Emerging Contaminants最新文献

{"title":"Seasonal differences, source, and fate of antibiotics in a plain river network-informed watershed","authors":"Shuting Pang ,&nbsp;Tao Li ,&nbsp;Ye Li ,&nbsp;Yadong Shi ,&nbsp;Donghao Wu ,&nbsp;Ce Wang","doi":"10.1016/j.emcon.2025.100540","DOIUrl":"10.1016/j.emcon.2025.100540","url":null,"abstract":"<div><div>The source apportionment and ecological risk assessment of antibiotics in plain river network areas have become a research hotspot. In this study, the Changxing Plain River Network in the Taihu Lake Basin was chosen as the research area, where the Positive Matrix Factorization (PMF) model was used for source apportionment and the Risk Quotient (RQ) and Hazard Index (HI) method were applied for ecological risk assessment. Seasonal variations revealed that antibiotic concentrations were higher during the dry season (N.D-138 ng/L) compared to the wet season (N.D ∼ 22 ng/L), with concentrations in the Jiapu River significantly exceeding those in the other three rivers. PMF model identified four major pollution sources: aquaculture (11 %), diffuse pollution (42 %), urban sewage (30 %), and agriculture (17 %), with diffuse pollution being the largest contributor to antibiotic pollution. Antibiotic flux calculations indicated that the Jiapu River contributed the highest antibiotic load to Taihu Lake, followed by the Changxing River. Ecological risk analysis based on RQ values revealed that erythromycin (ERY), sulfamethoxazole (SMX), and enrofloxacin (ENO) posed moderate risks during the dry season. This study underscores the impacts of various human activities on riverine antibiotic emissions; highlights the need for effective regulation of urban and diffuse pollution; and provides a scientific basis for the formulation of pollution prevention strategies for antibiotic management in Taihu Lake.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100540"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144517488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation and risk assessment of PCDDs, PCDFs, and dl-PCBs in Chinese mitten crab (Eriocheir sinensis) from the South Dongting lake area, China","authors":"Wei Xiang ,&nbsp;Fuhua Fu ,&nbsp;Xuebo Shang ,&nbsp;Jian Xu ,&nbsp;Fengxiang Yu ,&nbsp;Dengni Lai ,&nbsp;Yang Shan","doi":"10.1016/j.emcon.2025.100521","DOIUrl":"10.1016/j.emcon.2025.100521","url":null,"abstract":"<div><div>Dioxins are among the common persistent organic pollutants in crabs. To clarify the potential risk of dioxins pollution in Chinese mitten crab, eight types of samples were collected in the South Dongting Lake area for the analysis of 17 PCDD/Fs and 12 dl-PCBs. The results indicate that the concentration of Σ PCDD/Fs and Σ dl-PCBs in crabs was between 0.993–10.8 and 35.0–282 pg/g w.w., respectively. The mean WHO-TEQ value of Σ PCDD/Fs in crabs was 0.248 ± 0.205 pg TEQ/g w.w., and the mean WHO-TEQ value of Σ PCDD/Fs + dl-PCBs in crabs was 0.359 ± 0.280 pg TEQ/g w.w. The total toxic equivalent of bottom sediment, surrounding soil, crab brown meat and juvenile crab were relatively high, which were 2.88, 2.67, 1.50 and 1.30 pg TEQ/g w.w., respectively. In the case of 99th percentile, the WHO-TEQ values of Σ PCDD/Fs and Σ PCDD/Fs + dl-PCBs in crab white meat were all within the maximum permitted levels as specified in commission regulation (EU) 2023/915. The <em>HQ</em> values of 99th percentile of Σ PCDD/Fs + dl-PCBs were 0.0783, 0.00703 and 0.0853 for eating brown meat products, eating white meat products and eating whole crabs, respectively. The coordinate points of the samples are connected to the origin by a straight line in the correspondence analysis map. The angle formed by the straight lines of crab brown meat/crab white meat and juvenile crab was acute angle, as did the feed. The angles between the straight line of bottom sediment/surrounding soil and that of other samples were all obtuse angles. In conclusion, although the dioxins of bottom sediment and surrounding soil are obvious, the dioxins of adult crabs are mainly related to that of the juvenile crabs and feed. At present, the intake of dioxins from Chinese mitten crab by Chinese residents is at a safe level because of low annual consumption. It is recommended that adults limit their weekly crab consumption to 1–4 crabs, or only 23.1–105 g of crab brown meat per week, or solely 435–1242 g of crab white meat per week.