EJNMMI Physics最新文献

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Myocardial perfusion imaging SPECT left ventricle segmentation with graphs. 心肌灌注显像SPECT左心室分割图。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-03-10 DOI: 10.1186/s40658-025-00728-5
Ádám István Szűcs, Béla Kári, Oszkár Pártos
{"title":"Myocardial perfusion imaging SPECT left ventricle segmentation with graphs.","authors":"Ádám István Szűcs, Béla Kári, Oszkár Pártos","doi":"10.1186/s40658-025-00728-5","DOIUrl":"10.1186/s40658-025-00728-5","url":null,"abstract":"<p><strong>Purpose: </strong>Various specialized and general collimators are used for myocardial perfusion imaging (MPI) with single-photon emission computed tomography (SPECT) to assess different types of coronary artery disease (CAD). Alongside the wide variability in imaging characteristics, the apriori \"learnt\" information of left ventricular (LV) shape can affect the final diagnosis of the imaging protocol. This study evaluates the effect of prior information incorporation into the segmentation process, compared to deep learning (DL) approaches, as well as the differences of 4 collimation techniques on 5 different datasets.</p><p><strong>Methods: </strong>This study was implemented on 80 patients database. 40 patients were coming from mixed black-box collimators, 10 each, from multi-pinhole (MPH), low energy high resolution (LEHR), CardioC and CardioD collimators. The testing was evaluated on a new continuous graph-based approach, which automatically segments the left ventricular volume with prior information on the cardiac geometry. The technique is based on the continuous max-flow (CMF) min-cut algorithm, which performance was evaluated in precision, recall, IoU and Dice score metrics.</p><p><strong>Results: </strong>In the testing it was shown that, the developed method showed a good improvement over deep learning reaching higher scores in most of the evaluation metrics. Further investigating the different collimation techniques, the evaluation of receiver operating characterstic (ROC) curves showed different stabilities on the various collimators. Running Wilcoxon signed-rank test on the outlines of the LVs showed differentiability between the collimation procedures. To further investigate these phenomena the model parameters of the LVs were reconstructed and evaluated by the uniform manifold approximation and projection (UMAP) method, which further proved that collimators can be differentiated based on the projected LV shapes alone.</p><p><strong>Conclusions: </strong>The results show that prior information incorporation can enhance the performance of segmentation methods and collimation strategies have a high effect on the projected cardiac geometry.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"21"},"PeriodicalIF":3.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11893936/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The first human study of add-on PET: A PET-integrated RF coil for 3 T MRI. 附加PET的首次人体研究:用于3t MRI的PET集成射频线圈。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-03-06 DOI: 10.1186/s40658-025-00731-w
Miwako Takahashi, Fumihiko Nishikido, Go Akamatsu, Hideaki Tashima, Yuma Iwao, Mikio Suga, Taiga Yamaya
{"title":"The first human study of add-on PET: A PET-integrated RF coil for 3 T MRI.","authors":"Miwako Takahashi, Fumihiko Nishikido, Go Akamatsu, Hideaki Tashima, Yuma Iwao, Mikio Suga, Taiga Yamaya","doi":"10.1186/s40658-025-00731-w","DOIUrl":"10.1186/s40658-025-00731-w","url":null,"abstract":"<p><strong>Background: </strong>Combined PET and MRI scanners allow for simultaneous image acquisition, simplifying the interpretation of both PET and MRI images. We prototyped an insert-type PET that can convert a standalone MRI to a PET-MRI system, named Add-on PET. In Add-on PET, we fully integrated the PET modules into a head radiofrequency (RF) coil so that PET detectors can be close to the brain and avoid placing the RF coil in the field of view of PET. This study aimed at confirming the feasibility of human brain simultaneous PET and MRI imaging using a prototype of add-on PET.