ecancermedicalscience最新文献

{"title":"Breast cancer in Cape Verde: a 24-year retrospective study of clinical presentation, treatment and outcomes at Agostinho Neto University Hospital.","authors":"Pamela Borges, Hirondina Borges Spencer, Stefani Furtado, Victor Costa, Carla Barbosa, Lúcio Lara Santos","doi":"10.3332/ecancer.2025.1826","DOIUrl":"10.3332/ecancer.2025.1826","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer is a significant health concern in Cape Verde, but comprehensive data on its presentation, management and outcomes are limited. This study aims to provide insights into breast cancer patterns in this island nation.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of 586 breast cancer patients treated at Agostinho Neto University Hospital in Praia, Cape Verde, from January 2000 to May 2024. Data on demographics, clinical presentation, diagnostic methods, treatment modalities and survival outcomes were collected and analysed.</p><p><strong>Results: </strong>The study population comprised 578 (98.6%) females and 8 (1.4%) males. The mean age at diagnosis was 52.1 years (SD 13.6) for females and 70 years (SD 16.7) for males. Stage III was the most common presentation (39.4%). Invasive ductal carcinoma was the predominant histological type. Immunohistochemical analysis in 307 patients revealed 69.4% luminal, 26.1% triple-negative and 4.6% HER2-positive subtypes. Treatment primarily involved surgery combined with chemotherapy and/or hormone therapy, with 33.4% receiving radiotherapy. The median follow-up was 36.5 months (range: 1-298 months), and the median survival time was 137.1 months.</p><p><strong>Conclusion: </strong>This study reveals breast cancer patterns in Cape Verde that share similarities with other African nations, including younger age at diagnosis and higher rates of late-stage presentation compared to Western countries. However, encouraging trends in survival outcomes and diagnostic capabilities were observed. These findings highlight the need for improved early detection strategies and expanded access to comprehensive treatment modalities, particularly radiotherapy, in Cape Verde.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"19 ","pages":"1826"},"PeriodicalIF":1.2,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver metastasis of retinoblastoma.","authors":"Elily D Apumayta, Mario Buitrago, Marco Rioja, Sandra Alarcon, Jhonatanael Salvador, Eloy Ruiz","doi":"10.3332/ecancer.2025.1824","DOIUrl":"10.3332/ecancer.2025.1824","url":null,"abstract":"<p><strong>Objective: </strong>To outline the clinical manifestations, imaging, management and prognosis of patients with liver metastases of retinoblastoma (RB).</p><p><strong>Methodology: </strong>Retrospective analysis of two cases diagnosed with liver metastasis of RB between 2018 and 2023 at the National Institute of Neoplastic Diseases in Lima, Peru.</p><p><strong>Results: </strong>A total of 2 (0.71%) out of 283 patients had liver metastases from RB, as confirmed by pathology. A 12-month-old female patient with unilateral RB pT1 without risk factors remains under observation after enucleation. After 5 months, she presented with multiple heterogeneous hepatic lesions up to 10 cm in size, with a hypodense center and slightly contrast-enhancing surface. She received chemotherapy and died 7 months later. The second case was a 2-year-old female with unilateral RB, pT3b and G3 with retrolaminar involvement of the optic nerve and choroidal invasion. She received adjuvant chemotherapy. After 21 months, she presented with multiple hypodense lesions with diffuse distribution in hepatic parenchyma, with distinct peripheral enhancement, some of which were confluent. She died without treatment 1 month later.</p><p><strong>Conclusion: </strong>Hepatic metastasis of RB is rare. In these two cases, they were presented as heterogeneous, predominantly hypodense lesions with mild contrast enhancement on the CT scan. These events were simultaneously associated with recurrence in the central nervous system, even in the absence of risk factors for metastasis and dissemination.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"19 ","pages":"1824"},"PeriodicalIF":1.2,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959138/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative and end-of-life care initiatives for people dying from cancer in India: a narrative review.","authors":"Naveen Salins, Krithika Rao, Anuja Damani, Sushma Bhatnagar, Srinagesh Simha","doi":"10.3332/ecancer.2024.1822","DOIUrl":"10.3332/ecancer.2024.1822","url":null,"abstract":"<p><p>India is facing a growing burden of cancer, resulting in high cancer-associated mortality. However, the rise in cancer incidence is disproportionately high compared to access and provision of palliative care. This review aims to identify gaps in Indian cancer palliative care and recognises initiatives instituted to mitigate them. The narrative review was conducted using the four-step method described by Demiris et al., synthesising both empirical and non-empirical literature. A lack of capacity to provide palliative care was identified as a significant barrier. Initiatives such as setting up palliative care services in cancer treatment centres, improving community palliative care access, structured palliative care training to develop specialists, improving opioid availability and creating policies have been helpful. A significant proportion of people in India experience health-related suffering, and developing a tool to identify this suffering proactively would be beneficial. Several cancer centres are testing integrated cancer palliative care models in various cancer subsites. However, these are preliminary works and are yet to be established. People in India face distress due to high health-related costs, and initiatives like hospices and home-based palliative care services with no cost to patients and families provide significant relief. Caregivers experience a considerable burden while caring for their loved ones with life-limiting illnesses, and they are supported through respite palliative care services offered in some parts of India.