Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy最新文献_第4页

Potential novel roles of luteinizing hormone and human chorionic gonadotropin during early pregnancy in women. 促黄体生成素和人绒毛膜促性腺激素在妇女妊娠早期的潜在新作用。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-03-01

C V Rao

引用次数: 0

In vivo evidence for the existence of a threshold for hyperglycemia-induced major fetal malformations: relevance to the etiology of diabetic teratogenesis. 体内存在高血糖诱导的主要胎儿畸形阈值的证据:与糖尿病致畸的病因学相关。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-03-01

A Torchinsky, V Toder, H Carp, H Orenstein, A Fein

{"title":"In vivo evidence for the existence of a threshold for hyperglycemia-induced major fetal malformations: relevance to the etiology of diabetic teratogenesis.","authors":"A Torchinsky, V Toder, H Carp, H Orenstein, A Fein","doi":"","DOIUrl":"","url":null,"abstract":"The present study was carried out to evaluate whether hyperglycemia-induced major fetal anomalies are thresholded phenomena. Streptozotocin (STZ)-treated female ICR mice were examined on day 19 of pregnancy by methods routinely used in Segment II teratological studies. Simultaneously, the glucose and hemoglobin A1c (HbA1c) levels in maternal-blood were measured and mice with glucose levels > 9.5 mmol/l (mean + 3 SD) were considered to be diabetic. The occurrence of litters with fetuses having gross structural anomalies was clearly associated with glucose levels > 27.8 mmol/l. A wide range of HbA1c levels (between 6 and 18 SD above the mean) were observed, within which only single malformed fetuses were found in the litters of diabetic females. A decreased pregnancy rate in diabetic ICR mice was associated with glucose levels > 16.7 mmol/l and with HBA1c levels > 6 SD above the mean. The results of this study suggest that there is a threshold glucose level associated with a clear increase of the number of litters with severely malformed fetuses in diabetic ICR mice. Results of this study also suggest the existence of HbA1c-associated factors determining, along with glucose, the teratogenic response of ICR mice to diabetes. The interpretation of results obtained in terms of the multifactorial/threshold model leads to the hypothesis that the teratogenic potential of diabetes may consist of two components; one associated with 'direct' teratogens perturbing developmental processes in embryos at a 'critical moment' in organogenesis, and a second component, associated with a direct or indirect influence of the diabetic environment on developmental processes in the preimplantation embryos.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 1","pages":"27-33"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20207304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of nicotine on progesterone and estradiol production of cultured human granulosa cells. 尼古丁对培养的人颗粒细胞产生孕酮和雌二醇的影响。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-03-01

J Bódis, V Hanf, A Török, H R Tinneberg, P Borsay, I Szabó

{"title":"Influence of nicotine on progesterone and estradiol production of cultured human granulosa cells.","authors":"J Bódis, V Hanf, A Török, H R Tinneberg, P Borsay, I Szabó","doi":"","DOIUrl":"","url":null,"abstract":"The purpose of this study was to investigate the direct action of one of the main constituents of cigarette smoke on corpus luteum function. Progesterone and estradiol production were measured in the presence and absence of nicotine as free base or bitartrate salt with or without luteinizing hormone (LH) stimulation using radioimmunoassay in an in vitro granulosa cell culture system. Human granulosa cells were obtained from 19 patients undergoing in vitro fertilization embryo transfer treatment for infertility at the University Women's Hospital, Tübinge, Germany. Nicotine free base augmented estradiol secretion and inhibited progesterone secretion by human granulosa cells in a dose-dependent manner. Nicotine bitartrate had little effect on steroid secretion. If granulosa cells were stimulated with LH, both nicotine preparations suppressed estradiol secretion, however, only nicotine bitartrate additionally inhibited progesterone secretion. The results suggest that cigarette smoking specifically affects the control mechanisms of intraovarian processes which are responsible for normal luteal function.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 1","pages":"34-7"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20206573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Termination of early pregnancy in the rat by a single dose of human menopausal gonadotropin. 单剂量人绝经期促性腺激素终止大鼠早期妊娠。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-03-01