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100521"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144166753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anion-mediated pathways in organophosphate degradation in the Oconee River watershed in Georgia","authors":"Grace Stamm ,&nbsp;Gayatri Basapuram ,&nbsp;Srimanti Duttagupta ,&nbsp;Avishek Dutta","doi":"10.1016/j.emcon.2025.100542","DOIUrl":"10.1016/j.emcon.2025.100542","url":null,"abstract":"<div><div>The degradation of organophosphate pesticides in aquatic ecosystems is influenced by various environmental factors. This study investigates the influence of nitrate, sulfate, and phosphate on the degradation of malathion, a commonly used organophosphate pesticide, in the North Oconee River watershed in Georgia. Microcosm experiments were conducted to simulate environmental conditions and assess both microbial and non-microbial transformation pathways. Nitrate, sulfate, and phosphate were found to enhance malathion degradation through microbially mediated oxidative and hydrolytic pathways. The presence of mercuric chloride, which suppressed microbial activity, resulted in slower degradation rates across all conditions, underscoring the pivotal role of microbial communities in pesticide transformation. Non-targeted analyses identified key degradation products, including malaoxon, succinic acid, and diethyl succinate, primarily under nitrate and sulfate conditions, supporting the involvement of these anions in the degradation process. These findings highlight the complex interactions between nutrient dynamics and pesticide persistence, offering valuable insights for sustainable water management and pollution control in agro-impacted freshwater systems.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100542"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144596009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and persistence of contact lenses in wastewater treatment plants: Environmental implications","authors":"Rita Martins- Alves ,&nbsp;Ana Vera Machado ,&nbsp;Fernanda Cássio ,&nbsp;Madalena Lira","doi":"10.1016/j.emcon.2025.100505","DOIUrl":"10.1016/j.emcon.2025.100505","url":null,"abstract":"<div><div>Contact Lens (CLs) are often disposed of via toilet or sinks, ending up in the wastewater treatment plants (WWTPs). Millions of CLs enter WWTPs worldwide each year in macro and micro sizes. Despite WWTPs' ability to remove solids, CLs can persist and potentially contaminate watercourses and soils.</div><div>This study evaluates whether different CLs degrade in WWTP aeration tanks. Six daily CLs (Nelfilcon A, Delefilcon A, Nesofilcon A, Stenfilcon A, Narafilcon A, Somofilcon A) and four monthly CLs (Lotrafilcon B, Comfilcon A, Senofilcon A, and Samfilcon A) were immersed in aeration tanks for twelve weeks. Their physical and chemical properties, including water content (WC), refractive index (RI), chemical properties (Fourier Transform Infrared Spectroscopy), and mechanical properties were assessed.</div><div>Results show that all CLs maintained their physical appearance after 12 weeks. Neither Nelfilcon A nor Narafilcon A exhibited significant changes in WC and RI, (p &gt; 0.05, Tukey test), while other daily lenses showed variations in at least one parameter.</div><div>Among monthly CLs, only Senofilcon A showed significant differences in both WC (<em>p</em> &lt; 0.001, Tukey test) and RI (<em>p</em> &lt; 0.0001, Tukey test). No differences in Young's modulus were observed for any lenses (p &gt; 0.05 Tukey test). However, Somofilcon A displayed significant changes in stress at break (<em>p</em> &lt; 0.0001, Tukey test), and Elongation at Break (<em>p</em> &lt; 0.05, Tukey test). No changes were found in the chemical structure of any CLs suggesting that twelve weeks in WWTP aeration tanks is insufficient for CLs degradation. These findings highlight CLs as a potential emerging pollutant, emphasizing their persistence in sludge or migration into watercourses and soils.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100505"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143806783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing contamination and risk profiles of per- and polyfluoroalkyl substances across various types of water in South Africa: trends over the past decade (2014–2024)","authors":"Nhlanhla Hlongwa ,&nbsp;Victor Parry ,&nbsp;Kevin Winter ,&nbsp;David Ikumi ,&nbsp;Amber Abrams ,&nbsp;Kirsty Carden","doi":"10.1016/j.emcon.2025.100535","DOIUrl":"10.1016/j.emcon.2025.100535","url":null,"abstract":"<div><div>This study investigates the occurrence, spatial distribution, and ecological and human health risks of per- and polyfluoroalkyl