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1822"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' and nurses' perception of the Hospice-On-Wheels service in Kazakhstan: a qualitative study.","authors":"Anele Bekturova, Angelika Saryan, Gulnara Kunirova","doi":"10.3332/ecancer.2024.1818","DOIUrl":"10.3332/ecancer.2024.1818","url":null,"abstract":"<p><strong>Background: </strong>In Kazakhstan, the Comprehensive Cancer Control Plan has led to the establishment of 214 mobile teams funded by the Ministry of Health to offer in-home palliative care for terminal cancer patients. However, due to a shortage of trained and dedicated personnel, only about 25% of these teams provide high-quality, specialised care in the comfort of patient's homes, with the majority offering only consultative services. Given the country's sparse population, ensuring dedicated care is challenging and many staff members continue as part-time primary care workers. In this landscape, the 'Amazonka' Foundation's Hospice-On-Wheels initiative emerges as the sole NGO non-government organisation (NGO)-based service delivering in-home palliative care of comparable quality. Distinguished by its contract with the Ministry of Labour and Social Protection, Hospice-On-Wheels enjoys greater organisational flexibility and provides a broader spectrum of services, all while maintaining rigorous standards of multidisciplinary care.</p><p><strong>Aims: </strong>The aims of this study are to assess the effectiveness and sustainability of an NGO-based in-home palliative care service in Kazakhstan and to discuss the qualitative methodology and its characteristics to Kazakhstani nurses, unfamiliar with quality nursing research.</p><p><strong>Methods: </strong>The study commenced with a descriptive phenomenological approach and a service design methodology, later transitioning from phenomenological thematic analysis to content analysis.</p><p><strong>Results: </strong>These rapid research findings highlight the exceptional effectiveness, customer satisfaction and cost-saving advantages of the NGO-based initiative. These benefits extend not only to the government and health authorities but also to patients and their families. The 'Amazonka' service significantly enhances the quality of life for incurable cancer patients through improved palliative care. Consequently, expanding their infrastructure and educational initiatives is essential to promote better palliative care in Kazakhstan, particularly in rural areas.</p><p><strong>Discussion: </strong>The insights from this study can advocate for the home-based palliative care model employed by the 'Amazonka' team, encouraging its adoption by both governmental organisations and NGOs in Kazakhstan and beyond, thus opening new opportunities for local funding in resource-limited conditions.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1818"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Teaching empathy and compassion to healthcare providers in palliative care: a scoping review.","authors":"Seema Rajesh Rao, Mithili Narayan Sherigar, Michelle Normen, Udita Joshi","doi":"10.3332/ecancer.2024.1817","DOIUrl":"10.3332/ecancer.2024.1817","url":null,"abstract":"<p><p>Empathy and compassion are core competencies that healthcare providers (HCPs) require when caring for patients and families with life-threatening illnesses like cancer. These constructs are often challenging to define and generalise and are often used interchangeably. Medical education has evolved from the traditional curriculum-based approach to a more eclectic competency-based approach. The purpose of this review is to explore the current evidence on teaching compassionate care for palliative care issues in cancer settings in lower-middle-income countries. A preliminary search of the Scopus database from 2,000 until now identified 1,502 records, of which 54 peer-reviewed articles were included in this review. Training in compassion and empathy was delivered in three formats: online, face-to-face and blended learning or hybrid. The training modalities were didactic, experiential and reflective, with many educational interventions using a multimodal approach. The educational interventions reported a positive outcome and improvement in empathetic and compassionate behaviours. However, they were limited due to inadequately defined constructs, use of self-reported outcome measures and difficulty in ascertaining if these skills were retained long-term and were translated into the clinical settings. Given that compassion and empathy are multidimensional constructs, it is imperative that educational interventions be multimodal and learner-centred, focusing on developing the knowledge, attitudes, skills and behaviours of the HCP in providing compassionate care while aiming for conceptual clarity regarding definition and more robust validated outcome measures.