Endocrinologia japonica最新文献_第4页

Resolution of possible paradoxical responses of gonadotropins to thyrotropin-releasing hormone with bromocriptine therapy in a patient with follicle-stimulating hormone-secreting pituitary adenoma. 促卵泡激素分泌垂体腺瘤患者用溴隐亭治疗促性腺激素对促甲状腺激素释放激素可能的矛盾反应的解决。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.401

L B Mercado-Asis, K Yasuda, M Ishizawa, T Ishizuka, M Murayama, K Shimokawa, K Miura

引用次数: 3

Pre-Cushing's syndrome: a case report. 库欣综合征:1例报告。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.407

P Cugini, C Campisi, G Castagna, P Battisti, L Di Palma, A Coppola, M Di Paola, H Sasaki, K Uezono, T Kawasaki

引用次数: 4

Insulin dependent diabetes mellitus accompanied by nephrocalcinosis and renal failure. 胰岛素依赖型糖尿病伴肾钙质沉着和肾功能衰竭。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.397

H Kodama, T Kuramatsu, M Yanagisawa, T Uchiya, A Takahashi

引用次数: 3

Differences in pathological findings and growth hormone responses in patients with growth hormone-producing pituitary adenoma. 促生长激素垂体腺瘤患者的病理表现和生长激素反应的差异。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.355

H Bando, T Sano, T Ohshima, C Y Zhang, R Yamasaki, K Matsumoto, S Saito

{"title":"Differences in pathological findings and growth hormone responses in patients with growth hormone-producing pituitary adenoma.","authors":"H Bando, T Sano, T Ohshima, C Y Zhang, R Yamasaki, K Matsumoto, S Saito","doi":"10.1507/endocrj1954.39.355","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.355","url":null,"abstract":"Plasma growth hormone (GH) responses to various stimuli were examined in 21 patients with GH-producing pituitary adenomas, classified into three types by the immunohistochemistry of cytokeratin and the glycoprotein hormone alpha-subunit distribution. Seven type 1 adenomas were exclusively composed of cells in which the cytokeratin formed a dot-like pattern; they were chromophobic to hematoxylin and eosin (H&E), occasionally positive for GH, and almost completely negative for the alpha-subunit. Thirteen type 2 adenomas were composed of cells with cytokeratin that had a perinuclear distribution; they were eosinophilic to H&E, and diffusely positive for both GH and the alpha-subunit. One patient had a type 3 adenoma which had a mixed pattern of intracellular cytokeratin distribution and was chromophobic and eosinophilic to H&E. Clinically, type 1 is characterized by earlier onset, larger tumor size, and more frequent aggressive extension. Paradoxical GH responses to TRH and OGTT were seen in 1 of 6 patients (16.7%) of type 1 and 8 of 9 patients (88.9%) of type 2, and 0% of type 1 and 62.5% of type 2, respectively. Type 2 cases showed higher plasma GH response to GH-releasing hormone, and a tendency to greater suppression of plasma GH by bromocriptine compared with type 1. Octreotide acetate administration revealed that the nadir/basal ratio of plasma GH levels was 42.9 +/- 6.6% in type 1 and 13.5 +/- 5.8% in type 2. These results suggest that there is a pathophysiological difference between these two distinct types of GH-producing pituitary adenomas.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 4","pages":"355-63"},"PeriodicalIF":0.0,"publicationDate":"1992-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.355","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12618542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

The effects of new steroidal anti-androgen, TZP-4238, and chlormadinone acetate on the pituitary, prostate and adrenal gland of the rat: histopathological and immunocytochemical studies. 新型类固醇抗雄激素TZP-4238和醋酸氯麦地那酮对大鼠垂体、前列腺和肾上腺的影响:组织病理学和免疫细胞化学研究。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.331

