Domestic animal endocrinology最新文献_第2页

Granulosa cell function in domestic animals: A review on the in vitro effects of FSH, insulin and insulin-like growth factor 1

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-23 DOI: 10.1016/j.domaniend.2025.106919

Leon J. Spicer , Excel Rio S. Maylem , Luis Fernando Schütz

{"title":"Granulosa cell function in domestic animals: A review on the in vitro effects of FSH, insulin and insulin-like growth factor 1","authors":"Leon J. Spicer , Excel Rio S. Maylem , Luis Fernando Schütz","doi":"10.1016/j.domaniend.2025.106919","DOIUrl":"10.1016/j.domaniend.2025.106919","url":null,"abstract":"<div><div>Ovarian granulosa cells produce a variety of biologically active compounds in addition to steroid hormones that include numerous families of growth factors, cytokines and adipokines. Many of these function as endocrine, paracrine and autocrine hormones to regulate ovarian activity. The goal of this review is to provide an update on the evidence in domestic animals on how FSH, insulin and IGF1 regulate the function of granulosa cells with a focus on ovarian steroidogenesis and cell proliferation with comparisons across six domestic animals: pigs, cattle, horses, water buffalo, goats and sheep. In most species, FSH was not a mitogenic stimulus to granulosa cells whereas insulin and IGF1 were stimulatory to cell proliferation in the species it was evaluated. FSH, insulin and IGF1 were all stimulatory to granulosa cell steroidogenesis in the species it was studied. More research is needed to evaluate the role of insulin in the regulation of cell proliferation and steroidogenesis in water buffalo and goats. The role of IGF1 in regulating granulosa cell function in horses also needs further study. Most granulosa-cell secreted factors have direct effects (either positive or negative) on FSH-, insulin- and IGF1-induced steroid production in ovarian cells, but how they all work together to create a cumulative effect to regulate fertility will require further research.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"91 ","pages":"Article 106919"},"PeriodicalIF":1.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gonadotropins, local factors and a variety of adipokines contribute to regulate swine granulosa cell function 促性腺激素、局部因子和多种脂肪因子参与调节猪颗粒细胞功能。

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-18 DOI: 10.1016/j.domaniend.2025.106918

G. Basini, F. Grasselli

引用次数: 0

Utero-placental adaptations in response to intrauterine growth restriction in swine

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-16 DOI: 10.1016/j.domaniend.2025.106917

Morgan S. Clemens , Maria F. Tyree , Claire Stenhouse

引用次数: 0

Fish oil a source of omega-3 fatty acids affects hypothalamus heat resistance genes expressions and fatty acid composition in heat-stressed chicks

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-14 DOI: 10.1016/j.domaniend.2025.106915

Hatem M. El-Tahan , Chun Ik Lim , Ahmad R. Alhimaidi , Aiman A. Ammari , Sungbo Cho , In Ho Kim , Hossam M. El-Tahan

{"title":"Fish oil a source of omega-3 fatty acids affects hypothalamus heat resistance genes expressions and fatty acid composition in heat-stressed chicks","authors":"Hatem M. El-Tahan , Chun Ik Lim , Ahmad R. Alhimaidi , Aiman A. Ammari , Sungbo Cho , In Ho Kim , Hossam M. El-Tahan","doi":"10.1016/j.domaniend.2025.106915","DOIUrl":"10.1016/j.domaniend.2025.106915","url":null,"abstract":"<div><div>This study investigated the effects of fish oil (FO) supplementation on the hypothalamus heat resistance gene expressions and fatty acid composition of chicks under acute high-temperature stress, for treating Cholestasis. A total of 48 chicks (Ross 308) at age of 14 days were acclimatized to corn oil or FO (n = 24 for each) by oral gavaging for 10 days, and then subjected to heat stress (35 ± 1 °C, HT) for 3 h or maintained at the normal temperature (26 ± 1 °C, NT) as grouped as NT and FO-NT control and HT and FO-HT (n = 12 for each).. The results showed that FO supplementation had no significant (P > 0.05) effect on feed intake or body weight. The FO-HT group exhibited (<em>P</em> <em><</em> <em>0.05</em>) a lower rectal temperature, and plasma interleukin-6 (IL-6), triglyceride and corticosterone levels, in accompany with lower expressions of hypothalamic adenine nucleotide translocators (ANT) and uncoupling protein (UCP) but increased (<em>P</em> <em><</em> <em>0.05</em>) plasma superoxide dismutase activity and hypothalamic neuropeptide-Y (NPY) and heat shock protein-70 (HSP-70) expressions.. Additionally, the FO-HT group (P < 0.05) demonstrated a higher unsaturated fatty acid/saturated fatty acid (UFA/SFA) ratio in the breast muscle. These findings suggest that FO supplementation can enhance the heat resistance of broiler chicks under acute heat stress and alter the fatty acid composition of their breast muscle. However, further studies are needed to determine whether desirable fatty acids can cross the blood-brain barrier and their implications for human health.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"91 ","pages":"Article 106915"},"PeriodicalIF":1.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From spermatogenesis to fertilisation: the role of melatonin on ram spermatozoa 从精子形成到受精：褪黑素对雄性精子的作用。

