels were retrospectively analyzed. The total psoas muscle area significantly decreased after induction therapy in all 15 patients. A significant correlation was observed between the rate of change in total psoas muscle area and IGF-1 levels (n = 9; p < 0.05; r = -0.84). However, no correlation was identified between the rate of change in total psoas muscle area and height velocity before and after treatment. In conclusion, skeletal muscle mass decreased following treatment initiation in pediatric patients with acute leukemia. The degree of muscle mass loss was more severe in patients with higher pre-treatment IGF-1 levels.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of pre-pregnant body mass index and gestational weight gain on the development of hypertensive disorders of pregnancy: the KODMO study. 孕前体重指数和妊娠期体重增加对妊娠期高血压疾病发展的影响：KODMO研究

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-09 DOI: 10.1507/endocrj.EJ25-0031

Yuka Matoba, Misato Ishikawa, Natsuo Tsutsumida, Kentaro Yamada, Naohiro Imazono, Kano Hayashi, Junki Abe, Kosuke Kawakami, Naofumi Ookura, Yoshihiro Ogawa

{"title":"Impact of pre-pregnant body mass index and gestational weight gain on the development of hypertensive disorders of pregnancy: the KODMO study.","authors":"Yuka Matoba, Misato Ishikawa, Natsuo Tsutsumida, Kentaro Yamada, Naohiro Imazono, Kano Hayashi, Junki Abe, Kosuke Kawakami, Naofumi Ookura, Yoshihiro Ogawa","doi":"10.1507/endocrj.EJ25-0031","DOIUrl":"https://doi.org/10.1507/endocrj.EJ25-0031","url":null,"abstract":"Obese pregnant women are more likely to develop hypertensive disorders of pregnancy (HDP), which puts them at risk for future cardiovascular events and type 2 diabetes. This study aimed to investigate the relationship between body weight and HDP in nondiabetic singleton-pregnant women. We examined the KODMO database, which included 5,120 pregnant women who gave birth at NHO Kokura Medical Center between January 2009 and December 2019, excluding those with pre-existing diabetes mellitus, hypertension, or multiple pregnancies. A multivariate logistic regression analysis of potential HDP risk factors revealed that both pre-pregnancy body mass index (BMI) and gestational weight gain (GWG) were independent risk factors. The estimated impact was considerably greater in women with higher pre-pregnancy BMI, with odds ratios of 1.60 (95% CI: 1.18-2.18, p = 0.0025) for obesity degree 1 (25 ≤ BMI < 30 kg/m2) and 3.42 (95% CI: 2.35-5.01, p < 0.0001) for obesity degree ≥2 (BMI ≥ 30 kg/m2) (reference: normal weight [18.5 ≤ BMI < 25 kg/m2]). GWG was further investigated by stratifying BMI categories, which revealed that obese pregnant women have a risk of developing HDP even with the normal GWG defined by current guidelines. The odds ratio of HDP in pregnant women with normal GWG was 1.79 (95% CI: 1.02-3.41, p = 0.0436) in obesity degree 1 and 3.25 (95% CI: 1.57-6.74, p < 0.0001) in obesity degree ≥2. The impact of GWG as a modifiable factor of HDP varies with pre-pregnancy BMI, highlighting the importance of weight management before and during pregnancy.","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery. 日本内分泌外科协会于2024年修订了甲状腺肿瘤治疗临床指南。

IF 1.3 4区医学

Endocrine journal Pub Date : 2025-05-07 Epub Date: 2025-03-08 DOI: 10.1507/endocrj.EJ24-0644

Iwao Sugitani, Naomi Kiyota, Yasuhiro Ito, Naoyoshi Onoda, Tomo Hiromasa, Kiyomi Horiuchi, Seigo Kinuya, Tetsuo Kondo, Sueyoshi Moritani, Kiminori Sugino, Hisato Hara

{"title":"The 2024 revised clinical guidelines on the management of thyroid tumors by the Japan Association of Endocrine Surgery.","authors":"Iwao Sugitani, Naomi Kiyota, Yasuhiro Ito, Naoyoshi Onoda, Tomo Hiromasa, Kiyomi Horiuchi, Seigo Kinuya, Tetsuo Kondo, Sueyoshi Moritani, Kiminori Sugino, Hisato Hara","doi":"10.1507/endocrj.EJ24-0644","DOIUrl":"10.1507/endocrj.EJ24-0644","url":null,"abstract":"The Japan Association of Endocrine Surgery published the first edition of the \"Clinical guidelines on the management of thyroid tumors\" in 2010 and the revised edition in 2018. The guideline presented herein is the English translation of the revised third edition, issued in 2024. The aim is to enhance health outcomes for patients suffering from thyroid tumors by facilitating evidence-based shared decision-making between healthcare providers and patients, as well as standardizing the management of thyroid tumors. The focus is on adult patients with thyroid tumors, addressing clinically significant issues categorized into areas such as an overview of the diagnosis and treatment of thyroid nodules, treatment strategies by histological type, radioactive iodine therapy, treatment of advanced differentiated carcinoma, pharmacotherapy, and complications and safety management associated with thyroid surgery. Thirty-two clinical questions were established in these areas. Following a comprehensive search of the literature and systematic review to evaluate the overall evidence, we aimed to present optimal recommendations by considering the balance of benefits and harms from the patient's perspective. We integrated evidence and clinical experience to determine the \"Certainty of evidence\" and \"Strength of recommendations\". Based on these, we illustrated overall flows of care as \"Clinical algorithms\". Necessary background knowledge of diseases and established clinical procedures for understanding the recommendations are presented in \"Notes\", while information that may be clinically useful but for which evidence remains insufficient is included in \"Columns\", based on the current state of evidence. Finally, future challenges for the next revision are presented as \"Future research questions\".","PeriodicalId":11631,"journal":{"name":"Endocrine journal","volume":" ","pages":"545-635"},"PeriodicalIF":1.3,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0