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Molecular Docking Study of Flavonoids to Block the Aryl Hydrocarbon Receptor 黄酮类化合物阻断芳烃受体的分子对接研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11766
Oscar Collado García, H. De Winter, P. Cos, M. Matos, E. Uriarte, Gabriel Llauradó Maury, J. De Waele, G. C. Santiago, E. Molina
{"title":"Molecular Docking Study of Flavonoids to Block the Aryl Hydrocarbon Receptor","authors":"Oscar Collado García, H. De Winter, P. Cos, M. Matos, E. Uriarte, Gabriel Llauradó Maury, J. De Waele, G. C. Santiago, E. Molina","doi":"10.3390/ecsoc-25-11766","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11766","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89245703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic Approach to Diversified Imidazo[2,1-b][1,3]thiazines and Its Evaluation as Non-Steroidal Anti-Inflammatory Agents † 多元咪唑[2,1-b][1,3]噻嗪类化合物的合成及非甾体抗炎剂的评价
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11692
N. Slyvka, S. Holota, L. Saliyeva, M. Vovk
{"title":"Synthetic Approach to Diversified Imidazo[2,1-b][1,3]thiazines and Its Evaluation as Non-Steroidal Anti-Inflammatory Agents †","authors":"N. Slyvka, S. Holota, L. Saliyeva, M. Vovk","doi":"10.3390/ecsoc-25-11692","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11692","url":null,"abstract":": The present work is devoted to the synthesis of imidazo[2,1- b ][1,3]thiazine derivatives as possible anti-inflammatory agents. The synthetic approach to (2-pyridinyloxy)substituted imid-azo[2,1- b ][1,3]thiazines based on the interaction of the polysubstituted 2-chloropyridines with 3-hydroxy-imidazo[2,1- b ][1,3]thiazines was proposed. Selective nucleophilic substitution in position 2 of pyridine ring was observed in the mentioned reaction. The synthesized (2-pyridinyloxy)substi-tuted imidazo[2,1- b ][1,3]thiazines drug-like properties were studied in silico using SwissADME and anti-inflammatory activity in carrageenan test in vivo. Hit-compounds with satisfactory drug-like and pharmacological features were identified as promising objects for futhercoming structure opti-mization and in-depth studies.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"93 1-2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77945243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dysprosium(III)-Mediated Carboxylate Formation from a Schiff Base 镝(III)介导的席夫碱生成羧酸盐
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11740
Julio Corredoira-Vázquez, Cristina González-Barreira, A. G. Deibe, J. Sanmartín-Matalobos, M. Fondo
{"title":"Dysprosium(III)-Mediated Carboxylate Formation from a Schiff Base","authors":"Julio Corredoira-Vázquez, Cristina González-Barreira, A. G. Deibe, J. Sanmartín-Matalobos, M. Fondo","doi":"10.3390/ecsoc-25-11740","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11740","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"67 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91081063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Heterocycles and Nucleosides Forming Higher—Order Structures 形成高阶结构的杂环和核苷的合成
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11705
Z. Váradi, G. Paragi, Z. Kupihar, Z. Kele, L. Kovács
{"title":"Synthesis of Heterocycles and Nucleosides Forming Higher—Order Structures","authors":"Z. Váradi, G. Paragi, Z. Kupihar, Z. Kele, L. Kovács","doi":"10.3390/ecsoc-25-11705","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11705","url":null,"abstract":": Nucleic acid analogues play a multifaceted role in biology and materials science. Our efforts towards unveiling these roles led to xanthine derivatives that form higher–order structures with quadruplex-forming abilities. In this paper we present further modifications of the xanthine core resulting into 9-deaza and 8-aza-9-deaza heterocycles (pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines, respectively) that form tetrads and other higher–order structures. Addi-tionally, the ring contraction of 5-fluoro-2 (cid:48) ,3 (cid:48) - O -isopropylideneuridine gave rise to the formation of an imidazolidine-4-carboxylic acid nucleoside derivative. Our computational predictions forecasted that the latter derivative will form stable triads.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90805197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Characterization of a Dansyl-Based Fluorescent Probe for Analytical Purposes 一种分析用丹西尔荧光探针的合成与表征
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11775
J. Sanmartín-Matalobos, P. Bermejo-Barrera, Yeneva Alves-Iglesias, A. M. García-Deibe, M. Fondo
{"title":"Synthesis and Characterization of a Dansyl-Based Fluorescent Probe for Analytical Purposes","authors":"J. Sanmartín-Matalobos, P. Bermejo-Barrera, Yeneva Alves-Iglesias, A. M. García-Deibe, M. Fondo","doi":"10.3390/ecsoc-25-11775","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11775","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87974472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Comparative Study of the Effects of Aqueous Micellar Media Formed by Amphiphilic Ionic Liquids and Conventional Surfactants on Reactions of Synthetic Interest 两亲性离子液体与常规表面活性剂形成的胶束水介质对合成兴趣反应影响的比较研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11745
