Drug Delivery and Translational Research最新文献_第9页

Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis. 基于白藜芦醇纳米晶体的高效溶解微针可用于治疗类风湿关节炎。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-03-31 DOI: 10.1007/s13346-024-01581-2

Ningning Diao, Yan Liu, Wenxin Wang, Min Cao, Xiaowei Liu, Weili Yang, Yuxin Cao, Tianying Sun, Huijie Pei, Chunjing Guo, Daquan Chen

{"title":"Resveratrol nanocrystals based dissolving microneedles with highly efficient for rheumatoid arthritis.","authors":"Ningning Diao, Yan Liu, Wenxin Wang, Min Cao, Xiaowei Liu, Weili Yang, Yuxin Cao, Tianying Sun, Huijie Pei, Chunjing Guo, Daquan Chen","doi":"10.1007/s13346-024-01581-2","DOIUrl":"10.1007/s13346-024-01581-2","url":null,"abstract":"Rheumatoid arthritis (RA) is a common immune disease characterized mainly by erosive arthritis with extensive clinical sequelae. Resveratrol (Res) has pharmacological effects in the treatment of RA, but it has not been widely used in the clinic due to its poor water solubility and low bioavailability. In this study, a drug delivery system (Res-NC MNs) of dissolved microneedles (MNs) loaded with Res nanocrystals (NC) was designed for the treatment of RA. Res-NC MNs can improve the drawbacks of long-term oral drug delivery with toxic side effects and low compliance associated with intra-articular drug delivery. In this study, Res-NC was prepared by media milling and loaded into soluble microneedles prepared from hyaluronic acid (HA) by vacuum casting for the treatment of RA. HA has high mechanical strength and can penetrate the cuticle layer of the skin for effective drug delivery. In in vivo pharmacodynamic experiments, Res-NC MNs achieved better therapeutic efficacy in the treatment of RA compared with oral Res. These findings suggest that Res-NC MNs may be an effective and promising drug delivery strategy for the treatment of RA.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"203-215"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140331604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer. 多柔比星综合综述：乳腺癌的机制、毒性、临床试验、联合疗法和纳米制剂。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-06-17 DOI: 10.1007/s13346-024-01648-0

Anjali Bisht, Dubey Avinash, Kantrol Kumar Sahu, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi

{"title":"A comprehensive review on doxorubicin: mechanisms, toxicity, clinical trials, combination therapies and nanoformulations in breast cancer.","authors":"Anjali Bisht, Dubey Avinash, Kantrol Kumar Sahu, Preeti Patel, Ghanshyam Das Gupta, Balak Das Kurmi","doi":"10.1007/s13346-024-01648-0","DOIUrl":"10.1007/s13346-024-01648-0","url":null,"abstract":"Doxorubicin is a key treatment for breast cancer, but its effectiveness often comes with significant side effects. Its actions include DNA intercalation, topoisomerase II inhibition, and reactive oxygen species generation, leading to DNA damage and cell death. However, it can also cause heart problems and low blood cell counts. Current trials aim to improve doxorubicin therapy by adjusting doses, using different administration methods, and combining it with targeted treatments or immunotherapy. Nanoformulations show promise in enhancing doxorubicin's effectiveness by improving drug delivery, reducing side effects, and overcoming drug resistance. This review summarizes recent progress and difficulties in using doxorubicin for breast cancer, highlighting its mechanisms, side effects, ongoing trials, and the potential impact of nanoformulations. Understanding these different aspects is crucial in optimizing doxorubicin's use and improving outcomes for breast cancer patients. This review examines the toxicity of doxorubicin, a drug used in breast cancer treatment, and discusses strategies to mitigate adverse effects, such as cardioprotective agents and liposomal formulations. It also discusses clinical trials evaluating doxorubicin-based regimens, the evolving landscape of combination therapies, and the potential of nanoformulations to optimize delivery and reduce systemic toxicity. The review also discusses the potential of liposomes, nanoparticles, and polymeric micelles to enhance drug accumulation within tumor tissues while sparing healthy organs.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"102-133"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141330588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gaussian processes modeling for the prediction of polymeric nanoparticle formulation design to enhance encapsulation efficiency and therapeutic efficacy. 高斯过程建模用于预测聚合物纳米粒子配方设计，以提高封装效率和疗效。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-05-20 DOI: 10.1007/s13346-024-01625-7

