Domestic animal endocrinology最新文献

{"title":"HDAC5 mediates the regulation of muscle-derived interleukin 6 on the differentiation of porcine intramuscular pre-adipocytes","authors":"Weimin Lin,&nbsp;Hongbing Song,&nbsp;Chongfan Du,&nbsp;Jing Wang,&nbsp;Xiaohan Zhang,&nbsp;Chu Yang,&nbsp;Tianfang Xiao,&nbsp;Ruiyi Lin","doi":"10.1016/j.domaniend.2025.106992","DOIUrl":"10.1016/j.domaniend.2025.106992","url":null,"abstract":"<div><div>Intramuscular fat (IMF) deposition is a critical determinant of pork quality, with pre-adipocyte differentiation serving as a pivotal regulatory process. Although muscle-derived interleukin-6 (IL-6) is recognized for its role in promoting lipolysis and fatty acid oxidation, the epigenetic mechanisms governing its regulation remain poorly characterized. This study elucidates the epigenetic regulation of histone deacetylase 5 (HDAC5) on muscle-derived IL-6 transcription and secretion, and its consequent effects on porcine IMF deposition. Western blot (WB) and quantitative PCR (qPCR) analyses demonstrated that elevated IL-6 expression in the porcine longissimus dorsi muscle was negatively correlated with IMF content. Chromatin immunoprecipitation (ChIP)-PCR and adipogenic induction assays revealed that HDAC5 suppresses IL-6 transcription and secretion, thereby enhancing intramuscular pre-adipocyte differentiation. Through co-immunoprecipitation (Co-IP), dual-luciferase reporter assays, and differentiation induction experiments, we identified a functional interaction between HDAC5 and myocyte enhancer factor 2A (MEF2A). Mechanistically, MEF2A binds to the IL-6 promoter to activate its transcription and secretion, which subsequently inhibits pre-adipocyte differentiation. Dual-interference assays further confirmed that HDAC5 regulates IL-6 expression by directly binding to and repressing MEF2A activity, ultimately modulating IMF deposition. These findings uncover a novel epigenetic pathway through which HDAC5 governs muscle-derived IL-6 to regulate pre-adipocyte differentiation and IMF accumulation in pigs, offering critical molecular insights for strategies aimed at optimizing pork quality.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"95 ","pages":"Article 106992"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145721754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Backfat thickness at first insemination as a determinant of endocrine regulation of appetite during the gestation–lactation transition in primiparous gilt","authors":"Rosa E. Pérez ,&nbsp;Gerardo Ordaz ,&nbsp;Manuel López ,&nbsp;Ruy Ortiz","doi":"10.1016/j.domaniend.2026.106997","DOIUrl":"10.1016/j.domaniend.2026.106997","url":null,"abstract":"<div><div>The gestation–lactation transition involves high metabolic demand, and backfat thickness (BFT) better reflects adiposity and endocrine function than body weight (BW). This study evaluated the relationships between body condition indicators (BFT and BW), daily feed intake (DFI), and metabolic and endocrine markers during the gestation–lactation transition in primiparous gilts. Metabolic and endocrine indicators of energy balance were assessed, and their associations with body condition and feed intake were analyzed using correlation analyses and regression models. Sows with greater BFT at first insemination exhibited lower DFI during lactation (3.1 vs. 4.2 kg; <em>P</em> &lt; 0.05) compared with sows with lower BFT. At farrowing, these sows showed higher leptin concentrations (3.2 vs. 2.1 ng/mL; <em>P</em> &lt; 0.01) and higher HOMA-IR values (5.5 vs. 3.6; <em>P</em> &lt; 0.05), whereas ghrelin concentrations were lower (246.9 vs. 305.0 pg/mL; <em>P</em> &lt; 0.05). In contrast, classification by BW had no significant effects on DFI or on the main endocrine indicators during lactation. BFT showed stronger associations with DFI (r = −0.47; <em>P</em> &lt; 0.01) and leptin (r = 0.58; <em>P</em> &lt; 0.001) than BW. Partial correlation analyses indicated that the DFI–leptin and DFI–ghrelin associations remained significant after adjustment for BFT, but not after adjustment for BW. Regression models confirmed a greater predictive capacity of BFT than BW for DFI during lactation. These results indicate that BFT is a physiologically more informative indicator than BW for assessing metabolic status and endocrine regulation of appetite during the gestation–lactation transition in primiparous gilts.