Jesica B. Soffietti, C. Adam, C. Della Rosa
{"title":"Comparative Study of the Effects of Aqueous Micellar Media Formed by Amphiphilic Ionic Liquids and Conventional Surfactants on Reactions of Synthetic Interest","authors":"Jesica B. Soffietti, C. Adam, C. Della Rosa","doi":"10.3390/ecsoc-25-11745","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11745","url":null,"abstract":": For polar Diels–Alder (DA) reactions, one of the most relevant aspects is its dependence on the reaction media; thus, in this work, the objective is to analyze the effect of aqueous micellar systems on the synthesis of compounds of biological interest. Based on the system formed by isoprene and 2-nitrofuran, the experiments were carried out in micellar media formed by amphiphilic ionic liquid ( N , N -dodecylmethylimidazolium bromide) and by conventional surfactants (SDS and CTAB). In this sense, there are few studies that involve DA reactions in micro-heterogeneous systems. The challenge is to have the knowledge about the behavior of ILs in order to take advantage of all their potentialities in order to replace a toxic molecular solvent with ILs, which allows the development of a methodology framed within the concepts of Green Chemistry.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89238569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioavailability of Rapeseed Oil Fortified with Ethyl Sinapate 新加坡酸乙酯强化菜籽油的生物利用度
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11725
Dobrochna Rabiej-Kozioł, Marek P. Krzemiński, I. Wiśniewska, A. Szydłowska-Czerniak
{"title":"Bioavailability of Rapeseed Oil Fortified with Ethyl Sinapate","authors":"Dobrochna Rabiej-Kozioł, Marek P. Krzemiński, I. Wiśniewska, A. Szydłowska-Czerniak","doi":"10.3390/ecsoc-25-11725","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11725","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"117 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91408742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(1H)-Ones 新型3,4 -二氢嘧啶-2-(1H)- 1的高效合成及抗菌活性研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11720
N. Pawar, P. N. Patil, Rajashri N. Pachpande
{"title":"An Efficient Synthesis and Antibacterial Activity of Some Novel 3,4–Dihydropyrimidin-2-(1H)-Ones","authors":"N. Pawar, P. N. Patil, Rajashri N. Pachpande","doi":"10.3390/ecsoc-25-11720","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11720","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"16 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73515029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and Evaluation of Verdant Tablets Containing Saponin-Coalesced Silver Nanoparticles Got from Fenugreek Seed Extract 胡芦巴籽提取物中皂苷-纳米银绿片的制备及评价
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11765
J. Patil, Hamid Sayyed, H. Suryawanshi, Bhavika Patil
{"title":"Formulation and Evaluation of Verdant Tablets Containing Saponin-Coalesced Silver Nanoparticles Got from Fenugreek Seed Extract","authors":"J. Patil, Hamid Sayyed, H. Suryawanshi, Bhavika Patil","doi":"10.3390/ecsoc-25-11765","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11765","url":null,"abstract":": Presently, nanoparticles are in demand due to several applications. Commercially used metallic nanoparticles are usually comprised of synthetic chemicals. These chemicals are noxious and combustible. Current research had the objective to explore the advantages of nanoparticles using herbal material; hence, we developed silver nanoparticles of aqueous extract of Trigonellafoenum graecum (Fenugreek) seeds and formulated them into tablets. Fenugreek seeds contain steroidal sapogenins and are responsible for the reduction of blood cholesterol levels, control diabetes, enhance breast milk production, digestion aid, and helps in weight loss hence prepared formulation can be recommended in all the above cases. The pre-compression parameters evaluated for formulations are bulk density, tapped density, Carr’s index, Hausner’s ratio, and angle of repose, and the results are 0.16 gm/cc, 0.86 gm/cc, 14.16, ratio 1.13 and 32 ◦ , respectively; whereas post-compression parameters are weight variation, friability, hardness, thickness, and disintegration, and the results are 0.504 gm, 0.2%, 3.21 gm/cm 2 , 2.55 mm, and 7 min, respectively.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76292783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Synthesis and Biological Activity of New Derivatives of Isoindoline-1,3-dione as Non-Steroidal Analgesics 异吲哚-1,3-二酮非甾体镇痛药新衍生物的合成及生物活性研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11773
Y. Trukhanova, D. A. Kolesnik, E. Kuvaeva, G. V. Ksenofontova, M. V. Sopova, I. Yakovlev
{"title":"Synthesis and Biological Activity of New Derivatives of Isoindoline-1,3-dione as Non-Steroidal Analgesics","authors":"Y. Trukhanova, D. A. Kolesnik, E. Kuvaeva, G. V. Ksenofontova, M. V. Sopova, I. Yakovlev","doi":"10.3390/ecsoc-25-11773","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11773","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73795030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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