Endokrinologie最新文献_第4页

Different binding of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor of the rat seminal vesicle: a step toward the understanding of the anabolic action of nortesterone. 睾酮、去甲睾酮及其5个α还原衍生物与大鼠精囊雄激素受体的不同结合:了解去甲睾酮合成代谢作用的一步。

Endokrinologie Pub Date : 1982-10-01

M Tóth, T Zakár

{"title":"Different binding of testosterone, 19-nortestosterone and their 5 alpha-reduced derivatives to the androgen receptor of the rat seminal vesicle: a step toward the understanding of the anabolic action of nortesterone.","authors":"M Tóth, T Zakár","doi":"","DOIUrl":"","url":null,"abstract":"Binding to the androgen receptor of rat seminal vesicle was studied in vitro using cell-free extract or minced tissue. Relative binding affinities of 5 alpha-dihydrotestosterone (DHT), 5 alpha-dihydro-19-nortestosterone (DHN), nortestosterone and testosterone were estimated from their competition with [3H]-DHT for the binding sites. In contrast with the conflicting results obtained with cell-free systems incubated at 0-15 degrees C, studies performed with vesicular mince at 37 degrees C proved to be useful to demonstrate characteristic differences in binding affinity and to gain information about binding both to cytosol and nuclear receptors. Competition data were graphically analyzed, and after correction for steroid metabolism the following relative competition indices were obtained: DHT = 1.00; nortestosterone = 0.32-0.4; testosterone = 0.1-0.2; DHN = 0.12. However, binding to cytosolic and nuclear receptors did not differ significantly. It is concluded that testosterone and 19-nortestosterone (which are equally good substrates for 5 alpha-reductase) are converted in the seminal vesicles to metabolites, of which DHT exhibits an affinity to the androgen receptor nearly one order of magnitude higher than that of DHN. On the other hand, in skeletal muscles that are practically devoid of 5 alpha-reductase activity, the 3-fold higher affinity of nortestosterone to the receptor, expectedly, results in a myotropic activity that is superior to that of testosterone.","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":"80 2","pages":"163-72"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18175488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pituitary-thyroid dysfunction in severe non-thyroidal disease: "low-T4 syndrome". 严重非甲状腺疾病的垂体-甲状腺功能障碍:“低t4综合征”。

Endokrinologie Pub Date : 1982-10-01

P Bratusch-Marrain, H Vierhapper, B Grubeck-Loebenstein, W Waldhäusl, G Kleinberger

{"title":"Pituitary-thyroid dysfunction in severe non-thyroidal disease: \"low-T4 syndrome\".","authors":"P Bratusch-Marrain, H Vierhapper, B Grubeck-Loebenstein, W Waldhäusl, G Kleinberger","doi":"","DOIUrl":"","url":null,"abstract":"Thyroid function tests were obtained from 335 consecutive patients admitted to an intensive care unit. Twenty patients suffering from severe non-endocrine diseases (septicaemia, fulminant hepatic and renal failure, acute pancreatitis, polytrauma, cerebral haemorrhage) were found to have serum thyroxine levels in the hypothyroid range (less than 4 micrograms/dl). Serum concentrations of total thyroxine (2.3 +/- 0.2 micrograms/dl), triiodothyronine (0.23 +/- 0.03 ng/ml), and thyroxine binding globulin (15.1 +/- 1.3 micrograms/ml) were reduced, but were above normal for reverse triiodothyronine (0.43 +/- 0.06 ng/ml). Response of TSH secretion to iv TRH was found to be either normal, lowered or absent. Primary hypothyroidism was excluded, as no enhanced TSH response was observed in any case. Although decreased thyroxine levels may be due to increased thyroid hormone degradation it appears that associated impaired TSH responsiveness to TRH may result from illness-related inhibition of pituitary TSH release. Although the finding of decreased thyroid hormone levels is not rare in care patients, it represents an index of poor prognosis. Differentiation between this \"low-T4 syndrome\" and true hypothyroidism depends essentially on clinical symptoms and course of disease.","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":"80 2","pages":"207-12"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17870066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Clinical value of a sensitive TSH-RIA]. [敏感TSH-RIA的临床价值]。

Endokrinologie Pub Date : 1982-10-01

C Seidel, D Ziegelitz, A Weber, T Dittmer, H Gerl, G Knappe, H J Correns

{"title":"[Clinical value of a sensitive TSH-RIA].","authors":"C Seidel, D Ziegelitz, A Weber, T Dittmer, H Gerl, G Knappe, H J Correns","doi":"","DOIUrl":"","url":null,"abstract":"Based on a sensitive TSH-RIA (measuring-range 0.2-25 mU/l, 50%-intercept 2 mU/l, coefficients of between-assay-variation 5-10%) and on nearly 1200 cases, it is demonstrated that clinical results can be received by determination of basal serum-TSH alone. Values above 0.5 mU TSH/l indicate positive TRH-tests in a good correlation between increasing basal concentrations and pituitary TSH-reserve. TSH-levels below 0.3 mU/l proceed with negative TRH-tests. In selected healthy subjects, we found all TSH-values between 0.7 and nearly 5 mU/l (means = 1.99). In euthyroid goiters, TSH-levels are normally in the same range, but in nodular goiters, subnormal values were found accumulated. TSH-levels below 0.3 mU/l are helpful to discover non-suppressibility. Hormone-treatment of goiters is successful above all in case of high-normal pretherapeutic TSH-values. \"Fine-tuning\" of hormone-dosage (goiter-treatment, postoperative prophylaxis, suppression-therapy in thyroid carcinoma) as well as monitoring of thyrotoxicosis-treatment is recommended to be performed by means of basal TSH-determination. In pituitary disorders, thyroid hormone-treatment seems to be necessary only at TSH-levels below 0.5 mU/l. Combination of basal TSH and total T-3 is economical and describes nearly all functional situations in diagnosis and treatment of thyroid diseases.","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":"80 2","pages":"181-93"},"PeriodicalIF":0.0,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17871030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of gonadotropins and gonadal hormones on climbing perch thyroid nucleic acids. 促性腺激素和性腺激素对鲈鱼甲状腺核酸的影响。

Endokrinologie Pub Date : 1982-10-01

P Chakraborti, S Bhattacharya

引用次数: 0

Effect of human chorionic gonadotropin on the plasma levels of testosterone, estradiol, sex hormone binding globuline and free testosterone in Klinefelter syndrome. 人绒毛膜促性腺激素对克氏综合征患者血浆睾酮、雌二醇、性激素结合球蛋白和游离睾酮水平的影响。

Endokrinologie Pub Date : 1982-10-01

A Attanasio, B Blank, K Rager, D Gupta

引用次数: 0

Short-term regulation of hepatic carbohydrate and lipid metabolism by insulin and glucagon. 胰岛素和胰高血糖素对肝脏碳水化合物和脂肪代谢的短期调节。

Endokrinologie Pub Date : 1982-10-01

A C Beynen