</p><p><strong>Results: </strong>The PET images obtained with and without simultaneous MRI sequences were identical (Pearson's correlation coefficient, r = 0.953). Background noise was observed in the MRI images acquired during the PET scan; however, the noise decreased when the count rates of PET declined. The MRI obtained simultaneously was used for attenuation correction, providing well-correlated voxel values with those using the CT-based attenuation correction method (r = 0.989).</p><p><strong>Conclusions: </strong>The simultaneous PET and MRI images were performed without noticeable artifacts. There was no significant interference in PET images caused by the simultaneous MRI sequence; however, some background noise was observed in the MRI, likely due to the electric current from PET modules used for counting a clinically used radioactivity concentration.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"19"},"PeriodicalIF":3.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
13N-NH3 myocardial perfusion imaging with reduced scan duration: a feasibility study in the era of total-body PET/CT. 缩短扫描时间的13N-NH3心肌灌注成像:全身PET/CT时代的可行性研究
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-03-04 DOI: 10.1186/s40658-025-00729-4
Xiaochun Zhang, Zeyin Xiang, Fanghu Wang, Xiaoqiang Pan, Qing Zhang, Peng Wang, Lei Jiang, Hui Yuan
{"title":"<sup>13</sup>N-NH<sub>3</sub> myocardial perfusion imaging with reduced scan duration: a feasibility study in the era of total-body PET/CT.","authors":"Xiaochun Zhang, Zeyin Xiang, Fanghu Wang, Xiaoqiang Pan, Qing Zhang, Peng Wang, Lei Jiang, Hui Yuan","doi":"10.1186/s40658-025-00729-4","DOIUrl":"10.1186/s40658-025-00729-4","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the feasibility of reducing scan duration of <sup>13</sup>N-NH<sub>3</sub> myocardial perfusion imaging (MPI) using a total-body PET/CT scanner.</p><p><strong>Methods: </strong>Forty-five patients with known or suspected coronary artery disease (CAD) performing rest <sup>13</sup>N-NH<sub>3</sub> MPI with total-body PET/CT were retrospectively included. PET data were acquired in list mode for 10 min, and reconstructed into sequence images of different scan duration: 10-min, 7-min, 5-min, 3-min, and 2-min (G10 to G2). Subjective visual evaluation including overall impression, image noise and lesion visibility was evaluated using 5-point Likert scale. Quantitative parameters including perfusion defect extent (Extent), total perfusion defect (TPD), summed rest score (SRS), end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and myocardial blood flow (MBF) were analyzed. The full-time images (G10) were served as the reference.</p><p><strong>Results: </strong>There were no significant differences in subjective visual scores between G7-G5 and G10 groups (p > 0.05). A significant decrease in overall impression and image noise of G3-G2 was observed when compared to G10 (p < 0.05). However, no significant difference in lesion visibility was noted between G3 and G10 (p > 0.05). All G3 image quality was clinically acceptable (≥ 3 points). Except for EDV and ESV, other quantitative parameters showed no significant difference between G7-G3 and G10 (p > 0.05) and agreements were good (ICC = 0.974-0.998). For G2, only TPD exhibited no significant difference when compared to G10 (p > 0.05).</p><p><strong>Conclusion: </strong>Regarding imaging quality and parametric quantification accuracy of <sup>13</sup>N-NH<sub>3</sub> MPI, a 3-min scan is clinically acceptable, while a 5-min scan is sufficiently reliable.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"18"},"PeriodicalIF":3.0,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
openSSS: an open-source implementation of scatter estimation for 3D TOF-PET. openSSS: 3D TOF-PET散射估计的开源实现。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-02-28 DOI: 10.1186/s40658-025-00730-x
Rodrigo José Santo, André Salomon, Hugo W A M de Jong, Simon Stute, Thibaut Merlin, Casper Beijst