L L Espey, S Stacy, H Hayter, S Fujii

{"title":"Termination of early pregnancy in the rat by a single dose of human menopausal gonadotropin.","authors":"L L Espey, S Stacy, H Hayter, S Fujii","doi":"","DOIUrl":"","url":null,"abstract":"Human menopausal gonadotropin (hMG) is commonly used to induce ovarian follicular development and ovulation in infertile women. This report is a preliminary analysis of the ability of hMG to cause folliculogenesis and ovulation in pregnant laboratory animals. Wistar rats were injected subcutaneously with 0.5 mg of hMG on selected days of pregnancy. In addition, 2 days after receiving hMG, one group of animals was injected with 50 IU of human chorionic gonadotropin (hCG) as a substitute for an ovulation-inducing dose of luteinizing hormone. A single dose of hMG caused follicular development and ovulation in the pregnant animals. Furthermore, the results show that such hormone treatment usually terminated the gravid state of the animals. The frequency of pregnancy termination was greater (1) When hMG was administered during the first quarter of the 21-day gestation period; (2) When higher doses of hMG were used; and (3) When the hMG injection was followed 2 days later by hCG. In conclusion, hMG can terminate early pregnancy in a laboratory animal like the rat, and this observation raises the possibility that it may also act as an abortifacient agent in humans. Therefore, a more extensive analysis of the effects of hMG on pregnancy is warranted.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 1","pages":"23-6"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20207303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenotypic comparison of natural killer cells from peripheral blood and from early pregnancy decidua. 外周血与早孕蜕膜自然杀伤细胞表型比较。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-03-01

L Schallhammer, W Walcher, R Wintersteiger, G Dohr, P Sedlmayr

引用次数: 0

Current progress in early pregnancy investigation. 早期妊娠研究进展。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-03-01

B M Polliotti

引用次数: 0

Effect of excessive GnRH-binding substance on circulating maternal hCG in human pregnancy. 妊娠期过量gnrh结合物质对循环母体hCG的影响。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1997-03-01

T M Siler-Khodr, C B Smikle, K A Sorem, M A Grayson, D K Spencer, B A Yoder, G S Khodr

{"title":"Effect of excessive GnRH-binding substance on circulating maternal hCG in human pregnancy.","authors":"T M Siler-Khodr, C B Smikle, K A Sorem, M A Grayson, D K Spencer, B A Yoder, G S Khodr","doi":"","DOIUrl":"","url":null,"abstract":"Gonadotropin-releasing hormone (GnRH) can stimulate the release of placental human chorionic gonadotropin (hCG). Thus, at the onset of these studies it was the objective to define the relationship of hCG to GnRH in the maternal circulation throughout pregnancy, focusing on early pregnancy. Blood samples were collected at 8, 10, 12, 14, 16, 28 and 36 weeks of gestation during labor and the GnRH and hCG levels were determined by radioimmunoassay. Of 39 pregnancies, a GnRH-binding substance was found in the maternal circulation of three. This GnRH-binding substance resulted in erroneous GnRH levels, due to the very high non-specific binding. In the pregnant women without this GnRH-binding substance, GnRH attained highest concentrations at 12-14 weeks. The typical peak of hCG at 8-10 weeks of gestation was observed in this group, while the group of patients having the GnRH-binding substance had significantly lower hCG levels. Each of the patients with circulating GnRH-binding substance had prior pregnancy(s) and two of the three had a prior pregnancy loss. The nature of this GnRH-binding substance was investigated using gel chromatography. After incubation of [125I]GnRH with patient plasma for 3 days this substance was shown to be of high molecular weight which was ethanol precipitable. This binding substance may therefore be an antibody, since it appears to be a high molecular weight protein requiring a number of days to bind the [125I] GnRH. This GnRH-binding substance may be of physiological importance, since the circulating hCG level was significantly less in the group of patients with this substance than in those without.","PeriodicalId":11444,"journal":{"name":"Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy","volume":"3 1","pages":"10-4"},"PeriodicalIF":0.0,"publicationDate":"1997-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20207301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Developing biotechnological and pharmacotherapeutic advances in early pregnancy. 发展早期妊娠的生物技术和药物治疗进展。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-12-01

R J Ablin

引用次数: 0

A stroll across the epigenetic landscape: bringing Waddington's ideas into molecular biology. 在表观遗传学领域漫步:将沃丁顿的思想带入分子生物学。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-12-01

D Gatherer

引用次数: 0

Current progress in early pregnancy investigation. 早期妊娠研究进展。

Early pregnancy : biology and medicine : the official journal of the Society for the Investigation of Early Pregnancy Pub Date : 1996-12-01

B M Polliotti

引用次数: 0