Diabetes & metabolism最新文献

{"title":"The transformative role of artificial intelligence in diabetes care and research","authors":"Dulce Canha , Charline Bour , Sara Barraud , Gloria Aguayo , Guy Fagherazzi","doi":"10.1016/j.diabet.2024.101565","DOIUrl":"10.1016/j.diabet.2024.101565","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101565"},"PeriodicalIF":4.6,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141794487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of different types of hypertensive disorders of pregnancy and their duration on incident post-partum risk of diabetes mellitus: Results from the French nationwide study CONCEPTION","authors":"Grégory Lailler ,&nbsp;Sandrine Fosse-Edorh ,&nbsp;Elodie Lebreton ,&nbsp;Nolwenn Regnault ,&nbsp;Catherine Deneux-Tharaux ,&nbsp;Vassilis Tsatsaris ,&nbsp;Geneviève Plu-Bureau ,&nbsp;Sandrine Kretz ,&nbsp;Jacques Blacher ,&nbsp;Valérie Olie","doi":"10.1016/j.diabet.2024.101564","DOIUrl":"10.1016/j.diabet.2024.101564","url":null,"abstract":"<div><h3>Aims</h3><p>To evaluate the impact of onset time, duration, and severity of various types of hypertensive disorders of pregnancy (HDP) on the risk of incident DM.</p></div><div><h3>Methods</h3><p>We used data from the ongoing French nationwide prospective cohort study CONCEPTION. We included all primiparous women in CONCEPTION who delivered between 2010 and 2018 (<em>n</em> = 2,816,793 women). Follow-up spanned from childbirth to 31 December 2021. HDP and incident DM onset during follow-up were identified using algorithms combining ICD-10 coded diagnoses during hospitalization and/or medication dispensing. We used Cox models to assess the associations between incident DM and preexisting chronic hypertension, gestational hypertension (GH), and various phenotypes of pre-eclampsia.</p></div><div><h3>Results</h3><p>Pre-eclampsia and GH alone occurred in 2.6 % and 4.6 % of the population, respectively. During follow-up (mean = 4.5 years), 16,670 women had incident DM. The cumulative incidences of DM were 15.8 % and 1.8 % in women who had pre-eclampsia during pregnancy with and without concomitant gestational diabetes, respectively. The risk of DM was higher after HDP (all types) irrespective of gestational diabetes status during pregnancy. In women without gestational diabetes, compared with those who had no HDP, the risk of incident DM was higher in women who had GH (adjusted hazard ratio, aHR = 1.97 [1.81–2.16]), pre-eclampsia (aHR = 2.42 [2.21–2.65]), and preexisting chronic hypertension prior to pregnancy (aHR = 3.35 [3.03–3.70]). Pre-eclampsia duration was significantly associated with a higher risk of DM.</p></div><div><h3>Conclusion</h3><p>Women who experienced an HDP had twice the risk of developing DM. Early blood glucose assessment and blood pressure monitoring should be more widely recommended after HDP diagnosis.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101564"},"PeriodicalIF":4.6,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141768420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of NAFLD, MAFLD, and MASLD: NHANES 1999-2018","authors":"Jie Pan ,&nbsp;Feilong Wu ,&nbsp;Mingtao Chen ,&nbsp;Jinsen He ,&nbsp;Yingying Gu ,&nbsp;Lei Pei ,&nbsp;Xuye Lai ,&nbsp;Zhenfeng Zhang ,&nbsp;Lili Yang","doi":"10.1016/j.diabet.2024.101562","DOIUrl":"10.1016/j.diabet.2024.101562","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 6","pages":"Article 101562"},"PeriodicalIF":4.6,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of nudge strategy-based dietary education intervention in patients with type 2 diabetes mellitus: A cluster randomized controlled trial","authors":"","doi":"10.1016/j.diabet.2024.101563","DOIUrl":"10.1016/j.diabet.2024.101563","url":null,"abstract":"<div><h3>Objectives</h3><p>We aimed to assess the clinical effects of dietary education intervention utilizing the nudge strategy in individuals with type 2 diabetes mellitus (T2DM).</p></div><div><h3>Background</h3><p>The global prevalence of T2DM and its associated complications presents a significant health challenge. While the benefits of dietary education intervention for blood glucose management are widely acknowledged, patients often struggle to adhere to dietary recommendations. The implementation of the nudge strategy may offer a promising solution to change unhealthy dietary behavior and enhance diabetes control among individuals with T2DM.</p></div><div><h3>Methods</h3><p>This is a sub-study within a broader cluster-randomized trial that evaluated the effects of nudge-based dietary education and traditional dietary education intervention. Measurements of HbA1c, fasting blood glucose (FBG), body mass index (BMI), blood lipid levels, blood pressure, dietary behavior, and diabetes distress were assessed at baseline and 3 months after the intervention in 147 individuals with T2DM from six primary care practices in Beijing, China.