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Deutsche Medizinische Wochenschrift最新文献

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Erhöhen Depressionen das Krebsrisiko? 抑郁症增加患癌症的风险吗?
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1986-0775
{"title":"Erhöhen Depressionen das Krebsrisiko?","authors":"","doi":"10.1055/a-1986-0775","DOIUrl":"https://doi.org/10.1055/a-1986-0775","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Artificial Intelligence for computer-aided leukemia diagnostics]. [用于计算机辅助白血病诊断的人工智能]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1965-7044
Christian Matek, Carsten Marr, Michael von Bergwelt-Baildon, Karsten Spiekermann
{"title":"[Artificial Intelligence for computer-aided leukemia diagnostics].","authors":"Christian Matek,&nbsp;Carsten Marr,&nbsp;Michael von Bergwelt-Baildon,&nbsp;Karsten Spiekermann","doi":"10.1055/a-1965-7044","DOIUrl":"10.1055/a-1965-7044","url":null,"abstract":"<p><p>The manual examination of blood and bone marrow specimens for leukemia patients is time-consuming and limited by intra- and inter-observer variance. The development of AI algorithms for leukemia diagnostics requires high-quality sample digitization and reliable annotation of large datasets. Deep learning-based algorithms using these datasets attain human-level performance for some well-defined, clinically relevant questions such as the blast character of cells. Methods such as multiple - instance - learning allow predicting diagnoses from a collection of leukocytes, but are more data-intensive. Using \"explainable AI\" methods can make the prediction process more transparent and allow users to verify the algorithm's predictions. Stability and robustness analyses are necessary for routine application of these algorithms, and regulatory institutions are developing standards for this purpose. Integrated diagnostics, which link different diagnostic modalities, offer the promise of even greater accuracy but require more extensive and diverse datasets.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 17","pages":"1108-1112"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advanced non-small cell lung cancer - pioneer in personalized oncology]. [晚期癌症-个性化肿瘤学的先驱]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1935-1939
Felix Carl Saalfeld, Daniela E Aust, Martin Wermke
{"title":"[Advanced non-small cell lung cancer - pioneer in personalized oncology].","authors":"Felix Carl Saalfeld,&nbsp;Daniela E Aust,&nbsp;Martin Wermke","doi":"10.1055/a-1935-1939","DOIUrl":"10.1055/a-1935-1939","url":null,"abstract":"<p><p>In no other cancer is clinical practice as close to the ideals of personalized oncology as in the treatment of non-small cell lung cancer (NSCLC). Here, we briefly outline the basic principles of molecular analysis. The focus of the article is on the clinical utility of targeted therapy. Finally, we highlight the challenges for medical staff and structural solutions reflecting the situation in Germany.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 18","pages":"1166-1173"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10201043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Alcoholic hepatitis - current and future treatment approaches]. [酒精性肝炎-当前和未来的治疗方法]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1941-7187
Philipp Kasper, Münevver Demir
{"title":"[Alcoholic hepatitis - current and future treatment approaches].","authors":"Philipp Kasper,&nbsp;Münevver Demir","doi":"10.1055/a-1941-7187","DOIUrl":"10.1055/a-1941-7187","url":null,"abstract":"<p><p>Acute severe alcoholic hepatitis is a serious disease with poor prognosis. As a result of an improved understanding of the underlying pathomechanisms, a variety of new, innovative therapeutic modalities are currently being investigated that may help to improve prognosis. New approaches include the application of anti-inflammatory agents (e.g., interleukin-1 inhibitors), modifications of the gut-liver axis via fecal microbiome transfer or the administration of non-absorbable antibiotics (e.g., rifaximin), and drugs to enhance hepatocellular regeneration (e.g., interleukin-22 agonists). This article describes current management concepts of alcoholic hepatitis and provides an overview of new potential treatment approaches.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 17","pages":"1095-1101"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10063066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Management of drug-resistant tuberculosis]. [耐药结核病的管理]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-09-15 DOI: 10.1055/a-1939-0000
Christoph Lange
{"title":"[Management of drug-resistant tuberculosis].","authors":"Christoph Lange","doi":"10.1055/a-1939-0000","DOIUrl":"10.1055/a-1939-0000","url":null,"abstract":"<p><p>The spread of multidrug-resistant Mycobacterium tuberculosis bacteria jeopardizes tuberculosis control, especially in the WHO Europe region. Following the availability of novel drugs and treatment regimens the World Health Organization has updated management recommendations for patients affected by drug-resistant tuberculosis. These novel recommendations include a significant reduction in the duration of therapy. This review presents the epidemiology and diagnostics of antibiotic-resistant tuberculosis as well as up-to-date treatment recommendations.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 19","pages":"1236-1241"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hepatitis C: nie zu früh für eine Behandlung 肝炎:从不是早期治疗
