Egyptian dental journal最新文献

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Remineralization and Antibacterial efficacy of Ashwagandha, Maca and Ginger-based mouthwashes versus Fluoride-based mouthwash on initial enamel caries: An in-vitro study 芦荟、玛咖和生姜漱口水与含氟漱口水对初期釉质龋齿的再矿化和抗菌功效:体外研究
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.260586.2864
P. M. Abd El Aziz, Raghda Kamh, Esraa El gezawy
{"title":"Remineralization and Antibacterial efficacy of Ashwagandha, Maca and Ginger-based mouthwashes versus Fluoride-based mouthwash on initial enamel caries: An in-vitro study","authors":"P. M. Abd El Aziz, Raghda Kamh, Esraa El gezawy","doi":"10.21608/edj.2024.260586.2864","DOIUrl":"https://doi.org/10.21608/edj.2024.260586.2864","url":null,"abstract":"Purpose : Non-invasive management of non-cavitated caries lesions by the medicinal use of plant extracts is the goal of modern dentistry; this study was accomplished to assess the remineralizing and antibacterial potential of some herbals (Ashwagandha, Maca, and Ginger) in comparison to Fluoride-based mouthwash on initial enamel carious lesions. Materials and Methods : In this study, fifty extracted premolars were allocated evenly into five groups of 10 teeth each. Group A: teeth treated with 0.5% Ashwagandha-based mouthwash (n=10); Group M: teeth treated with 0.5% Maca-based mouthwash (n=10); Group G: teeth treated with 0.5% Ginger-based mouthwash (n=10); Group F: teeth treated with Fluoride-based mouthwash as a positive control group (n=10); and Group C; negative control group: teeth not exposed to any treatment and stored in artificial saliva. All teeth were evaluated using the DIAGNOdent pen® at baseline, after demineralization, and after 14 days with different remineralizing materials. The antimicrobial properties of fluoride and plant extracts against Streptococcus mutans and Lactobacillus acidophilus were quantitatively evaluated by an antimicrobial susceptibility test. The data were statistically analyzed using an ANOVA test. Results: All experimental treated groups confirmed a reduction in DIAGNOdent pen® values. Group G showed the most significant decrease (-8.3±2.16), followed by Group M (-7.3±0.82), and Group A (-7.3±1.25), then Group F (-6.5±0.53). The lowest reduction was observed in the control group (-3.60.97). The distinction between groups was statistically significant (p=0.000). All used mouthwashes had antibacterial properties against Streptococcus mutans and Lactobacillus acidophilus bacteria, with no statistically significant difference. Conclusion: Herbal-based-mouthwashes of 0.5 % Ashwagandha, Maca, and Ginger are effective remineralizing agents on initial enamel carious lesions with antimicrobial activity against Streptococcus mutans and Lactobacillus acidophilus.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140797196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cyclic fatigue and Structural Analysis of Three Rotary Nickel Titanium Files 三种旋转式镍钛锉的循环疲劳和结构分析
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.264175.2891
Mahmoud Abdelaaty, Ahmed Hashem, Shady Hussien
{"title":"Cyclic fatigue and Structural Analysis of Three Rotary Nickel Titanium Files","authors":"Mahmoud Abdelaaty, Ahmed Hashem, Shady Hussien","doi":"10.21608/edj.2024.264175.2891","DOIUrl":"https://doi.org/10.21608/edj.2024.264175.2891","url":null,"abstract":"Nickel-titanium (NiTi) rotary shaping techniques were devised as a solution to the drawbacks associated with manual filing systems.The study was conducted to evaluate the cyclic fatigue resistance and martensitic/austenitic phase at body and room temperatures for HyFlex CM, Fanta (AH wire), Soco files. Twenty files of each system were used. Ten of them were used at room temperature and ten were used at body temperature. Dynamic cyclic fatigue testing was performed with a specific device, which allowed the instruments to rotate freely inside a Stainless-Steel artificial canal while providing an axial movement with amplitude of 3mm up and down movement. The time was calculated until instrument fracture occurred. A Sample with weight 10 to 15 grams of each instrument was evaluated using Differential Scanning Calorimetry (DSC).The DSC analyses were conducted over a temperature range from 0°C to 60°C . The results showed that HyFlex CM exhibited higher cyclic fatigue, followed by Fanta(AH wire), while soco showed the lowest values for both room and body temperatures. Temperature showed an effect (between body and room temperature) on cyclic fatigue resistance of some of CM wire type of instruments (Fanta and soco files).The differential scanning calorimetry confirmed the presence of the martensitic R-phase in Hyflex CM in both body and room temperatures which improved the cyclic fatigue resistance of this file, while presence of the martensitic phase only in room temperature for Fanta and Soco files not in body temperature which significantly decreases their cyclic fatigue resistance.