Duke Mathematical Journal最新文献_第2页

Socioeconomic Status and Kawasaki Disease Outcomes in a Single-Payer Health Care System. 单一付款人医疗保健系统中的社会经济地位和川崎病结局。

1区数学

Duke Mathematical Journal Pub Date : 2022-11-01 eCollection Date: 2022-12-01 DOI: 10.1016/j.cjcpc.2022.10.007

Jonathan P Wong, Kyle Runeckles, Cedric Manlhiot, Sunita O'Shea, Tanveer Collins, Bailey Bernknopf, Pedrom Farid, Nita Chahal, Brian W McCrindle

{"title":"Socioeconomic Status and Kawasaki Disease Outcomes in a Single-Payer Health Care System.","authors":"Jonathan P Wong, Kyle Runeckles, Cedric Manlhiot, Sunita O'Shea, Tanveer Collins, Bailey Bernknopf, Pedrom Farid, Nita Chahal, Brian W McCrindle","doi":"10.1016/j.cjcpc.2022.10.007","DOIUrl":"10.1016/j.cjcpc.2022.10.007","url":null,"abstract":"Background: For patients with Kawasaki disease (KD), lower socioeconomic status (SES) may adversely affect the timeliness of presentation and initiation of intravenous immune globulin, and coronary artery outcomes. Multipayer systems have been shown to affect health care equity and access to health care negatively. We sought to determine the association of SES with KD outcomes in a single-payer health care system.Methods: Patients with KD presenting from 2007 to 2017 at a single institution were included. SES data were obtained by matching patient postal code district with data from the 2016 Census Canada.Results: SES data were linked for 1018 patients. The proportion of households living below the after-tax low-income cutoff in the patient's postal code district was 13% for not treated, 13% for delayed intravenous immune globulin treatment, and 12% for prompt treatment (P = 0.58). Likewise, the average median annual household income was unrelated to delayed or no treatment. The percentage >15 years of age with advanced education differed between groups at 33%, 29%, and 31% for delayed treatment, prompt treatment, and missed groups, respectively (P = 0.004). SES variables were not significantly different for those with vs without coronary artery aneurysms (max Z-score: >2.5), including the proportion of households living below low-income cutoff (12% vs 13%; P = 0.37), average median annual household income (CAD$81,220 vs $82,055; P = 0.78), and proportion with a university degree (33% vs 31%; P = 0.49), even after adjusting for sex, age, year, and KD type.Conclusions: Timeliness of treatment for KD and coronary artery outcomes were not associated with SES variables within a single-payer health care system.","PeriodicalId":11447,"journal":{"name":"Duke Mathematical Journal","volume":"61 1","pages":"248-252"},"PeriodicalIF":0.0,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10642103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88083758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Supporting newly qualified nurses to develop their leadership skills. 支持新获得资格的护士发展领导技能。

1区数学

Duke Mathematical Journal Pub Date : 2022-10-06 DOI: 10.7748/nm.2022.e2031

Debbie Rainey, Catherine Monaghan

引用次数: 0

Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination. 可吸入的聚合物纳米颗粒用于通用mRNA传递和粘膜疫苗接种。

1区数学

Duke Mathematical Journal Pub Date : 2022-03-23 DOI: 10.1101/2022.03.22.485401

Alexandra Suberi, Molly K Grun, Tianyang Mao, Benjamin Israelow, Melanie Reschke, Julian Grundler, Laiba Akhtar, Teresa Lee, Kwangsoo Shin, Alexandra S Piotrowski-Daspit, Robert J Homer, Akiko Iwasaki, Hee Won Suh, W Mark Saltzman

{"title":"Inhalable polymer nanoparticles for versatile mRNA delivery and mucosal vaccination.","authors":"Alexandra Suberi, Molly K Grun, Tianyang Mao, Benjamin Israelow, Melanie Reschke, Julian Grundler, Laiba Akhtar, Teresa Lee, Kwangsoo Shin, Alexandra S Piotrowski-Daspit, Robert J Homer, Akiko Iwasaki, Hee Won Suh, W Mark Saltzman","doi":"10.1101/2022.03.22.485401","DOIUrl":"10.1101/2022.03.22.485401","url":null,"abstract":"An inhalable platform for mRNA therapeutics would enable minimally invasive and lung targeted delivery for a host of pulmonary diseases. Development of lung targeted mRNA therapeutics has been limited by poor transfection efficiency and risk of vehicle-induced pathology. Here we report an inhalable polymer-based vehicle for delivery of therapeutic mRNAs to the lung. We optimized biodegradable poly(amine-co-ester) polyplexes for mRNA delivery using end group modifications and polyethylene glycol. Our polyplexes achieved high transfection of mRNA throughout the lung, particularly in epithelial and antigen-presenting cells. We applied this technology to develop a mucosal vaccine for SARS-CoV-2. Intranasal vaccination with spike protein mRNA polyplexes induced potent cellular and humoral adaptive immunity and protected K18-hACE2 mice from lethal viral challenge.One-sentence summary: Inhaled polymer nanoparticles (NPs) achieve high mRNA expression in the lung and induce protective immunity against SARS-CoV-2.","PeriodicalId":11447,"journal":{"name":"Duke Mathematical Journal","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8963702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88068112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anderson–Bernoulli localization on the three-dimensional lattice and discrete unique continuation principle 三维点阵的Anderson-Bernoulli局部化及离散唯一延拓原理