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-08-01 DOI: 10.1055/a-2034-2423
{"title":"Hepatitis C: nie zu früh für eine Behandlung","authors":"","doi":"10.1055/a-2034-2423","DOIUrl":"https://doi.org/10.1055/a-2034-2423","url":null,"abstract":"Jahrzehnte erhielten Erkrankte mit einer chronischen Hepatitis C eine interferonbasierte Behandlung, die nicht nur nebenwirkungsreich, sondern darüber hinaus wenig wirksam war. Direkt antiviral wirksame Medikamente (DAA) haben seit 2014 das Management grundlegend verändert. Die Studiengruppe überprüfte retrospektiv die Effekte auf hepatische und nicht hepatische Komplikationen sowie die Mortalität. Verglichen mit Unbehandelten profitierten Behandelte von den DAA deutlich.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136065098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardiovascular prevention: Better safe than sorry]. [心血管预防：安全总比遗憾好]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-08-01 Epub Date: 2023-08-04 DOI: 10.1055/a-1922-1626
Stefan Frantz
{"title":"[Cardiovascular prevention: Better safe than sorry].","authors":"Stefan Frantz","doi":"10.1055/a-1922-1626","DOIUrl":"10.1055/a-1922-1626","url":null,"abstract":"","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 16","pages":"997"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diabetes in old age]. [老年糖尿病]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-08-01 Epub Date: 2023-07-21 DOI: 10.1055/a-1801-5971
Jürgen Wernecke, Anke Bahrmann
{"title":"[Diabetes in old age].","authors":"Jürgen Wernecke,&nbsp;Anke Bahrmann","doi":"10.1055/a-1801-5971","DOIUrl":"10.1055/a-1801-5971","url":null,"abstract":"<p><p>Diabetes is one of the most common chronical diseases in old age. More than 50 % of the patients are older than 65 years. Elderly with diabetes often suffer from functional or cognitive deficits that should be registered in therapy. These include special geriatric syndromes like memory failure, frailty, falls, immobility or higher vulnerability for drug interactions. Comorbidity und functional deficits influence each other. Simple therapy regimens should be preferred to avoid polypharmacia and to preserve patient's independence. Specific risks of old age under new antidiabetic drugs should be noted. Check-ups and treatment of diabetic complications, especially the diabetic foot should be consequently induced considerating age-specific features.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 15","pages":"974-987"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9879152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Renal insufficiency and cardiovascular risk]. [肾功能不全和心血管风险]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-08-01 Epub Date: 2023-08-04 DOI: 10.1055/a-1922-1719
Christoph Wanner, Anna Laura Herzog, Jule Pinter
{"title":"[Renal insufficiency and cardiovascular risk].","authors":"Christoph Wanner,&nbsp;Anna Laura Herzog,&nbsp;Jule Pinter","doi":"10.1055/a-1922-1719","DOIUrl":"10.1055/a-1922-1719","url":null,"abstract":"<p><p>Patients with chronic renal insufficiency often show symptoms that are atypical for cardiovascular problems. The correct interpretation of the symptoms is crucial in order to correctly assess the risk of a heart-related emergency and to take preventive measures and initiate the right therapy. Biomarkers such as NT-proBNP, troponin T or hsCRP (highly sensitive CRP) are independent predictors of mortality, but do not replace instrument-based diagnostics. Patients with renal insufficiency often have stiff vessels which, due to the premature reflection of the pulse wave, can lead to left ventricular dysfunction and ultimately to heart failure.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 16","pages":"1020-1024"},"PeriodicalIF":0.6,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10302350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Typ-2-Diabetes: SGLT2-Inhibitoren und DPP4-Inhibitoren im Vergleich 2型糖尿病:斯glt2抑制剂和dpp4抑制剂比较起来
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-08-01 DOI: 10.1055/a-2058-1545
{"title":"Typ-2-Diabetes: SGLT2-Inhibitoren und DPP4-Inhibitoren im Vergleich","authors":"","doi":"10.1055/a-2058-1545","DOIUrl":"https://doi.org/10.1055/a-2058-1545","url":null,"abstract":"SGLT2-Inhibitoren und DPP4-Inhibitoren kommen heute in der Behandlung des Typ-2-Diabetes regelhaft zum Einsatz. Dabei stellt sich vor einer individuellen Therapieentscheidung die Frage nach der Rolle der Höhe des prätherapeutischen HbA1c-Wertes für Sicherheit und Wirksamkeit beider Antidiabetika. D’Andrea et al. wollten Antworten finden und haben eine groß angelegte Vergleichsstudie zur Frage durchgeführt.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136065104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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