substances (PFAS) in South African water systems over the period 2014–2024. In the absence of direct drinking water data, ecological risk assessments and indirect human exposure evaluations via potential crop irrigation were conducted using PFAS concentrations measured in surface water and wastewater across four regional zones: north (Gauteng, Limpopo, Mpumalanga, Northwest), west (Northern Cape), east (KwaZulu-Natal, Free State), and south (Eastern and Western Cape). Among the compounds analysed, perfluorooctanoic acid (PFOA) was the most prevalent, with concentrations ranging from 315 ng/L in the Eastern Cape to 420 ng/L in the Vaal River (Gauteng), yielding ecological risk quotient (RQ) values of 3.15 and 4.05, respectively, both exceeding the RQ safety threshold of 1. Perfluoro butanoic acid (PFBA) and perfluoro hexanoic acid (PFHxA) also presented moderate ecological risks, with peak concentrations of 380 ng/L (west) and 267 ng/L (north), corresponding to RQ values of 1.10–1.78. The north zone, particularly sites like the Vaal River and Hartbeespoort Dam, exhibited the highest PFAS burden. A strong correlation (r = 0.95) between PFOA and PFHxA suggests common sources of contamination. Spatial variability was more pronounced for PFHxA (CV = 12.84 %) than for PFOA (CV = 9.92 %). Indirect human health risks from crop ingestion were negligible, with hazard quotient (HQ) values below 0.019 and incremental lifetime cancer risk (ILCR) estimates below 2.70 × 10⁻⁸. Despite minimal human health risks, the persistent ecological threats particularly in the north zone underscore the need for enhanced regulatory oversight, long-term monitoring, and targeted PFAS treatment strategies.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100535"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144322938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic resistance occurrence and ecological impact in landfill leachate: A review on compound effect of antibiotics and non-antibiotics","authors":"Yongtao Xu ,&nbsp;Dan Li ,&nbsp;Ying Yuan ,&nbsp;Fei Fang ,&nbsp;Beidou Xi ,&nbsp;Wenbing Tan","doi":"10.1016/j.emcon.2025.100508","DOIUrl":"10.1016/j.emcon.2025.100508","url":null,"abstract":"<div><div>Landfilling remains one of the primary methods for managing municipal solid waste (MSW), processing approximately 350 million tons of waste annually. Among the various components of landfill waste, pharmaceuticals and personal care products (PPCPs), including both antibiotics and non-antibiotic compounds, pose significant environmental challenges. Landfill leachate is a highly complex medium, consisting of diverse contaminants such as non-antibiotic pharmaceuticals (average concentration ∼1.74 μg/L), antibiotics (average concentration ∼527 ng/L), heavy metals, dissolved organic matter, and micro/nano-plastics (concentration range 0.64–2.16 mg/L). This unique mixture can alter the native microbial community structure, profoundly impacting antibiotic resistance, potentially disrupting soil and groundwater ecosystems, and threatening ecological balance. Existing research has extensively investigated the composition, physicochemical properties, environmental behavior, and microbial community structure of landfill leachate, leading to significant advancements in the field. However, due to the complexity and large volume of landfill leachate, current risk assessment approaches predominantly rely on conventional pollutant indicators, and most treatment strategies are designed for general contaminants. There is a lack of systematic descriptions that integrate pollutants with their direct impacts on microbial communities. This review focuses on the current pollution status, spatiotemporal trends, interactions, and migration risks of antibiotics and non-antibiotic pollutants in landfill leachate. In particular, we explore the in situ emergence of antibiotic resistance in landfill leachate (rather than the horizontal transfer of antibiotic resistance genes) and examine the influence of various leachate components on antibiotic resistance. By emphasizing the importance of understanding the combined effects of antibiotics and non-antibiotic pollutants in landfill environments, this review highlights the necessity of long-term ecological risk assessments for antibiotic-induced resistance as an emerging contaminant.