地塞米松对大鼠胎儿生长发育的影响:核酸和蛋白质含量的变化。

Endokrinologie Pub Date : 1982-11-01
R Klepac
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引用次数: 0

摘要

从妊娠第15 ~ 22天开始,用地塞米松(10微克/毫升)灌胃妊娠大鼠。地塞米松在妊娠第17 ~ 22天显著降低胎鼠体重,降低胎鼠肾上腺、肝脏、胎盘、脑、肾、心、肺、睾丸和垂体中DNA、RNA和蛋白质的浓度。这些数据表明,给妊娠大鼠地塞米松可能导致对胎儿大鼠发育的潜在有害影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Influence of dexamethasone on growth and development of rat fetuses: changes in nucleic acids and protein content.

Pregnant rats were treated with dexamethasone in drinking water (10 micrograms/ml) from the 15th to the 22nd day of pregnancy. Dexamethasone significantly reduced the weight of rat fetuses and concentration of DNA, RNA and proteins in fetal adrenal glands, liver, placenta, brain, kidneys, heart, lung, testes and pituitary from the 17th to the 22nd day of pregnancy. These data show that dexamethasone given to pregnant rat may lead to potentially deleterious effects on fetal rat development.

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