Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy最新文献_第3页

Characterization of human chorionic gonadotropin in normal and abnormal pregnancies. 人绒毛膜促性腺激素在正常和异常妊娠中的特征。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-09-01

H H Ho, J F O'Connor, S T Nakajima, J Tieu, J W Overstreet, B L Lasley

{"title":"Characterization of human chorionic gonadotropin in normal and abnormal pregnancies.","authors":"H H Ho, J F O'Connor, S T Nakajima, J Tieu, J W Overstreet, B L Lasley","doi":"","DOIUrl":"","url":null,"abstract":"In this study circulating human chorionic gonadotropin (hCG) levels in the peri-implantation period of natural cycles of normal women were characterized. The hypothesis that the bioactivity of hCG in abnormal pregnancies is different from that in normal pregnancies was tested daily through serum hCG measurements in two immunoenzymometric assays, a radioreceptor assay and a human luteinizing hormone/human chorionic gonadotropin--cyclic adenosine monophosphate--luciferase bioassay. In normal pregnancies, the levels of immunoreactive and bioactive hCG were higher than in abnormal pregnancies (p < 0.05). In addition, the slopes of the rise in concentration of hCG as measured in all four assays were significantly greater for normal pregnancies than for abnormal pregnancies (p < 0.01). The rate of rise of hCG bioactivity was significantly greater than the rise of immunoreactivity or receptor-binding activity in normal pregnancies, but this difference was not observed in abnormal pregnancies. These results indicate that: (1) A steep rise of bioactive hCG is a consistent feature of the peri-implantation period of normal pregnancies. (2) Abnormal pregnancies had a deficiency in the production of hCG, which was reflected in both the hCG levels and the rate of increase, even in the first week of implantation. (3) Some abnormal pregnancies produced hCG with lower biological activity than the hCG of normal pregnancies.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 3","pages":"213-24"},"PeriodicalIF":0.0,"publicationDate":"1997-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20958708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothesis: antiphospholipid antibodies associated with congenital anomalies? 假设:抗磷脂抗体与先天性异常有关?

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

C B Coulam

{"title":"Hypothesis: antiphospholipid antibodies associated with congenital anomalies?","authors":"C B Coulam","doi":"","DOIUrl":"","url":null,"abstract":"Antiphospholipid antibodies have been associated with pregnancy loss. We now present a possible association between antiphospholipid antibodies, recurrent spontaneous abortion and congenital anomalies. L.M. is a 32-year-old woman, gravida 6, para 2023, whose obstetric history includes three spontaneous abortions and two infants with congenital anomalies including kidney atresia and oromandibular hypogenesis. The only normal offspring are twins born after receiving treatment of aspirin 80 mg daily during the pregnancy. Laboratory evaluation revealed the presence of circulating antiphospholipid antibodies. Antiphospholipid antibodies cause endothelial cell activation which has been proposed as a cause of congenital malformations. This case suggests the risk of not only recurrent spontaneous abortion but also congenital anomalies in the offspring of a women with antiphospholipid antibodies. The congenital anomalies are 'regional' and could result from embryonic vascular accidents as a result of antiphospholipid antibody interaction with endothelial cells. The only 'successful' pregnancy was with treatment with aspirin. If the associations illustrated in this obstetric history can be substantiated by population-based studies, it may be concluded that antiphospholipid antibodies are a risk factor for embryo teratogenicity as well as mortality.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 2","pages":"109-12"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20359383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunobiology and immunopathology of early pregnancy. 早孕的免疫生物学和免疫病理学。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

D Rukavina, T J Gill

引用次数: 0

Ultrastructure of intermediate trophoblast cells during morphogenesis of syncytiotrophoblast in early human pregnancy. 人妊娠早期合胞滋养细胞形态发生过程中中间滋养细胞的超微结构。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

M Jaggi, P K Mehrotra, S C Maitra, S L Agarwal, K Das

{"title":"Ultrastructure of intermediate trophoblast cells during morphogenesis of syncytiotrophoblast in early human pregnancy.","authors":"M Jaggi, P K Mehrotra, S C Maitra, S L Agarwal, K Das","doi":"","DOIUrl":"","url":null,"abstract":"During human embryonic development the process of differentiation begins in the cells covering the blastocyst, resulting in the formation of outer syncytial and inner cytotrophoblastic cell layers. Although the outer syncytial layer is known to be derived from the underlying layer of mononuclear cytotrophoblasts, the cellular mechanism involved in its morphogenesis is not clear. Furthermore, there is another type of cells, designated as intermediate trophoblasts, which play a vital role in syncytium formation. Using early first-trimester (6-10 weeks' gestation) human chorionic villi, a study was carried out to illustrate the ultrastructural features of these cells. It was observed that while there was a large number of coated vesicles, vacuoles, lysosomes and dense granules in the syncytiotrophoblast, in cytotrophoblasts there was a relatively smaller number. In intermediate cells, however, these organelles were more abundant. Moreover, a discontinuity in the plasma membrane along with gap junctions was frequently observed in these cells. Since these features represent the transitional stage of a differentiating cell, it is possible that the syncytiotrophoblast is in fact formed by the differentiation of intermediate trophoblasts.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 2","pages":"113-8"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20359384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The embryo: a privileged entity in a privileged site: lessons learnt from embryonal development. 胚胎:特权地点的特权实体:从胚胎发育中学到的教训。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