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100508"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143838363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficient photocatalytic degradation of metoprolol using activated carbon supported NiFe-layered double hydroxides (NiFe-LDH/C) under solar-driven simulation","authors":"Raphael N. Biata ,&nbsp;Wendy Mabhulusa ,&nbsp;Lethula E. Mofokeng ,&nbsp;Rudzani Ratshiedana ,&nbsp;Tshimangadzo S. Munonde ,&nbsp;Edward N. Nxumalo","doi":"10.1016/j.emcon.2025.100532","DOIUrl":"10.1016/j.emcon.2025.100532","url":null,"abstract":"<div><div>The efficient photocatalytic degradation of pharmaceuticals in wastewater is critically important for environmental protection. The synthesis and characterization of NiFe-LDH/C for the photocatalytic degradation of selected β-blockers, specifically metoprolol, under UV light conditions were investigated in this study. The study aimed to explore the potential of NiFe-LDH/C as a catalyst for the degradation of metoprolol, a commonly used pharmaceutical compound in the treatment of chronic diseases such as high blood pressure and chest pains, which is frequently detected in wastewater. The selection of NiFe-LDH/C was driven by the need for materials with high photocatalytic activity, the ability to generate reactive oxygen species and enhance charge separation, and stability under solar light. Activated carbon was employed as a support to increase the surface area and improve the dispersion of the LDH particles, thereby enhancing overall photocatalytic efficiency. The results showed that NiFe-LDH/C exhibited excellent photocatalytic activity in degrading metoprolol under both UV and sunlight-mediated conditions, with degradation efficiencies of over 89 %. Furthermore, the characterization of the NiFe-LDH/C catalyst revealed its stability and recyclability, making it a promising candidate for the efficient removal of pharmaceutical compounds from wastewater through photocatalytic degradation. The characterization results showed that the NiFe-LDH/C exhibited a high degree of crystallinity and a well-defined layered structure. The photocatalytic experiments demonstrated that the NiFe-LDH/C was effective in degrading metoprolol and ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) was used to elucidate the degradation products of metoprolol in water.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100532"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the influence of redox and temperature variations on the attenuation of pharmaceuticals in groundwater: Insights from parallel batch reactor experiments","authors":"Alejandra Villa ,&nbsp;Nafiseh Salehi Siavashani ,&nbsp;Estanislao Pujades-Garnes ,&nbsp;Nicola Montemurro ,&nbsp;Sandra Pérez ,&nbsp;Jan Willem Foppen ,&nbsp;Marc Teixidó ,&nbsp;Anna Jurado","doi":"10.1016/j.emcon.2025.100537","DOIUrl":"10.1016/j.emcon.2025.100537","url":null,"abstract":"<div><div>Pharmaceuticals are present in the environment from anthropogenic pollution sources, leading to groundwater contamination when reaching urban aquifers. Once in the subsurface, their fate depends on the hydrochemical processes and environmental conditions within the aquifer. In this context, this study investigates how different redox and temperature conditions affect the natural attenuation of pharmaceuticals in the subsurface. Batch experiments were conducted under oxic and suboxic (i.e., up to nitrate reduction) conditions and at two temperatures (25 °C and 35 °C). The controlled conditions achieved with parallel batch reactor systems allowed us a systematic investigation of the processes and factors involved in the fate of ten pharmaceuticals (atenolol, citalopram, climbazole, irbesartan, lamotrigine, sitagliptin, carbamazepine, metoprolol, trimethoprim, and venlafaxine), providing insights into the mechanisms governing their attenuation. The results showed that oxic conditions were highly effective in reducing pharmaceuticals concentrations, achieving up to 91 % attenuation for irbesartan, followed by citalopram (90 %), climbazole (77 %), sitagliptin (76 %) and metoprolol (75 %). Atenolol and climbazole were also attenuated regardless of redox conditions. High temperatures increased the total removal of citalopram, irbesartan, sitagliptin, and trimethoprim by 5–12 %, while slightly enhancing the sorption affinity of carbamazepine, irbesartan, and atenolol by 5 %. However, trimethoprim, carbamazepine, and lamotrigine were the most persistent compounds, with average removal rates of 6 %, 15 %, and 24 %, respectively. Overall, more than half of the targeted pharmaceuticals showed significant average removal (&gt;60 %), highlighting the influence of the processes involved in groundwater on the natural attenuation of these compounds. Sorption seemed to be the primary process contributing to the target pharmaceuticals attenuation in oxic conditions, while biodegradation played a secondary role, particularly for atenolol and metoprolol. These findings contribute to improve our understanding of the behaviour of pharmaceuticals in aquatic environment and thus to improve management practices for better water quality.