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"95 ","pages":"Article 106997"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146124230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic islet remodeling in horses with hyperinsulinemia and pituitary dysfunction","authors":"P. Teague,&nbsp;M. Dark,&nbsp;D. Verdugo,&nbsp;D. Freeman,&nbsp;D. McFarlane","doi":"10.1016/j.domaniend.2026.106998","DOIUrl":"10.1016/j.domaniend.2026.106998","url":null,"abstract":"<div><div>The equine pancreas remains understudied, particularly in the context of endocrine disease. This study aimed to characterize regional islet distribution and composition in the normal equine pancreas and investigate how hyperinsulinemia (HI) and pituitary pars intermedia dysfunction (PPID) influence pancreatic islet morphology and hormone expression. In the first experiment, pancreas samples from eight healthy horses were collected and analyzed across three anatomical locations: left lobe, body, and right lobe. The left lobe exhibited a greater relative islet area and perimeter compared to the body and right lobe, though islet composition remained consistent with a similarly proportional alpha-cell core, beta-cell mantle, and scattered delta-cells. In the second experiment, pancreas tissues from thirty-five horses with defined endocrine disease status were evaluated. HI was associated with larger islets and greater insulin immunostaining, while PPID was associated with increased islet number without changes in islet size or insulin immunostaining, suggesting divergent disease-specific adaptations. Findings support the hypothesis that HI drives islet expansion as a compensatory response to insulin resistance, whereas PPID promotes islet neogenesis. The observed increase in islet number in PPID horses may reflect a previously unrecognized mechanism influenced by chronic endocrine stimulation. These results established foundational knowledge of normal equine islet architecture and highlight the dynamic adaptability of the endocrine pancreas in response to metabolic and pituitary disorders.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"95 ","pages":"Article 106998"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146218893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carbetocin - a long-acting oxytocin analogue - increases the blood supply to the reproductive tract of rams","authors":"Mariana Garcia Kako Rodriguez ,&nbsp;Juan Pedro Bottino ,&nbsp;Rodolfo Ungerfeld","doi":"10.1016/j.domaniend.2026.107001","DOIUrl":"10.1016/j.domaniend.2026.107001","url":null,"abstract":"<div><div>The aim of this study was to determine whether carbetocin administration alters blood flow in the reproductive tract and scrotal skin surface temperature of rams. Eight rams were evaluated in a crossover arrangement, in which each animal received a standard (0.2 mg/100 kg; STAC) or high (0.4 mg/100 kg; HIGHC) dose of carbetocin, or no treatment (CON). Each animal received all treatments. Hemodynamic characteristics of the male reproductive tract were assessed using spectral Doppler ultrasonography, and scrotal surface temperatures were recorded by infrared thermography at 0, 30, and 120 min after cabertocin administration. Thirty minutes after treatment, the resistive index (RI) of the internal iliac artery was lower in STAC than in CON (P=0.008) and HIGHC (P=0.02) treated rams. Carbetocin or its interaction with time did not affect blood flow in the marginal or supratesticular arteries or the scrotal surface temperatures. In conclusion, the standard dose of carbetocin transiently reduced internal iliac artery RI, resulting in a temporary increase in blood flow to the accessory sex glands, without altering scrotal skin temperature in rams.