E R Barnea

引用次数: 0

Trophoblast differentiation and invasion: its significance for human embryo implantation. 滋养细胞的分化和侵袭:对人胚胎着床的意义。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

P Bischof, A Campana

引用次数: 0

Non-placental production of pregnancy-associated plasma protein A (PAPP-A): old and new evidence. 妊娠相关血浆蛋白A (PAPP-A)的非胎盘产生:新旧证据

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

N A Bersinger, H J Altermatt, M H Birkhäuser, M L Brizot, A Kappeler, M D Muller, H Schneider

引用次数: 0

Current progress in early pregnancy investigation. 早期妊娠研究进展。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

B M Polliotti

引用次数: 0

Incidence of autoantibodies in the infertile population. 不孕人群自身抗体的发生率。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

J Cubillos, A Lucena, C Lucena, J C Mendoza, H Ruiz, A Arango, G Quiroga, J Ferro, E Lucena

{"title":"Incidence of autoantibodies in the infertile population.","authors":"J Cubillos, A Lucena, C Lucena, J C Mendoza, H Ruiz, A Arango, G Quiroga, J Ferro, E Lucena","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study was to determine the incidence of autoantibodies in patients with no term pregnancies. Patients selected included 43 with primary infertility and 110 with a history of pregnancy loss. In the first group the incidence of antinuclear antibodies (ANA) and IgG and IgM antiphospholipid antibodies (APL) was 37.2% (p < 0.05) and 53.5% (p < 0.05), respectively. In the group of patients with a history of miscarriage, 31.8% (p < 0.05) were positive for ANA and 38.2% (p < 0.05) for APL. Controls were 35 healthy patients with proven fertility and no history of pregnancy loss or autoimmune disease. In this group the incidence of ANA was 5.7% and 11.4% for APL. The high incidence of autoantibodies found in patients with primary infertility might suggest a direct involvement of these antibodies in reproductive failure and consequently in IVF and assisted fertility procedures. The prevalence of ANA and APL has been extensively described in patients with a history of recurrent pregnancy losses (RPL). In this study we observed antibodies even after the first miscarriage. We therefore conclude that patients with a history of reproductive failure should be immunologically evaluated and treated before undergoing assisted fertilization techniques or before a new pregnancy in those cases of RPL.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 2","pages":"119-24"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20359385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decidual leukemia inhibitory factor production and action on human chorionic gonadotropin secretion at different stages of gestation in vitro. 蜕膜白血病抑制因子的产生及其对人绒毛膜促性腺激素分泌的影响。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-06-01

S G Ren, S Melmed, G D Braunstein

{"title":"Decidual leukemia inhibitory factor production and action on human chorionic gonadotropin secretion at different stages of gestation in vitro.","authors":"S G Ren, S Melmed, G D Braunstein","doi":"","DOIUrl":"","url":null,"abstract":"Leukemia inhibitory factor (LIF) is a pleiotropic cytokine essential for uterine blastocyst implantation. We investigated human LIF production and action on human chorionic gonadotropin (hCG) secretion at different stages of gestation. Decidual and chorionic tissues were obtained at the first and second trimesters of pregnancy, and at term. Decidual and trophoblast cells were isolated and cultured separately and medium LIF or hCG levels were measured by radioimmunoassay. Decidual cells derived from the first and second trimester, and term were cultured for 72 h in serum-containing medium and produced 374 +/- 162 (mean +/- SEM), 140 +/- 14 and 466 +/- 134 ngLIF/mg protein, respectively. Pregnant mare serum gonadotropin (10 U/ml) did not affect LIF production from first-trimester decidual cells, but inhibited second-trimester LIF production to 37% of that of controls (p < 0.05), and stimulated LIF production from term decidual cells to 125% of that of controls (p < 0.05). First-trimester trophoblast cells treated with 10 nmol/l hLIF for 72 h in serum-free medium increased hCG secretion by 125% (p = 0.05). Conversely, hLIF dose-dependently inhibited basal and cAMP-stimulated hCG secretion in trophoblasts derived during the second trimester and at term, as well as in cultured JEG-3 choriocarcinoma cells. LIF exhibited more potent inhibitory action in the second trimester, maximally reducing hCG production by 37% from that of control values (p < 0.05) at a dose of 10 nmol/l. These findings indicate that (1) LIF is produced by decidual cells throughout pregnancy and may play a different regulatory role of hCG production at different stages of gestation; and (2) gonadotropin synthesized in trophoblasts may, in part, regulate LIF production through a paracrine pathway.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 2","pages":"102-8"},"PeriodicalIF":0.0,"publicationDate":"1997-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20359382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0