{"title":"openSSS: an open-source implementation of scatter estimation for 3D TOF-PET.","authors":"Rodrigo José Santo, André Salomon, Hugo W A M de Jong, Simon Stute, Thibaut Merlin, Casper Beijst","doi":"10.1186/s40658-025-00730-x","DOIUrl":"10.1186/s40658-025-00730-x","url":null,"abstract":"<p><strong>Background: </strong>Scatter correction is essential for quantitative and accurate time-of-flight (TOF) PET imaging. It is implemented by an accurate scatter estimation algorithm, to calculate the statistical distribution of scattered photons among the measured coincidences. However, to our knowledge, scatter estimation algorithms that account for TOF and that are compatible with custom geometries are not available in open-source reconstruction libraries, such as CASToR and STIR. To this end, we have developed an open-source implementation of the TOF-aware single-scatter-simulation (SSS) algorithm: openSSS.</p><p><strong>Results: </strong>openSSS is validated on NEMA phantoms and patient data, for three PET geometries, compared to Monte-Carlo simulations and two proprietary vendor-specific reconstruction platforms. The reconstructed images have similar contrast recovery and background variability, deviating by up to 3.7%-point on contrast recovery and 1.8 on background variability and looking visually similar.</p><p><strong>Conclusion: </strong>We have developed and validated an open-source scatter estimation library to complement reconstruction frameworks. By enabling vendor-independent clinical-grade reconstructions on custom scanner geometries, openSSS represents a crucial step in transparent research on quantitative PET and novel PET scanner designs.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"17"},"PeriodicalIF":3.0,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ASICs in PET: what we have and what we need. PET中的asic:我们有什么和我们需要什么。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-02-13 DOI: 10.1186/s40658-025-00717-8
Vanessa Nadig, Stefan Gundacker, Katrin Herweg, Stephan Naunheim, David Schug, Bjoern Weissler, Volkmar Schulz
{"title":"ASICs in PET: what we have and what we need.","authors":"Vanessa Nadig, Stefan Gundacker, Katrin Herweg, Stephan Naunheim, David Schug, Bjoern Weissler, Volkmar Schulz","doi":"10.1186/s40658-025-00717-8","DOIUrl":"10.1186/s40658-025-00717-8","url":null,"abstract":"<p><strong>Background: </strong>Designing positron emission tomography (PET) scanners involves several significant challenges. These include the precise measurement of the time of arrival of signals, accurate integration of the pulse shape, maintaining low power consumption, and supporting the readout of thousands of channels. To address these challenges, researchers and engineers frequently develop application-specific integrated circuits (ASICs), which are custom-designed readout electronics optimized for specific tasks. As a result, a wide range of ASIC solutions has emerged in PET applications. However, there is currently no comprehensive or standardized comparison of these ASIC designs across the field.</p><p><strong>Methods: </strong>In this paper, we evaluate the requirements posed to readout electronics in the field of PET, give an overview of the most important ASICs available for PET applications and discuss how to characterize their essential features and performance parameters. We thoroughly review the hardware characteristics of the different circuits, such as the number of readout channels provided, their power consumption, input and output design. Furthermore, we summarize their performance as characterized in literature.</p><p><strong>Results: </strong>While the ASICs described show common trends towards lower power consumption or a higher number of readout channels over the past two decades, their characteristics and also their performance assessment by the developers, producers and vendors differ in many aspects. To cope with the challenge of selecting a suitable ASIC for a given purpose and PET application from the varying information available, this article suggests a protocol to assess an ASIC's performance parameters and characteristics.</p><p><strong>Conclusion: </strong>ASICs developed for PET applications are versatile. With novel benchmarks set for the impact of scintillator and photosensor on the time-of-flight performance, the pressure on ASICs to deliver higher timing resolution and cope with an even higher data rate is enormous. Latest developments promise new circuits and improvements in time-of-flight performance. This article provides an overview on existing and emerging readout solutions in PET over the past 20 years, which is currently lacking in literature.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"16"},"PeriodicalIF":3.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11822191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143406405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A generative whole-brain segmentation model for positron emission tomography images. 正电子发射断层成像的生成式全脑分割模型。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-02-08 DOI: 10.1186/s40658-025-00716-9
Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu
{"title":"A generative whole-brain segmentation model for positron emission tomography images.","authors":"Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu","doi":"10.1186/s40658-025-00716-9","DOIUrl":"10.1186/s40658-025-00716-9","url":null,"abstract":"<p><strong>Purpose: </strong>Whole-brain segmentation via positron emission tomography (PET) imaging is crucial for advancing neuroscience research and clinical medicine, providing essential insights into biological metabolism and activity within different brain regions. However, the low resolution of PET images may have limited the segmentation accuracy of multiple brain structures. Therefore, we propose a generative multi-object segmentation model for brain PET images to achieve automatic and accurate segmentation.</p><p><strong>Methods: </strong>In this study, we propose a generative multi-object segmentation model for brain PET images with two learning protocols. First, we pretrained a latent mapping model to learn the mapping relationship between PET and MR images so that we could extract anatomical information of the brain. A 3D multi-object segmentation model was subsequently proposed to apply whole-brain segmentation to MR images generated from integrated latent mapping models. Moreover, a custom cross-attention module based on a cross-attention mechanism was constructed to effectively fuse the functional information and structural information. The proposed method was compared with various deep learning-based approaches in terms of the Dice similarity coefficient, Jaccard index, precision, and recall serving as evaluation metrics.</p><p><strong>Results: </strong>Experiments were conducted on real brain PET/MR images from 120 patients. Both visual and quantitative results indicate that our method outperforms the other comparison approaches, achieving 75.53% ± 4.26% Dice, 66.02% ± 4.55% Jaccard, 74.64% ± 4.15% recall and 81.40% ± 2.30% precision. Furthermore, the evaluation of the SUV distribution and correlation assessment in the regions of interest demonstrated consistency with the ground truth. Additionally, clinical tolerance rates, which are determined by the tumor background ratio, have confirmed the ability of the method to distinguish highly metabolic regions accurately from normal regions, reinforcing its clinical applicability.</p><p><strong>Conclusion: </strong>For automatic and accurate whole-brain segmentation, we propose a novel 3D generative multi-object segmentation model for brain PET images, which achieves superior model performance compared with other deep learning methods. In the future, we will apply our whole-brain segmentation method to clinical practice and extend it to other multimodal tasks.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"15"},"PeriodicalIF":3.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11805735/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143370526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
On the reduction of imaging time-points for dosimetry in radionuclide therapy. 减少放射性核素治疗中剂量学成像时间点的探讨。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-02-06 DOI: 10.1186/s40658-025-00721-y
Johan Gustafsson, Jan Taprogge
