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Endokrinologie最新文献

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A possible role for human growth hormone (HGH) in the protection from glucose-induced hyperkalemia in normaldosteronemic diabetes. 人生长激素(HGH)在正常固酮血症型糖尿病中防止葡萄糖诱导的高钾血症的可能作用。
Endokrinologie Pub Date : 1982-11-01
J P Radó
{"title":"A possible role for human growth hormone (HGH) in the protection from glucose-induced hyperkalemia in normaldosteronemic diabetes.","authors":"J P Radó","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>In a young male insulin-dependent diabetic patient with normal aldosterone levels an infusion of hypertonic glucose induced a paradoxical increase in serum potassium concentration and suppressed normally the elevated HGH levels, while on high sodium intake. On the other hand, during sodium restriction providing protection from the paradoxical hyperkalemia, a paradoxical increase in HGH level has been observed. A definite relationship was found between changes in serum potassium and HGH levels suggesting a possible role for the hypophyseal hormone in the cellular regulation of potassium distribution.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of liquid crystalline behaviour of adrenocortical lipids in the control of steroidogenesis. 肾上腺皮质脂质液晶行为在类固醇生成控制中的作用。
Endokrinologie Pub Date : 1982-11-01
D Szabó, J Szabon
{"title":"The role of liquid crystalline behaviour of adrenocortical lipids in the control of steroidogenesis.","authors":"D Szabó,&nbsp;J Szabon","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The physical state of rat adrenocortical lipids was studied by applying temperature-dependent techniques, including polarization microscopy and differential scanning calorimetry. Freeze-fracture detection was used for electron microscopic examinations. Temperature-dependent multiple phase transitions of adrenocortical lipids and their lamellar submicroscopic structure suggest a liquid crystalline state. This provides a possible explanation for the transition of storage lipids into liquid state, a precondition for their mobilization and processing by hydrolyzing enzyme system.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18182304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Influence of dexamethasone on growth and development of rat fetuses: changes in nucleic acids and protein content. 地塞米松对大鼠胎儿生长发育的影响:核酸和蛋白质含量的变化。
Endokrinologie Pub Date : 1982-11-01
R Klepac
{"title":"Influence of dexamethasone on growth and development of rat fetuses: changes in nucleic acids and protein content.","authors":"R Klepac","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pregnant rats were treated with dexamethasone in drinking water (10 micrograms/ml) from the 15th to the 22nd day of pregnancy. Dexamethasone significantly reduced the weight of rat fetuses and concentration of DNA, RNA and proteins in fetal adrenal glands, liver, placenta, brain, kidneys, heart, lung, testes and pituitary from the 17th to the 22nd day of pregnancy. These data show that dexamethasone given to pregnant rat may lead to potentially deleterious effects on fetal rat development.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17252087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of estradiol benzoate on hormonal profile and steroidogenic organs of immature and adult male rats. 苯甲酸酯雌二醇对未成熟和成年雄性大鼠激素谱和甾体生成器官的影响。
Endokrinologie Pub Date : 1982-11-01
N J Chinoy, M V Rao
{"title":"Effect of estradiol benzoate on hormonal profile and steroidogenic organs of immature and adult male rats.","authors":"N J Chinoy,&nbsp;M V Rao","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effects of estradiol benzoate (E2B) at a dose of 50 micrograms/day/rat for 15 days were investigated on ascorbate metabolism, steroidogenesis, protein, cholesterol levels of testis, adrenal and serum testosterone, LH and FSH profiles of rats. The data revealed that E2B manifested a direct effect on testicular and probably adrenal steroidogenesis. But serum gonadotrophin levels remained unchanged. The treatment also brought about a decline in ascorbate metabolism, activities of 3 beta and 17 beta hydroxysteroid dehydrogenases and alteration in protein level concomitant with the accumulation of cholesterol in both steroidogenic organs. Estrogen treatment was more effective in adult male rats than in the immature ones.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17361645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The nature of inhibition of thyroid monoamine oxidase by thyroxine in rat thyroid. 甲状腺素抑制大鼠甲状腺单胺氧化酶的性质。
Endokrinologie Pub Date : 1982-11-01
J Knopp
{"title":"The nature of inhibition of thyroid monoamine oxidase by thyroxine in rat thyroid.","authors":"J Knopp","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The effect of thyroxine on rat thyroid monoamine oxidase (MAO) activity in vivo and in vitro was studied in order to evaluate the nature of the inhibition of the enzyme. Monoamine oxidase activity was measured in rat thyroid homogenate. Thyroxine (200 micrograms kg-1) or triiodothyronine (40 micrograms kg-1) injected in vivo inhibited the activity of monoamine oxidase (MAO) significantly (P less than 0.05). Thyroxine (T4), 10 micrograms added to the incubation mixture during 20 min also inhibited MAO activity in thyroid homogenate. A Lineweaver-Burk plot of the data obtained shows that the inhibition is of the uncompetitive type.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Action of sex-hormones on thyroid gland function of the domestic duckling. 性激素对家鸭甲状腺功能的影响。
Endokrinologie Pub Date : 1982-11-01
B R Maiti, A Sahu
{"title":"Action of sex-hormones on thyroid gland function of the domestic duckling.","authors":"B R Maiti,&nbsp;A Sahu","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroid-binding properties of the androgen receptor of rat seminal vesicle. 大鼠精囊雄激素受体的类固醇结合特性。