Sihan Dong, Haolin Yu, Pascal Poupart, Emmanuel A Ho

{"title":"Gaussian processes modeling for the prediction of polymeric nanoparticle formulation design to enhance encapsulation efficiency and therapeutic efficacy.","authors":"Sihan Dong, Haolin Yu, Pascal Poupart, Emmanuel A Ho","doi":"10.1007/s13346-024-01625-7","DOIUrl":"10.1007/s13346-024-01625-7","url":null,"abstract":"Conventional drugs have been facing various drug delivery obstacles, including first-pass metabolism for oral medications, drug degradation by cellular enzymes, off-target effects, and cytotoxicity of healthy cells. Nanoparticles (NP) application in drug delivery can compensate for these drawbacks to a great extent. NPs can be fabricated using different materials and structures to achieve desired therapeutic effects. For each type of NP material, its physicochemical properties determine compatibility with specific drugs and other supplemental compositions. The optimized material selection becomes prominent in NP development to improve NP performances. Due to the nature of NP fabrication, the process is long and expensive. To accelerate NP composition optimization, machine learning (ML) techniques are among the most promising methods for efficient data predictions and optimizations.As a proof-of concept, we created Gaussian Process (GP) models to make predictions for drug encapsulation efficiency (EE%) and therapeutic efficacy of 32 poly (lactic-co-glycolic acid) (PLGA) NPs that are formed with materials with different physicochemical properties. Two model drugs, doxorubicin (DOX) and docetaxel (DTX) were loaded separately. The IC50 values for the various NPs formulations were evaluated using the OVCAR3 epithelial ovarian cancer cell line. EE% GP model has the highest prediction accuracy with the lowest normalized root-mean-squared-error (RMSE) of 0.187. The DOX and DTX IC50 GP models have normalized RMSEs of 0.296 and 0.206, respectively, which are higher than that of the EE% GP model.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"372-388"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141064939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing. 通过 DLP 印刷制备的含咪喹莫特纳米晶体的溶解微针。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-03-12 DOI: 10.1007/s13346-024-01567-0

Eliška Petrová, Stanislav Chvíla, František Štěpánek, Jarmila Zbytovská, Dimitrios A Lamprou

{"title":"Imiquimod nanocrystal-loaded dissolving microneedles prepared by DLP printing.","authors":"Eliška Petrová, Stanislav Chvíla, František Štěpánek, Jarmila Zbytovská, Dimitrios A Lamprou","doi":"10.1007/s13346-024-01567-0","DOIUrl":"10.1007/s13346-024-01567-0","url":null,"abstract":"The utilization of 3D printing- digital light processing (DLP) technique, for the direct fabrication of microneedles encounters the problem of drug solubility in printing resin, especially if it is predominantly composed of water. The possible solution how to ensure ideal belonging of drug and water-based printing resin is its pre-formulation in nanosuspension such as nanocrystals. This study investigates the feasibility of this approach on a resin containing nanocrystals of imiquimod (IMQ), an active used in (pre)cancerous skin conditions, well known for its problematic solubility and bioavailability. The resin blend of polyethylene glycol diacrylate and N-vinylpyrrolidone, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate as a photoinitiator, was used, mixed with IMQ nanocrystals in water. The final microneedle-patches had 36 cylindrical microneedles arranged in a square grid, measuring approximately 600 μm in height and 500 μm in diameter. They contained 5wt% IMQ, which is equivalent to a commercially available cream. The homogeneity of IMQ distribution in the matrix was higher for nanocrystals compared to usual crystalline form. The release of IMQ from the patches was determined ex vivo in natural skin and revealed a 48% increase in efficacy for nanocrystal formulations compared to the crystalline form of IMQ.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"158-170"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140109623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quality by design empowered preparation of itraconazole albumin nanoparticles for prostate cancer. 通过设计提高伊曲康唑白蛋白纳米粒子的制备质量，用于治疗前列腺癌。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-05-02 DOI: 10.1007/s13346-024-01592-z