</p></div><div><h3>Results</h3><p>All outcome measurements were complete at two time points for 134 participants. Results showed that compared to the control group, the intervention group achieved a significantly greater reduction in HbA1c, FBG, BMI, total cholesterol, low-density lipoprotein cholesterol, blood pressure, total energy intake, carbohydrate intake, fat intake, and protein intake and had lower diabetes distress. The intervention group also maintained HDL-C levels and had a significantly greater increase in vegetable intake, while changes in triglycerides were similar in the two groups.</p></div><div><h3>Conclusion</h3><p>The present study provides evidence that nudge strategy-based dietary education intervention is effective in improving blood glucose, BMI, blood lipid levels, and blood pressure and facilitating changes in patients' dietary behavior and diabetes distress. These findings suggest that implementing nudge strategies can contribute to the optimization of T2DM dietary management and overall patient well-being.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101563"},"PeriodicalIF":4.6,"publicationDate":"2024-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Different effects of bariatric surgery on epigenetic plasticity in skeletal muscle of individuals with and without type 2 diabetes","authors":"Leona Kovac ,&nbsp;Sofiya Gancheva ,&nbsp;Markus Jähnert ,&nbsp;Ratika Sehgal ,&nbsp;Lucia Mastrototaro ,&nbsp;Matthias Schlensak ,&nbsp;Frank A. Granderath ,&nbsp;Kilian Rittig ,&nbsp;Michael Roden ,&nbsp;Annette Schürmann ,&nbsp;Sabine Kahl ,&nbsp;Meriem Ouni","doi":"10.1016/j.diabet.2024.101561","DOIUrl":"10.1016/j.diabet.2024.101561","url":null,"abstract":"<div><h3>Aim</h3><p>Bariatric surgery is highly effective for the treatment of obesity in individuals without (OB<span>¹</span>) and in those with type 2 diabetes (T2D<span>²</span>). However, whether bariatric surgery triggers similar or distinct molecular changes in OB and T2D remains unknown. Given that individuals with type 2 diabetes often exhibit more severe metabolic deterioration, we hypothesized that bariatric surgery induces distinct molecular adaptations in skeletal muscle, the major site of glucose uptake, of OB and T2D after surgery-induced weight loss.</p></div><div><h3>Methods</h3><p>All participants (OB, <em>n</em> = 13; T2D, <em>n</em> = 13) underwent detailed anthropometry before and one year after the surgery. Skeletal muscle biopsies were isolated at both time points and subjected to transcriptome and methylome analyses using a comprehensive bioinformatic pipeline.</p></div><div><h3>Results</h3><p>Before surgery, T2D had higher fasting glucose and insulin levels but lower whole-body insulin sensitivity, only glycemia remained higher in T2D than in OB after surgery. Surgery-mediated weight loss affected different subsets of genes with 2,013 differentially expressed in OB and 959 in T2D. In OB differentially expressed genes were involved in insulin, PPAR signaling and oxidative phosphorylation pathways, whereas ribosome and splicesome in T2D. LASSO regression analysis revealed distinct candidate genes correlated with improvement of phenotypic traits in OB and T2D. Compared to OB, DNA methylation was less affected in T2D in response to bariatric surgery. This may be due to increased global hydroxymethylation accompanied by decreased expression of one of the type 2 diabetes risk gene, <em>TET2</em>, encoding a demethylation enzyme in T2D.</p></div><div><h3>Conclusion</h3><p>OB and T2D exhibit differential skeletal muscle transcriptome responses to bariatric surgery, presumably resulting from perturbed epigenetic flexibility.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101561"},"PeriodicalIF":4.6,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1262363624000533/pdfft?md5=b5f28bd399a0921a59de3602b28d6f98&pid=1-s2.0-S1262363624000533-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141560677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measuring phosphate levels in diabetic ketoacidosis: A sacred cow?","authors":"","doi":"10.1016/j.diabet.2024.101559","DOIUrl":"10.1016/j.diabet.2024.101559","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101559"},"PeriodicalIF":4.6,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141539146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive factors, genetic susceptibility and risk of type 2 diabetes: A prospective cohort study","authors":"Gaojie Fan,&nbsp;Qing Liu,&nbsp;Jianing Bi,&nbsp;Xiya Qin,&nbsp;Qing Fang,&nbsp;Fei Luo,&nbsp;Xiaofeng Huang,&nbsp;Heng Li,&nbsp;Youjie Wang,&nbsp;Lulu Song","doi":"10.1016/j.diabet.2024.101560","DOIUrl":"10.1016/j.diabet.2024.101560","url":null,"abstract":"<div><h3>Aim</h3><p>To explore the relationships of multiple reproductive factors with type 2 diabetes mellitus (T2DM) risk and the joint effects of reproductive factors and genetic susceptibility.