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In-Vitro Evaluation of Strain Induced by Various Extra Coronal Attachment Materials in Removable Partial Dentures Restoring Mandibular Kennedy Class I Following Clinical Simulation for One Year 临床模拟一年后,对各种冠外基托材料在可摘局部义齿修复下颌肯尼迪 I 级时引起的应变进行体外评估
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.269202.2935
Yasser M. Shawky
{"title":"In-Vitro Evaluation of Strain Induced by Various Extra Coronal Attachment Materials in Removable Partial Dentures Restoring Mandibular Kennedy Class I Following Clinical Simulation for One Year","authors":"Yasser M. Shawky","doi":"10.21608/edj.2024.269202.2935","DOIUrl":"https://doi.org/10.21608/edj.2024.269202.2935","url":null,"abstract":"Purpose: The objective of this study was to evaluate the strain induced by various extra coronal attachment materials retaining removable partial dentures restoring mandibular Kennedy class I following clinical simulation for one year. Materials and Methods: Twelve identical models, fabricated by 3D printing, representing Kennedy class I mandibular partially edentulous cases with bilateral first premolars as primary abutments were used. Each model had four removable dies; canines and first premolars bilaterally. On these dies, bilateral splinted crowns were fabricated and grouped according to the extra coronal attachment material used (PEEK/BioHPP, zirconia and metal). Each group included four models, each model was designed having four slots for strain gauges (two on each side). These slots were positioned 1mm distal to the 1 st premolar (SG1 and SG3) and at the edentulous ridge (SG2 and SG4) 1 cm away from the first one. Removable partial dentures were fabricated, and a universal testing machine was employed to assess the strain induced under unilateral and bilateral loading conditions. This assessment was conducted both prior to and after clinical simulation for one year. The clinical simulation involved chewing simulator sessions and cycles of insertion and removal for the denture. Results: PEEK (BioHPP) group exhibited the least strain induced, both prior to and after clinical simulation for one year, under both unilateral and bilateral loading conditions. Conclusions: PEEK (BioHPP) extra coronal attachment used for retaining removable partial denture provides more favorable stress dissipation in comparison to zirconia and metal attachments.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of postoperative pain following treatment using S-ONE Pro Single Niti Reciprocation file and One Curve Endodontic file systems 使用 S-ONE Pro 单尼特往复锉和 One Curve 根管锉系统治疗后的术后疼痛评估
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.258472.2853
Rasha Sameh, Dina Abdel-Ghany
{"title":"Evaluation of postoperative pain following treatment using S-ONE Pro Single Niti Reciprocation file and One Curve Endodontic file systems","authors":"Rasha Sameh, Dina Abdel-Ghany","doi":"10.21608/edj.2024.258472.2853","DOIUrl":"https://doi.org/10.21608/edj.2024.258472.2853","url":null,"abstract":"Post endodontic pain is any degree of discomfort that develops after the start of root canal treatment. Post endodontic pain may be attributed to the employment of different types of movement patterns, the size of the apical preparation, the number of appointments and obturation operations","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the effect of canine guided versus group function occlusion on the vertical bone loss around implants retaining mandibular hybrid prostheses 比较犬引导与群功能咬合对种植体固定下颌混合义齿周围垂直骨质流失的影响
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.264088.2890
nour kodera, Ahmed ahmed shawky, D. Bahig
