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Comparative efficacy of different computer-aided detection products in colonoscopy: a network meta-analysis of randomized controlled trials. 不同计算机辅助检测产品在结肠镜检查中的比较疗效:随机对照试验的网络荟萃分析。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-13 DOI: 10.1055/a-2936-2838
Marcello Maida, Giulio Calabrese, Louis H S Lau, Zhouyao Qian, Alessandro Vitello, Giovanni Marasco, Luigi Colecchia, Sandro Sferrazza, Antonio Facciorusso, Cesare Hassan
{"title":"Comparative efficacy of different computer-aided detection products in colonoscopy: a network meta-analysis of randomized controlled trials.","authors":"Marcello Maida, Giulio Calabrese, Louis H S Lau, Zhouyao Qian, Alessandro Vitello, Giovanni Marasco, Luigi Colecchia, Sandro Sferrazza, Antonio Facciorusso, Cesare Hassan","doi":"10.1055/a-2936-2838","DOIUrl":"10.1055/a-2936-2838","url":null,"abstract":"<p><strong>Background: </strong>Multiple computer-aided detection (CADe) systems have been developed to improve adenoma detection during colonoscopy, but their comparative efficacy and consistency of effect remain uncertain. This network meta-analysis aimed to compare the efficacy of different CADe systems across multiple detection outcomes.</p><p><strong>Methods: </strong>MEDLINE, Embase, Scopus, and the Cochrane library were systematically searched for randomized controlled trials (RCTs) comparing CADe-assisted colonoscopy versus colonoscopy without CADe or other CADe systems. The primary outcome was the adenoma detection rate (ADR). Secondary outcomes were adenomas per colonoscopy (APC) and the adenoma miss rate (AMR). A random-effects network meta-analysis was performed to synthesize direct and indirect evidence.</p><p><strong>Results: </strong>41 RCTs (31 789 patients; 14 CADe systems) were included. In the exploratory complete-network analysis, 10/14 systems significantly improved ADR (risk ratio [RR] 1.14-1.76), nine increased APC, and three reduced the AMR. In the FDA-cleared systems analysis, 3/6 improved ADR (RR 1.14-1.25), whereas three did not. Several systems retained a significant benefit in studies meeting the control-arm ADR thresholds recommended by ESGE (≥25%) and ASGE/ACG (≥35%), although effects varied across platforms and attenuation at higher baseline ADR was not uniform. Baseline ADR was not associated with treatment effects on meta-regression.</p><p><strong>Conclusions: </strong>The effectiveness of CADe-assisted colonoscopy is not uniform across platforms and varies according to the specific product. These findings support a system-specific rather than class-based evaluation of CADe technologies. However, comparative estimates should be interpreted cautiously given the low certainty of evidence for several outcomes and the absence of head-to-head comparisons and closed loops within the network.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148711575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic duodenal injection of autologous stromal vascular fraction in type 2 diabetes: a pilot clinical study of safety, feasibility, and preliminary metabolic effects. 内镜下十二指肠注射自体间质血管部分治疗2型糖尿病:安全性、可行性和初步代谢效果的初步临床研究
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-13 DOI: 10.1055/a-2955-8663
Manoel Galvão Neto, Flavio Fontes Pirozzi, Marília Wellichan Mancini, Luciana Almeida-Lopes, Patricio Centurion, Luiz Gustavo de Quadros
{"title":"Endoscopic duodenal injection of autologous stromal vascular fraction in type 2 diabetes: a pilot clinical study of safety, feasibility, and preliminary metabolic effects.","authors":"Manoel Galvão Neto, Flavio Fontes Pirozzi, Marília Wellichan Mancini, Luciana Almeida-Lopes, Patricio Centurion, Luiz Gustavo de Quadros","doi":"10.1055/a-2955-8663","DOIUrl":"https://doi.org/10.1055/a-2955-8663","url":null,"abstract":"","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of metachronous esophageal squamous cell carcinoma after endoscopic submucosal dissection in patients with multiple Lugol-voiding lesions: a long-term study. 内镜下粘膜下剥离后多发lugoll -排尿病变患者发生异时性食管鳞状细胞癌的风险:一项长期研究。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-12 DOI: 10.1055/a-2948-9340