{"title":"On the reduction of imaging time-points for dosimetry in radionuclide therapy.","authors":"Johan Gustafsson, Jan Taprogge","doi":"10.1186/s40658-025-00721-y","DOIUrl":"10.1186/s40658-025-00721-y","url":null,"abstract":"<p><strong>Background: </strong>The aim was to develop a theoretical framework for how errors in estimated activities propagate to a dispersion in time-integrated activity in radionuclide-therapy dosimetry and how this affects the comparison of radionuclide-therapy dosimetry schemes.</p><p><strong>Methods: </strong>Formulae for the variance of relative errors of estimated time-integrated activities and relative differences in time-integrated activities between measurement schemes when one or more time-points are removed were derived using the law of propagation of uncertainty for a population of time-activity-curve parameters. The formulae were derived under the assumptions of fixed coefficients of variation for estimated activities, and underlying mono-exponential curves. Analytical predictions were compared with results from numerical simulations and data for kidneys, liver, and spleen from a data-set of 18 patients treated with <sup>177</sup>Lu-DOTA-TATE.</p><p><strong>Results: </strong>The dispersion in time-integrated activity is minimized if the time-points used for curve fitting have a large dispersion and are centered over the mean of <math><mrow><mi>τ</mi> <mo>=</mo> <msubsup><mi>λ</mi> <mrow><mtext>eff</mtext></mrow> <mrow><mo>-</mo> <mn>1</mn></mrow> </msubsup> </mrow> </math> over the population, where <math><msub><mi>λ</mi> <mtext>eff</mtext></msub> </math> is the effective decay constant (i.e., the sum of the biological and physical decay constants). For large dispersions of decay constants in the population, the centering of time-points becomes gradually less important. The analytical expressions replicated the main trends from the numerical simulations. Furthermore, the analytical expressions predicted correctly the optimal reduced imaging schedule in 9 of 12 pairwise comparisons between schedules for patients.</p><p><strong>Conclusions: </strong>The dispersion of errors and deviations in estimated time-activity curves can be predicted using simple formulae. These formulae have the potential to be used for optimization of dosimetry measurement schemes for established and new radiopharmaceuticals as long as the mean and dispersion of biological half-lives are known in the patient population.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"14"},"PeriodicalIF":3.0,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner. 在长轴视场 PET/CT 扫描仪上使用[18F]SiTATE 进行低活性[18F]-somatostatin 受体(SSTR)成像。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-02-05 DOI: 10.1186/s40658-025-00720-z
Nils F Trautwein, Eduardo Calderón, Pia M Linder, Gerald Reischl, Philippe Driessen, Wenhong Lan, Andreas S Brendlin, Thorben Groß, Helmut Dittmann, Martina Hinterleitner, Christian la Fougère, Fabian P Schmidt, Lena S Kiefer
{"title":"Low-activity [<sup>18</sup>F]-somatostatin receptor (SSTR) imaging using [<sup>18</sup>F]SiTATE on a long axial field-of-view PET/CT scanner.","authors":"Nils F Trautwein, Eduardo Calderón, Pia M Linder, Gerald Reischl, Philippe Driessen, Wenhong Lan, Andreas S Brendlin, Thorben Groß, Helmut Dittmann, Martina Hinterleitner, Christian la Fougère, Fabian P Schmidt, Lena S Kiefer","doi":"10.1186/s40658-025-00720-z","DOIUrl":"10.1186/s40658-025-00720-z","url":null,"abstract":"<p><strong>Purpose: </strong><sup>18</sup>F-labelled somatostatin receptor tracers have recently gained popularity due to their better spatial resolution, longer half-life and lower costs compared to <sup>68</sup>Ga-labeled tracers. The aim of this study was to evaluate the impact and limitations of reduced administered activities of [<sup>18</sup>F]SiTATE on image quality, lesion detectability and quantitative PET parameters in a long axial field-of-view (LAFOV) PET/CT scanner.</p><p><strong>Methods: </strong>Twenty-four patients with histologically confirmed neuroendocrine tumor, who underwent clinically indicated [<sup>18</sup>F]SiTATE PET/CT examination (3.0 MBq/kg, 5 min PET scan time) on a Siemens Biograph Vision Quadra LAFOV PET/CT, were included retrospectively in this study. PET list-mode data were rebinned for shorter frame durations to simulate 5 min scans with lower activities of injected radiotracer. A comparison of image reconstruction in high sensitivity (HS) and ultra-high sensitivity mode (UHS) mode was performed. Subjective image quality, noise and lesion detectability of n = 122 lesions were rated using a 5-point Likert scale. The molecular tumor volume (MTV), signal-to-noise ratio (SNR), tumor-to-liver activity concentration ratio (TLR) and standardized uptake values (SUV) were analyzed.