{"title":"Comparing the effect of canine guided versus group function occlusion on the vertical bone loss around implants retaining mandibular hybrid prostheses","authors":"nour kodera, Ahmed ahmed shawky, D. Bahig","doi":"10.21608/edj.2024.264088.2890","DOIUrl":"https://doi.org/10.21608/edj.2024.264088.2890","url":null,"abstract":"Aim: The aim of this study was to evaluate the amount of marginal bone loss around mandibular fixed hybrid prostheses with different occlusal schemes among mandibular completely edentulous patients opposed by dentate maxilla. Materials and methods: This study was conducted on 18 patients. The patients were distributed in two groups. All patients were with mandibular completely edentulous arch and were rehabilitated with five intra-foraminal implants which were restored by implant supported fixed hybrid prosthesis. For the first group: (C) canine guided occlusal scheme was used. As for the second group: (G) group function occlusal scheme was used. The amount of marginal bone loss in each group was measured by CBCT at 0, 6 and 12 months after delivery. Results: Within both intervals, for left implant (1) and right implant (2), distal bone loss values measured in group function group were significantly higher than those in canine guided group (p<0.05). While for other implants the difference was not statistically significant (p>0.05) at the end of the study. There was no significant difference between total bone loss values measured in both groups (p>0.05) at the end of the study. Conclusion: Both canine guided and group function occlusion are accepted occlusal schemes for fixed implant prosthetics, but canine guided occlusion tends to distribute the forces more evenly leading to more even bone loss than group function which concentrates stresses on the distal implants threatening the longevity of the distal implant.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140771577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression of Cystatin SA in Oral lichen planus 胱抑素 SA 在口腔扁平苔藓中的表达
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.253274.2815
nader tolba, Weam A. M. Rashwan, LailaA Rashed
{"title":"Expression of Cystatin SA in Oral lichen planus","authors":"nader tolba, Weam A. M. Rashwan, LailaA Rashed","doi":"10.21608/edj.2024.253274.2815","DOIUrl":"https://doi.org/10.21608/edj.2024.253274.2815","url":null,"abstract":"Objectives : identify the diagnostic accuracy of tissue Cystatin (SA) in diagnosis of oral lichen planus Methodology: The present study included 58 Patients divided into 2 groups, group I: 29 healthy control patients and group II: 29 Patients clinically diagnosed with oral lichen planus. Tissue biopsy was taken and the production of tissue cystatin SA was determined by enzyme immunoassay. We described and compared the protein profiles (Cystatin SA) in the tissues, from patients who presented with oral lichen planus and from healthy controls. Data were presented as mean and standard deviation values and were analyzed using independent t-test. Correlations were analyzed using Spearman’s rank order correlation coefficient. Results: The Oral Lichen Planus group had a significantly higher Cystatin-SA level than the control group (p<0.001). The mean value of the cystatin SA in the Oral Lichen Planus group was 19.68±3.69, whereas the mean value of the cystatin SA in the control group was 7.22±1.6, suggesting a role for the cystatin SA in the diagnosi of Oral Lichen Planus. Conclusions: Cystatin-SA expression in Oral Lichen Planus patients was more outstanding than in healthy control subjects.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140769075","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Salivary levels of Cathelicidin LL-37 in patients with oral potentially malignant lesions, A case control study 口腔潜在恶性病变患者唾液中的卡他列汀 LL-37 水平,一项病例对照研究
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.257255.2928
N. Tarrad, Sandy Shaaban, Olfat Shaker, Mai Zakaria