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1817"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creating the evidence base for palliative care in cancer - models and strategies to build research capacity.","authors":"Eve Namisango, Tonia Onyeka, Nafula Esther, Emmanuel B K Luyirika, Zipporah Ali, Richard A Powell","doi":"10.3332/ecancer.2024.1819","DOIUrl":"10.3332/ecancer.2024.1819","url":null,"abstract":"<p><strong>Background: </strong>The need for palliative care in cancer is highest in resource-limited settings given the high disease burden, which is projected to double by 2050, and late patient presentation. To stimulate service development and ensure care is aligned to patients' and families' needs, robust evidence is needed. However, Africa continues to be under-represented globally in evidence development, due to lack of a critical research mass and financial and infrastructure challenges. Despite these limitations, the region is witnessing growth in research for palliative care in cancer. This review aimed to identify models, strategies and practices for building capacity for research and creation of an evidence base for palliative care in cancer in Africa.</p><p><strong>Approach: </strong>We reviewed grey and published literature to identify models, strategies and practices for building capacity for research and creation of an evidence base for palliative care in cancer in Africa. The findings were summarised using narrative synthesis.</p><p><strong>Findings: </strong>Models and strategies identified, which are not mutually exclusive, include: community engagement; centres of excellence; knowledge exchange platforms; research networks; practice-based research networks; local collaboration and Global South-to-South partnerships and Global North-to-South partnerships.</p><p><strong>Conclusion: </strong>The evidence base for palliative care in cancer in Africa is growing in Africa and identifiable models can and are steering this growth.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1819"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric palliative care in cancer.","authors":"Julia Downing, Alexandra Daniels, Michael J McNeil, Mariam Ndagire, Gayatri Palat, Rime S Rassam, Justin N Baker","doi":"10.3332/ecancer.2024.1823","DOIUrl":"10.3332/ecancer.2024.1823","url":null,"abstract":"<p><p>More than 21 million children globally need access to palliative care (PC) - including children with cancer. Providing Paediatric Palliative Care (PPC) for children with cancer is an ethical imperative with pain relief being recognised as a human right and an important public health consideration, with PPC being essential for reducing suffering in children and families. PPC addresses children's symptoms and aims to provide comfort even if a cure is not possible. PC for children with cancer is about ensuring that the child and family have the best possible quality of life starting at diagnosis and throughout the disease trajectory regardless of cancer treatment outcomes. Many principles of PPC for children with cancer are similar to those for children with other serious health conditions. These include the following: promotion of quality of life; provision of PC care across the continuum of care (from diagnosis through to bereavement); pain and symptom management; emotional support; social care; spiritual care; good communication with children and family; advance care planning; end-of-life care; and bereavement care. PPC should be provided across the range of care settings, wherever the child and their family need care, by an inter-disciplinary team providing support to the child, their families (including siblings) and other significant others, and consider the financial impact of having a child with cancer. It should not be a last resort, but an essential component of care. In this paper, we provide a brief overview of the integration of PPC into paediatric cancer care through the review of challenges in providing PPC in paediatric oncology, global examples of clinical provision of PPC in paediatric cancer care, a review of global research priorities in this area and examples of global education programmes aimed at improving PPC in paediatric cancer care.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1823"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial toxicity in cancer palliative care in India: Addressing existence and beyond - Seeking remedies for a balanced financial journey.","authors":"Saurabh Joshi, Anuja Damani, Anant Garg, Sunny Malik, Ajay Kumar Dewan, Rakesh Sharma, Upkar Joshi","doi":"10.3332/ecancer.2024.1820","DOIUrl":"10.3332/ecancer.2024.1820","url":null,"abstract":"<p><p>Financial toxicity (FT) places a significant burden on individuals undergoing cancer care, leading to emotional distress, social isolation and financial burnout. In India, the growing number of cancer cases and the ever-expanding population, combined with insufficient government investment in public healthcare, inadequate insurance coverage, poor financial literacy among medical and non-medical communities and the lack of comprehensive financial planning exacerbate the financial difficulties faced by patients. This article aims to address FT as a source of suffering and explores potential frameworks and solutions for preventing and managing FT in patients undergoing cancer treatment and seeking palliative and hospice care in India. We conducted a literature search to review the burden of FT, across diverse healthcare settings for cancer patients. The prevalence of FT in cancer care ranges from 30% to 90.1% and is influenced by various