DNA Sequence最新文献_第10页

Structure of the Mouse Calcitonin/Calcitonin Gene-Related Peptide Alpha and Beta Genes 小鼠降钙素/降钙素基因相关肽α和β基因的结构

DNA Sequence Pub Date : 2001-01-01 DOI: 10.3109/10425170109047567

P. Thomas, I. Nasonkin, Hongquan Zhang, R. Gagel, G. Cote

引用次数: 12

Short Communication: Molecular Cloning and Sequence Analysis of C57BL/6 Mouse Contrapsin cDNA 短通信:C57BL/6小鼠对照蛋白cDNA的克隆与序列分析

DNA Sequence Pub Date : 2001-01-01 DOI: 10.3109/10425170109025005

Koji Yoshida, Yasuyuki Suzuki, H. Sinohara

引用次数: 2

Short Communication: Homology Study of Two Polyhydroxyalkanoate (PHA) Synthases from Pseudomonas Aureofaciens 短通讯:金黄色假单胞菌两种聚羟基烷酸酯合成酶的同源性研究

DNA Sequence Pub Date : 2001-01-01 DOI: 10.3109/10425170109025003

F. Umeda, T. Nishikawa, H. Miyasaka, I. Maeda, M. Kawase, Kiyohito Yagγ

引用次数: 0

The Gene Causing the Best's Macular Dystrophy (BMD) Encodes a Putative Ion Exchanger 导致最佳黄斑营养不良(BMD)的基因编码一个假定的离子交换器

DNA Sequence Pub Date : 2001-01-01 DOI: 10.3109/10425170109084470

A. Gómez, J. Cedano, B. Oliva, J. Piñol, E. Querol

引用次数: 8

Identification of the Human Homologue of the Early-Growth Response Gene Snk, Encoding a Serum-Inducible Kinase 编码血清诱导激酶的早期生长反应基因Snk的人类同源物的鉴定

DNA Sequence Pub Date : 2001-01-01 DOI: 10.3109/10425170109041337

K. Liby, Huiyun Wu, B. Ouyang, Shecao Wu, Jie Chen, W. Dai

引用次数: 29

Identification of the First Human Glutaredoxin Pseudogene Localized to Human Chromosome 20qll.2 第一个定位于人类20qll染色体的Glutaredoxin假基因的鉴定

DNA Sequence Pub Date : 2001-01-01 DOI: 10.3109/10425170109041338

A. Miranda-Vizuete, G. Spyrou

{"title":"Identification of the First Human Glutaredoxin Pseudogene Localized to Human Chromosome 20qll.2","authors":"A. Miranda-Vizuete, G. Spyrou","doi":"10.3109/10425170109041338","DOIUrl":"https://doi.org/10.3109/10425170109041338","url":null,"abstract":"Thiol-disulfide interchange reactions are one of the most important regulatory systems in cells. Two kinds of molecules are responsible for this process: non-protein low molecular weight thiols and thiol-containing proteins of higher molecular weight (Zlieger, 1985). Among the first type, glutathione arises as the most important reductant in cell, while thioredoxin (Trx), glutaredoxin (Grx) and protein disulfide isomer-ase (PDI) are the best known examples of regulatory proteins by thiol-disulfide interchange reactions (Holmgren, 1989). Thioredoxins and glutaredoxins share many common features like being small, heat-stable, globular proteins (around 12 kDa), with a similar tridimensional structure (thioredoxin fold) and both using NADPH as source of reducing equivalents (Holmgren, 1989). However, while the electron from NADPH is transferred to the flavoenzyme thioredoxin reductase that in turn reduces thioredoxin (the so-called thioredoxin system), glutaredoxin is reduced by the sequential transfer of reducing power from NADPH to glutathione reductase and glutathione (the so-called glutaredoxin system) (Holmgren, 1989). Once reduced, Trx and Grx can act as general disulfide oxidoreductases with preference shown by Trx for peptide substrates while Grx shows preference for low-molecular weight dithiol- containing molecules (Holmgren, 1989). Grx was initially discovered as an alternative hydrogen donor for the essential enzyme ribonucleotide reductase in a thioredoxin-deficient mutant of E. coli (Holmgren, 1976; Holmgren, 1979). Since then Grx has also been shown to be an electron donor for enzymes like adenosine 3′-phos- phate-5′-phosphosulfate reductase and methionine sulfoxide reductase, functions that Trx also displays (Holmgren, 1989). In addition, Grx has been implicated in deiodination of thyroxine to triiodothyronine and has shown dehydroascor- bate reductase activity that generates ascorbic acid which protects neutrophils against the deleterious effects of the respiratory burst (Goswami and Rosenberg, 1985; Park and Levine, 1996).","PeriodicalId":11381,"journal":{"name":"DNA Sequence","volume":"26 1","pages":"535 - 539"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76951198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Isolation and Characterization of Two Genes Encoding Ubiquitin Fused to a Ribosomal Protein of 53 Amino Acids in Rice 水稻53个氨基酸核糖体蛋白泛素编码基因的分离与鉴定