{"title":"Salivary levels of Cathelicidin LL-37 in patients with oral potentially malignant lesions, A case control study","authors":"N. Tarrad, Sandy Shaaban, Olfat Shaker, Mai Zakaria","doi":"10.21608/edj.2024.257255.2928","DOIUrl":"https://doi.org/10.21608/edj.2024.257255.2928","url":null,"abstract":"Aim : The recognition of practical early diagnostic biomarkers is a cornerstone of improved prevention and treatment of cancer thus the current study estimated salivary level of Cathelicidin LL-37 in patients suffering from potentially malignant lesions and control subjects to corroborate Cathelicidin LL-37 as a diagnostic marker for early detection of potentially malignant diseases and revealing its possible role in carcinogenesis. Methodology : 45 systemically healthy individuals were subdivided into three groups: Group I: 15 Healthy participants without any oral lesions. Group II: 15 Patients having atrophic/erosive oral lichen planus (OLP). Group III: 15 Patients having oral leukoplakia. Enzyme linked immune-sorbent assay (ELIZA) kit was used to evaluate the level of LL-37 in whole unstimulated salivary samples collected from all participants. To reveal AUC, sensitivity, specificity, and diagnostic accuracy of LL-37 receiver operating curve (ROC) analysis was done. Results : The highest salivary level of LL-37 was revealed in OLP patients followed by oral leukoplakia patients whereas it was the lowest in healthy controls. ROC analysis exhibited excellent diagnostic accuracy of salivary LL-37 in differentiating both OLP and leukoplakia from control and OLP from leukoplakia. Conclusions : LL-37 appears to have a potential role in potentially malignant lesions (OLP & leukoplakia). The remarkable diagnostic accuracy of salivary LL-37 in differentiating potentially malignant lesion and healthy control could confirm its utilization as an innovative marker to early diagnose potentially malignant lesions. Salivary LL-37 being non-invasive accurate marker could be a chair-side diagnostic method that detect potentially malignant lesions. Clinical relevance: Salivary Cathelicidin LL-37 being non-invasive could serve as a chair-side diagnostic technique for potentially malignant lesions.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140796328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of air abrasion and Er,Cr:YSGG laser on shear bond strength of cubic zirconia to two resin cement types. 气磨和 Er,Cr:YSGG 激光对立方氧化锆与两种树脂水泥的剪切粘接强度的影响。
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.251862.2806
Amira Abd Elsabour, Tarek Salah, Soha Osama
{"title":"The influence of air abrasion and Er,Cr:YSGG laser on shear bond strength of cubic zirconia to two resin cement types.","authors":"Amira Abd Elsabour, Tarek Salah, Soha Osama","doi":"10.21608/edj.2024.251862.2806","DOIUrl":"https://doi.org/10.21608/edj.2024.251862.2806","url":null,"abstract":"Aim : To examine how various pre-sintering surface treatments affect the shear bond strength (SBS) between cubic zirconia and two types of resin cement. Materials and methods: Sixty cubic zirconia plates were Separated into three groups based on the pre-sintering surface treatment: Group A: air abraded using alumina particles; Group S: air abraded using silica-coated alumina particles and Group L: laser treated using Er,Cr,YSGG laser. All plates were sintered according to the manufacturer’s instructions. Phosphate-containing resin cement (subgroup P) was bonded to half of the plates, while conventional composite resin cement (subgroup C) was bonded to the other half. The strength of the shear bond was determined using a universal testing machine, and the failure mode was noticed using a digital microscope. Statistical analysis: A two-way ANOVA was utilised, followed by Tukey’s post hoc test. Results: Only surface treatment had a significant effect on bond strength (p 0.001). The highest value was found in Group A (6.680.70) Mpa, followed by Group S (4.820.73) Mpa, while the lowest value was found in Group L (0.570.08) Mpa. Conclusions: Air abrasion of pre-sintered cubic zirconia using alumina provided the highest bond strength to both types of resin cement.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histological and Immunohistochemical analysis of possible ameliorative effect of Ashwagandha on Methotrexate-Induced Oral Mucositis in Albino Rats 灰树花对甲氨蝶呤诱发的白化大鼠口腔黏膜炎的可能改善作用的组织学和免疫组化分析
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.261718.2875
H. Moubarak