Yosuke Kishi, Yusuke Horiuchi, Wataru Kurihara, Chika Fukuyama, Hiroyuki Yamamoto, Toshiaki Hirasawa, Akiyoshi Ishiyama, Takahisa Matsuda, Toshiyuki Yoshio
{"title":"Risk of metachronous esophageal squamous cell carcinoma after endoscopic submucosal dissection in patients with multiple Lugol-voiding lesions: a long-term study.","authors":"Yosuke Kishi, Yusuke Horiuchi, Wataru Kurihara, Chika Fukuyama, Hiroyuki Yamamoto, Toshiaki Hirasawa, Akiyoshi Ishiyama, Takahisa Matsuda, Toshiyuki Yoshio","doi":"10.1055/a-2948-9340","DOIUrl":"https://doi.org/10.1055/a-2948-9340","url":null,"abstract":"<p><strong>Background: </strong>Multiple Lugol-voiding lesions (LVLs) confer a high risk of metachronous multiple esophageal squamous cell carcinomas (ESCCs) after endoscopic submucosal dissection (ESD); however, risk heterogeneity within this high-risk group remains unclear. Precise stratification could help optimize the surveillance intensity and reduce the burden of Lugol chromoendoscopy. We aimed to identify risk factors for metachronous multiple ESCCs among patients with multiple LVLs and to explore practical risk stratification.</p><p><strong>Methods: </strong>This single-center retrospective exploratory cohort study included patients who underwent initial ESD for superficial ESCC between 2014 and 2022 and had grade C LVLs, defined as ≥10 LVLs per endoscopic field of view. Grade C LVLs were subclassified by LVL counts as subgrade α (10-20), β (21-30), and γ (≥31).</p><p><strong>Results: </strong>Among 331 patients (median follow-up 57 months), 163 (49.2%) developed metachronous multiple ESCCs; the 5-year cumulative incidence was 55.2% (95%CI 48.8-61.7). In multivariable analysis, positive flushing response (hazard ratio [HR] 1.59, 95%CI 1.10-2.31) and subgrade γ (HR 5.34 vs. α, 95%CI 2.36-12.1) were independently associated with increased risk. Subgrade γ showed higher 5-year incidence than subgrade α/β among both flushing-positive (71.4% vs. 27.2%; P < 0.001) and flushing-negative (57.5% vs. 16.9%; P = 0.004) patients. No confirmed ESCC-related deaths occurred during follow-up.</p><p><strong>Conclusions: </strong>Within grade C LVLs, subgrade γ and flushing positivity were associated with an increased risk of metachronous multiple ESCCs. Combining LVL subclassification and flushing status may provide clinically relevant risk stratification and may help inform risk-adapted surveillance after ESD.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of endoscopic ultrasound in cholangiocarcinoma staging: a systematic review and meta-analysis. 内镜超声对胆管癌分期的影响:系统回顾和荟萃分析。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-12 DOI: 10.1055/a-2944-4167
Nasruddin Sabrie, Michael Youssef, Yibing Ruan, Marcus Vaska, Samir C Grover, Paul D James, Nauzer Forbes, Vinay Chandrasekhara, Lydi M J W van Driel, David M de Jong, Rishad Khan
{"title":"Impact of endoscopic ultrasound in cholangiocarcinoma staging: a systematic review and meta-analysis.","authors":"Nasruddin Sabrie, Michael Youssef, Yibing Ruan, Marcus Vaska, Samir C Grover, Paul D James, Nauzer Forbes, Vinay Chandrasekhara, Lydi M J W van Driel, David M de Jong, Rishad Khan","doi":"10.1055/a-2944-4167","DOIUrl":"10.1055/a-2944-4167","url":null,"abstract":"<p><strong>Background: </strong>Accurate staging is crucial for managing cholangiocarcinoma (CCA). Endoscopic ultrasound with tissue acquisition (EUS-TA) may enhance cross-sectional imaging-based staging; however, the impact of EUS on CCA management decision-making is unclear.</p><p><strong>Methods: </strong>6 electronic databases were searched through to 10 July 2025 for studies on EUS-TA in staging CCA cases eligible for surgical resection or liver transplantation. The primary outcome was the pooled proportion of patients excluded from curative-intent surgery based on the EUS findings, which included newly detected findings and confirmation by EUS-TA of cross-sectional imaging findings. Secondary outcomes included the pooled incremental benefit of EUS (IBEUS) over cross-sectional imaging and EUS-specific adverse events. The IBEUS was defined as the proportion of patients with malignant lymph nodes identified by EUS-TA but not by cross-sectional imaging, relative to all patients who underwent cross-sectional imaging.