发布求助
文献互助 智能选刊 最新文献

ECSOC-25最新文献

筛选
英文 中文
Synthesis and Antibacterial Activity of Thymyl Ethers 百里甲醚的合成及其抑菌活性
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11747
Jagdish U. Patil, P. N. Patil, N. Pawar
{"title":"Synthesis and Antibacterial Activity of Thymyl Ethers","authors":"Jagdish U. Patil, P. N. Patil, N. Pawar","doi":"10.3390/ecsoc-25-11747","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11747","url":null,"abstract":": We have reported herein a simple and efficient synthesis method of thymyl ethers for structural modifications of natural products such as monoterpenoids and studies of ether derivatives of thymol in biological importance. The investigations showed that thymol reacts very smoothly with different types of substituted acetanilides. The synthesized compounds have been tested for their bacterial potency against four bacterial species. Such a structural modification will be beneficial in the field of pest management for designing the active molecules","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78224301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of New bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (MPro) from SARS-CoV-2 新型双呋喃基吡咯[3,4-b]吡啶-5- 1的Ugi-Zhu反应合成及SARS-CoV-2主蛋白酶(MPro)对接研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11771
Ivette Morales-Salazar, S. L. Castañón-Alonso, Daniel Canseco-González, E. Díaz-Cervantes, E. González-Zamora, A. Islas-Jácome
{"title":"Synthesis of New bis-furanyl-pyrrolo[3,4-b]pyridin-5-ones via the Ugi-Zhu Reaction and Docking Studies on the Main Protease (MPro) from SARS-CoV-2","authors":"Ivette Morales-Salazar, S. L. Castañón-Alonso, Daniel Canseco-González, E. Díaz-Cervantes, E. González-Zamora, A. Islas-Jácome","doi":"10.3390/ecsoc-25-11771","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11771","url":null,"abstract":": The synthesis of five new bis -furanyl-pyrrolo[3,4-b ]pyridin-5-ones in 30 to 40% yields through a domino sequence based on the Ugi-Zhu three-component reaction is described. Then, on the main protease M Pro (PDB: 6lu7) from the SARS-CoV-2, the synthesized products and co-crystallized ligands of M Pro were in silico evaluated using the docking technique, finding moderate to good binding energies and some interesting interactions, demonstrating that the ligand 8c can be considered as a drug candidate against the SARS-CoV-2-M Pro due to its LE value ( − 5.96 kcal/mol), which is better than other synthesized and reported molecules in the literature. At the same time, hydrophobic interactions play a crucial role in the ligand target molecular couplings, demonstrated through a hydrophobicity surfaces analysis. Finally, 8a and 8b can also be considered as drug candidates. Thus, some synthesized bis -furanyl-pyrrolo[3,4-b ]pyridin-5-ones may be used for further in vitro assays against the virus.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79969813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Characterization and Evaluation of a Carbazolyl-BODIPY as a Fluorimetric Chemosensor for F-  氟-荧光化学传感器咔唑基bodipy的合成、表征及评价
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11752
Sónia C. S. Pinto, R. Gonçalves, S. Costa, M. Raposo
{"title":"Synthesis, Characterization and Evaluation of a Carbazolyl-BODIPY as a Fluorimetric Chemosensor for F- ","authors":"Sónia C. S. Pinto, R. Gonçalves, S. Costa, M. Raposo","doi":"10.3390/ecsoc-25-11752","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11752","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90258326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Synthesis, Characterization and Preliminary Antibacterial Evaluation against Staphylococcus aureus of a New 2,4,5-Tri(hetero)arylimidazole Derivative Based on Azaindole Heterocycle 基于叠氮哚杂环的新型2,4,5-三(杂)芳咪唑衍生物的合成、表征及对金黄色葡萄球菌的抑菌活性初步评价
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11781
Nuna L. P. Ramos, Rui Oliveira, S. Costa, M. Raposo
{"title":"Synthesis, Characterization and Preliminary Antibacterial Evaluation against Staphylococcus aureus of a New 2,4,5-Tri(hetero)arylimidazole Derivative Based on Azaindole Heterocycle","authors":"Nuna L. P. Ramos, Rui Oliveira, S. Costa, M. Raposo","doi":"10.3390/ecsoc-25-11781","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11781","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86261218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Structural Study of a New β-Turn Inducer Peptidomimetic Incorporating 1-Amino-1-Aminomethylcyclohexane 含1-氨基-1-氨基甲基环己烷的新型β-转诱导剂拟肽的合成及结构研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11684
M. Campos, Víctor M. Sánchez-Pedregal, Pablo López-Carracedo, R. Estévez, J. Estévez
{"title":"Synthesis and Structural Study of a New β-Turn Inducer Peptidomimetic Incorporating 1-Amino-1-Aminomethylcyclohexane","authors":"M. Campos, Víctor M. Sánchez-Pedregal, Pablo López-Carracedo, R. Estévez, J. Estévez","doi":"10.3390/ecsoc-25-11684","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11684","url":null,"abstract":"A new β-turn inducer peptidomimetic incorporating 1-amino-1-aminomethylcyclohexane (compound 3) was synthetized and structurally studied. It was established that there is a rapid conformational equilibrium between the expected β-turn inducer structure and other extended conformations.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"88 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84198201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Approach for the Synthesis of N-Arylamides Starting from Benzonitriles
