Endokrinologie最新文献_第7页

The effect of alpha-melanocyte-stimulating hormone on the adrenal cortex of the fetal rat. α -黑色素细胞刺激激素对胎鼠肾上腺皮质的影响。

Endokrinologie Pub Date : 1982-07-01

H Sugihara, S Miyabara, K Yun, K Ohta, N Yonemitsu

引用次数: 0

[Results of endocrinologic studies of the 3d international crew of the scientific orbital station complex: Soyuz 29 - Salyut 6 - Soyuz 31 (joint space flight enterprise of the USSR - GDR). 3. Corticosteroid excretion in urine]. [科学轨道站综合体:联盟29号-礼炮6号-联盟31号(苏联-德意志民主共和国联合太空飞行企业)的3d国际机组人员的内分泌学研究结果]。3.[尿中皮质类固醇的排泄]。

Endokrinologie Pub Date : 1982-07-01

R A Tigranjan, H Haase, L I Voronin, N F Kalita, B Jarsumbeck

{"title":"[Results of endocrinologic studies of the 3d international crew of the scientific orbital station complex: Soyuz 29 - Salyut 6 - Soyuz 31 (joint space flight enterprise of the USSR - GDR). 3. Corticosteroid excretion in urine].","authors":"R A Tigranjan, H Haase, L I Voronin, N F Kalita, B Jarsumbeck","doi":"","DOIUrl":"","url":null,"abstract":"In the present study the attempt was made to evaluate the functional state of the adrenal cortex after space flight by means of the urinary corticosteroid content. The urine collected over 24 hours was analysed. The following parameters were determined: Total 17-hydroxycorticosteroids (17-OHCS), their free forms, glucuronides and sulphates; cortisol (F), cortisone (E), corticosterone (B), 11-desoxycortisol (S), 11-dehydrocorticosterone (A), tetrahydrocortisol (THF), tetrahydrocortisone (THE), tetrahydrocorticosterone (THB), tetrahydro-11-desoxycortisol (THS), and aldosterone. In order to characterize the activity of the 11-hydroxylase the quotient of THS + S/THF + F + THE + E was formed. The activity of the 17-hydroxylase was determined indirectly by the quotient of THF + THE + THS + F + E + S/THB + B + A = 17-OHCS/17-DOHCS. The expected distinct increase of the 17-OHCS after the space flight failed to appear. This finding may be due to an adrenocortical dysfunction. In the space ship commander the quotients indicate a reduced 11- and 17-hydroxylation during the process of synthesis of the glucocorticoids. In the flight engineer they give evidence of an unchanged biosynthesis except on the day of landing. A hitherto not fully intensified substance (\"white spot\") was found in the chromatogram of the space ship commander on the first and second day after the flight. Moreover, the investigations show that the reaction of the adrenal cortex after space flights exhibits a number of individual characteristics.","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18186482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Kinetics of distribution and retention of 3H-oestradiol-17 beta in rat tissues: a comparative study with free oestradiol and after its incorporation into liposomes. 3h -雌二醇-17 β在大鼠组织中的分布和保留动力学:与游离雌二醇及与脂质体结合后的比较研究。

Endokrinologie Pub Date : 1982-07-01

Q Jehan, S Srivasta, M Akhlaq, A Ahmad, B S Setty

{"title":"Kinetics of distribution and retention of 3H-oestradiol-17 beta in rat tissues: a comparative study with free oestradiol and after its incorporation into liposomes.","authors":"Q Jehan, S Srivasta, M Akhlaq, A Ahmad, B S Setty","doi":"","DOIUrl":"","url":null,"abstract":"With a view to impart selective uptake of estrogen by the target tissues of rat, liposomes in which (6,7-3H) oestradiol-17 beta constituted a part of lipid bilayer were used as carriers of the hormone. The distribution and retention of the radioactivity was determined in blood plasma, uterus, liver, kidney, spleen and leg muscle of ovariectomized rat at different time intervals up to 72 hr following a single intravenous injection of free oestradiol (1.61 muCi) or an equivalent amount of liposomal-oestradiol. When free oestradiol was administered, uterus showed peak amount of radioactivity between 30 min to 2 hr and remained high up to 6 hr. In the other tissues examined, maximum amount of radioactivity was seen at 15 min followed by a marked fall at 30 min and also at other subsequent intervals. The pattern of uptake and retention of radioactivity after administration of liposomal-oestradiol was not much different from that of free oestradiol between 1 and 6 hr. A moderate increase in the amount of radioactivity in the nongenital tissues at 24 hr was the only difference noticed with liposomal-oestradiol. It is concluded that targeting of oestradiol preferentially to the uterus could not be achieved through liposomal delivery system.","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18189417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormonal and metabolic parameters following insulin-induced hypoglycemia. 胰岛素诱导的低血糖后的激素和代谢参数。