</p><p><strong>Results: </strong>9 studies with 831 patients were included. The rate of exclusion from curative-intent surgery based on EUS findings was 10% overall (95%CI 6%-18%; 9 studies), 7% for perihilar CCA (pCCA; 95%CI 2%-19%; 5 studies), 10% for those planned for resection (95%CI 4%-22%; 5 studies), and 8% for those planned for transplantation (95%CI 3%-22%; 3 studies). The pooled IBEUS was 3% (95%CI 1%-10%; 5 studies) overall, 4% (95%CI 1%-17%; 3 studies) for pCCA, 1% (95%CI 0%-3%; 2 studies) in patients intended for operative resection, and 7% (95%CI 1%-26%; 2 studies) in those intended for transplantation.</p><p><strong>Conclusion: </strong>EUS may impact CCA staging and support treatment decisions.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148826199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ambient green lighting during ERCP. ERCP期间的环境绿色照明。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-09 DOI: 10.1055/a-2963-2239
Daryl Ramai, David Jonason, Andrew Fuller, Abdulrahman Qatomah, Baylee Barnes, Christopher C Thompson
{"title":"Ambient green lighting during ERCP.","authors":"Daryl Ramai, David Jonason, Andrew Fuller, Abdulrahman Qatomah, Baylee Barnes, Christopher C Thompson","doi":"10.1055/a-2963-2239","DOIUrl":"https://doi.org/10.1055/a-2963-2239","url":null,"abstract":"","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149149114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Artificial intelligence in endoscopy: a call for joint leadership between ESGE and Endoscopy. 内窥镜中的人工智能:呼吁ESGE和内窥镜联合领导。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-09 DOI: 10.1055/a-2954-8396
Yuichi Mori, Cesare Hassan, Jacques J G H M Bergman
{"title":"Artificial intelligence in endoscopy: a call for joint leadership between ESGE and Endoscopy.","authors":"Yuichi Mori, Cesare Hassan, Jacques J G H M Bergman","doi":"10.1055/a-2954-8396","DOIUrl":"https://doi.org/10.1055/a-2954-8396","url":null,"abstract":"","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long-term risk of metachronous gastric neoplasms after curative endoscopic submucosal dissection for early gastric cancer. 早期胃癌内镜下粘膜下剥离治疗后发生异时性胃肿瘤的长期风险。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-09 DOI: 10.1055/a-2936-0365
Jong Sun Park, Eunyoung Angela Lee, Ji Hyun Park, Bumhee Park, Jong Hoon Park, Min Jae Yang, Sun Gyo Lim, Sung Jae Shin, Sung Soo Ahn, Gil Ho Lee, Choong-Kyun Noh
{"title":"Long-term risk of metachronous gastric neoplasms after curative endoscopic submucosal dissection for early gastric cancer.","authors":"Jong Sun Park, Eunyoung Angela Lee, Ji Hyun Park, Bumhee Park, Jong Hoon Park, Min Jae Yang, Sun Gyo Lim, Sung Jae Shin, Sung Soo Ahn, Gil Ho Lee, Choong-Kyun Noh","doi":"10.1055/a-2936-0365","DOIUrl":"10.1055/a-2936-0365","url":null,"abstract":"<p><strong>Background: </strong>There is currently no consensus on long-term risk stratification for metachronous gastric neoplasms (MGNs) occurring beyond 5 years following endoscopic submucosal dissection (ESD). This study aimed to investigate the time-dependent changes in predictive factors for MGN after curative ESD for early gastric cancer (EGC) and analyze the clinicopathological features of late MGNs.</p><p><strong>Methods: </strong>We retrospectively reviewed patients who underwent ESD for early gastric neoplasms between March 2005 and June 2020. MGN was defined as a new gastric neoplasm detected at a different site >12 months after ESD. Survival data were collected and analyzed using multivariable and time-split Cox hazard regression models.