DNA Sequence Pub Date : 2001-01-01 DOI: 10.3109/10425170109042050

A. Kato, Ritsuko Nishi And, Masahiko Ozak1

引用次数: 3

Complete Genomic Sequence of 195 Kb of Human DNA Containing the Gene GABRG2 含GABRG2基因的195 Kb人DNA全基因组序列

DNA Sequence Pub Date : 2000-01-01 DOI: 10.3109/10425170009033988

Songshan Jiang, Jun Yu, Jian Wang, Zeng Tan, H. Xue, G. Feng, Lin He, H. Yang

{"title":"Complete Genomic Sequence of 195 Kb of Human DNA Containing the Gene GABRG2","authors":"Songshan Jiang, Jun Yu, Jian Wang, Zeng Tan, H. Xue, G. Feng, Lin He, H. Yang","doi":"10.3109/10425170009033988","DOIUrl":"https://doi.org/10.3109/10425170009033988","url":null,"abstract":"G ABA (gamma-aminobutyric acid), as the main inhibitory neurotransmitter in the brain, plays an essential role for the overall balance between neuronal excitation and inhibition by acting on GABAA receptors, which are ligand-gated chloride channels. Impaired GABAergic function contributes to certain forms of epilepsy, schizophrenia, Alzheimer's Disease, and other neurological disorders. In order to identify possible genetic features and to further study biological regulation of GABAA receptor genes whose promoter elements and sequence anomalies may contribute to epileptic disorders, as an initial step, we shot-gun sequenced a BAC clone, dj082c10 (195,909-bp in size), encompassing human γ2 subunit of GABAA receptor (GABRG2). It is, we believe, the first genomic sequence of the GABA receptor gamma subunit family. Four contigs were assembled from 2950 reads prior to gap in an average redundancy of eight folds over the entire region. The precision of the consensus sequence was predicted to be 99.999% after closing gaps and finishing weak regions. The nine exons of GABRG2 spans an 85-kb region that had 81 SINEs comprising 22.32%, and nine LI elements comprising 3.40%, respectively. However, the density of L1 in the regions flanking GABRG2 gene (29.45% by 45 elements) is significantly higher than that within the gene. The length of GABRG2 introns varies in the range of 1.5 kb to 38.1 kb.","PeriodicalId":11381,"journal":{"name":"DNA Sequence","volume":"11 1","pages":"373 - 382"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74015005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Short Sequence Repeat Polymorphism in the Mouse slc4al Gene Encoding the AE1 C1-/HCO3- Exchanger 小鼠AE1 C1-/HCO3-交换基因slc4al的短序列重复多态性

DNA Sequence Pub Date : 2000-01-01 DOI: 10.3109/10425170009033995

B. Shmukler, S. Wilhelm, S. Alper

引用次数: 0

Cloning and Sequencing of the Rabbit FGFR2 cDN A 兔FGFR2 cDN的克隆与测序

DNA Sequence Pub Date : 2000-01-01 DOI: 10.3109/10425170009033994

Zi-Wei Yang, M. Mooney, R. Ferrell

{"title":"Cloning and Sequencing of the Rabbit FGFR2 cDN A","authors":"Zi-Wei Yang, M. Mooney, R. Ferrell","doi":"10.3109/10425170009033994","DOIUrl":"https://doi.org/10.3109/10425170009033994","url":null,"abstract":"Normal development of the mammalian skull requires differentiation and coordination of all the outgrowing bones, particularly at sites of articulation knows as sutures. Such growth is necessary to accommodate an enlarging brain., Approximately 1 in 2500 human infants is born with craniosynostosis, the premature fusion of one or more calvarial sutures. This condition disrupts allometric growth and results in classic craniofacial features, including abnormal head shape, protruding eyes and midface underdevelopment (Hunter and Rudd, 1976; 1977; Lajeunie et al., 1995; 1996). Approximately 100 syndromes which include craniosynostosis are known and these syndromes are usually monogenic with an autosomal dominant mode of transmission. Recently, a number of mutations have been identified in three of the four members of the fibroblast growth factor receptor (FGFR) family as a cause of simple craniosynostosis and syndromes which include craniosynostosis as part of the phenotype, including Pfeiffer, Crouzon and Jackson-Weiss syndromes (Webster and Donoghue, 1997). The FGFRs are high-affinity receptors for the fibroblast growth factors, a family of at least 13 structurally related proteins (Smallwood et al., 1996) involved in a wide range of biological processes, including cell growth, differentiation, migration, wound healing and angiogenesis, depending on the target cell type and developmental stage (Basilico and Moscatelli, 1992; Fernig and Gallagher, 1994). The four FGFRs that have been described thus far exhibit a similar structure, consisting of an extracellular region made of three immunoglobulin-like (Ig-like) domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain (Jaye et al., 1992; Partanen et al., 1993).","PeriodicalId":11381,"journal":{"name":"DNA Sequence","volume":"29 1","pages":"439 - 446"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81771532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1