socio-demographic, disease and healthcare-related factors. The sources of distress financing include consumption of savings, asset sales and borrowing, which add to the financial suffering. This interdisciplinary collaborative research paper highlights the dearth of financial literacy in our population and emphasises the pressing need to enhance financial awareness for healthcare professionals, cancer patients and their families. More than 30% of the Indian population lacks any form of insurance coverage, and many of those who do have it mostly lack 'adequate' coverage. We explore essential financial strategies, such as budgeting, expense analysis, asset consolidation, liquidity management, understanding estate planning tools and banking operations, streamlining paperwork, ensuring smooth transactions, adopting methods like low-interest loans and crowdfunding platforms, advance care planning, early palliative care ntegration and timely transition to hospice care. We also highlight the importance of available community resources, non-profit organisations, cancer foundations, health insurance and government support. Overall, integrating financial planning into cancer palliative care seems essential for reducing FT and enhancing the quality of cancer care in India. Further research on the topic is needed.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1820"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of pain in cancer patients - an update.","authors":"María Laura Daud, Gustavo G De Simone","doi":"10.3332/ecancer.2024.1821","DOIUrl":"10.3332/ecancer.2024.1821","url":null,"abstract":"<p><p>Pain is one of the most detrimental symptoms exhibited by cancer patients, being an indication for opioid therapy in up to half of the patients receiving chemotherapy and even more for those with advanced cancer. This article aims to briefly overview current knowledge on cancer-related pain with a focus on assessment and new approaches and trends. We will also provide some insight on the lower- and middle-income countries context.</p><p><strong>Data sources: </strong>A narrative review of the literature was conducted including relevant guidelines and recommendations from scientific societies and WHO.</p><p><strong>Data summary: </strong>Data on the approach and assessment of cancer pain as well as current and novel approaches have been displayed with the help of tables and figures.</p><p><strong>Conclusion: </strong>Since the initial recommendations of the WHO analgesic ladder method, new insights have emerged. Scientific progress reaches its maximum social sense when populations and governments prioritise the value of relief and compassion, and concrete actions are implemented with the aim of relieving cancer pain.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1821"},"PeriodicalIF":1.2,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Should we perform baseline NGS testing in precursor T lymphoblastic leukaemias: a single centre experience from Eastern India.","authors":"Prateek Das, Sujeet Kumar, Raghwesh Ranjan, Pradeep Arumugam, Nilesh Dhole, RohitKumar Kori, Anil Yadav, Anil Singh, Vikramjit Kanwar, Neha Singh","doi":"10.3332/ecancer.2024.1815","DOIUrl":"10.3332/ecancer.2024.1815","url":null,"abstract":"<p><strong>Introduction: </strong>T-lymphoblastic leukaemia accounts for approximately one-fourth of acute lymphoblastic leukaemia cases. Sequencing approaches have identified >100 genes that can be mutated in T-cell acute lymphoblastic leukaemia (T-ALL). However, the revised WHO 2022 edition of lymphoid neoplasms still does not incorporate molecular signatures into the T-ALL subgrouping unlike B-ALLs and acute myeloid leukemia, which are classified mainly based on molecular landscapes.</p><p><strong>Methods: </strong>This retrospective observational study included all newly diagnosed patients of T-lymphoblastic leukaemia of all age groups who presented during the period between January 2022 and October 2023 in whom complete baseline diagnostic work-up was available including flow cytometry, fluorescence in situ hybridization and next generation sequencing studies.</p><p><strong>Results: </strong>There was a lower frequency of karyotypic abnormalities in adult early T progenitor (ETP)-ALLs than in other sub-groups. Non-ETP ALLs showed significant association with NOTCH1 mutations (<i>p</i> ≤ 0.00001), followed by JAK3 (<i>p</i> = 0.01), FBXW7 (<i>p</i> = 0.066) and PHF6 (<i>p</i> = 0.09) mutations. There was no difference between adult and pediatric patients, in terms of genomic profiling except in the PHF6 gene. There was no significant difference between NOTCH1-mutated and NOTCH1-wild T-ALL patients as well as NOTCH1-heterodimerization versus NOTCH1-PEST mutated patients in terms of measurable residual disease (MRD), relapse-free survival (RFS) and/or overall survival (OS). 45.1% of all TALL patients harboured ≥3 mutations. However, the complex molecular profile did not correlate significantly with MRD positivity and poor RFS and/or OS rates.</p><p><strong>Conclusion: </strong>Molecular profiling of TALLs do not significantly impact long-term survival outcomes. In resource-constrained settings, we can get away by not doing comprehensive molecular profiling of TALLs at baseline and restrict the sequencing assay to only those cases that are persistently MRD positive or have relapsed.</p>","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1815"},"PeriodicalIF":1.2,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11959121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}