</p><p><strong>Results: </strong>Among 5571 patients treated with ESD, 876 were included, with a median follow-up of 58 months. The cumulative incidence of MGN was 10.8% at 5 years and continued to accumulate beyond 5 years (26.7% at 10 years). All MGNs were stage I and there was no gastric cancer-related mortality. Cox regression analysis identified family history of gastric cancer (adjusted hazard ratio [aHR] 2.12, 95%CI 1.32-3.41) and extensive intestinal metaplasia (aHR 6.50, 95%CI 3.73-11.36) as independent predictors of MGN. Histological upgrade was not associated with MGN during the first 5 years, but emerged as a significant risk factor in the late period (interaction <i>P</i> = 0.005).</p><p><strong>Conclusion: </strong>MGNs may develop even beyond 5 years following ESD with curative resection in patients with EGC. These findings highlight the long-term risk of MGN after ESD, providing a framework for clinical risk estimation.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria. 过期的内窥镜设备保持无菌和功能:一项挑战当前保质期标准的国际多中心研究。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-09 DOI: 10.1055/a-2977-6099
Enrique Rodriguez de Santiago, David Villaescusa Arenas, Elia Gómez G de la Pedrosa, Marina García-Castellanos, João A Cunha Neves, Anastasia Tsalouka, Christoph Römmele, Mathieu Pioche, Marianna Arvanitakis, Javier Tejedor-Tejada, Glòria Fernández-Esparrach, Andrei Voiosu, Patricia Pedregal-Pascual, Eduardo Valdivielso Cortázar, Mikel Fiallegas Cano, Miguel Pantaleón Sánchez, Heiko Pohl, Sílvia Ferraz, Neil Robert O'Morain, Kareem Khalaf, Alexander Meining, Douglas Graham Penman, Pedro J Rosón, Francesc Bas-Cutrina, Luca Elli, Matilde Topa, Rosa Sáiz-Chumillas, Federico Soria, Guillermo Vilariño-Feltrer, Vicente Pons-Beltran, Ana Garcia Garcia de Paredes, Oliva Ros-Fargas, Isabel Tort-Ausina, Konstantinos Triantafyllou, Arnaud Lemmers, Mário Dinis-Ribeiro, Fausto R Pons, Dorothea Henniger, Enrique Vazquez-Sequeiros, Alberto Campillo-Fernández, Vicente Lorenzo-Zúñiga
{"title":"Expired endoscopic devices remain sterile and functional: an international multicentre study challenging current shelf-life criteria.","authors":"Enrique Rodriguez de Santiago, David Villaescusa Arenas, Elia Gómez G de la Pedrosa, Marina García-Castellanos, João A Cunha Neves, Anastasia Tsalouka, Christoph Römmele, Mathieu Pioche, Marianna Arvanitakis, Javier Tejedor-Tejada, Glòria Fernández-Esparrach, Andrei Voiosu, Patricia Pedregal-Pascual, Eduardo Valdivielso Cortázar, Mikel Fiallegas Cano, Miguel Pantaleón Sánchez, Heiko Pohl, Sílvia Ferraz, Neil Robert O'Morain, Kareem Khalaf, Alexander Meining, Douglas Graham Penman, Pedro J Rosón, Francesc Bas-Cutrina, Luca Elli, Matilde Topa, Rosa Sáiz-Chumillas, Federico Soria, Guillermo Vilariño-Feltrer, Vicente Pons-Beltran, Ana Garcia Garcia de Paredes, Oliva Ros-Fargas, Isabel Tort-Ausina, Konstantinos Triantafyllou, Arnaud Lemmers, Mário Dinis-Ribeiro, Fausto R Pons, Dorothea Henniger, Enrique Vazquez-Sequeiros, Alberto Campillo-Fernández, Vicente Lorenzo-Zúñiga","doi":"10.1055/a-2977-6099","DOIUrl":"https://doi.org/10.1055/a-2977-6099","url":null,"abstract":"<p><p>Background and study aims Expired medical devices represent an environmental and economic concern, yet their magnitude and true shelf life remain poorly defined. We aimed to quantify the volume and cost of expired endoscopic devices and evaluate their sterility and functionality beyond the labelled expiry date. Methods We conducted an investigator-initiated, prospective study (December 2023-May 2025) across 25 endoscopy units from Europe, Canada, and the USA. Expired devices were inventoried during one-week audits. An institutional questionnaire assessed storage practices. Microbiological sterility and ex vivo functionality were assessed in randomly selected samples. Physicomechanical testing included matched case-control comparison with non-expired counterparts. Results We identified 1,448 expired devices (median per centre, 42; range 3-262), with an estimated cost of €192,141.67. Of these, 273 underwent microbiological testing, 210 ex vivo functional assessment, and 57 physicomechanical evaluation. No microorganism growth was detected in any evaluated device (100%, 95% CI 98.6-100). All but one overtube retained functionality (99.5%; 95% CI 97.4-99.9). Physicomechanical