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"95 ","pages":"Article 107001"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147276140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential profiles of GH, IGF-1, and fructosamine in follicular fluid and plasma of cyclic mares","authors":"Katiuska Satué ,&nbsp;Esterina Fazio ,&nbsp;Maria Gemma Velasco-Martínez ,&nbsp;Giuliana Barbiera ,&nbsp;Deborah La Fauci","doi":"10.1016/j.domaniend.2026.107000","DOIUrl":"10.1016/j.domaniend.2026.107000","url":null,"abstract":"<div><div>Growth hormone (GH) influences follicular development mainly by stimulating insulin-like growth factor 1 (IGF-1), which acts systemically and locally within the ovary. However, the metabolic profile of follicular fluid (FF) in mares, particularly markers such as fructosamine (FRUCT), an indicator of glucose metabolism, remains poorly characterized. This study aimed to evaluate GH, IGF-1, and FRUCT concentrations in plasma and FF and their variation across follicle sizes. Sixty ovaries were collected during the breeding season from 30 clinically normal mares raised for meat production. Blood samples were obtained prior to slaughter. Follicles were classified as small (20–30 mm), medium (31–40 mm), and large (≥41 mm), and FF was aspirated individually. GH was measured by enzyme immunoassay, IGF-1 by ELISA, and FRUCT by spectrophotometry. GH concentrations did not differ significantly between plasma and FF across follicle sizes. IGF-1 remained low in small and medium follicles but increased in large preovulatory follicles (<em>p</em> &lt; 0.05). FRUCT concentrations in FF progressively rose with follicular development and were higher than plasma values (<em>p</em> &lt; 0.05). IGF-1 and FRUCT were positively correlated (<em>r</em> = 0.65; <em>p</em> &lt; 0.05). These findings suggest that IGF-1 plays a role in final follicular maturation, while FRUCT accumulation reflects enhanced local carbohydrate metabolism during follicular growth. Moreover, the positive correlation between IGF-1 and FRUCT indicates a potential link between metabolic activity and growth signaling within the follicular microenvironment.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"95 ","pages":"Article 107000"},"PeriodicalIF":2.1,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Threshold dose of 1,25-dihydroxycholecalciferol-glycosides on mineral metabolism and circulating serotonin and dopamine in bovines","authors":"Douglas M. Souza ,&nbsp;Maximiliane A. Zambom ,&nbsp;Ryana C. Markmann ,&nbsp;Brenda Souza ,&nbsp;Tamires M. Schuster ,&nbsp;Kathrin Bühler ,&nbsp;Ériton E.L. Valente","doi":"10.1016/j.domaniend.2025.106963","DOIUrl":"10.1016/j.domaniend.2025.106963","url":null,"abstract":"<div><div>Plant-derived 1,25(OH)₂D₃-glycosides modulate calcium (Ca) and phosphorus (P) metabolism, but the safety of sustained oral supplementation in cattle remains unclear. The objective of this study was to establish a safe upper limit for dietary supplementation of 1,25(OH)₂D₃-glycosides in steers and to assess its impact on mineral and neurotransmitters metabolism. Six Holstein steers (452 ± 61.5 kg) were used in a replicated 3 × 3 Latin Square design. Treatments consisted of oral administration of 1,25(OH)₂D₃-glycosides at doses of 0, 0.2, and 0.4 µg/kg body weight (BW) for five consecutive days. Blood samples were collected prior to the initiation of treatment, as well as immediately before (0 h) and at 3, 6, 12, 24, 48, 72, 96, and 168 hours following the final dose on day 5. The serum Ca remained (<em>P &lt; 0.001</em>) elevated up to 72 h and 96 h following the final administration of 1,25(OH)₂D₃-glycoside at doses of 0.2 µg/kg BW and 0.4 µg/kg BW, respectively. In contrast, serum P concentrations remained significantly elevated (<em>P = 0.001</em>) for more than 168 hours post-treatment, regardless of the administered dose. No significant effects were observed on serum alkaline phosphatase (ALP) activity (<em>P = 0.298</em>), parathyroid hormone (PTH; <em>P = 0.183</em>) concentrations, or circulating serotonin (<em>P = 0.428</em>) and dopamine (<em>P = 0.846</em>). Additionally, no clinical signs consistent with vitamin D intoxication were observed. Oral supplementation with 1,25(OH)₂D₃-glycosides at doses up to 0.4 µg/kg BW for 5 days induces a sustained elevation in serum Ca and P concentrations, more evidently at higher dosages, without altering serum concentration of ALP, PTH, serotonin or dopamine indicating that 0.4 µg/kg BW dosage might be close to the upper threshold of 1,25(OH)₂D₃-glycosides in cattle while 0.2 µg/kg BW can be considered as safe.