{"title":"急性去卵巢大鼠视交叉周病变增加促性腺激素分泌。","authors":"F Döcke, D N Lung, W Rohde, G Dörner","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Diestrous female rats were bilaterally lesioned in the perisuprachiasmatic region (peri-SCN region) or in the medial preoptic area (MPOA) and ovariectomized immediately after lesioning. Blood was collected at one hour before and at 4.24 and 48 h after surgery. Radioimmunological determination of the serum gonadotropin concentrations revealed that lesioning of the peri-SCN region enhanced significantly the castration-induced increase of FSH and LH secretion at 4 and 24 h, whereas MPOA lesions did not influence the serum hormone levels as compared to the sham-lesioned controls. The findings suggest that the peri-SCN region, but not the MPOA may be involved in the control of the increase of gonadotropin secretion following ovariectomy in rats.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"1982-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Perisuprachiasmatic lesions enhance the increase of gonadotropin secretion in acutely ovariectomized rats.\",\"authors\":\"F Döcke, D N Lung, W Rohde, G Dörner\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Diestrous female rats were bilaterally lesioned in the perisuprachiasmatic region (peri-SCN region) or in the medial preoptic area (MPOA) and ovariectomized immediately after lesioning. Blood was collected at one hour before and at 4.24 and 48 h after surgery. Radioimmunological determination of the serum gonadotropin concentrations revealed that lesioning of the peri-SCN region enhanced significantly the castration-induced increase of FSH and LH secretion at 4 and 24 h, whereas MPOA lesions did not influence the serum hormone levels as compared to the sham-lesioned controls. The findings suggest that the peri-SCN region, but not the MPOA may be involved in the control of the increase of gonadotropin secretion following ovariectomy in rats.</p>\",\"PeriodicalId\":11605,\"journal\":{\"name\":\"Endokrinologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endokrinologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endokrinologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Perisuprachiasmatic lesions enhance the increase of gonadotropin secretion in acutely ovariectomized rats.
Diestrous female rats were bilaterally lesioned in the perisuprachiasmatic region (peri-SCN region) or in the medial preoptic area (MPOA) and ovariectomized immediately after lesioning. Blood was collected at one hour before and at 4.24 and 48 h after surgery. Radioimmunological determination of the serum gonadotropin concentrations revealed that lesioning of the peri-SCN region enhanced significantly the castration-induced increase of FSH and LH secretion at 4 and 24 h, whereas MPOA lesions did not influence the serum hormone levels as compared to the sham-lesioned controls. The findings suggest that the peri-SCN region, but not the MPOA may be involved in the control of the increase of gonadotropin secretion following ovariectomy in rats.
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