IF 2.5 1区数学

Duke Mathematical Journal Pub Date : 2022-02-01 DOI: 10.1215/00127094-2021-0038

Linjun Li, Lingfu Zhang

引用次数: 9

Fourier multipliers in SLn(R) SLn（R）中的傅立叶乘法器

IF 2.5 1区数学

Duke Mathematical Journal Pub Date : 2022-01-01 DOI: 10.1215/00127094-2021-0042

Javier Parcet, Éric Ricard, Mikael de la Salle

{"title":"Fourier multipliers in SLn(R)","authors":"Javier Parcet, Éric Ricard, Mikael de la Salle","doi":"10.1215/00127094-2021-0042","DOIUrl":"https://doi.org/10.1215/00127094-2021-0042","url":null,"abstract":"We establish precise regularity conditions for Lp-boundedness of Fourier multipliers in the group algebra of SLn(R). Our main result is inspired by Hörmander-Mikhlin criterion from classical harmonic analysis, although it is substantially and necessarily different. Locally, we get sharp growth rates of Lie derivatives around the singularity and nearly optimal regularity order. The asymptotics also match Mikhlin formula for a exponentially growing metric with respect to the word length. Additional decay comes imposed by this growth and Mikhlin condition for high order terms. Lafforgue/de la Salle’s rigidity theorem fits here. The proof includes a new relation between Fourier and Schur Lp-multipliers for nonamenable groups. In SLn(R), this holds in terms of Harish-Chandra’s almost L2 matrix coefficients. By transference, matters are reduced to a rather nontrivial RCp-inequality for SLn(R)-twisted forms of Riesz transforms associated to fractional laplacians. Our second result gives a new and much stronger rigidity theorem for radial multipliers in SLn(R). More precisely, additional regularity and Mikhlin type conditions are proved to be necessary up to an order ∼ | 1 2 − 1 p |(n − 1) for large enough n in terms of p. Locally, necessary and sufficient growth rates match up to that order. Asymptotically, extra decay for the symbol and its derivatives imposes more accurate and additional rigidity in a wider range of Lp-spaces. This rigidity increases with the rank, so we can construct radial generating functions satisfying our Hörmander-Mikhlin sufficient conditions in a given rank n and failing the rigidity conditions for ranks m >> n. We also prove automatic regularity and rigidity estimates for first and higher order derivatives of K-biinvariant multipliers in the rank 1 groups SO(n, 1).","PeriodicalId":11447,"journal":{"name":"Duke Mathematical Journal","volume":"1 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43652466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"数学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

An intersection formula for CM cycles on Lubin–Tate spaces Lubin-Tate空间上CM环的交点公式

IF 2.5 1区数学

Duke Mathematical Journal Pub Date : 2022-01-01 DOI: 10.1215/00127094-2021-0062

Qi-Rui Li

引用次数: 3

Honda–Tate theory for Shimura varieties 志村变异的Honda-Tate理论

IF 2.5 1区数学

Duke Mathematical Journal Pub Date : 2022-01-01 DOI: 10.1215/00127094-2021-0063

M. Kisin, Keerthi Madapusi Pera, S. Shin

引用次数: 21

A planarity estimate for pinched solutions of mean curvature flow 平均曲率流缩紧解的平面性估计

IF 2.5 1区数学

Duke Mathematical Journal Pub Date : 2022-01-01 DOI: 10.1215/00127094-2021-0026

Keaton Naff

引用次数: 9

On holonomy singularities in general relativity and the Cloc0,1-inextendibility of space-times 广义相对论中的完整奇点与时空的cloc1,1不可扩展性

IF 2.5 1区数学

Duke Mathematical Journal Pub Date : 2022-01-01 DOI: 10.1215/00127094-2022-0040

Jan Sbierski

引用次数: 12

Closed hypersurfaces of low entropy in R4 are isotopically trivial R4中的低熵闭超曲面是同位素平凡的

IF 2.5 1区数学

Duke Mathematical Journal Pub Date : 2022-01-01 DOI: 10.1215/00127094-2022-0012

J. Bernstein, Lu Wang

引用次数: 12