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"94 ","pages":"Article 106963"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The transcriptome of the ovine choroid plexus is regulated by thyroid hormone but not by photoperiod","authors":"H. Dardente ,&nbsp;D. Lomet ,&nbsp;O. Lasserre ,&nbsp;A.A. Gonzalez ,&nbsp;X. Mialhe ,&nbsp;J. Cognié","doi":"10.1016/j.domaniend.2025.106975","DOIUrl":"10.1016/j.domaniend.2025.106975","url":null,"abstract":"<div><div>The photoperiodic control of seasonal functions requires the action of melatonin at the <em>pars tuberalis</em> of the pituitary and subsequent control of local thyroid hormone (TH) signaling by tanycytes lining the basolateral part of the third ventricle. Therefore, TH supply of tanycytes through the cerebrospinal fluid (CSF) produced by the choroid plexuses (CP) is central to photoperiodism. Here, the transcriptome of the CP of the lateral ventricles was established by RNAseq in ewes maintained under three experimental conditions: ewes exposed to a short photoperiod (SP; 8.5 h of light), intact ewes submitted to an acute 3-week exposure to a long photoperiod (LP-Sham; 15.5 h of light) and ewes thyroidectomized prior to the LP exposure (LP-THX). Photoperiod impacted the expression of 1169 genes (SP vs LP-Sham) while 575 genes were sensitive to TH (LP vs LP-THX). Compared to TH-responsive genes, photoperiod-responsive genes displayed rather weak transcriptional changes. In line with this, RT-qPCR for select candidate genes validated the impact of TH, but not that of photoperiod. We demonstrate weak expression of the melatonin MT1 receptor in the CP, which provides a functional rationale for this. In conclusion, the CP appears as a permissive tissue to the expression of TH-dependent seasonality governed by tanycytes rather than being an integral component of the melatonin-dependent photoperiodic response.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"94 ","pages":"Article 106975"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145118482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunogenicity of recombinant gonadotropin-releasing hormone contraceptive vaccines in male pigs","authors":"Jean Vitor Bondavalli ,&nbsp;Monike Willemin Quirino ,&nbsp;Neida Conrad ,&nbsp;Vanessa Peripolli ,&nbsp;Elizabeth Schwegler ,&nbsp;Matheus Folgearini Silveira ,&nbsp;Yuso Tutida ,&nbsp;Bernardo Garziera Gasperin ,&nbsp;Fábio Pereira Leivas Leite ,&nbsp;Ivan Bianchi ,&nbsp;Fabiana Moreira","doi":"10.1016/j.domaniend.2025.106979","DOIUrl":"10.1016/j.domaniend.2025.106979","url":null,"abstract":"<div><div>This study assessed the contraceptive effects of two vaccines formulated with recombinant gonadotropin-releasing hormone antigen (rGnRH antigen) conjugated with the heat-labile enterotoxin B subunit (LTB) protein from <em>Escherichia coli</em> in male pigs. Thirty-two piglets were assigned to four groups: Surg, surgically castrated at 3 days old; Vvx, non-castrated and vaccinated with a commercial vaccine (Vivax®) at 101 and 135 days old; rGnRH-400 and rGnRH-300, non-castrated and vaccinated at 101 and 135 days old with recombinant vaccines containing 400 µg or 300 µg rGnRH/LTB per dose, respectively. Growth performance was not affected by treatment (<em>p</em> ≥ 0.25). At 155 and 165 days old, piglets in the rGnRH-400 and rGnRH-300 groups exhibited anti-GnRH/LTB antibody levels were similar to those in the Vvx group (<em>p</em> &gt; 0.05) or higher (<em>p &lt;</em> 0.05) than those in the Vvx group. However, rGnRH-400 and rGnRH-300 piglets showed higher testosterone concentrations at 155 and 165 days old and greater testicular volumes at 165 days old than Vvx piglets (<em>p</em> &lt; 0.05). Severe testicular lesions (scores 3 and 4) were more frequent in the Vvx group, while those in the rGnRH-400 group were mainly scored as 3, and only mild lesions (scores 1 and 2) were observed in the rGnRH-300 group. Overall, both recombinant vaccines elicited strong anti-GnRH/LTB antibody levels; however, they did not produce the same degree of testicular alterations or testosterone reduction as the commercial vaccine. Further studies are warranted to evaluate the contraceptive potential of these recombinant formulations, particularly the 400 µg rGnRH/LTB vaccine.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"94 ","pages":"Article 106979"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of protein-bound iron supplementation on reproductive performance of sows and growth performance of piglets","authors":"Hongxuan Ye ,&nbsp;Junyi Wu ,&nbsp;Xuexun Feng ,&nbsp;Qiling Chen ,&nbsp;Zihao Huang ,&nbsp;Bin Su ,&nbsp;Songfeng Yang ,&nbsp;Lili Wang ,&nbsp;Hefeng Luo ,&nbsp;Chengquan Tan","doi":"10.1016/j.domaniend.2025.106978","DOIUrl":"10.1016/j.domaniend.2025.106978","url":null,"abstract":"<div><div>Iron is an essential nutrient for maternal health and fetal development. 