Saurabh Shah, Paras Famta, Anamika Sharma, Rahul Kumar, Giriraj Pandey, Ganesh Vambhurkar, Dadi A Srinivasarao, Akshay Shinde, Sajja Bhanu Prasad, Amit Asthana, Saurabh Srivastava

{"title":"Quality by design empowered preparation of itraconazole albumin nanoparticles for prostate cancer.","authors":"Saurabh Shah, Paras Famta, Anamika Sharma, Rahul Kumar, Giriraj Pandey, Ganesh Vambhurkar, Dadi A Srinivasarao, Akshay Shinde, Sajja Bhanu Prasad, Amit Asthana, Saurabh Srivastava","doi":"10.1007/s13346-024-01592-z","DOIUrl":"10.1007/s13346-024-01592-z","url":null,"abstract":"The current advent explores the potential of itraconazole (ITR) in prostate cancer (PCa), by its incorporation into albumin nanoparticles (NP). ITR as a repurposed moiety has displayed tremendous potential in various cancers. However, poor aqueous solubility poses hurdles towards its clinical translation. Amorphisation of ITR was observed post-incorporation within NP matrix which could prevent its precipitation in aqueous media. ITR NP was developed using quality by design and multivariate analysis and evaluated for cellular uptake, cell proliferation inhibition and the mechanism of PCa cell inhibition. Time and concentration-dependent serum stability and hemolytic potential revealed safety of ITR NP. Morphological changes and nuclear staining studies revealed the efficacy of ITR and ITR NP in promoting growth inhibition of PC-3 cells. Superior qualitative and quantitative uptake, reactive oxygen species (ROS) and mitochondrial impairment for ITR NP in comparison with ITR and control group was observed. Cell cycle study revealed remarkable G2/M phase inhibition in PC-3 cells. ITR NP demonstrated superior anticancer potential in 3D tumoroids mimicking the micro-metastatic lesions compared to control and ITR. Hence, ITR NP can be a favorable alternative therapeutic alternative in PCa.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"253-268"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140854097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation. 负载槲皮素的聚合物溶解微阵列贴片：制造、表征和评估。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-05-09 DOI: 10.1007/s13346-024-01616-8

Qonita Kurnia Anjani, Natalia Moreno-Castellanos, Masoud Adhami, Delly Ramadon, Jangga Jangga, Ryan F Donnelly

{"title":"Quercetin loaded polymeric dissolving microarray patches: fabrication, characterisation and evaluation.","authors":"Qonita Kurnia Anjani, Natalia Moreno-Castellanos, Masoud Adhami, Delly Ramadon, Jangga Jangga, Ryan F Donnelly","doi":"10.1007/s13346-024-01616-8","DOIUrl":"10.1007/s13346-024-01616-8","url":null,"abstract":"Quercetin, a natural compound, shows promising potential in wound healing by reducing fibrosis, limiting scar formation, and boosting fibroblast proliferation. However, its effectiveness is hindered by poor solubility, resulting in low bioavailability and necessitating high doses for therapeutic efficacy. This study presents a novel approach, fabricating quercetin-loaded microarray patches (MAPs) using widely employed solubility enhancement strategies. Fabricated MAPs exhibited favourable mechanical strength and could be inserted into excised porcine skin to a depth of 650 μm. Furthermore, formulations containing Soluplus® significantly increased the drug loading capacity, achieving up to 2.5 mg per patch and complete dissolution within an hour of application on excised porcine skin. In vitro studies on full-thickness neonatal porcine skin demonstrated that Soluplus®-enhanced MAPs effectively delivered quercetin across various skin layers, achieving a delivery efficiency exceeding 80% over 24 h. Additionally, these prototype MAPs displayed anti-inflammatory properties and demonstrated biocompatibility with human keratinocyte skin cells. Therefore, quercetin-loaded MAPs employing Soluplus® as a solubility enhancer present a promising alternative strategy for wound healing and anti-inflammatory therapy applications.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"355-371"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140897789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment. 用于癌症治疗的植物外泌体纳米颗粒。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-05-17 DOI: 10.1007/s13346-024-01621-x