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-14 DOI: 10.1016/j.domaniend.2025.106916

Adriana Casao, Victoria Peña-Delgado, Rosaura Pérez-Pe

{"title":"From spermatogenesis to fertilisation: the role of melatonin on ram spermatozoa","authors":"Adriana Casao, Victoria Peña-Delgado, Rosaura Pérez-Pe","doi":"10.1016/j.domaniend.2025.106916","DOIUrl":"10.1016/j.domaniend.2025.106916","url":null,"abstract":"<div><div>This review presents recent findings on the effect of melatonin on ram spermatozoa. This hormone regulates seasonal reproduction in the ovine species through the hypothalamic-pituitary-gonadal axis, but it also exerts direct effects on spermatogenesis, seminal quality and fertility. In the testis, melatonin stimulates blood flow to this organ, but it also appears to be involved in the differentiation of spermatogonial stem cells and the secretion of testosterone through the MT1 and MT2 receptors. In the epididymis, this hormone modulates sperm maturation and the secretory activity of epidydimal epithelial cells. In addition, the antioxidant activity of melatonin may protect spermatozoa from oxidative damage during their formation in the testis and their maturation in the epididymis. After ejaculation, the melatonin present in seminal plasma may also protect sperm from oxidative damage and premature capacitation and may improve seminal quality. Finally, once the sperm begins its transit through the female genital tract, melatonin may modulate sperm capacitation. Thus, melatonin could have a bimodal activity in ram sperm capacitation, so high concentrations, such as those in seminal plasma, have a decapacitating effect. In contrast, low concentrations, such as those present in the female reproductive tract, may promote it, likely through interaction with MT2 receptors. In addition, melatonin could also be involved in chemotaxis and fertilisation, although further studies are needed to elucidate the specific role of melatonin in these processes. Finally, the effect of latitude and melatonin receptor gene polymorphisms in ram reproduction is also discussed.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"91 ","pages":"Article 106916"},"PeriodicalIF":1.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations in serum concentrations of visfatin and betatrophin in dogs with diabetes mellitus 糖尿病犬血清visfatin和betatrophin浓度的变化。

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-13 DOI: 10.1016/j.domaniend.2025.106914

Alexandra Slon, Michal Mazaki-Tovi

{"title":"Alterations in serum concentrations of visfatin and betatrophin in dogs with diabetes mellitus","authors":"Alexandra Slon, Michal Mazaki-Tovi","doi":"10.1016/j.domaniend.2025.106914","DOIUrl":"10.1016/j.domaniend.2025.106914","url":null,"abstract":"<div><div>Canine diabetes mellitus (DM) is associated with hyperglycemia and hyperlipidemia. Visfatin and betatrophin are adipokines involved in the pathophysiology of insulin resistance and deranged lipid metabolism, and are also altered in obesity. We hypothesized that visfatin and betatrophin serum concentrations are altered in diabetic dogs, irrespective of their body condition. The study included 23 newly-diagnosed DM (NDDM) dogs, 34 insulin-treated DM (ITDM) dogs and 24 healthy dogs. Body condition score was determined and fasted serum samples were collected for measurement of betatrophin, visfatin and insulin serum concentrations. Visfatin concentrations (mean, 95% CI) were lower in overweight NDDM (4.5 ng/mL, 2.5-8.1, P=0.05) and ITDM (2.8 ng/mL 1.8-4.3, P=0.006) than healthy (7.7 ng/mL, 5.0-11.7) dogs, but were not different among lean dogs, and were negatively correlated to betahydroxybutyric acid in ITDM dogs (r=-0.59, P=0.05). Betatrophin concentrations were lower in NDDM (69 pg/mL, 43-112, P<0.001) and ITDM (53 pg/mL, 34-84, P<0.001) than healthy (267 pg/mL, 167-426) dogs. Among NDDM dogs, betatrophin concentrations were higher in those with concurrent liver disease (203 pg/mL, 49-844) than those with no evidence of liver disease (19 pg/mL, 4-90, P=0.007), and were negatively correlated with glucose concentrations (r=-0.44, P=0.04) and creatinine (r=-0.60, P=0.003). Insulin concentrations were not different among NDDM and healthy dogs. Among NDDM dogs, insulin concentrations were negatively correlated to concentrations of betahydroxybutyric acid (r=-0.65, P=0.002) and were lower in dogs with concurrent kidney disease (5.6 mU/L, 2.1-15.3) compared to those with no evidence of kidney disease (20.6 mU/L, 8.0-53.2, P=0.018). In conclusion, DM in dogs is associated with alteration in visfatin and betatrophin concentrations that are not resolved by insulin treatment.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"91 ","pages":"Article 106914"},"PeriodicalIF":1.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

