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[Vasculitis oft the skin after cocaine use]. [吸食可卡因后皮肤出现血管炎]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2142-1530
Rubi Stephani Hellwege, Thomas Sitter, Markus Wörnle
{"title":"[Vasculitis oft the skin after cocaine use].","authors":"Rubi Stephani Hellwege,&nbsp;Thomas Sitter,&nbsp;Markus Wörnle","doi":"10.1055/a-2142-1530","DOIUrl":"10.1055/a-2142-1530","url":null,"abstract":"<p><strong>History and clinical findings: </strong>A 20-years-old patient presented himself to our emergency room with extensive and extremely painful purpura with necrotizing spots and blisters, especially on the lower extremities, but also on the arms, trunk and ears. There was a pre-existing use of cocaine.</p><p><strong>Medical examinations: </strong>Laboratory tests showed increased signs of inflammation as well as an increase in proteinase 3- and myeloperoxidase-ANCA (Anti-neutrophil cytoplasmatic antibody).</p><p><strong>Diagnosis: </strong>In combination with the medical history, the clinical findings, and the laboratory values, vasculitis of the skin after cocaine use was revealed.</p><p><strong>Therapy and course: </strong>Under therapy with steroids and cocaine abstinence, there was a regression of the changes.</p><p><strong>Conclusion: </strong>Vasculitis is a serious complication of cocaine use.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10201047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtuelle Medizin: Wie gut beantwortet „Dr. Chatbot“ Patientenfragen? 我的答案如何?Chatbot " Patientenfragen ?
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2123-6315
{"title":"Virtuelle Medizin: Wie gut beantwortet „Dr. Chatbot“ Patientenfragen?","authors":"","doi":"10.1055/a-2123-6315","DOIUrl":"https://doi.org/10.1055/a-2123-6315","url":null,"abstract":"Die Möglichkeit, medizinische Fragen ohne persönlichen Kontakt zu Arzt oder Ärztin über elektronische Nachrichten zu klären, gewinnt in der Bevölkerung zunehmend an Beliebtheit. Allerdings bedeutet die virtuelle Gesundheitsversorgung eine erhebliche Zusatzbelastungen für die Ärzteschaft. Ob künstliche Intelligenz dabei helfen kann, dieses Problem zu lösen, untersuchte nun ein Forscherteam aus den USA.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schaden Zucker oder Süßstoffe der Leber? 损坏肝脏的糖或糖分吗?
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1986-0831
{"title":"Schaden Zucker oder Süßstoffe der Leber?","authors":"","doi":"10.1055/a-1986-0831","DOIUrl":"https://doi.org/10.1055/a-1986-0831","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Eklatanter Diversitätsmangel bei Peer-Reviews 在电台评论中明显的多样化缺失
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2112-2901
{"title":"Eklatanter Diversitätsmangel bei Peer-Reviews","authors":"","doi":"10.1055/a-2112-2901","DOIUrl":"https://doi.org/10.1055/a-2112-2901","url":null,"abstract":"Das Peer-Reviewing ist ein Grundpfeiler der Qualitätssicherung wissenschaftlicher Publikationen, an denen sich Mediziner und Gesundheitspolitiker in ihrem täglichen Handeln orientieren. Die Studie offenbart eine mangelnde Diversität, sowohl bei den Anfragen als auch den durchlaufenen Prozessen. Die COVID-19-Pandemie verstärkte geografische Ungleichheiten.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135347166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Burn surgery]. [烧伤手术]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1957-4457
Sonja Schmidt, Marius Drysch, Marcus Lehnhardt
{"title":"[Burn surgery].","authors":"Sonja Schmidt,&nbsp;Marius Drysch,&nbsp;Marcus Lehnhardt","doi":"10.1055/a-1957-4457","DOIUrl":"10.1055/a-1957-4457","url":null,"abstract":"<p><p>Burn injuries represent a special type of injury that requires special expertise. Both in adequate wound treatment and in intensive medical care, there are various special features that must be considered and due to which treatment by experienced medical personnel is necessary. In the clinical, but also in the preclinical course, the most important points in the treatment of the burn injury should be known to be able to guarantee adequate treatment. In this context, in addition to the knowledge of the different degrees of burns, the estimation of the burned body surface area (VKOF) is essential. Intensive medical treatment as well as surgical therapy of deep burn wounds should then be performed in a burn center. The article provides an overview of the classifications of burn injuries, the management of wound care, the various therapeutic options, both conservative and surgical, and the special features of burn disease.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
[Antagonizing anticoagulants in intracranial hemorrhage - step by step]. [抗凝血药治疗颅内出血-循序渐进]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-09-15 DOI: 10.1055/a-2116-4526
Maximilian Schell, Felix Leonard Nägele, Götz Thomalla
{"title":"[Antagonizing anticoagulants in intracranial hemorrhage - step by step].","authors":"Maximilian Schell,&nbsp;Felix Leonard Nägele,&nbsp;Götz Thomalla","doi":"10.1055/a-2116-4526","DOIUrl":"10.1055/a-2116-4526","url":null,"abstract":"<p><p>Intravenous thrombolysis for acute ischemic stroke is an indispensable tool and current standard of care in neurology. However, until recently direct therapeutic options for intracranial hemorrhage under existing anticoagulation were not available. With the introduction of two new medications - Idarucizumab and Andexanet alfa - neurologists take a more targeted approach in treating these patients.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Thromboseprophylaxe in doppelter Standarddosierung bei schwerer COVID-19-Pneumonie sinnvoll 心肌梗死预防双标准剂量严重covid肺炎
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2112-3013