Chun Yi, Linzhu Lu, Zhaosheng Li, Qianqian Guo, Longyun Ou, Ruoyu Wang, Xuefei Tian

{"title":"Plant-derived exosome-like nanoparticles for microRNA delivery in cancer treatment.","authors":"Chun Yi, Linzhu Lu, Zhaosheng Li, Qianqian Guo, Longyun Ou, Ruoyu Wang, Xuefei Tian","doi":"10.1007/s13346-024-01621-x","DOIUrl":"10.1007/s13346-024-01621-x","url":null,"abstract":"Plant-derived exosome-like nanoparticles (PELNs) are natural nanocarriers and effective delivery systems for plant microRNAs (miRNAs). These PELN-carrying plant miRNAs can regulate mammalian genes across species, thereby increasing the diversity of miRNAs in mammals and exerting multi-target effects that play a crucial role in diseases, particularly cancer. PELNs demonstrate exceptional stability, biocompatibility, and targeting capabilities that protect and facilitate the up-take and cross-kingdom communication of plant miRNAs in mammals. Primarily ingested and absorbed within the gastrointestinal tract of mammals, PELNs preferentially act on the intestine to regulate intestinal homeostasis through functional miRNA activity. The oncogenesis and progression of cancer are closely associated with disruptions in intestinal barriers, ecological imbalances, as well as secondary changes, such as abnormal inflammatory reactions caused by them. Therefore, it is imperative to investigate whether PELNs exert their anticancer effects by regulating mammalian intestinal homeostasis and inflammation. This review aims to elucidate the intrinsic crosstalk relationships and mechanisms of PELNs-mediated miRNAs in maintaining intestinal homeostasis, regulating inflammation and cancer treatment. Furthermore, serving as exceptional drug delivery systems for miRNAs molecules, PELNs offer broad prospects for future applications, including new drug research and development along with drug carrier selection within targeted drug delivery approaches for cancer therapy.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"84-101"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis. 以高迁移率组框 1 细胞因子为靶点的白藜芦醇局部给药纳米凝胶，用于治疗特应性皮炎。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-03-20 DOI: 10.1007/s13346-024-01565-2

Shweta Nene, Geetanjali Devabattula, Ganesh Vambhurkar, Kamatham Pushpa Tryphena, Pankaj Kumar Singh, Dharmendra Kumar Khatri, Chandraiah Godugu, Saurabh Srivastava