</p></div><div><h3>Methods</h3><p>We included 262,368 women without prevalent T2DM from the UK biobank. Cox proportional hazards regression models were employed to estimate the relationships of reproductive factors with T2DM risk and the joint effects of reproductive factors and genetic susceptibility.</p></div><div><h3>Results</h3><p>During a mean follow-up of 12.2 years, 8,996 T2DM cases were identified. Early menarche (&lt;12 years, hazard ratio (HR) 1.08 [95 % confidence interval (CI) 1.02;1.13]), late menarche (≥15 years, HR 1.11 [1.04;1.17]), early menopause (&lt;45 years, HR 1.20 [1.12;1.29]), short reproductive lifespan (&lt;30 years, HR 1.25 [1.16;1.35]), hysterectomy (1.31, HR [1.23;1.40]), oophorectomy (HR 1.28 [1.20;1.36]), high parity (≥4, HR 1.25 [1.17;1.34]), early age at first live birth (&lt;20 years, HR 1.23 [1.16;1.31]), miscarriage (HR 1.13 [1.07;1.19]), stillbirth (HR 1.14 [1.03;1.27]), and ever used hormonal replacement therapy (HR 1.19 [1.14;1.24]) were related to a higher T2DM risk, while ever used oral contraceptives (HR 0.93 [0.89;0.98]) was related to a lower T2DM risk. Furthermore, women with reproductive risk factors and high genetic risk had the highest T2DM risk compared to those with low genetic risk and without reproductive risk factors.</p></div><div><h3>Conclusion</h3><p>Our findings show that multiple reproductive factors are related to T2DM risk, particularly in women with high genetic risk.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101560"},"PeriodicalIF":4.6,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations of dietary magnesium intake with the risk of atherosclerotic cardiovascular disease and mortality in individuals with and without type 2 diabetes: A prospective study in the UK Biobank","authors":"Ruyu Huang ,&nbsp;Xinxin Kong ,&nbsp;Rui Geng ,&nbsp;Jingwei Wu ,&nbsp;Jiong Li ,&nbsp;Yong Gu ,&nbsp;Yaqian Wu ,&nbsp;Dongfang You ,&nbsp;Yang Zhao ,&nbsp;Senmiao Ni ,&nbsp;Zihang Zhong ,&nbsp;Jianling Bai","doi":"10.1016/j.diabet.2024.101554","DOIUrl":"10.1016/j.diabet.2024.101554","url":null,"abstract":"<div><h3>Background</h3><p>The association between dietary magnesium (Mg) intake and the risk of atherosclerotic cardiovascular disease (ASCVD) remains uncertain. We aimed to examine the associations of dietary Mg intake with the risk of ASCVD events and mortality in individuals with and without type 2 diabetes.</p></div><div><h3>Methods</h3><p>A total of 149,929 participants (4603 with type 2 diabetes) from the UK Biobank were included in the analyses. The hazard ratios (HRs) and 95 % confidence intervals (CIs) were estimated using Cox proportional hazard models. Furthermore, interactions of dietary Mg intake with type 2 diabetes status were examined on multiplicative and additive scales.</p></div><div><h3>Results</h3><p>During a median follow-up of 12.0 and 12.1 years, 7811 incident ASCVD events and 5000 deaths (including 599 ASCVD deaths) were documented, respectively. There were significantly negative associations between sufficient dietary Mg intake (equal to or greater than the recommended daily intake) and the risk of ASCVD incidence (HR 0.63 [95 % CI 0.49;0.82]), ASCVD mortality (0.45 [0.24;0.87]), and all-cause mortality (0.71 [0.52;0.97]) in participants with type 2 diabetes, whereas no significant association was observed in participants without type 2 diabetes (1.01 [0.94;1.09] for ASCVD incidence; 1.25 [0.93;1.66] for ASCVD mortality; 0.97 [0.88;1.07] for all-cause mortality). Multiplicative and additive interactions of dietary Mg intake with type 2 diabetes status were both observed.</p></div><div><h3>Conclusion</h3><p>Sufficient dietary Mg intake was significantly associated with lower risks of ASCVD events and mortality in individuals with type 2 diabetes but not in those without type 2 diabetes. Our findings provide insight into the importance of dietary Mg intake for reducing modifiable cardiovascular burden in individuals with type 2 diabetes, which may inform future personalized dietary guidelines.</p></div>","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101554"},"PeriodicalIF":4.6,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141478281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is plasma 16:0 ceramide a marker of cardiovascular risk?","authors":"","doi":"10.1016/j.diabet.2024.101553","DOIUrl":"10.1016/j.diabet.2024.101553","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 6","pages":"Article 101553"},"PeriodicalIF":4.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Averaged glycaemic variability or by average: More than a simple question of wording","authors":"Louis Monnier ,&nbsp;Claude Colette ,&nbsp;Fabrice Bonnet","doi":"10.1016/j.diabet.2024.101550","DOIUrl":"10.1016/j.diabet.2024.101550","url":null,"abstract":"","PeriodicalId":11334,"journal":{"name":"Diabetes & metabolism","volume":"50 5","pages":"Article 101550"},"PeriodicalIF":4.6,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141474392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}