Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy最新文献_第9页

Abortion rate in assisted reproduction--true increase? 辅助生殖的流产率——真的增加了吗?

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-09-01

Y Ezra, J G Schenker

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The effect of short- vs. long-term platelet-activating factor exposure on mouse preimplantation embryo development. 短期与长期血小板活化因子暴露对小鼠着床前胚胎发育的影响。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-09-01

G Radonjic-Lazovic, W E Roudebush

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Endothelins inhibit FSH-mediated function via ETA receptors in cultured human granulosa-lutein cells. 内皮素通过ETA受体在培养的人颗粒叶黄素细胞中抑制fsh介导的功能。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-09-01

C Furger, J R Zorn, F Ferré

{"title":"Endothelins inhibit FSH-mediated function via ETA receptors in cultured human granulosa-lutein cells.","authors":"C Furger, J R Zorn, F Ferré","doi":"","DOIUrl":"","url":null,"abstract":"Endothelins (ETs) are a family of vasoactive peptides involved in granulosa and luteal cell function in some animal species. However, the potential relevance of ETs in ovarian physiology remains unclear, and the direct action of the peptides in the human ovary has not been studied to date. Experiments were conducted to determine whether ET-1 and ET-3 could regulate the follicle stimulating hormone (FSH)-induced cell response in human granulosa-lutein cells in culture. The FSH-mediated cell rounding process was used as an indicator of cell response, as previously described (Lawrence et al., 1979). Forskolin, cholera toxin, 8-Br-cyclic AMP, isobutylmethylxanthine (IBMX), rolipram and FSH all stimulated similar cell morphological changes, indicating that the cell rounding process was mediated by cyclic AMP. Although ET-1 and ET-3 alone failed to alter cell shape, the FSH-induced cell response was totally inhibited by treatment with ET-1 (10(-10) mol/l) and ET-3 (10(-7) mol/l). In addition, treatment of the cells with BQ123, an antagonist of ET binding on ETA receptor subtype, totally prevented the inhibitory effects of ET-1 and ET-3 on the FSH-induced response. The data presented here show that human granulosalutein cells are a site of ET reception and action. Endothelins inhibit cyclic AMP-dependent FSH-mediated function and the ET(A) receptor participates in this effect.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"1 3","pages":"188-95"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20293008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The relationship of corpus luteum volume to relaxin, estradiol, progesterone, 17-hydroxyprogesterone and human chorionic gonadotropin levels in early normal pregnancy. 正常妊娠早期黄体体积与舒张素、雌二醇、黄体酮、17-羟黄体酮及绒毛膜促性腺激素水平的关系

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-09-01

J L Glock, S T Nakajima, D R Stewart, G J Badger, J R Brumsted

{"title":"The relationship of corpus luteum volume to relaxin, estradiol, progesterone, 17-hydroxyprogesterone and human chorionic gonadotropin levels in early normal pregnancy.","authors":"J L Glock, S T Nakajima, D R Stewart, G J Badger, J R Brumsted","doi":"","DOIUrl":"","url":null,"abstract":"Our purpose was to characterize the growth pattern of the corpus luteum of early normal human pregnancy and correlate this growth with the corpus luteum hormone products: relaxin, progesterone, estradiol and 17-hydroxyprogesterone. A prospective study of seven patients was initiated at a mean gestational age of 4 weeks and 2 days. Corpus luteum volume and hormone concentrations were determined for each study patient every 48 h for a period of 2 weeks. Transvaginal imaging of the corpus luteum was performed by a single observer. Corpus luteum volume was calculated using the formula for an ellipsoid (4/3 pi abc/8). Correlation between corpus luteum volume and hormone concentrations was tested using Pearson's r. There was a mean three-fold increase in corpus luteum volume between 4 and 6 weeks' gestational age. Concomitantly, relaxin and estradiol concentrations increased, 17-hydroxyprogesterone declined slightly, progesterone remained stable and human chorionic gonadotropin (hCG) increased exponentially. Mean positive correlations were shown between corpus luteum volume and relaxin (r = 0.72), corpus luteum volume and hCG (r = 0.68), and hCG and relaxin (r = 0.82). However, there was a lack of correlation between corpus luteum volume and estradiol, progesterone and 17-hydroxyprogesterone. We have shown that a rapid increase in the corpus luteum volume occurs in early normal human pregnancy without a parallel rise in the classic corpus luteum steroid products. We interpret these findings to suggest that growth of the corpus luteum in early human pregnancy is largely derived from the proliferation of non-steroid secreting cells. The precise role of these cells in controlling steroidogenesis in this gland has yet to be defined.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"1 3","pages":"206-11"},"PeriodicalIF":0.0,"publicationDate":"1995-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20293011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin-1 alpha in the rabbit uterus during early pregnancy. 兔妊娠早期子宫中白细胞介素-1 α的变化。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-09-01