{"title":"High mobility group box 1 cytokine targeted topical delivery of resveratrol embedded nanoemulgel for the management of atopic dermatitis.","authors":"Shweta Nene, Geetanjali Devabattula, Ganesh Vambhurkar, Kamatham Pushpa Tryphena, Pankaj Kumar Singh, Dharmendra Kumar Khatri, Chandraiah Godugu, Saurabh Srivastava","doi":"10.1007/s13346-024-01565-2","DOIUrl":"10.1007/s13346-024-01565-2","url":null,"abstract":"Resveratrol is a polyphenolic compound showing anti-inflammatory activity by inhibition of high mobility group box 1 cytokine responsible for the activation of nuclear factor-κB pathway in atopic dermatitis. To evaluate the efficacy of resveratrol through topical route we have developed resveratrol-loaded nanoemulgel for the effective management of atopic dermatitis in mice model. The resveratrol-loaded nanoemulsion (0.5%, 0.75% and 1% w/w) was optimized by spontaneous nano-emulsification. The optimized resveratrol-loaded nanoemulsions showed average globule size in the 180-230 nm range and found to be monodispersed. The resveratrol nanoemulgel was prepared with a SEPINEO™ P 600 gel base and propylene glycol. Ex vivo permeation and retention study resulted in significantly higher skin retention of resveratrol from resveratrol-loaded nanoemulgel than free resveratrol-loaded gel. Preclinical efficacy of resveratrol nanoemulgel displayed promising therapeutic outcomes where, western blotting of skin tissues disclosed a significant reduction in the relative expression of high mobility group box 1, the receptor for advanced glycation end products, toll-like receptor-4 and phosphorylated nuclear factor-κB. Further, real-time polymerase chain reaction also disclosed a significant reduction in pro-inflammatory cytokines such as thymic stromal lymphopoietin, interleukin-4, interleukin-13, interleukin-31, tumor necrosis factor-α and interleukin-6. The histopathological examination of skin sections showed improvement in the skin condition. Collectively, the findings from our study showcased the significant improvement in the atopic dermatitis skin condition in mice model after topical application of resveratrol loaded nanoemulgel.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"134-157"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140179439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perfluorodecalin allows resuspension and prevents sediment solidification of extended-release drug formulations in primary packaging. 全氟萘烷可以使缓释药物制剂在初级包装中重新悬浮并防止沉淀凝固。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-05-04 DOI: 10.1007/s13346-024-01598-7

Daniel Primavessy, Sarah Büttner, Sigrid Saaler-Reinhardt

引用次数: 0

Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools. 利用混合人工智能工具，通过顺序设计工程化甘露糖功能纳米结构脂质载体。

IF 5.7 3区医学

Drug Delivery and Translational Research Pub Date : 2025-01-01 Epub Date: 2024-05-09 DOI: 10.1007/s13346-024-01603-z

Rebeca Martinez-Borrajo, Patricia Diaz-Rodriguez, Mariana Landin

{"title":"Engineering mannose-functionalized nanostructured lipid carriers by sequential design using hybrid artificial intelligence tools.","authors":"Rebeca Martinez-Borrajo, Patricia Diaz-Rodriguez, Mariana Landin","doi":"10.1007/s13346-024-01603-z","DOIUrl":"10.1007/s13346-024-01603-z","url":null,"abstract":"Nanostructured lipid carriers (NLCs) hold significant promise as drug delivery systems (DDS) owing to their small size and efficient drug-loading capabilities. Surface functionalization of NLCs can facilitate interaction with specific cell receptors, enabling targeted cell delivery. Mannosylation has emerged as a valuable tool for increasing the ability of nanoparticles to be recognized and internalized by macrophages. Nevertheless, the design and development of functionalized NLC is a complex task that entails the optimization of numerous variables and steps, making the process challenging and time-consuming. Moreover, no previous studies have been focused on evaluating the functionalization efficiency. In this work, hybrid Artificial Intelligence technologies are used to help in the design of mannosylated drug loaded NLCs. Artificial neural networks combined with fuzzy logic or genetic algorithms were employed to understand the particle formation processes and optimize the combinations of variables for the different steps in the functionalization process. Mannose was chemically modified to allow, for the first time, functionalization efficiency quantification and optimization. The proposed sequential methodology has enabled the design of a robust procedure for obtaining stable mannosylated NLCs with a uniform particle size distribution, small particle size (< 100 nm), and a substantial positive zeta potential (> 20mV). The incorporation of mannose on the surfaces of these DDS following the established protocols achieved > 85% of functionalization efficiency. This high effectiveness should enhance NLC recognition and internalization by macrophages, thereby facilitating the treatment of chronic inflammatory diseases.","PeriodicalId":11357,"journal":{"name":"Drug Delivery and Translational Research","volume":" ","pages":"343-354"},"PeriodicalIF":5.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0