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Pharmakogenetisches Panel reduziert unerwünschte Arzneimittelreaktionen 药物遗传学材料减少不想的药物反应
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-27 DOI: 10.1055/a-2034-2346
{"title":"Pharmakogenetisches Panel reduziert unerwünschte Arzneimittelreaktionen","authors":"","doi":"10.1055/a-2034-2346","DOIUrl":"https://doi.org/10.1055/a-2034-2346","url":null,"abstract":"Genetische Varianten können sich auf die Metabolisierung, die Ziele und die Wirkung von Medikamenten auswirken. Die niederländische Pharmacogenetics Working Group (DPWG) entwickelte einen Leitfaden mit mehr als 100 Gen-Medikament-Paaren. Daraus ging ein Panel mit den 12 wichtigsten, pharmakologisch bedeutsamen Genen hervor. In der PREPARE-Studie berücksichtigten Ärzte und Ärztinnen das Testergebnis oder verordneten nach dem Standard. Bei Berücksichtigung der Genanalysen waren Arzneimittelnebenwirkungen erheblich seltener.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schleimpfropfen erhöhen Mortalität bei COPD 咽喉药物死亡率上升
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-27 DOI: 10.1055/a-2112-2934
{"title":"Schleimpfropfen erhöhen Mortalität bei COPD","authors":"","doi":"10.1055/a-2112-2934","DOIUrl":"https://doi.org/10.1055/a-2112-2934","url":null,"abstract":"In Computertomografien lassen sich bei Patienten mit chronisch obstruktiver Lungenerkrankung (COPD) häufig sogenannte Mucus-Plugs (Schleimpfropfen) identifizieren, die im mittel- und längerfristigen Verlauf in der Mehrzahl der Fälle persistieren. Hieraus resultiert offenbar ein erhöhtes Mortalitätsrisiko, wie eine aktuelle multizentrische Studie aus den USA zeigte.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virusnegatives HCC: Bessere Prognose? 病毒呈阳性反应
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-27 DOI: 10.1055/a-1986-1183
{"title":"Virusnegatives HCC: Bessere Prognose?","authors":"","doi":"10.1055/a-1986-1183","DOIUrl":"https://doi.org/10.1055/a-1986-1183","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kommentar zu „Schleimpfropfen erhöhen Mortalität bei COPD“ "可用粘液注射死亡率"
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-27 DOI: 10.1055/a-2112-2980
{"title":"Kommentar zu „Schleimpfropfen erhöhen Mortalität bei COPD“","authors":"","doi":"10.1055/a-2112-2980","DOIUrl":"https://doi.org/10.1055/a-2112-2980","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KHK-Risiko durch Spenderherz? 吻合血管吗
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-27 DOI: 10.1055/a-1986-1239
{"title":"KHK-Risiko durch Spenderherz?","authors":"","doi":"10.1055/a-1986-1239","DOIUrl":"https://doi.org/10.1055/a-1986-1239","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Onkologie: Systemtherapie bei COVID-19 肿瘤学：COVID-19 的系统疗法
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-27 DOI: 10.1055/a-1986-1225
{"title":"Onkologie: Systemtherapie bei COVID-19","authors":"","doi":"10.1055/a-1986-1225","DOIUrl":"https://doi.org/10.1055/a-1986-1225","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gefahr durch lange Bildschirmzeiten? 长时间抓屏幕危险吗?
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-27 DOI: 10.1055/a-1986-1211
{"title":"Gefahr durch lange Bildschirmzeiten?","authors":"","doi":"10.1055/a-1986-1211","DOIUrl":"https://doi.org/10.1055/a-1986-1211","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135534472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[An update on Behçet's syndrome]. [关于贝赛特综合征的最新消息]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1958-2338
Theodoros Xenitidis, Jörg Christoph Henes
{"title":"[An update on Behçet's syndrome].","authors":"Theodoros Xenitidis,&nbsp;Jörg Christoph Henes","doi":"10.1055/a-1958-2338","DOIUrl":"10.1055/a-1958-2338","url":null,"abstract":"<p><p>Behçet's syndrome (BS, synonym: Behçet's disease, or Adamantiades-Behçet's disease, ABD) is classified as a vasculitis of variable vessel size and can manifest itself in both arterial and venous vessels. Its extensive and at the same time interindividually very different clinical picture is not uncommon a challenge, both with regard to the diagnosis of this rheumatic systemic disease, which is rather rare in our latitudes, and its therapeutic options. In addition to the four cardinal symptoms of recurrent oral aphthae, genital aphthae, skin and eye lesions, the clinical picture offers numerous other manifestations which often require interdisciplinary cooperation. In addition to the above mentioned ocular involvement, which can still lead to blindness if inadequately treated, this is especially true for intestinal and cerebral manifestations as well as for large vessel vasculitis.A final revision of the European League Against Rheumatism recommendations for the management of Behcet's syndrome (EULAR) was made in 2018, and the recommendations are now established internationally as an important treatment guide. Therapy is based on the leading organ involvement. After adalimumab received approval for the treatment of posterior ocular involvement in 2016, another agent, apremilast, became available in 2020. The drug is recommended for the treatment of recurrent oral aphthae in adult Behçet's patients requiring systemic therapy. Nevertheless, there is a further need for new drugs.This article aims to highlight recent findings in the areas of epidemiology, immunopathogenesis & genetics, clinical findings, and therapy, with an emphasis on clinical relevance.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Advances in the management of asthma]. [哮喘治疗进展]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1990-2341
Dirk Westhölter, Sebastian Reuter, Christian Taube
{"title":"[Advances in the management of asthma].","authors":"Dirk Westhölter,&nbsp;Sebastian Reuter,&nbsp;Christian Taube","doi":"10.1055/a-1990-2341","DOIUrl":"10.1055/a-1990-2341","url":null,"abstract":"<p><p>Asthma is a heterogeneous inflammatory airway disease that causes relevant morbidity across individuals of all age cohorts. In recent years, advances in the understanding of asthma pathophysiology have led to the development of treatments tailored to specific pheno- and endotypes of the disease. This has significantly changed asthma management, especially for patients with severe disease. These new treatment options offer individuals with asthma access to personalized and disease-modifying therapies. The present paper is a comprehensive overview of recent clinical studies and of German and international guideline updates on asthma management.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Anticoagulation in older patients]. [老年患者的抗凝治疗]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-2020-0196
Heinrich Burkhardt
{"title":"[Anticoagulation in older patients].","authors":"Heinrich Burkhardt","doi":"10.1055/a-2020-0196","DOIUrl":"10.1055/a-2020-0196","url":null,"abstract":"<p><p>Prescribing oral anticoagulation in older patients for e.g. stroke prophylaxis has proven to be beneficial, but some special risks have to be considered. Renal function may be substantial impaired and dose reduction in at least some of the substances is recommended. Therefore, a closer monitoring of renal function is essential. Further as bleeding risk also increases with age usual scoring lists do less help this therapeutic dilemma than in younger patients. Adequate blood pressure control is essential in preventing intracerebral hemorrhage. Fall risk has to be assessed to initiate early compensation for this risk. Only high and unimprovable fall incidence may outweigh the benefits of oral anticoagulation therapy (>1 hospital admission per month due to a fall incident). Comprehensive geriatric assessment is crucial for early detection of specific adherence problems in older patients and is also helpful for discussion of individual deprescribing options in an end of live situation.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":null,"pages":null},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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