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11726
P. Debnath
{"title":"A New Approach for the Synthesis of N-Arylamides Starting from Benzonitriles","authors":"P. Debnath","doi":"10.3390/ecsoc-25-11726","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11726","url":null,"abstract":": N -Arylamides are a ubiquitous component of a broad range of natural products and biologically active compounds. In this paper, a new synthetic protocol for the preparation of N arylamides was developed via the hypervalent iodine-mediated aza -Hofmann-type rearrangement of amidines. The reaction proceeded smoothly at 100 ◦ C in the presence of PhINTs in toluene solvent. The requisite amidine substrates were prepared from amines and nitriles by applying the Pinner reaction approach. Considering the easy access of amidines from nitriles, the overall process is the conversion of nitriles to acetanilide and N -arylamides. As an application of the protocol, the preparation of paracetamol from 4-cyanophenol is also described.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"213 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79466275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of N-(hydroxymethylene)thioamides by N-hydroxymethylation of 2-cyanothioacrylamides 2-氰硫丙烯酰胺N-羟甲基化合成N-(羟基亚甲基)硫酰胺
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11799
A. G. Levchenko, P. Dahno, V. Dotsenko
{"title":"Synthesis of N-(hydroxymethylene)thioamides by N-hydroxymethylation of 2-cyanothioacrylamides","authors":"A. G. Levchenko, P. Dahno, V. Dotsenko","doi":"10.3390/ecsoc-25-11799","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11799","url":null,"abstract":"The condensation products of cyanothioacetamide with aldehydes – (E)-arylmethylenyanothioacetamides – have proven to be readily available and multifunctional starting reagents in the chemistry of S,N-containing compounds. We decided to study the interaction of formaldehyde with thioamides as a possible way to obtain N-(hydroxymethylene)thioamides are promising thioamidoalkylating agents and new ligands for complexation. It was found that the reaction of thioamides and formaldehyde proceeds easily when the reagents are heated in the absence of catalysts in an aqueous-alcohol medium, and leads with good yields to the expected N-(hydroxymethylene)thioamides. Structure of N-(hydroxymethylene)thioamides 2 was confirmed by IR and NMR spectroscopy data.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80990482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, Development, and In Silico Study of Pyrazoline-Based Mycobactin Analogs as Anti-Tubercular Agents 吡唑啉类分枝杆菌素类似物抗结核药物的设计、开发和计算机研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11767
Gourav Rakshit, S. Murtuja, Venkatesan Jayaprakash
{"title":"Design, Development, and In Silico Study of Pyrazoline-Based Mycobactin Analogs as Anti-Tubercular Agents","authors":"Gourav Rakshit, S. Murtuja, Venkatesan Jayaprakash","doi":"10.3390/ecsoc-25-11767","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11767","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"40 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79167880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Eugenol Ester Derivatives: Synthesis, Insecticidal Activity and Computational Studies 丁香酚酯衍生物:合成、杀虫活性及计算研究
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11787
J. Coelho, Tatiana F. Vieira, R. Pereira, David M. Pereira, E. M. Castanheira, A. Fortes, S. Sousa, M. J. Fernandes, M. Gonçalves
{"title":"Eugenol Ester Derivatives: Synthesis, Insecticidal Activity and Computational Studies","authors":"J. Coelho, Tatiana F. Vieira, R. Pereira, David M. Pereira, E. M. Castanheira, A. Fortes, S. Sousa, M. J. Fernandes, M. Gonçalves","doi":"10.3390/ecsoc-25-11787","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11787","url":null,"abstract":": Specific structural modifications in eugenol molecule can simultaneously improve the biological activity and reduce side effects of the respective analogues. The esterification of eugenol by two different experimental procedures, and subsequently conversion of one of the esters into the corresponding oxirane was carried out. All derivatives obtained were then evaluated for their effect on the viability of Sf9 ( Spodoptera frugiperda ), cells. In addition, a structured-based inverted virtual screening protocol was employed to identify the potential proteins associated to the observed insecticidal activity. The encouraging results obtained allowed to establish a preliminary structure-activity relationship.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74266929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Is the Impact of Ethylammonium Nitrate on Soil Basal Respiration Modified by Addition of Aluminium Salt to Improve the Performance in Electrochemical Applications? 硝酸乙铵对土壤基础呼吸的影响是否可以通过添加铝盐来改善其电化学应用性能?
ECSOC-25 Pub Date : 2021-11-14 DOI: 10.3390/ecsoc-25-11789
Teresa Sixto, M. E. Priano, J. J. Parajó, C. Trasar-Cepeda
{"title":"Is the Impact of Ethylammonium Nitrate on Soil Basal Respiration Modified by Addition of Aluminium Salt to Improve the Performance in Electrochemical Applications?","authors":"Teresa Sixto, M. E. Priano, J. J. Parajó, C. Trasar-Cepeda","doi":"10.3390/ecsoc-25-11789","DOIUrl":"https://doi.org/10.3390/ecsoc-25-11789","url":null,"abstract":"","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80889973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信