M Murakoshi, M Tagawa, R Inada, M Shoji, M Suzuki, K Watanabe

{"title":"The effects of new steroidal anti-androgen, TZP-4238, and chlormadinone acetate on the pituitary, prostate and adrenal gland of the rat: histopathological and immunocytochemical studies.","authors":"M Murakoshi, M Tagawa, R Inada, M Shoji, M Suzuki, K Watanabe","doi":"10.1507/endocrj1954.39.331","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.331","url":null,"abstract":"The atrophic effects of a synthetic steroidal anti-androgen, TZP-4238, on the pituitary, prostate and adrenal gland of rats were investigated. Male Sprague-Dawley rats were divided into three experimental groups. Group 1 consisted of controls. Groups 2 and 3 received chlormadinone acetate (CMA) 50 mg/kg/day and TZP-4238 10 mg/kg/day p.o., respectively, for 3 weeks. CMA (Group 2) produced marked atrophy of the prostate. Furthermore, CMA caused marked atrophy of the adrenal gland. Histopathologically, the remarkable atrophy was observed in the adrenal cortical cells of zonae fasciculata and reticularis. The most striking ultrastructural alterations were noted in the mitochondria. In addition, intramitochondrial localization of glutathione-peroxidase (GSH-PO) which effectively reduces the lipid peroxides, was less than that in the controls. In the anterior pituitary gland, CMA induced a reduction in the size of ACTH cells. TZP-4238 (Group 3) produced marked atrophy of the prostate. However, TZP-4238 exerted no effect on the adrenal gland or anterior pituitary ACTH cells. In addition, the present histopathological study showed that TZP-4238 or CMA exerted no effect on the testes or anterior pituitary LH cells. Therefore, it is suggested that TZP-4238 causes atrophy of the prostate without any significant histopathological changes in the adrenal glands or anterior pituitary ACTH cells under the present experimental conditions. We further speculated that TZP-4238 had a more potent anti-prostatic effect than CMA and TZP-4238 had a less inhibitory influence than CMA on the pituitary-adrenal axis.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 4","pages":"331-40"},"PeriodicalIF":0.0,"publicationDate":"1992-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.331","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12454984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Effect of a phorbol ester on immunoreactive endothelin-1 release from cultured porcine aortic endothelial cells. 一种酚酯对培养猪主动脉内皮细胞免疫反应性内皮素-1释放的影响。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.341

Y Hattori, K Kasai, N Banba, S Hattori, T Nakamura, S Shimoda

{"title":"Effect of a phorbol ester on immunoreactive endothelin-1 release from cultured porcine aortic endothelial cells.","authors":"Y Hattori, K Kasai, N Banba, S Hattori, T Nakamura, S Shimoda","doi":"10.1507/endocrj1954.39.341","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.341","url":null,"abstract":"This study was designed to examine how protein kinase C (PKC) regulates the release of endothelin-1 (ET-1) from cultured porcine aortic endothelial cells. We measured the release of immunoreactive (IR)-ET-1 from cells cultured for up to 72 h in the presence or absence of a phorbol ester TPA. The release of IR-ET-1 from control cells (no TPA) increased according to time for up to 72 h. In the presence of TPA, the release of IR-ET-1 from the cells was higher than the control level for up to 8 h, but was lower thereafter and reached a plateau after 48 h. TPA dose-dependently stimulated IR-ET-1 release during incubation for 4 h, but suppressed it after incubation for 72 h. Stimulation of PKC by diacylglycerol mimicked the early (4 h) action of TPA. On the other hand, pretreatment of cells with TPA to downregulate PKC significantly suppressed basal and thrombin- or FCS-stimulated IR-ET-1 release. These findings suggest that the activation of PKC is related to the stimulation of ET-1 release and that down-regulation of PKC leads to the suppression of ET-1 release from cultured endothelial cells.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 4","pages":"341-5"},"PeriodicalIF":0.0,"publicationDate":"1992-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.341","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12618540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Translation of rat ovarian mRNA to two 20 alpha-hydroxysteroid dehydrogenase isozymes in Xenopus oocytes. 大鼠卵巢mRNA对爪蟾卵母细胞中两个20 α -羟基类固醇脱氢酶同工酶的翻译。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.365

S Yoshida, R Miura, K Noda, K Shiota, M Takahashi

{"title":"Translation of rat ovarian mRNA to two 20 alpha-hydroxysteroid dehydrogenase isozymes in Xenopus oocytes.","authors":"S Yoshida, R Miura, K Noda, K Shiota, M Takahashi","doi":"10.1507/endocrj1954.39.365","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.365","url":null,"abstract":"20 alpha-Hydroxysteroid dehydrogenase (20 alpha-HSD) in rat luteal tissue catalyzes the conversion of progesterone into a biologically inactive steroid, 20 alpha-hydroxypregn-4-en-3-one (20 alpha-OHP) and depletes the output of progesterone into the circulation. An increase in 20 alpha-HSD activity in luteal tissue is therefore a prerequisite for the regression of functional corpora lutea in rats. We have reported that ovarian 20 alpha-HSD is composed of two isoforms (HSD1 and HSD2). In this study, among batches of ovaries collected randomly during the estrous cycle, we selected two batches (batches A and B): the cytosol preparation from batch A contained both HSD1 and HSD2 activities, whereas that from batch B contained only HSD1 activity. From these 2 batches, we extracted mRNA, and each mRNA preparation was subjected to translation in Xenopus oocytes. The translation products of batch A exhibited both HSD1 and HSD2 activities, and those of batch B only HSD1 activity in accordance with the enzymatic activities observed in the respective cytosolic preparations. The results are compatible with the presence of two distinct mRNAs coding HSD1 and HSD2, and if so their transcription will be regulated separately according to the functional state of the ovary.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 4","pages":"365-9"},"PeriodicalIF":0.0,"publicationDate":"1992-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12618543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Type A-insulin resistance with lipopexia on extremities: a case report. 四肢a型胰岛素抵抗伴脂降症1例。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.347

