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[Histology-agnostic tumor treatment - a farewell to tumor entities?] 组织学不可知的肿瘤治疗——告别肿瘤实体?］
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1933-8141
Irina Kerle, Christoph Heining
{"title":"[Histology-agnostic tumor treatment - a farewell to tumor entities?]","authors":"Irina Kerle,&nbsp;Christoph Heining","doi":"10.1055/a-1933-8141","DOIUrl":"https://doi.org/10.1055/a-1933-8141","url":null,"abstract":"<p><p>Considerable efforts concerning the molecular characterization and targeted treatment of cancer have significantly improved treatment options and prognosis of tumor patients. Nevertheless, in tumor entities without recurrent genetic alterations the application of molecular testing for potentially targetable lesions remains heterogeneous and, in most cases, the approval of targeted therapies is still restricted to defined tumor entities harboring corresponding predictive biomarkers.The broad genomic analysis of different tumor entities including rare cancers within several genome sequencing initiatives and precision oncology programs has revealed the occurrence of addressable molecular alterations across many tumor entities, although their incidence may differ significantly in the context of the underlying cancer type. The treatment of molecularly defined patient cohorts demonstrated an impressive tumor-agnostic efficacy of certain therapeutics such as NTRK inhibitors, while the outcome of other targeted therapies, such as ERBB or BRAF inhibitors, varied in the context of the underlying disease.In the meantime, a handful targeted therapeutics addressing NRTK and RET fusions, the BRAF V600E mutation or different features of defective DNA mismatch repair and high tumor mutational burden has been approved for histology-agnostic treatment of tumors harboring these target lesions. Ongoing molecularly stratified basket trials will further investigate the tumor-agnostic efficacy of different targeted treatment approaches.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 18","pages":"1174-1181"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10194132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ärztliche Tätigkeit auf der Antarktisstation „Princess Elisabeth“ 在南极洲“伊丽莎白公主”病房工作
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2118-1767
Barbara Weith, Martin Leitl
{"title":"Ärztliche Tätigkeit auf der Antarktisstation „Princess Elisabeth“","authors":"Barbara Weith, Martin Leitl","doi":"10.1055/a-2118-1767","DOIUrl":"https://doi.org/10.1055/a-2118-1767","url":null,"abstract":"Die belgische Antarktisstation „Princess Elisabeth“ ist eine der neueren Forschungsstationen auf dem antarktischen Kontinent, genauer gesagt auf dem Gebiet Dronning-Maud-Land in der Ostantarktis. Die Station wird im antarktischen Sommer, von November bis Februar betrieben, wobei für die 20–40 Teilnehmer der Antarktisexpedition auch jeweils ein Arzt benötigt wird. Die Ärztin Dr. med. Barbara Weith und der Arzt und Bergführer Dr. med. Martin Leitl berichten von ihrer Tätigkeit.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chronische Schmerzen: Gruppenintervention reduziert Opioidbedarf 慢性疼痛:"团队干预"减少鸦片需求
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2106-8677
{"title":"Chronische Schmerzen: Gruppenintervention reduziert Opioidbedarf","authors":"","doi":"10.1055/a-2106-8677","DOIUrl":"https://doi.org/10.1055/a-2106-8677","url":null,"abstract":"Die Anwendung einer Opioidtherapie zur Behandlung chronischer, nicht maligner Schmerzen geht oftmals mit schweren Nebenwirkungen einher. Vor diesem Hintergrund wollten Sandhu und Arbeitsgruppe die Auswirkungen einer mehrkomponentigen und gruppenbasierten Selbstmanagement-Intervention mit chronischen Schmerzpatient*innen auf den Opioidbedarf überprüfen, und kommen in ihrer multizentrischen randomisierten Studie zu einem positiven Ergebnis.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Direkte orale Antikoagulantien verhindern Thrombose-Rezidive bei Tumorpatienten 直接口服抗凝剂防止肿瘤病人血栓交叉
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2112-3090
{"title":"Direkte orale Antikoagulantien verhindern Thrombose-Rezidive bei Tumorpatienten","authors":"","doi":"10.1055/a-2112-3090","DOIUrl":"https://doi.org/10.1055/a-2112-3090","url":null,"abstract":"Im Rahmen einer Malignom-Erkrankung ist das Risiko für venöse thromboembolische Ereignisse (VTE) um das bis zu 7-Fache erhöht. Die Leitlinien empfehlen in dieser Patientengruppe nach einer stattgehabten Thrombose oder Lungenembolie eine langfristige Antikoagulation mit niedermolekularem Heparin. Die Rezidivprophylaxe mit einem direkten oralen Antikoagulans scheint jedoch vergleichbar effektiv und sicher zu sein, wie eine aktuelle prospektive Studie zeigte.","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"371 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Hypercholesterolemia - who, when, how to treat?] [高胆固醇血症-谁、何时、如何治疗？]
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1956-9851
Martin Merkel