{"title":"Histological and Immunohistochemical analysis of possible ameliorative effect of Ashwagandha on Methotrexate-Induced Oral Mucositis in Albino Rats","authors":"H. Moubarak","doi":"10.21608/edj.2024.261718.2875","DOIUrl":"https://doi.org/10.21608/edj.2024.261718.2875","url":null,"abstract":"Introduction: Oral mucositis is a common side effect of methotrexate chemotherapy; it represents a challenge for a successful cancer treatment, as it may lead to discontinuity of the chemotherapy. Ashwagandha is one of the most familiar Ayurveda herbs in India. Recently, it has gained attention due to its favorable biological effects. Aim: Investigation of the possible protective effect of Ashwagandha roots extract on methotrexate-induced oral mucositis in albino rats. Materials and methods: 40 rats were divided equally into 4 groups: (C): received distilled water, (ASH): received 300mg/kg ashwagandha root extract for 8 days, (MTX): received single dose of 60 mg/kg intraperitoneal injection of methotrexate on day 4, and (MTX/ASH): received 300mg/kg ashwagandha root extract daily for 8 days interrupted with 60 mg/kg i.p injection of methotrexate on day 4. Results: Histopathological examination revealed normal appearance of tongue and buccal mucosa in C and ASH groups. In MTX group there was atrophy of tongue papilla, decrease of epithelial thickness, flattening of rete pegs, nuclear pyknosis, nuclear hyperchromatism, karyorrhexis, disruption of basement membrane, inflammatory cells infiltrate, blood vessels congestion, muscle atrophy in both mucosae. In MTX/ASH group, both mucosae maintained normal appearance. Immunohistochemical results revealed significant decrease of Ki67 staining in MTX group compared to C and MTX/ASH groups in both mucosae, COX2 staining revealed significant increase in MTX group compared to C and MTX/ASH groups. Conclusion: Prophylactic administration of Ashwagandha root extract ameliorated the oral mucositis induced by methotrexate chemotherapy, therefore it could be a good adjuvant therapy during chemotherapeutic treatment.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140775967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameliorative Effect of L-Carnitine against Histopathological Changes Induced by Methotrexate on the Lingual Mucosa of Albino Rats 左旋肉碱对甲氨蝶呤引起的白化大鼠口腔黏膜组织病理学变化的改善作用
Egyptian dental journal Pub Date : 2024-04-01 DOI: 10.21608/edj.2024.265069.2902
Merhan Elmansy, Rasha Afifi, Randa El-sherbiny
{"title":"Ameliorative Effect of L-Carnitine against Histopathological Changes Induced by Methotrexate on the Lingual Mucosa of Albino Rats","authors":"Merhan Elmansy, Rasha Afifi, Randa El-sherbiny","doi":"10.21608/edj.2024.265069.2902","DOIUrl":"https://doi.org/10.21608/edj.2024.265069.2902","url":null,"abstract":"Background and objectives: Methotrexate (MTX) is a chemotherapeutic drug that is used in the treatment of many cancers and chronic inflammatory illnesses. Oral mucositis is a common side effect of MTX, which may lead to the discontinuation of chemotherapy. The study aimed to evaluate the possible protective effect of L-carnitine (LC) on the lingual mucosa of MTX-treated Albino rats. Material and Methods: Forty male albino rats were used in this experiment. The rats were divided into four experimental groups: Group 1 (negative control group), Group 2 (LC group), Group 3 (MTX group), and Group 4 (LC+MTX treated group). Rats were euthanized separately on day 14 th . Tongue specimens were processed for hematoxylin & eosin staining and immunohistochemically prepared for TNF-α, COX-2, and Bax expression. The data was analyzed and expressed statistically by the one-way ANOVA test. Results: The negative control and LC groups showed normal histological structures of the lingual mucosa. The MTX group showed destruction in normal histological structure, while the group that took LC as a protective agent before MTX induction, showed a marked protection to the lingual mucosa from the destructive effect of MTX. Immunohistochemical results revealed mild to moderate immune reactivity to TNF-α, COX-2, and Bax in the negative control, LC, and LC+MTX groups, while a strong immune reactivity was observed in the MTX group (p<0.05). Conclusion: The current study proved that LC could act as a prophylactic agent before MTX treatment to prevent oral mucositis.","PeriodicalId":11504,"journal":{"name":"Egyptian dental journal","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140768224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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