N Nakashima, T Miyamura, T Yamashita, T Yamauchi, F Umeda, Y Kawada, M Noda, H Nawata

{"title":"Type A-insulin resistance with lipopexia on extremities: a case report.","authors":"N Nakashima, T Miyamura, T Yamashita, T Yamauchi, F Umeda, Y Kawada, M Noda, H Nawata","doi":"10.1507/endocrj1954.39.347","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.347","url":null,"abstract":"We present the unusual case of a 17-year-old female with insulin-resistant diabetes, acanthosis nigricans, hirsutism, amenorrhea, dental dysplasia and lipopexia on the extremities. She had been diagnosed as having border line diabetes with hyperinsulinemia at age 12 when she was not obese and diabetes mellitus at age 13. On admission, she was obese and had lipopexia only on the extremities. The presence of hyperinsulinemia and poor response to exogenous insulin suggested severe insulin resistance. Insulin binding to transformed B-lymphoblasts derived from her was extremely low compared to the normal control, showing decreased receptor affinity. Her parents and sister exhibited hypersecretion of insulin in response to a 75 g oral glucose tolerance test. Her mother was diabetic, and her father and sister had border line diabetes, whereas her brother had a normal response. These findings support strongly the diagnosis of a type A syndrome with severe insulin resistance associated with lipopexia on the extremities. A genetic defect in the insulin receptor gene may be responsible.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 4","pages":"347-53"},"PeriodicalIF":0.0,"publicationDate":"1992-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.347","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12618541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Thyrotropin-secreting pituitary adenoma: a case report. 垂体促甲状腺激素腺瘤1例报告。

Endocrinologia japonica Pub Date : 1992-08-01 DOI: 10.1507/endocrj1954.39.413

K Nagai, S Sakata, C C Wu, H Wada, K Yokoyama, M Takada, T Kashiwai, N Tokimitsu

引用次数: 0

Synergistic actions of cytokines and growth factors in enhancing porcine granulosa cell growth. 细胞因子和生长因子在促进猪颗粒细胞生长中的协同作用。

Endocrinologia japonica Pub Date : 1992-06-01 DOI: 10.1507/endocrj1954.39.277

M Fukuoka, K Yasuda, S Taii, T Mori

{"title":"Synergistic actions of cytokines and growth factors in enhancing porcine granulosa cell growth.","authors":"M Fukuoka, K Yasuda, S Taii, T Mori","doi":"10.1507/endocrj1954.39.277","DOIUrl":"https://doi.org/10.1507/endocrj1954.39.277","url":null,"abstract":"In our studies of the growth-promoting effect of a cytokine, interleukin-1 (IL-1), on cultured porcine granulosa cells, we found that the potency of IL-1 action correlated with the serum concentration in the culture medium and that IL-1 acted synergistically with insulin to increase the number of cells in the presence of low serum concentrations (0.1-1%). With granulosa cells maintained in a quiescent state under serum-free conditions, we therefore examined the effects of combined treatment with IL-1 and peptide growth factors, including insulin, on [3H]thymidine incorporation by these cells. IL-1 by itself enhanced [3H]thymidine incorporation in a concentration-dependent manner. Moreover, IL-1 acted synergistically with insulin, epidermal growth factor (EGF), or fibroblast growth factor (FGF) to enhance [3H]thymidine incorporation. Combinations of maximally effective concentrations of insulin (1 micrograms/ml), EGF (1 ng/ml), or FGF (50 ng/ml) with the maximally effective concentration of IL-1 (10 ng/ml) increased the levels of [3H]thymidine incorporation to 10-, 22-, and 20-fold, respectively, over the control values. Whereas IL-2 (0.1-100 ng/ml) did not affect [3H]thymidine incorporation, tumor necrosis factor alpha (TNF alpha) stimulated [3H]thymidine incorporation by itself and reproduced the actions of IL-1 to act synergistically with insulin, EGF, or FGF. When IL-1 and TNF alpha were added together in relatively low concentrations (1 ng/ml each), the combination had synergistic effects in enhancing [3H]thymidine incorporation. The present study demonstrates that cytokines and peptide growth factors act synergistically to markedly enhance porcine granulosa cell growth in vitro.","PeriodicalId":11534,"journal":{"name":"Endocrinologia japonica","volume":"39 3","pages":"277-88"},"PeriodicalIF":0.0,"publicationDate":"1992-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1507/endocrj1954.39.277","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12597238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12