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100537"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144522280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular response of Physarum melleum GZ381 to anatase TiO2 nanoparticles: Characteristic and application","authors":"Zhi Zhang ,&nbsp;Cheng Xin Wu ,&nbsp;Qin Hui Lu ,&nbsp;Xiu Yi Liang ,&nbsp;Zhi Cheng Liang ,&nbsp;Yi Yang","doi":"10.1016/j.emcon.2025.100539","DOIUrl":"10.1016/j.emcon.2025.100539","url":null,"abstract":"<div><div>Environmental pollution caused by nano titanium dioxide (nTiO₂) has become an increasingly pressing issue. Investigating environmental organisms capable of tolerating nTiO₂ stress, along with their molecular responses, can help us combat such pollution. In this study, we used multi-omics approaches, genetic manipulation, and physiological and biochemical methods to analyze the responses of <em>Physarum melleum</em> GZ381—which tolerates anatase-type nTiO₂ (nTiO₂-A) approximately 30 nm in size—and its responsive biomolecules. We observed that the primary molecular response characteristic of GZ381 was related to metabolism. Furthermore, we found that GZ381 utilizes circular RNA08121 in a competitive endogenous RNA network to regulate the transcriptional abundance of many metabolism-related genes, facilitating metabolic reprogramming and conferring obvious anti-nTiO₂-A stress capabilities. Based on these findings, we designed mitigation schemes that markedly enhanced the tolerance of various non-tolerant cells to nTiO₂-A of different sizes (approximately 30, 60, and 90 nm) under light and dark conditions. Overall, this study reports some important biomolecules that can enhance cellular nTiO₂-A resistance and may be used to combat such pollution in the future, deepens the understanding of environmental organisms, especially those tolerant to nTiO₂ stress, and provides new inspiration for combating such pollution challenges.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100539"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unleashing the power of receptor-based assay on high-throughput detection: Assessing the feasibility of enzyme-linked immunosorbent assay on large-scale antibiotic monitoring","authors":"Yun Yang ,&nbsp;Jinxin Wang ,&nbsp;Lulu Li ,&nbsp;Haofei Yang ,&nbsp;Yu Quan ,&nbsp;Jason Jia Shun Liao ,&nbsp;Wei Ouyang ,&nbsp;Gang Yu ,&nbsp;Li Ling","doi":"10.1016/j.emcon.2025.100511","DOIUrl":"10.1016/j.emcon.2025.100511","url":null,"abstract":"<div><div>Antibiotics are detected in aquatic environments with heterogeneity in their occurrence and associated risk levels. Thus, high spatiotemporal resolution monitoring in a large scale is essential to better cope with their risks. Mass spectrometry (MS) techniques are sensitive and precise, yet complex, expensive, and time-consuming for antibiotic detection. The enzyme-linked immunosorbent assay (ELISA) is among a mature receptor-based assays that offer a cost-effective alternative and are particularly notable for their high throughput analytical capabilities. However, its high throughput power on environmental monitoring is underutilized. ELISA is remarkably rapid (3800–37,000 tests per day), inexpensive ($1.8 per test, capital costs ranging from $35,000 to $270,000), and ready-to-use (97 commercial kits available) for detecting frequently reported antibiotics. Adopting solid phase extraction decreases their limits of detection to as low as 0.125 ng/L. Their quantification results are robust as they also generally agreed well with those of MS methods. A conservative way at present is to use ELISA for initial screening of large numbers of samples, with subsequent quantification of a small proportion of “positive” samples through MS methods. Yet, the applicability of ELISA can be further improved, such as developing a standardized quantification procedure for ELISA and microfluid chip-based ELISA kits and instruments.</div></div>","PeriodicalId":11539,"journal":{"name":"Emerging Contaminants","volume":"11 3","pages":"Article 100511"},"PeriodicalIF":5.3,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}