testing showed no clinically relevant differences compared with non-expired devices. Only six centres (24%) reported written protocols to minimise accumulation of expired accessories, and three (12%) had electronic tracking systems. Conclusions Expired endoscopic consumables are frequent and costly, with suboptimal inventory management within endoscopy units. In this multicentre bench and ex vivo study, analysed devices preserved sterility and functional performance beyond their labelled expiry dates. These findings challenge current shelf-life assumptions and support further regulatory evaluation, but should not be interpreted as evidence supporting routine clinical use of expired devices.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149147499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endoscopic ultrasound-guided gastroenterostomy: an international consensus on current and expanding indications, techniques, periprocedural care, and institutional requirements. 超声内镜引导下的胃肠造口术:关于当前和扩大适应症、技术、围手术期护理和机构要求的国际共识。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-09 DOI: 10.1055/a-2948-2876
Giuseppe Vanella, Albrecht Neesse, Cecilia Binda, Jeanin E van Hooft, Antonio Facciorusso, Manuel Perez-Miranda, Giovanni Marchegiani, Michiel Bronswijk, Marco Spadaccini, Alexander Arlt, Lucio Carrozza, Pedro Moutinho-Ribeiro, Chiara Coluccio, Tajana Pavic, Fausto Catena, Enrique Pérez-Cuadrado-Robles, Maria Cristina Conti Bellocchi, Roy L J van Wanrooij, Edoardo Forti, Andrada Seicean, Andrea Lisotti, Marcello Maida, Aurelio Mauro, Schalk W van der Merwe, Stefano Mazza, Margherita Pizzicannella, Giacomo Emanuele Maria Rizzo, Gianfranco Donatelli, Daniela Scimeca, Serena Stigliano, Edoardo Troncone, Andrea Anderloni, Carlo Fabbri, Ilaria Tarantino, Joan B Gornals, Lorenzo Fuccio
{"title":"Endoscopic ultrasound-guided gastroenterostomy: an international consensus on current and expanding indications, techniques, periprocedural care, and institutional requirements.","authors":"Giuseppe Vanella, Albrecht Neesse, Cecilia Binda, Jeanin E van Hooft, Antonio Facciorusso, Manuel Perez-Miranda, Giovanni Marchegiani, Michiel Bronswijk, Marco Spadaccini, Alexander Arlt, Lucio Carrozza, Pedro Moutinho-Ribeiro, Chiara Coluccio, Tajana Pavic, Fausto Catena, Enrique Pérez-Cuadrado-Robles, Maria Cristina Conti Bellocchi, Roy L J van Wanrooij, Edoardo Forti, Andrada Seicean, Andrea Lisotti, Marcello Maida, Aurelio Mauro, Schalk W van der Merwe, Stefano Mazza, Margherita Pizzicannella, Giacomo Emanuele Maria Rizzo, Gianfranco Donatelli, Daniela Scimeca, Serena Stigliano, Edoardo Troncone, Andrea Anderloni, Carlo Fabbri, Ilaria Tarantino, Joan B Gornals, Lorenzo Fuccio","doi":"10.1055/a-2948-2876","DOIUrl":"10.1055/a-2948-2876","url":null,"abstract":"<p><strong>Background: </strong> Endoscopic ultrasound-guided gastroenterostomy (EUS-GE) and related EUS-guided anastomoses are increasingly used for gastric outlet obstruction (GOO) and other complex gastrointestinal scenarios, but the indications, technical standards, and periprocedural care remain heterogeneous.</p><p><strong>Methods: </strong> An international panel of 66 experts (i-EUS) developed statements using a structured modified Delphi process. Literature searches were performed up to 30 April 2025. Comparative PICO-framed questions with extractable evidence underwent structured evidence synthesis and GRADE assessment, whereas procedural, technical, and organizational statements were classified as consensus based. Consensus was predefined as ≥ 85 % agreement.