{"title":"[Hypercholesterolemia - who, when, how to treat?]","authors":"Martin Merkel","doi":"10.1055/a-1956-9851","DOIUrl":"10.1055/a-1956-9851","url":null,"abstract":"<p><p>In recent years, clinical scientific data on LDL cholesterol and atherosclerosis has led to lowering of LDL-C targets and the expansion of the indication for lipid drug therapy to larger populations or patients. The calculators SCORE2 and SCORE-OP were newly developed to calculate the cardiovascular risk in primary prevention. When assessing the cardiovascular risk of patients, in addition to e.g., pre-existing cardiovascular disease, familial hypercholesterolaemia and type II diabetes, type I diabetes, diabetic complications, renal insufficiency and subclinical arteriosclerosis are also considered. Statins are the basic therapy for hypercholesterolemia. Alternative medication are ACL inhibitors e.g., Bempedoic acid and Inclisiran which represent new drug therapy options for statin intolerance. Nevertheless, a dietary intervention belongs at the beginning of every lipid-lowering therapy.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 17","pages":"1088-1094"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cardiovascular assessment and management of patients undergoing non-cardiac surgeries - A case based resumé]. [接受非心脏手术的患者的心血管评估和管理-基于病例的结果]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1977-3059
Maximilian Winhard, Julinda Mehilli
{"title":"[Cardiovascular assessment and management of patients undergoing non-cardiac surgeries - A case based resumé].","authors":"Maximilian Winhard,&nbsp;Julinda Mehilli","doi":"10.1055/a-1977-3059","DOIUrl":"10.1055/a-1977-3059","url":null,"abstract":"<p><p>In August 2022, the European Society of Cardiology (ESC) published new guidelines on cardiovascular assessment and management of patients undergoing non-cardiac surgery. In order to cope with the complexity of the patients and the multidisciplinary, representatives of the European Society of Anesthesia and Intensive Care Medicine as well as 2 patient representatives were involved in the development of the published document in addition to authors from the European Society of Cardiology. As a result, the document contains 147 recommendations on this complex topic, with more than half of them being grade I recommendations.The interdisciplinarity and the need for interdisciplinary cooperation in this context is particularly emphasized. Particular attention was also paid to recommendations for action for a structured preoperative risk stratification. The new guidelines also focus on increasing vigilance for perioperative myocardial damage and identifying it at an early stage.In the following article, some of the essential innovations and revisions will be highlighted using practical clinical case studies.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 17","pages":"1118-1122"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Targeted temperature management after cardiac arrest]. [心脏骤停后有针对性的体温管理]。
IF 0.6 4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 Epub Date: 2023-08-23 DOI: 10.1055/a-1940-0405
Sandra Finkbeiner, Katrin Fink, Hans-Jörg Busch
{"title":"[Targeted temperature management after cardiac arrest].","authors":"Sandra Finkbeiner,&nbsp;Katrin Fink,&nbsp;Hans-Jörg Busch","doi":"10.1055/a-1940-0405","DOIUrl":"10.1055/a-1940-0405","url":null,"abstract":"<p><p>Actively avoiding fever is the only possibility to improve neurological outcome after cardiac arrest. It is uncertain if and which patients benefit from a lower target temperature. The ERC Guidelines in 2021 recommended targeted temperature management (TTM) for all patients after in- and out-of-hospital cardiac arrest with a target temperature of 32-36 °C for at least 24 hours. These recommendations were updated in 2022 by the ERC/ESICM Guidelines suggesting to avoid fever only within the first 72 hours after the event. Divergent results of recent trials lead to these guideline changes. The large TTM2 Trial in 2021 did not show a benefit neither in survival nor in neurological outcome in the group of hypothermia at 33°C compared to normothermia. Although leading to the updated guidelines, applying these study results to the German population is restricted as the rate of bystander cardiopulmonary resuscitation (CPR) or shockable rhythms is much lower in Germany. Further studies are needed to allow a better differentiation of subpopulations and to implement a more individual classification und therapy.</p>","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"148 17","pages":"1113-1117"},"PeriodicalIF":0.6,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10069305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Blutdruck und Gewicht unter Steroidtherapie 血压和血压低于类固醇治疗
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1986-0817
{"title":"Blutdruck und Gewicht unter Steroidtherapie","authors":"","doi":"10.1055/a-1986-0817","DOIUrl":"https://doi.org/10.1055/a-1986-0817","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kommentar zu „Direkte orale Antikoagulantien verhindern Thrombose-Rezidive bei Tumorpatienten“ 有关“直接口服抗凝血抑制肿瘤输血”的评论
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-2112-3123
{"title":"Kommentar zu „Direkte orale Antikoagulantien verhindern Thrombose-Rezidive bei Tumorpatienten“","authors":"","doi":"10.1055/a-2112-3123","DOIUrl":"https://doi.org/10.1055/a-2112-3123","url":null,"abstract":"","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135346939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antibiotikaresistenzen durch Feinstaub? 4级?
4区 医学
Deutsche Medizinische Wochenschrift Pub Date : 2023-09-01 DOI: 10.1055/a-1986-0761
{"title":"Antibiotikaresistenzen durch Feinstaub?","authors":"","doi":"10.1055/a-1986-0761","DOIUrl":"https://doi.org/10.1055/a-1986-0761","url":null,"abstract":"Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study","PeriodicalId":11370,"journal":{"name":"Deutsche Medizinische Wochenschrift","volume":"129 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135347167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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