L-thyroxine and 4-pregnane-3,20‑dione preserves pregnancy in bitches with hypothyroidism and hypoluteoidism

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-12 DOI: 10.1016/j.domaniend.2025.106913

Marcelo Martínez-Barbitta , Silvia Edelweiss Crusco , Beniamino Cenci Goga , Massimo Zerani

{"title":"L-thyroxine and 4-pregnane-3,20‑dione preserves pregnancy in bitches with hypothyroidism and hypoluteoidism","authors":"Marcelo Martínez-Barbitta , Silvia Edelweiss Crusco , Beniamino Cenci Goga , Massimo Zerani","doi":"10.1016/j.domaniend.2025.106913","DOIUrl":"10.1016/j.domaniend.2025.106913","url":null,"abstract":"<div><div>Hypoluteoidism is characterized by insufficient secretion of progesterone (P4) by the corpus luteum (CL) during pregnancy, resulting in embryonic resorption and miscarriage. In dogs, hypothyroidism can occur concurrently with hypoluteoidism, therefore, the aim of this study was to propose a combination therapy to treat these two conditions in bitches. The study included 30 bitches that were artificially inseminated and divided into three experimental groups. The control group (G1) included 10 bitches with a history of normal pregnancies, normal thyroid activity and P4 levels. This group received no clinical treatment. Treatment groups included 20 bitches diagnosed with reproductive hypothyroidism and hypoluteoidism: 10 dogs in the G2 group were treated with L-thyroxine (20 μg/kg/day) only and 10 dogs in the G3 group were treated with L-thyroxine and a long-acting synthetic P4 analogue (4-pregnane-3,20-dione, 1.0 mg/kg every 72 h until cesarean section on day 61). In all dogs, pregnancy and embryonic viability was monitored by ultrasound until term. G1 females had normal pregnancies (P4: day 24, 33.33 ± 2.95 ng/mL [106.00 ± 9.38 nmol/L]; day 38, 23.95 ± 1.21 ng/mL [76.16 ± 3.85 nmol/L]; day 50, 10.53 ± 0.82 ng/mL [33.49 ± 2.61 nmol/L]; day 63, 1.11 ± 0.22 ng/mL [3.53 ± 0.70 nmol/L]; <em>p</em> < 0.001). G2 females suffered embryonic death detected between day 31 and day 33 by ultrasound (P4: 4.67 ng/mL ± 0.41 ng/mL, [14.85 ± 1.30 nmol/L]; <em>p</em> < 0.001). In contrast, G3 females had similar plasma P4 levels to G1 dogs, and pregnancy was maintained until the scheduled cesarean section. These data suggest that combination therapy of L-thyroxine and 4-pregnane-3,20-dione maintains pregnancy to term in dogs with concomitant hypothyroidism and hypoluteoidism.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"92 ","pages":"Article 106913"},"PeriodicalIF":1.9,"publicationDate":"2025-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143422535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in our understanding of the estrous cycle and applications for improving targeted reproductive management in livestock 家畜发情周期的认识进展及其在提高针对性生殖管理中的应用。

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2025-01-08 DOI: 10.1016/j.domaniend.2025.106912

Robert A. Cushman , Shelby L. Rosasco , Kacie L. McCarthy , Alexandria P. Snider , George A. Perry , Clay A. Lents