Endokrinologie Pub Date : 1982-11-01
T Zakár, M Tóth
{"title":"Steroid-binding properties of the androgen receptor of rat seminal vesicle.","authors":"T Zakár,&nbsp;M Tóth","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The binding of 19 steroids to the vesicular androgen receptor has been studied under cell-free conditions. Rate constants of association and dissociation were determined for the binding of 3H-5 alpha-dihydrotestosterone (3H-DHT) and 3H-testosterone with the receptor. The Scatchard-analyses of the two reactions were also performed to determine the equilibrium binding constants. The values obtained were significantly different from those calculated from the kinetic constants, which was due to the relative inaccuracy of equilibrium analysis in our system.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18182302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thyroid gland responses to intermale aggression in an inherently aggressive wild rat. 天生具有攻击性的野生大鼠的甲状腺对雄性间攻击的反应。
Endokrinologie Pub Date : 1982-11-01
S K Gupta, G Bhat, B R Maiti
{"title":"Thyroid gland responses to intermale aggression in an inherently aggressive wild rat.","authors":"S K Gupta,&nbsp;G Bhat,&nbsp;B R Maiti","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The aim of the present investigation was to ascertain whether intermale aggression (by fighting) affects thyroid gland activity in wild rat. Following intermale aggression for three hours, thyro-follicular epithelial height was significantly decreased and colloidal content in follicular lumen increased only in the subordinate rats whereas the thyroid gland of the dominant rats was not perceptibly changed. Thus, aggression inhibits thyroid gland activity only in the subordinate rats. It is suggested that this effect may be due to psychosomatic rather than physical stress during aggression.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17940700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of androgen and estrogen on food intake and body weight in rats--age dependency. 雄激素和雌激素对大鼠食物摄取量和体重的影响——年龄依赖性。
Endokrinologie Pub Date : 1982-11-01
S Kuchár, S Mozes, K Boda, J Koppel
{"title":"The effect of androgen and estrogen on food intake and body weight in rats--age dependency.","authors":"S Kuchár,&nbsp;S Mozes,&nbsp;K Boda,&nbsp;J Koppel","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The age dependency of changes in food intake and body weight in Wistar rats after androgen and estrogen treatment was followed. The 5 age categories of female rats were treated by androgen and the 6 age categories of male rats were treated by estrogen. The androgen treatment induced an expressive increase in weight gains in all age categories of female rats, except the 1st (after birth), during 25 days from the beginning of the experiments. The increase of weight gains resulted in significantly higher body weight on the 25th day of experiments in the experimental rats. The differences in weight gains among the individual experimental groups after androgen treatment show a rising effect with the age of the animals. There was only a slight increase of food intake in the older experimental groups during the androgen treatment. The estrogen treatment in male rats induced an expressive decrease in weight gains in the 2nd age category (after weaning) and losses of body weight in older experimental groups during 20 days from the beginning of the treatment. The body weight of experimental animals on the 20th day was significantly lower than in the control ones. The losses of the body weight after the estrogen treatment rose with the age of the rats. The food intake was also considerably decreased by estrogen treatments, approximately equally in all experimental groups. The comparison of magnitude of the changes in food intake and body weight after androgen and estrogen treatments indicates that the primary effect of these hormones is their anabolic or catabolic activity which secondarily induces the changes in food intake and its utilization.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18181112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Relationship between structure and mode of action of 16 alpha, 17 alpha-cycloalkanoprogesterones (pregna-D'-pentaranes). 16 α， 17 α -环烷孕酮(孕d -戊烷)的结构与作用方式的关系。
Endokrinologie Pub Date : 1982-11-01
I S Levina, A V Kamernitzky, N D Fanchenko, V I Simonov
{"title":"Relationship between structure and mode of action of 16 alpha, 17 alpha-cycloalkanoprogesterones (pregna-D'-pentaranes).","authors":"I S Levina,&nbsp;A V Kamernitzky,&nbsp;N D Fanchenko,&nbsp;V I Simonov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A new class of modified progesterones with an additional 16 alpha, 17 alpha-carbocycle (pregna-D'-pentaranes) is obtained. These compounds were found to exhibit a high progestational activity in the Clauberg-McPhail assay and to be active as well in the pregnancy maintenance test in ovariectomized rabbits. Some of the pentaranes displayed a remarkable contraceptive effect in combination with mestranol. X-Ray data were employed for the description of molecular conformations of D'-pentaranes. On this base, their biological responses are considered to be connected with the conformational changes of D and D' rings as well as 17 beta-acetyl side chain. Accordingly, the contraceptive effect of D'3-6-pentaranes is correlated with the value of C(15)-C(16)-C(17)-C(20) torsion angle of the corresponding molecules. The relative binding affinities of some D'6-pentaranes to the progestin receptor were determined and compared with their in vivo biological responses.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1982-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18182303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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