</p><p><strong>Results: </strong>Subjective image quality decreased with simulated reduction of injected activity with generally superior ratings in the UHS mode compared to the HS mode. Despite a reduction to 1 MBq/kg of [<sup>18</sup>F]SiTATE all lesions were still detected while at 0.25 MBq/kg lesion detectability decreased to 70% (HS) and 93% (UHS). Only minor changes in SUV<sub>mean</sub> and TLR were detected with reduced activity. However, reduced activities led to an increase in SUV<sub>SD</sub>, which in turn caused a decrease in SNR (at 1 MBq/kg: 7.3 in HS and 9.0 in UHS mode and an increase in deviation of the MTV.</p><p><strong>Conclusion: </strong>Reducing the administered activity of injected [<sup>18</sup>F]SiTATE by 66% to 1 MBq/kg (HS & UHS) is feasible in a LAFOV PET/CT scanner, maintaining clinically diagnostic image quality without statistically significant deviations in PET uptake parameters and MTV. Furthermore, in low activity [<sup>18</sup>F]SiTATE PET/CT, the UHS mode improves image quality and noise as well as lesion detectability compared to HS mode, further reinforcing the clinical benefits of this recently introduced reconstruction mode.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"13"},"PeriodicalIF":3.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799470/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discordance between 90Y-PET/CT(MR)-estimated activity and dose calibrator measured administered activity: an international study in SIRT patients treated with resin and glass microspheres. 90Y-PET/CT(MR)估计活性与剂量校准器测量的给药活性之间的不一致性:一项针对使用树脂和玻璃微球治疗 SIRT 患者的国际研究。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-02-05 DOI: 10.1186/s40658-025-00725-8
Thomas Carlier, Silvano Gnesin, Justin K Mikell, Maurizio Conti, John O Prior, Niklaus Schaefer, Maria Del Sol Pérez Lago, Clément Bailly, Yuni K Dewaraja, Thiago V M Lima
{"title":"Discordance between <sup>90</sup>Y-PET/CT(MR)-estimated activity and dose calibrator measured administered activity: an international study in SIRT patients treated with resin and glass microspheres.","authors":"Thomas Carlier, Silvano Gnesin, Justin K Mikell, Maurizio Conti, John O Prior, Niklaus Schaefer, Maria Del Sol Pérez Lago, Clément Bailly, Yuni K Dewaraja, Thiago V M Lima","doi":"10.1186/s40658-025-00725-8","DOIUrl":"10.1186/s40658-025-00725-8","url":null,"abstract":"<p><strong>Purpose: </strong>Therapeutic administration of <sup>90</sup>Y-loaded microspheres is routinely used for primary and secondary liver tumours. For activity-based therapeutic prescription the activity must be within 10% of the intended activity. Previous studies reported significant discrepancies between manufacturer-declared vial activities and both experimental and Monte-Carlo assessments, greater than 10%, for resin/glass <sup>90</sup>Y-microspheres. The objective of this work was to investigate whether these discrepancies were also seen in patients.</p><p><strong>Methods: </strong>We analysed patient <sup>90</sup>Y-PET reconstructions (99 glass and 15 resin microspheres) from 4 different institutions and 4 different systems. We considered tail-fitting background scaling (TFBS) and absolute scaling (ABS), for scatter correction. Residuals after therapeutic injection were measured. Eighty-one patients were imaged with PET/CT and 33 with PET/MR. The PET measured activity (A<sub>PET</sub>) was assessed in the whole liver. The ratio A<sub>PET</sub>/A<sub>calibrator</sub> was calculated for each patient, where A<sub>calibrator</sub> was the injected activity measured by the dose calibrator corrected for residual and lung shunt.</p><p><strong>Results: </strong>Quantification ratio between calibrators and PET was significantly different from 1, regardless of the scatter correction used. In glass microspheres, the mean A<sub>PET/CT</sub>/A<sub>calibrator</sub> was 0.84 ± 0.06 for TFBS and 0.90 ± 0.06 for ABS (0.66 ± 0.09 and 0.76 ± 0.07 for (A<sub>PET/MR</sub>/A<sub>calibrator</sub>)). The mean A<sub>PET/CT</sub>/A<sub>calibrator</sub> ratio for resin microspheres was 1.16 ± 0.09 for TFBS and 1.30 ± 0.12 for ABS.