EndoscopyPub Date : 2026-10-16DOI: 10.1055/a-2957-0455
Ying Wu, Ying Qu, Wen Wen, Ni Xie, Guanhao Su, Kai Xu, Jianbo Ni, Kui Peng, Lungen Lu, Xin Zeng, Hongtan Chen, Baiwen Li
{"title":"Rapid versus slow puncture in endoscopic ultrasound-guided liver biopsy: a multicenter randomized crossover trial.","authors":"Ying Wu, Ying Qu, Wen Wen, Ni Xie, Guanhao Su, Kai Xu, Jianbo Ni, Kui Peng, Lungen Lu, Xin Zeng, Hongtan Chen, Baiwen Li","doi":"10.1055/a-2957-0455","DOIUrl":"https://doi.org/10.1055/a-2957-0455","url":null,"abstract":"<p><strong>Background: </strong>Endoscopic ultrasound-guided liver biopsy (EUS-LB) is increasingly used for hepatic histologic assessment; however, optimal technical approaches remain undefined. This prospective, multicenter clinical study aimed to compare tissue acquisition and safety between the rapid and slow puncture techniques for EUS-LB.</p><p><strong>Methods: </strong>This was a multicenter randomized crossover study. Patients undergoing EUS-LB were randomized to receive both rapid puncture and slow puncture techniques in alternating sequence during the same session. The primary outcomes were the number of complete portal tracts (CPTs) and total specimen length (TSL). The secondary outcomes were diagnostic adequacy and adverse events. Linear mixed models and generalized linear mixed models were used to evaluate the technical performance.</p><p><strong>Results: </strong>A total of 62 specimens were analyzed. Compared with the conventional slow puncture technique, rapid puncture significantly increased CPTs (mean difference 2.39; 95%CI 1.50-3.27), as well as TSL (mean difference 15.19 mm; 95%CI 9.65-20.74), with corresponding improvements in diagnostic adequacy (odds ratio 16.27, 95%CI 2.41-109.97). Time period and center were not statistically significantly associated with the outcomes. No severe adverse events were reported.</p><p><strong>Conclusion: </strong>The modified rapid puncture technique was associated with improved specimen quality in EUS-LB. These findings support its potential utility in clinical practice; however, further validation in larger and more diverse populations is warranted.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EndoscopyPub Date : 2026-10-15DOI: 10.1055/a-2974-0900
Maxime Amoyel, Gabriel Marcellier, Paul Rivallin, Bénédicte Jais, Alain Berson, David Giannetta, Frédéric Prat
{"title":"Gastric peroral endoscopic myotomy through an altered anatomy with presternal oesocoloplasty.","authors":"Maxime Amoyel, Gabriel Marcellier, Paul Rivallin, Bénédicte Jais, Alain Berson, David Giannetta, Frédéric Prat","doi":"10.1055/a-2974-0900","DOIUrl":"https://doi.org/10.1055/a-2974-0900","url":null,"abstract":"","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149192061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-endoscopy upper gastrointestinal cancer in a United States multicenter cohort: site- and risk-stratified trends and survival.","authors":"Butros Fakhoury, Vinay Jahagirdar, Sachin Srinivasan, Leandro Sierra, Pojsakorn Danpanichkul, Krishan S Patel, Cesare Hassan, Leo Alexandre, Nirav Thosani, Nigel Trudgill, Prateek Sharma, Madhav Desai","doi":"10.1055/a-2948-3126","DOIUrl":"10.1055/a-2948-3126","url":null,"abstract":"<p><strong>Background: </strong>Post-endoscopy upper gastrointestinal cancer (PEUGIC) is an emerging quality metric, but varying definitions complicate benchmarking. We characterized PEUGIC rates and outcomes by anatomic site and coded high-risk condition (HRC) status in a large US cohort.</p><p><strong>Methods: </strong>This was a retrospective cancer-first cohort study of 14 814 patients with upper gastrointestinal cancer (UGIC) from a multicenter database (2016-2024). Index endoscopy-detected UGIC was diagnosed within 6 months of esophagogastroduodenoscopy. PEUGIC was defined as UGIC diagnosed 6-36 months after a nondiagnostic esophagogastroduodenoscopy. The primary outcome was PEUGIC rate by cancer type and HRC status. Secondary outcomes included 3-year overall survival.</p><p><strong>Results: </strong>The overall PEUGIC rate was 9.4% (esophageal cancer 9.6%, gastric cancer 8.6%, duodenal cancer 10.7%). Rates were higher with HRC (18.2%) than without HRC (5.0%; P < 0.001). PEUGIC rate without HRC plateaued (4.0%-5.1% in 2022-2024), while PEUGIC rate with HRC for esophageal cancer (16.8%) and gastric cancer (14.4%) decreased over time. In exploratory analysis, PEUGIC was associated with better survival vs. index endoscopy-detected UGIC for esophageal cancer (adjusted hazard ratio [aHR] 0.82, 95%CI 0.67-0.99) and gastric cancer (aHR 0.77, 0.62-0.96), and PEUGIC with HRC was associated with lower mortality vs. PEUGIC without HRC for esophageal cancer (aHR 0.51, 0.36-0.74) and gastric cancer (aHR 0.50, 0.34-0.73).