65 multiparous sows were used to determine the effects of maternal protein-bound iron (P-Iron) supplementation on reproductive performance of sows and growth of their offspring. Sows received either the farm’s control diet (total iron 180 mg/kg, including 80 mg/kg as ferrous sulfate; n = 32) or the same diet plus 120 mg Fe/kg as protein-bound iron (P-Iron; n = 33) from gestation day 85 to lactation day 21. The results showed that, relative to the control (CON), sows in the P-Iron group had higher hemoglobin at gestation day 110 and at farrowing (both <em>P</em> &lt; 0.05), and the P-Iron group exhibited improved antioxidant status, with lower serum malondialdehyde at farrowing (<em>P</em> &lt; 0.01), higher total antioxidant capacity (<em>P</em> &lt; 0.05), and a trend toward higher glutathione (<em>P</em> = 0.08). Newborn piglets in the P-Iron group had higher hemoglobin concentration (<em>P</em> &lt; 0.01). Reproductive performance in the P-Iron group showed a downward trend in mummified fetuses (<em>P</em> = 0.07). During lactation, colostrum and ordinary milk iron concentrations were higher in the P-Iron group than in CON (<em>P</em> &lt; 0.05). At weaning, piglets from the P-Iron group had higher serum iron and iron saturation (both <em>P</em> &lt; 0.05) and higher IgA levels (<em>P</em> &lt; 0.05). Litters in the P-Iron group also had greater weaning litter weights (<em>P</em> &lt; 0.05), with a trend toward improved survival (<em>P</em> = 0.09).Overall, dietary supplementation with 120 mg/kg P-Iron enhanced iron transfer from sows to offspring, resulting in increased hemoglobin levels in sows and newborn piglets, improved oxidative stress status, elevated iron and IgA concentration in serum, and ultimately higher litter weaning and pre-weaning survival rate.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"94 ","pages":"Article 106978"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145462584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment with chorionic gonadotropins during lactation inhibits post-weaning estrus expression in sows","authors":"Arthur Martelli ,&nbsp;Monike Willemin Quirino ,&nbsp;Michele Dezordi Franz ,&nbsp;Vanessa Peripolli ,&nbsp;Fabiana Moreira ,&nbsp;Bernardo Garziera Gasperin ,&nbsp;Rafael da Rosa Ulguim ,&nbsp;Vilceu Bordignon ,&nbsp;Thomaz Lucia Jr ,&nbsp;Ivan Bianchi","doi":"10.1016/j.domaniend.2025.106977","DOIUrl":"10.1016/j.domaniend.2025.106977","url":null,"abstract":"<div><div>This study evaluated the efficiency of protocols using two different dosages of eCG and hCG administered during lactation to delay post-weaning estrus expression in sows. Sixty-two sows were selected on D-14 (D0 = weaning) and allocated to one of three treatments: Control (<em>n</em> = 20; saline administration on D-7 and D-4); 500 IU (<em>n</em> = 21; 500 IU eCG on D-7 and 500 IU hCG on D-4); and 1000 IU (<em>n</em> = 21; 1000 IU eCG on D-7 and 1000 IU hCG on D-4). Estrus detection was performed twice daily after weaning, and blood samples were collected on D-7, D-1, D+6, and D+13. On D+15, the sows were slaughtered for ovarian evaluation. The percentage of sows detected in estrus post-weaning was greater in the Control group (90.0%) compared to the 500 IU (23.8%) and 1000 IU (9.5%) groups (<em>P</em> &lt; 0.01). The proportion of sows with corpus hemorrhagicum and/or corpus luteum and the total number of corpora lutea at slaughter were similar among treatments (<em>P</em> ≥ 0.41). On D+6, serum progesterone (P4) concentration was lower in the Control group than those in the 500 IU and 1000 IU groups (<em>P</em> &lt; 0.01). Administration of 500 or 1000 IU of eCG and hCG during lactation effectively induced the formation of corpora lutea and sustained high serum P4 levels for at least 13 d post-weaning, thereby inhibiting estrus expression in 76 to 90 % of treated sows.</div></div>","PeriodicalId":11356,"journal":{"name":"Domestic animal endocrinology","volume":"94 ","pages":"Article 106977"},"PeriodicalIF":2.1,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}