</p><p><strong>Conclusions: </strong>We observed in patients similar activity discrepancies as reported for vials, with a relative difference of 44 ± 16% between glass and resin <sup>90</sup>Y-loaded microspheres. In <sup>90</sup>Y hepatic radioembolization, the 10% accuracy prerequisite on knowing the administered therapeutic activity is then unlikely to be met.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"12"},"PeriodicalIF":3.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11799454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validation of a data-driven motion-compensated PET brain image reconstruction algorithm in clinical patients using four radiotracers. 使用四种放射性示踪剂的数据驱动运动补偿PET脑图像重建算法在临床患者中的验证。
IF 3 2区 医学
EJNMMI Physics Pub Date : 2025-02-03 DOI: 10.1186/s40658-025-00723-w
Ole L Munk, Anders B Rodell, Patricia B Danielsen, Josefine R Madsen, Mie T Sørensen, Niels Okkels, Jacob Horsager, Katrine B Andersen, Per Borghammer, Joel Aanerud, Judson Jones, Inki Hong, Sven Zuehlsdorff
{"title":"Validation of a data-driven motion-compensated PET brain image reconstruction algorithm in clinical patients using four radiotracers.","authors":"Ole L Munk, Anders B Rodell, Patricia B Danielsen, Josefine R Madsen, Mie T Sørensen, Niels Okkels, Jacob Horsager, Katrine B Andersen, Per Borghammer, Joel Aanerud, Judson Jones, Inki Hong, Sven Zuehlsdorff","doi":"10.1186/s40658-025-00723-w","DOIUrl":"10.1186/s40658-025-00723-w","url":null,"abstract":"<p><strong>Purpose: </strong>Patients with dementia symptoms often struggle to limit movements during PET examinations, necessitating motion compensation in brain PET imaging to ensure the high image quality needed for diagnostic accuracy. This study validates a data-driven motion-compensated (MoCo) PET brain image reconstruction algorithm that corrects head motion by integrating the detected motion frames and their associated rigid body transformations into the iterative image reconstruction. Validation was conducted using phantom scans, healthy volunteers, and clinical patients using four radiotracers with distinct tracer activity distributions.</p><p><strong>Methods: </strong>We conducted technical validation experiments of the algorithm using Hoffman brain phantom scans during a series of controlled movements, followed by two blinded reader studies assessing image quality between standard images and MoCo images in 38 clinical patients receiving dementia scans with [<sup>18</sup>F]Fluorodeoxyglucose, [<sup>18</sup>F]N-(3-iodopro-2E-enyl)-2beta-carbomethoxy-3beta-(4'-methylphenyl)-nortropane, [<sup>18</sup>F]flutemetamol, and a research group comprising 25 elderly subjects scanned with [<sup>18</sup>F]fluoroethoxybenzovesamicol.</p><p><strong>Results: </strong>The Hoffman brain phantom study demonstrated the algorithm's capability to detect and correct for even minimal movements, 1-mm translations and 1⁰ rotations, applied to the phantom. Within the clinical cohort, where standard images were deemed suboptimal or non-diagnostic, all MoCo images were classified as having acceptable diagnostic quality. In the research cohort, MoCo images consistently matched or surpassed the standard image quality even in cases with minimal head movement, and the MoCo algorithm never led to degraded image quality.</p><p><strong>Conclusion: </strong>The PET brain MoCo reconstruction algorithm was robust and worked well for four different tracers with markedly different uptake patterns. Moco images markedly improved the image quality for patients who were unable to lie still during a PET examination and obviated the need for any repeat scans. Thus, the method was clinically feasible and has the potential for improving diagnostic accuracy.</p>","PeriodicalId":11559,"journal":{"name":"EJNMMI Physics","volume":"12 1","pages":"11"},"PeriodicalIF":3.0,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11790531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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