{"title":"Thromboseprophylaxe in doppelter Standarddosierung bei schwerer COVID-19-Pneumonie sinnvoll","authors":"","doi":"10.1055/a-2112-3013","DOIUrl":"https://doi.org/10.1055/a-2112-3013","url":null,"abstract":"Im Rahmen einer COVID-19-Erkrankung besteht aufgrund der systemischen Inflammation mit Thrombozyten-Aktivierung und endothelialer Dysfunktion ein erhöhtes thromboembolisches Risiko. Im Vergleich zu einer Thromboseprophylaxe in Standarddosierung scheint eine höher dosierte Gabe von niedermolekularem Heparin Thrombosen effektiver zu verhindern, ohne dass daraus ein gesteigertes hämorrhagisches Risiko resultiert, wie eine aktuelle randomisierte Studie zeigte.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Molecular tumor diagnostics as the driving force behind precision oncology]. 【分子肿瘤诊断是精准肿瘤学背后的驱动力】。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1937-0347
Daniel Kazdal, Michael Menzel, Jan Budczies, Albrecht Stenzinger
{"title":"[Molecular tumor diagnostics as the driving force behind precision oncology].","authors":"Daniel Kazdal, Michael Menzel, Jan Budczies, Albrecht Stenzinger","doi":"10.1055/a-1937-0347","DOIUrl":"10.1055/a-1937-0347","url":null,"abstract":"<p><p>Molecular pathological diagnostics plays a central role in personalized oncology and requires multidisciplinary teamwork. It is just as relevant for the individual patient who is being treated with an approved therapy method or an individual treatment attempt as it is for prospective clinical studies that require the identification of specific therapeutic target structures or complex biomarkers for study inclusion. It is also of crucial importance for the generation of real-world data, which is becoming increasingly important for drug development. Future developments will be significantly shaped by improvements in scalable molecular diagnostics, in which increasingly complex and multi-layered data sets must be quickly converted into clinically useful information. One focus will be on the development of adaptive diagnostic strategies in order to be able to depict the enormous plasticity of a cancer disease over time.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10492415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[61-year-old female patient with diffuse and painless swelling adjacent to the joints]. [61岁女性患者，关节附近弥漫性无痛性肿胀]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-2061-4882
Anne Maria Urban, Ulf Müller-Ladner, Nils Schulz
{"title":"[61-year-old female patient with diffuse and painless swelling adjacent to the joints].","authors":"Anne Maria Urban,&nbsp;Ulf Müller-Ladner,&nbsp;Nils Schulz","doi":"10.1055/a-2061-4882","DOIUrl":"10.1055/a-2061-4882","url":null,"abstract":"Eine 61-jährige Patientin stellt sich mit seit einiger Zeit progredienten Schwellungen nahe verschiedener Gelenke ohne lokale Entzündungsreaktion vor. Am rechten Ellenbogen und den Füßen bestehe ein Spannungsgefühl ohne Druckdolenz. Zudem habe sie an den Fingern und Zehen, vor allem bei Kälteexposition, eine schmerzhafte Verfärbung und zeitweise offene Stellen bemerkt. Neben der laborchemischen Untersuchung erfolgte eine nativ-röntgenologische Bildgebung des rechten Ellenbogens und der Füße. Klinisch (▶ Abb. 1a) und röntgenologisch (▶ Abb. 1b, c) zeigen sich insgesamt 3 pathologische Befunde. FRAGEN ▪ Welche Befunde sind es? ▪ Erlauben diese Befunde eine Diagnose? Wenn ja, welche? ▪ Sind Differenzialdiagnosen möglich? Wenn ja, welche? ▶ Abb.1 a) Rechter Ellenbogen der Patientin; b) Nativ-röntgenologische Bildgebung des rechten Ellenbogens; c) Nativ-röntgenologische Bildgebung der Füße. Mediquiz","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Histology-agnostic tumor treatment - a farewell to tumor entities?] 组织学不可知的肿瘤治疗——告别肿瘤实体?］
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1933-8141
Irina Kerle, Christoph Heining
{"title":"[Histology-agnostic tumor treatment - a farewell to tumor entities?]","authors":"Irina Kerle,&nbsp;Christoph Heining","doi":"10.1055/a-1933-8141","DOIUrl":"https://doi.org/10.1055/a-1933-8141","url":null,"abstract":"<p><p>Considerable efforts concerning the molecular characterization and targeted treatment of cancer have significantly improved treatment options and prognosis of tumor patients. Nevertheless, in tumor entities without recurrent genetic alterations the application of molecular testing for potentially targetable lesions remains heterogeneous and, in most cases, the approval of targeted therapies is still restricted to defined tumor entities harboring corresponding predictive biomarkers.The broad genomic analysis of different tumor entities including rare cancers within several genome sequencing initiatives and precision oncology programs has revealed the occurrence of addressable molecular alterations across many tumor entities, although their incidence may differ significantly in the context of the underlying cancer type. The treatment of molecularly defined patient cohorts demonstrated an impressive tumor-agnostic efficacy of certain therapeutics such as NTRK inhibitors, while the outcome of other targeted therapies, such as ERBB or BRAF inhibitors, varied in the context of the underlying disease.In the meantime, a handful targeted therapeutics addressing NRTK and RET fusions, the BRAF V600E mutation or different features of defective DNA mismatch repair and high tumor mutational burden has been approved for histology-agnostic treatment of tumors harboring these target lesions. Ongoing molecularly stratified basket trials will further investigate the tumor-agnostic efficacy of different targeted treatment approaches.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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