{"title":"人绒毛膜促性腺激素对克氏综合征患者血浆睾酮、雌二醇、性激素结合球蛋白和游离睾酮水平的影响。","authors":"A Attanasio, B Blank, K Rager, D Gupta","doi":"","DOIUrl":null,"url":null,"abstract":"<p><p>Preliminary experiments showed that a course of 3 X 5000 IU Human Chorionic Gonadotropin (HCG) every alternate day in 5 patients with Klinefelter Syndrome caused increment in the circulating levels of testosterone, estradiol, and Sex Hormone Binding Globuline (SHBG). The levels of free testosterone, however, declined in 3 subjects and recorded no change in the remaining two. Estradiol/testosterone ratio on day 0 showed high correlation (r = 0.853) with augmented SHBG. It has been postulated that higher amount of SHBG is perhaps potentiating a reduction in the bioavailability of testosterone.</p>","PeriodicalId":11605,"journal":{"name":"Endokrinologie","volume":"80 2","pages":"129-34"},"PeriodicalIF":0.0000,"publicationDate":"1982-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effect of human chorionic gonadotropin on the plasma levels of testosterone, estradiol, sex hormone binding globuline and free testosterone in Klinefelter syndrome.\",\"authors\":\"A Attanasio, B Blank, K Rager, D Gupta\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Preliminary experiments showed that a course of 3 X 5000 IU Human Chorionic Gonadotropin (HCG) every alternate day in 5 patients with Klinefelter Syndrome caused increment in the circulating levels of testosterone, estradiol, and Sex Hormone Binding Globuline (SHBG). The levels of free testosterone, however, declined in 3 subjects and recorded no change in the remaining two. Estradiol/testosterone ratio on day 0 showed high correlation (r = 0.853) with augmented SHBG. It has been postulated that higher amount of SHBG is perhaps potentiating a reduction in the bioavailability of testosterone.</p>\",\"PeriodicalId\":11605,\"journal\":{\"name\":\"Endokrinologie\",\"volume\":\"80 2\",\"pages\":\"129-34\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"1982-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Endokrinologie\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Endokrinologie","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effect of human chorionic gonadotropin on the plasma levels of testosterone, estradiol, sex hormone binding globuline and free testosterone in Klinefelter syndrome.
Preliminary experiments showed that a course of 3 X 5000 IU Human Chorionic Gonadotropin (HCG) every alternate day in 5 patients with Klinefelter Syndrome caused increment in the circulating levels of testosterone, estradiol, and Sex Hormone Binding Globuline (SHBG). The levels of free testosterone, however, declined in 3 subjects and recorded no change in the remaining two. Estradiol/testosterone ratio on day 0 showed high correlation (r = 0.853) with augmented SHBG. It has been postulated that higher amount of SHBG is perhaps potentiating a reduction in the bioavailability of testosterone.
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