{"title":"Advances in our understanding of the estrous cycle and applications for improving targeted reproductive management in livestock","authors":"Robert A. Cushman , Shelby L. Rosasco , Kacie L. McCarthy , Alexandria P. Snider , George A. Perry , Clay A. Lents","doi":"10.1016/j.domaniend.2025.106912","DOIUrl":"10.1016/j.domaniend.2025.106912","url":null,"abstract":"<div><div>The scientific discipline of endocrinology has been invaluable to our understanding of the estrous cycle. In the second half of the twentieth century the development of immunoassay technologies provided a rapid and sensitive method to quantify circulating concentrations of reproductive hormones and relate them to stage of the estrous cycle and physiological status of the animal. Ovarian ultrasonography provided the ability to track the growth and regression of ovarian structures within the same animal across the estrous cycle in real time and, in combination with hormonal profiling, accurately identify mechanisms regulating the estrous cycle and early pregnancy. Before this, the best technique had been serial collections with each animal being a single endpoint. The availability of continuous data such as daily hormone concentrations and daily follicular measurements within animals led to the improvement of methods to synchronize estrus in each of the species. Unfortunately, the use of radio-immunoassays has been declining for two decades. While enzyme-linked immunosorbent assays have been developed for many endocrine, paracrine, and autocrine factors, their primary market is human medicine and rodent models of human health, leaving those available for livestock species economically infeasible. Automated sensors such as accelerometers apply the knowledge attained through decades of endocrinology and ultrasonography studies to identify females in estrus and measure parameters of the estrous cycle that are related to fertility. The ability of automated sensors to centralize and assimilate large amounts of behavioral and physiological data from numerous animals will enhance targeted reproductive management in livestock production systems.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"91 ","pages":"Article 106912"},"PeriodicalIF":1.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of GnRH administration on follicular development and ovulation during the early luteal phase in subtropical goats GnRH对亚热带山羊黄体前期卵泡发育和排卵的影响。

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2024-12-26 DOI: 10.1016/j.domaniend.2024.106911

Waqas Ahmad , Muhammad Irfan-ur-Rehman Khan , Amjad Riaz , Khalid Javed

{"title":"Effect of GnRH administration on follicular development and ovulation during the early luteal phase in subtropical goats","authors":"Waqas Ahmad , Muhammad Irfan-ur-Rehman Khan , Amjad Riaz , Khalid Javed","doi":"10.1016/j.domaniend.2024.106911","DOIUrl":"10.1016/j.domaniend.2024.106911","url":null,"abstract":"<div><div>This study aimed to evaluate the ovulatory response to GnRH treatment based on the day of its administration in the first follicular wave of the estrous cycle in goats. We hypothesized that maximum ovulatory response with GnRH treatment is dependent on the day of its administration during the early luteal phase of estrous cycle. Forty-eight goats were presynchronized with a single dose of PGF<sub>2α</sub>, and ultrasonography was performed to confirm ovulation (Day 0). Following ovulation, goats (<em>n</em> = 38) were randomly assigned to receive GnRH treatment on Days 2, 4, 6, or 8 of the estrous cycle. Follicular dynamics were assessed every 4 h after GnRH treatment and 37% of goats ovulated within 12.0 ± 1.5 h after treatment. Ovulation rate was significantly higher on Day 4 compared to Day 2 (<em>P</em> = 0.03) and gradually declined by Day 8. Goats with dominant follicles with diameters between 6.1 and 7.0 mm had significantly higher ovulation rate than goats < 6.1 mm (<em>P</em> = 0.01). A strong negative correlation was found between dominant follicle diameter at the time of GnRH administration and anovulation (r<sub>pb</sub> = -0.79). The growth rate of dominant follicles after GnRH administration remained higher in Day 4 than Day 8 (<em>P</em> < 0.05). Similarly, the interval to new follicular wave emergence was longer on Day 4 than on Days 2, 6 and 8 (<em>P</em> < 0.05). In conclusion, administering GnRH on Day 4 of the estrous cycle yielded the highest ovulatory response, particularly when the dominant follicle measured between 6.1-7.0 mm during the first follicular wave of estrous cycle.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"91 ","pages":"Article 106911"},"PeriodicalIF":1.9,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142908785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pregnancy-induced mechanisms regulating central and peripheral leptin sensitivity: lessons from sheep 妊娠诱导的调节中枢和外周瘦素敏感性的机制：来自绵羊的教训。

IF 1.9 2区农林科学

Domestic animal endocrinology Pub Date : 2024-12-23 DOI: 10.1016/j.domaniend.2024.106910

Malgorzata Szczesna, Katarzyna Kirsz, Dorota A. Zieba

引用次数: 0