Endokrinologie Pub Date : 1982-07-01

C Rosak, D Vogel, P H Althoff, M Neubauer, H M Brecht, K Schöffling

{"title":"Hormonal and metabolic parameters following insulin-induced hypoglycemia.","authors":"C Rosak, D Vogel, P H Althoff, M Neubauer, H M Brecht, K Schöffling","doi":"","DOIUrl":"","url":null,"abstract":"The present study was conducted in 12 healthy volunteers to determine the effect of porcine insulin (0.15 U/kg i.v.) on a number of different metabolic and hormonal parameters measured simultaneously. The nadir of blood glucose (19.0 +/- 2.7 ng/100 ml) is detected 30 min following insulin application, paralleled by suppressed levels of FFA and beta-hydroxybutyrate. The lowest level of potassium (3.39 +/- 0.09 mval/l) is observed 45 min following insulin application. The hormones of counterregulation show an uniform pattern of response. Peak levels of norepinephrine (228.9 +/- 36.0 ng/l) and epinephrine (720.6 +/- 125.6 ng/l) are observed at 30 and 45 min, those of cAMP (33.4 +/- 2.5 pmol/ml), glucagon (0.209 +/- 0.024 ng/ml), ACTH (166.0 +/- 40.1 ng/ml), and prolactin (28.1 +/- 7.8 ng/ml) at 45 min and finally those of cortisol (26.1 +/- 3.3 micrograms/100 ml) and growth hormone (21.6 +/- 3.1 ng/ml) at 60 min following insulin injection. As the blood glucose level is already rising after 30 min it is concluded that the catecholamines and glucagon play a major part in the restitution of normal blood glucose levels. At the end of the test, blood glucose and hormone levels have almost normalized, but FFA and beta-hydroxybutyrate levels are doubled and almost triplicated as compared to the starting point levels.","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17804370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An epidemiologic survey of thyroid enlargement among schoolchildren in a non-endemic area. 某非流行地区小学生甲状腺肿大的流行病学调查。

Endokrinologie Pub Date : 1982-07-01

D A Koutras, E K Katsouyanni, D P Livadas, G D Piperingos, A Tzonou, D Trichopoulos

{"title":"An epidemiologic survey of thyroid enlargement among schoolchildren in a non-endemic area.","authors":"D A Koutras, E K Katsouyanni, D P Livadas, G D Piperingos, A Tzonou, D Trichopoulos","doi":"","DOIUrl":"","url":null,"abstract":"In 534 unselected schoolchildren aged 6-14 yr from the greater Athens area the size of the thyroid gland was assessed by palpation, and information was obtained on sex, age, height, weight, skinfold thickness, socioeconomic class, eye colour and urinary iodine excretion. The results were analysed by discriminant analysis. Altogether 14% of these children had a thyroid enlargement (7% had a definite goitre and another 7% a smaller enlargement). The set of variables studied were significantly discriminatory (Wilk's lambda 0.926, p approximately equal to 0.004). Most of the discrimination was accounted for by height (positive association, b coefficient 0.0114, SE 0.0029, t = 3.95) and weight (negative association, b coefficient 0.0107, SE 0.0030, t = 3.61). No other parameter, including iodine excretion, showed a significant difference between goitrous and nongoitrous. It is concluded that the only genuine difference is that goitrous are heavier for a given height or shorter for a given weight, i.e. more obese. The reason for which obesity protects from sporadic nontoxic goitre is not entirely clear, but probably both nutritional and genetic factors are involved.","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18143559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of transformed steroid compounds on mRNA synthesis and glucocorticoid-receptor interaction in the thymocytes of adrenalectomized rats. 转化类固醇化合物对去肾上腺大鼠胸腺细胞mRNA合成及糖皮质激素受体相互作用的影响。

Endokrinologie Pub Date : 1982-07-01

P P Golikov, A S Bobkova, A V Kamernitzky, I G Reshetova

引用次数: 0

Further experiments in unicellular model system to substantiate receptor amplification. 在单细胞模型系统中进一步实验证实受体扩增。

Endokrinologie Pub Date : 1982-06-01

G Csaba, P Kovács

引用次数: 0

Perisuprachiasmatic lesions enhance the increase of gonadotropin secretion in acutely ovariectomized rats. 急性去卵巢大鼠视交叉周病变增加促性腺激素分泌。

Endokrinologie Pub Date : 1982-06-01

F Döcke, D N Lung, W Rohde, G Dörner