</p><p><strong>Conclusions: </strong>1 in 10 UGIC patients had a prior nondiagnostic endoscopy within 3 years. PEUGIC rates varied by anatomic site and HRC status, suggesting site- and HRC-stratified benchmarks may better capture endoscopic performance than aggregate metrics.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148849842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EndoscopyPub Date : 2026-10-13DOI: 10.1055/a-2974-6089
Andrés Gutiérrez, Reem Al Shabeeb, Mustafa Naveed, William Abel, Karin Fleischer, Klaus Mönkemüller
{"title":"Coexisting pulsion and traction diverticula revealed during planned Zenker peroral endoscopic myotomy.","authors":"Andrés Gutiérrez, Reem Al Shabeeb, Mustafa Naveed, William Abel, Karin Fleischer, Klaus Mönkemüller","doi":"10.1055/a-2974-6089","DOIUrl":"https://doi.org/10.1055/a-2974-6089","url":null,"abstract":"","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
EndoscopyPub Date : 2026-10-13DOI: 10.1055/a-2936-2838
Marcello Maida, Giulio Calabrese, Louis H S Lau, Zhouyao Qian, Alessandro Vitello, Giovanni Marasco, Luigi Colecchia, Sandro Sferrazza, Antonio Facciorusso, Cesare Hassan
{"title":"Comparative efficacy of different computer-aided detection products in colonoscopy: a network meta-analysis of randomized controlled trials.","authors":"Marcello Maida, Giulio Calabrese, Louis H S Lau, Zhouyao Qian, Alessandro Vitello, Giovanni Marasco, Luigi Colecchia, Sandro Sferrazza, Antonio Facciorusso, Cesare Hassan","doi":"10.1055/a-2936-2838","DOIUrl":"10.1055/a-2936-2838","url":null,"abstract":"<p><strong>Background: </strong>Multiple computer-aided detection (CADe) systems have been developed to improve adenoma detection during colonoscopy, but their comparative efficacy and consistency of effect remain uncertain. This network meta-analysis aimed to compare the efficacy of different CADe systems across multiple detection outcomes.</p><p><strong>Methods: </strong>MEDLINE, Embase, Scopus, and the Cochrane library were systematically searched for randomized controlled trials (RCTs) comparing CADe-assisted colonoscopy versus colonoscopy without CADe or other CADe systems. The primary outcome was the adenoma detection rate (ADR). Secondary outcomes were adenomas per colonoscopy (APC) and the adenoma miss rate (AMR). A random-effects network meta-analysis was performed to synthesize direct and indirect evidence.</p><p><strong>Results: </strong>41 RCTs (31 789 patients; 14 CADe systems) were included. In the exploratory complete-network analysis, 10/14 systems significantly improved ADR (risk ratio [RR] 1.14-1.76), nine increased APC, and three reduced the AMR. In the FDA-cleared systems analysis, 3/6 improved ADR (RR 1.14-1.25), whereas three did not. Several systems retained a significant benefit in studies meeting the control-arm ADR thresholds recommended by ESGE (≥25%) and ASGE/ACG (≥35%), although effects varied across platforms and attenuation at higher baseline ADR was not uniform. Baseline ADR was not associated with treatment effects on meta-regression.</p><p><strong>Conclusions: </strong>The effectiveness of CADe-assisted colonoscopy is not uniform across platforms and varies according to the specific product. These findings support a system-specific rather than class-based evaluation of CADe technologies. However, comparative estimates should be interpreted cautiously given the low certainty of evidence for several outcomes and the absence of head-to-head comparisons and closed loops within the network.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Endoscopic duodenal injection of autologous stromal vascular fraction in type 2 diabetes: a pilot clinical study of safety, feasibility, and preliminary metabolic effects.","authors":"Manoel Galvão Neto, Flavio Fontes Pirozzi, Marília Wellichan Mancini, Luciana Almeida-Lopes, Patricio Centurion, Luiz Gustavo de Quadros","doi":"10.1055/a-2955-8663","DOIUrl":"https://doi.org/10.1055/a-2955-8663","url":null,"abstract":"","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}