</p><p><strong>Results: </strong> Of 25 draft statements, 20 reached consensus and five did not. Six endorsed statements were GRADE based and 14 were consensus based. For malignant GOO, EUS-GE was recommended over duodenal stenting because of greater durability and fewer reinterventions, and suggested over surgical bypass because of comparable efficacy and fewer overall adverse events. Consensus-based statements addressed expert-center requirements, supervised training, catheter-based target-loop distension, freehand lumen-apposing metal stent (LAMS) deployment, fluoroscopy availability, antithrombotic management, refeeding, postprocedural imaging, recurrent obstruction, and misdeployment. Conditional recommendations addressed LAMS-diameter selection, selected benign GOO, EUS-directed transgastric endoscopic retrograde cholangiopancreatography (EDGE)/EUS-directed transgastric interventions (EDGI) in Roux-en-Y gastric bypass (RYGB), and malignant afferent limb syndrome. No formal recommendation was issued for peritoneal carcinomatosis, routine tracheal intubation, antibiotic prophylaxis, EUS-directed entero-enterostomy (EDEE) in non-RYGB anatomy, or EUS-guided coloenterostomy.</p><p><strong>Conclusions: </strong> These i-EUS recommendations provide a practical framework for EUS-GE and related anastomoses in expert settings. The evidence base remains limited, and prospective comparative studies are needed to refine patient selection, training requirements, and long-term outcomes.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholangioscopy-guided lithotripsy versus mechanical lithotripsy for large common bile duct stones during balloon enteroscopy-assisted ERCP after gastrectomy with a native papilla. 胆道镜引导下的碎石术与机械碎石术在有原生乳头的胃切除术后球囊肠镜辅助ERCP中的大胆总管结石。
IF 11.8 1区 医学
Endoscopy Pub Date : 2026-10-08 DOI: 10.1055/a-2975-5309
Tadahisa Inoue, Akinori Maruta, Yuhei Iwasa, Naoki Mita, Toji Murabayashi, Hiroshi Mori, Yumi Murashima, Rena Kitano, Hironao Ichikawa, Shinya Uemura, Keisuke Iwata, Masanao Nakamura, Kiyoaki Ito
{"title":"Cholangioscopy-guided lithotripsy versus mechanical lithotripsy for large common bile duct stones during balloon enteroscopy-assisted ERCP after gastrectomy with a native papilla.","authors":"Tadahisa Inoue, Akinori Maruta, Yuhei Iwasa, Naoki Mita, Toji Murabayashi, Hiroshi Mori, Yumi Murashima, Rena Kitano, Hironao Ichikawa, Shinya Uemura, Keisuke Iwata, Masanao Nakamura, Kiyoaki Ito","doi":"10.1055/a-2975-5309","DOIUrl":"https://doi.org/10.1055/a-2975-5309","url":null,"abstract":"<p><strong>Background: </strong>Balloon enteroscopy-assisted ERCP (BE-ERCP) for large common bile duct stones in patients with surgically altered anatomy (SAA) remains challenging. Mechanical lithotripsy (ML) is commonly used, but stone capture and fragmentation can often be difficult. This study evaluated the usefulness of a peroral cholangioscopy-guided lithotripsy (POCL)-first strategy compared with a conventional ML-first strategy.</p><p><strong>Methods: </strong>This study used a registry of patients with large common bile duct stones and SAA after gastrectomy in whom BE-ERCP was performed at seven institutions in Japan. From this registry, patients treated with an ML-first or POCL-first strategy were included. Outcomes were compared between patients treated with a POCL-first strategy and those treated with an ML-first strategy. The primary outcome was complete stone clearance during the initial session.</p><p><strong>Results: </strong>A total of 104 patients were analyzed: 39 in the POCL-first group and 65 in the ML-first group. Complete stone clearance during the initial session was achieved in 95% of the POCL-first group and 62% of the ML-first group (risk difference, 33.3%; 95% CI, 17.3-46.0%). POCL-first was associated with fewer patients requiring ≥2 sessions among those achieving final clearance (5% vs 32%; risk difference, -27.1%; 95% CI, -40.3 to -11.3). Adverse event rates did not differ significantly. After adjustment, POCL-first was associated with a higher probability of initial-session complete stone clearance (adjusted risk ratio, 1.40; 95% CI, 1.08-1.83).</p><p><strong>Conclusions: </strong>In this retrospective cohort of postgastrectomy patients with an accessible native papilla, a POCL-first strategy during BE-ERCP was associated with higher initial-session complete stone clearance, supporting prospective evaluation.</p>","PeriodicalId":11516,"journal":{"name":"Endoscopy","volume":" ","pages":""},"PeriodicalIF":11.8,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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