Z M Yang, D B Chen, S P Le, M J Harper

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Current progress in early pregnancy investigation. 早期妊娠研究进展。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-09-01

B M Polliotti

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Current progress in early pregnancy investigation. 早期妊娠研究进展。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-06-01

B Polliotti

引用次数: 0

Production of superoxide dismutase, beta 2-microglobulin and ubiquitin by human term decidua in vitro. 人蜕虫卵体外产生超氧化物歧化酶、β 2微球蛋白和泛素的研究。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-06-01

S G Ren, G D Braunstein

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Peroxidase activity and glutathione content in the human first-trimester placenta and decidua. 人妊娠早期胎盘和蜕膜中过氧化物酶活性和谷胱甘肽含量。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-06-01

E R Barnea, M Sorkin, J D Barnea

{"title":"Peroxidase activity and glutathione content in the human first-trimester placenta and decidua.","authors":"E R Barnea, M Sorkin, J D Barnea","doi":"","DOIUrl":"","url":null,"abstract":"Objective: Recently, a novel pathway of xenobiotic oxidation by peroxidase in the placenta at term was described. Herein, we aim to determine the potential of the first-trimester placenta and decidua to activate carcinogens and mutagens by peroxidase and to scavenge free radicals by glutathione.Methods: Placental and decidual peroxidase activity was measured using a sensitive, quantitative colorimetric kinetic assay, with O-phenylenediamine dihydrochloride (OPD) as substrate and H2O2 as co-substrate. Glutathione levels were measured using a colorimetric assay.Results: Peroxidase activity in cytosolic and CaCl2-extracted (membrane-bound) fractions was inhibited by a specific inhibitor, NaN3. The membrane-bound peroxidase activity was maximal at 12 weeks of gestation while cytosolic peroxidase activity did not change. Placental glutathione content remained unchanged during the first trimester. Decidual and placental peroxidase activities were similar; however decidual glutathione content was 15-fold lower, resulting in a higher decidual peroxidase activity/glutathione ratio (p < 0.03).Conclusions: We report for the first time that peroxidase may be an important pathway for xenobiotic activation at the maternal-embryonal interface. It remains to be established whether the low glutathione content limits the ability of the decidua but not placenta to protect against genomic damage induced through xenobiotic oxidation.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"1 2","pages":"141-7"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20292488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Regulation of placental prorenin secretion from the early human placenta in vitro. 早期人胎盘泌乳素分泌的体外调控。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1995-06-01

A Szilágyi, A K Mukhopadhyay, J Werling, I Szabó

{"title":"Regulation of placental prorenin secretion from the early human placenta in vitro.","authors":"A Szilágyi, A K Mukhopadhyay, J Werling, I Szabó","doi":"","DOIUrl":"","url":null,"abstract":"The presence of all components of the renin-angiotensin system within the human placenta appears to be well established, but their function and regulation remain obscure. In order to approach this question, placental tissue explants (50 mg) from early human placenta (9-12 weeks of gestation) were cultured in Medium 199. Prorenin was measured by direct immunoradiometric assay in the daily replaced culture medium. In a further series of experiments, progesterone, a progesterone antagonist (ZK 98,299) or estradiol was added to the medium at final concentrations of 10(-4)-10(-8) mol/l. Prorenin was detectable in the culture medium of early human placental explants, and prorenin values were decreased by progesterone in a dose-dependent manner. Progesterone antagonist and estradiol could also inhibit prorenin secretion, but the inhibition was less prominent. When progesterone and progesterone antagonist were co-administered at equimolar concentration, a decrease in prorenin secretion occurred, but it could not reach the inhibitory effect of progesterone given alone. It is concluded that prorenin activity is present in the early human placenta, and prorenin secretion may be influenced by progesterone and estradiol. Regulation of prorenin secretion by steroid hormones is partly similar to that of human chorionic gonadotropin, but its physiological significance awaits further exploration.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"1 2","pages":"119-23"},"PeriodicalIF":0.0,"publicationDate":"1995-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20292484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0